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Nutrition and Cancer Volume 40, 2001 - Issue 2
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Original Articles

Dose-Dependent Promotion by Phenylethyl Isothiocyanate, a Known Chemopreventer, of Two-Stage Rat Urinary Bladder and Liver Carcinogenesis

Kumiko Ogawa
,
Masao Hirose
,
Satoshi Sugiura
,
Lin Cui
,
Katsumi Imaida
,
Tadashi Ogiso
&
Tomoyuki Shirai
 show all
Pages 134-139 | Published online: 18 Nov 2009

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Costas Ioannides & Nattaya Konsue. (2015) A principal mechanism for the cancer chemopreventive activity of phenethyl isothiocyanate is modulation of carcinogen metabolism. Drug Metabolism Reviews 47:3, pages 356-373.
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Anna Minarini, Andrea Milelli, Carmela Fimognari, Elena Simoni, Eleonora Turrini & Vincenzo Tumiatti. (2014) Exploring the effects of isothiocyanates on chemotherapeutic drugs. Expert Opinion on Drug Metabolism & Toxicology 10:1, pages 25-38.
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Chantey R. Morris, Sheng C. Chen, Lin Zhou, Lawrence M. Schopfer, Xinxin Ding & Sidney S. Mirvish. (2004) Inhibition by Allyl Sulfides and Phenethyl Isothiocyanate of Methyl-n-pentylnitrosamine Depentylation by Rat Esophageal Microsomes, Human and Rat CYP2E1, and Rat CYP2A3. Nutrition and Cancer 48:1, pages 54-63.
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Kazushi Okazaki, Megumi Yamagishi, Hwa-Young Son, Takayoshi Imazawa, Fumio Furukawa, Hideaki Nakamura, Akiyoshi Nishikawa, Toshiaki Masegi & Masao Hirose. (2002) Simultaneous Treatment With Benzyl Isothiocyanate, a Strong Bladder Promoter, Inhibits Rat Urinary Bladder Carcinogenesis by N-Butyl-N-(4-Hydroxybutyl)Nitrosamine. Nutrition and Cancer 42:2, pages 211-216.
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Articles from other publishers (28)

Takeshi Toyoda & Kumiko Ogawa. (2022) Early detection of urinary bladder carcinogens in rats by immunohistochemistry for γ-H2AX: a review from analyses of 100 chemicals. Journal of Toxicologic Pathology 35:4, pages 283-298.
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Takanori Yamada, Takeshi Toyoda, Kohei Matsushita, Young-Man Cho, Jun-ichi Akagi, Tomomi Morikawa, Yasuko Mizuta & Kumiko Ogawa. (2020) Expression of stem cell markers as useful complementary factors in the early detection of urinary bladder carcinogens by immunohistochemistry for γ-H2AX. Archives of Toxicology 95:2, pages 715-726.
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Yuanyuan Zhu, Shuiping Liu, Sisi Yan, Ji Wang, Linyu Zhang, Xin LI, Lixin Wen & Jing Wu. (2019) Phenylethyl isothiocyanate induces oxidative damage of porcine kidney cells mediated by reactive oxygen species. Journal of Biochemical and Molecular Toxicology 34:2.
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Tomhiro Mastuo, Yasuyoshi Miyata, Tsutomu Yuno, Yuta Mukae, Asato Otsubo, Kensuke Mitsunari, Kojiro Ohba & Hideki Sakai. (2020) Molecular Mechanisms of the Anti-Cancer Effects of Isothiocyanates from Cruciferous Vegetables in Bladder Cancer. Molecules 25:3, pages 575.
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Shuiping Liu, Yuanyuan Zhu, Sisi Yan, Haisi Xiao, Jine Yi, Rongfang Li, Jing Wu & Lixin Wen. (2019) Phenethyl isothiocyanate induces IPEC-J2 cells cytotoxicity and apoptosis via S-G2/M phase arrest and mitochondria-mediated Bax/Bcl-2 pathway. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 226, pages 108574.
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Mizuki Sone, Takeshi Toyoda, Young‐Man Cho, Jun‐ichi Akagi, Kohei Matsushita, Yasuko Mizuta, Tomomi Morikawa, Akiyoshi Nishikawa & Kumiko Ogawa. (2019) Immunohistochemistry of γ‐H2AX as a method of early detection of urinary bladder carcinogenicity in mice. Journal of Applied Toxicology 39:6, pages 868-876.
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Taku Naiki, Aya Naiki-Ito, Keitaro Iida, Toshiki Etani, Hiroyuki Kato, Shugo Suzuki, Yoriko Yamashita, Noriyasu Kawai, Takahiro Yasui & Satoru Takahashi. (2018) GPX2 promotes development of bladder cancer with squamous cell differentiation through the control of apoptosis. Oncotarget 9:22, pages 15847-15859.
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Young-Man Cho, Mai Hasumura, Toshio Imai, Shigeaki Takami, Akiyoshi Nishikawa & Kumiko Ogawa. (2017) Horseradish extract promotes urinary bladder carcinogenesis when administered to F344 rats in drinking water. Journal of Applied Toxicology 37:7, pages 853-862.
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Isamu Suzuki, Young-Man Cho, Tadashi Hirata, Takeshi Toyoda, Jun-ichi Akagi, Yasushi Nakamura, Azusa Sasaki, Takako Nakamura, Shigehisa Okamoto, Koji Shirota, Noboru Suetome, Akiyoshi Nishikawa & Kumiko Ogawa. (2017) Toxic effects of 4-methylthio-3-butenyl isothiocyanate ( Raphasatin ) in the rat urinary bladder without genotoxicity . Journal of Applied Toxicology 37:4, pages 485-494.
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Hirokazu Tachibana, Min Gi, Minoru Kato, Shotaro Yamano, Masaki Fujioka, Anna Kakehashi, Yukiyoshi Hirayama, Yuki Koyama, Satoshi Tamada, Tatsuya Nakatani & Hideki Wanibuchi. (2017) Carbonic anhydrase 2 is a novel invasion-associated factor in urinary bladder cancers. Cancer Science 108:3, pages 331-337.
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Takeshi Toyoda, Young-Man Cho, Jun-Ichi Akagi, Yasuko Mizuta, Tadashi Hirata, Akiyoshi Nishikawa & Kumiko Ogawa. (2015) Early Detection of Genotoxic Urinary Bladder Carcinogens by Immunohistochemistry for γ-H2AX. Toxicological Sciences 148:2, pages 400-408.
Crossref
Omkara L. Veeranki, Arup Bhattacharya, Li Tang, James R. Marshall & Yuesheng Zhang. (2015) Cruciferous Vegetables, Isothiocyanates, and Prevention of Bladder Cancer. Current Pharmacology Reports 1:4, pages 272-282.
Crossref
Gaurav Kumar, Hardeep Singh Tuli, Sonam Mittal, Jitendra Kumar Shandilya, Anil Tiwari & Sardul Singh Sandhu. (2015) Isothiocyanates: a class of bioactive metabolites with chemopreventive potential. Tumor Biology 36:6, pages 4005-4016.
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Robert Tisserand & Rodney Young. 2014. Essential Oil Safety. Essential Oil Safety 483 647 .
S. V. Singh & K. Singh. (2012) Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research. Carcinogenesis 33:10, pages 1833-1842.
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Anna A. Powolny, Ajay Bommareddy & Shivendra V. Singh. 2012. Nutraceuticals and Cancer. Nutraceuticals and Cancer 231 258 .
Evelyn Lamy, Catharina Crößmann, Adal Saeed, Peter R. Schreiner, Mike Kotke & Volker Mersch‐Sundermann. (2009) Three structurally homologous isothiocyanates exert “Janus” characteristics in human HepG2 cells. Environmental and Molecular Mutagenesis 50:3, pages 164-170.
Crossref
Christopher D. Mann, Christopher P. Neal, Giuseppe Garcea, Margaret M. Manson, Ashley R. Dennison & David P. Berry. (2009) Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis. European Journal of Cancer Prevention 18:1, pages 13-25.
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. (2008) Flavouring Group Evaluation 38 (FGE.38) 3‐Butenyl isothiocyanate ‐ Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food. EFSA Journal 6:10.
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Shigeyuki Sugie, Pham Quang Vinh, K.M. Wahidur Rahman, Jun Ushida, Hiroyuki Kohno, Rikako Suzuki, Akira Hara, Le Bach Quang, Takuji Tanaka & Hideki Mori. (2005) Suppressive effect of 1,4-phenylene diisothiocyanate onN-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice. International Journal of Cancer 117:4, pages 524-530.
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J. Li, S. Yao & Y. Zhang. (2005) The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates. Food and Chemical Toxicology 43:9, pages 1373-1380.
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Yuesheng Zhang, Jun Li & Li Tang. (2005) Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress. Free Radical Biology and Medicine 38:1, pages 70-77.
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Yuesheng Zhang. (2004) Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 555:1-2, pages 173-190.
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Li Tang & Yuesheng Zhang. (2004) Dietary Isothiocyanates Inhibit the Growth of Human Bladder Carcinoma Cells. The Journal of Nutrition 134:8, pages 2004-2010.
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Kazushi Okazaki, Takashi Umemura, Takayoshi Imazawa, Akiyoshi Nishikawa, Toshiaki Masegi & Masao Hirose. (2005) Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine in rats after initiation. Cancer Science 94:11, pages 948-952.
Crossref
Keisuke Akagi, Masashi Sano, Kumiko Ogawa, Masao HiroseHideo Goshima & Tomoyuki Shirai. (2016) Involvement of Toxicity as an Early Event in Urinary Bladder Carcinogenesis Induced by Phenethyl Isothiocyanate, Benzyl Isothiocyanate, and Analogues in F344 Rats. Toxicologic Pathology 31:4, pages 388-396.
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