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Original Articles

Z-Ajoene Induces Apoptosis of HL-60 Cells: Involvement of Bcl-2 Cleavage

Pages 241-247 | Published online: 18 Nov 2009

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Roger Hunter , Catherine Kaschula, Nashia Stellenboom, Jonathan Cotton & M. Iqbal Parker. (2013) New Excursions Into the Synthesis and Medicinal Chemistry of the Disulfide Bond. Phosphorus, Sulfur, and Silicon and the Related Elements 188:11, pages 1497-1507.
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Wolf Bat-Chen, Tal Golan, Irena Peri, Zvi Ludmer & Betty Schwartz. (2010) Allicin Purified From Fresh Garlic Cloves Induces Apoptosis in Colon Cancer Cells Via Nrf2. Nutrition and Cancer 62:7, pages 947-957.
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Sheng‐Yuan Chen, Chien‐Chih Chiu, Chun‐Tzu Hung, Wen‐Hsiung Pan, Yen‐Chun Chen, Yung‐Ding Bow, Wan‐Ju Li, Sheng‐Kai Hsu, I‐Ling Lin, Zhi‐Hong Wen & Chang‐Yi Wu. (2023) Diphenyl disulfide potentiates the apoptosis of breast cancer cells through Bax proteolytic activation with accompanying autophagy. Environmental Toxicology 38:8, pages 2022-2030.
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Nagarjuna Reddy Desam & Abdul Jabbar Al-Rajab. 2022. Herbal Biomolecules in Healthcare Applications. Herbal Biomolecules in Healthcare Applications 435 474 .
Danielle De Greef, Emily M. Barton, Elise N. Sandberg, Courtney R. Croley, Joshua Pumarol, Tin Lok Wong, Niranjan Das & Anupam Bishayee. (2021) Anticancer potential of garlic and its bioactive constituents: A systematic and comprehensive review. Seminars in Cancer Biology 73, pages 219-264.
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Silvia Buonvino, Matteo Ciocci, Dror Seliktar & Sonia Melino. (2021) Photo-Polymerization Damage Protection by Hydrogen Sulfide Donors for 3D-Cell Culture Systems Optimization. International Journal of Molecular Sciences 22:11, pages 6095.
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Mahshad Sarvizadeh, Omid Hasanpour, Zari Naderi Ghale-Noie, Samaneh Mollazadeh, Mohammad Rezaei, Hossein Pourghadamyari, Mohammadjaber Masoud Khooy, Michael Aschner, Haroon Khan, Nima Rezaei, Layla Shojaie & Hamed Mirzaei. (2021) Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities. Frontiers in Oncology 11.
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Bartosz Jędrzejewski, Mateusz Musiejuk, Justyna Doroszuk & Dariusz Witt. (2021) Convenient Synthesis of Functionalized Unsymmetrical Vinyl Disulfides and Their Inverse Electron-Demand Hetero-Diels-Alder Reaction. Materials 14:6, pages 1342.
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Emilia Di Giovanni, Silvia Buonvino, Ivano Amelio & Sonia Melino. (2020) Glutathione–Allylsulfur Conjugates as Mesenchymal Stem Cells Stimulating Agents for Potential Applications in Tissue Repair. International Journal of Molecular Sciences 21:5, pages 1638.
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Mateusz Musiejuk, Justyna Doroszuk, Bartosz Jędrzejewski, Gregory Ortiz Nieto, Marisol Marin Navarro & Dariusz Witt. (2019) Diastereoselective Synthesis of Z‐Alkenyl Disulfides from α‐Thiophosphorylated Ketones and Thiosulfonates. Advanced Synthesis & Catalysis 362:3, pages 618-626.
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Rama Rao Malla. 2020. Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers. Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers 119 139 .
M. Musiejuk, J. Doroszuk & D. Witt. (2018) Convenient and efficient synthesis of functionalized unsymmetrical Z -alkenyl disulfanes . RSC Advances 8:18, pages 9718-9722.
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Irfan Ahmad Ansari, Imran Khan, Mohd Salman Khan & Mohd Sayeed Akhtar. 2017. Anticancer Plants: Clinical Trials and Nanotechnology. Anticancer Plants: Clinical Trials and Nanotechnology 253 272 .
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Alak Manna, Subrata Chattopadhyay & Mitali Chatterjee. 2016. 81 129 .
Ajay Bommareddy, Adam L. VanWert, Dan F. McCune, Sarah L. Brozena, Zbigniew Witczak & Shivendra V. Singh. 2016. Critical Dietary Factors in Cancer Chemoprevention. Critical Dietary Factors in Cancer Chemoprevention 111 152 .
M. Dvořáková, I. Weingartová, J. Nevoral, D. Němeček & T. Krejčová. (2015) Garlic Sulfur Compounds Suppress Cancerogenesis and Oxidative Stress: a Review. Scientia Agriculturae Bohemica 46:2, pages 65-72.
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T. K. LimT. K. Lim. 2015. Edible Medicinal and Non Medicinal Plants. Edible Medicinal and Non Medicinal Plants 210 360 .
Catherine H. Kaschula, Roger Hunter, Nashia Stellenboom, Mino R. Caira, Susan Winks, Thozama Ogunleye, Philip Richards, Jonathan Cotton, Kani Zilbeyaz, Yabing Wang, Vuyolwethu Siyo, Ellen Ngarande & M. Iqbal Parker. (2012) Structure–activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells. European Journal of Medicinal Chemistry 50, pages 236-254.
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Dušica Ilić, Ivan S. Ristić, Ljubiša Nikolić, Mihajlo Stanković, Goran Nikolić, Ljiljana Stanojević & Vesna Nikolić. (2011) Characterization and Release Kinetics of Allylthiosufinate and its Transforments from Poly(d,l-Lactide) Microspheres. Journal of Polymers and the Environment 20:1, pages 80-87.
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Dušica Ilić, Vesna Nikolić, Mihajlo Stanković, Ljubiša Nikolić, Ljiljana Stanojević, Ivana Mladenović-Ranisavljević & Andrija Šmelcerović. (2012) Transformation of Synthetic Allicin: The Influence of Ultrasound, Microwaves, Different Solvents and Temperatures, and the Products Isolation. The Scientific World Journal 2012, pages 1-7.
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Brigitte Czepukojc, Thomas Schneider, Torsten Burkholz, Vincent Jamier & Claus Jacob. 2012. Natural compounds as inducers of cell death. Natural compounds as inducers of cell death 293 327 .
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Anna Herman-Antosiewicz, Anna Kawiak & Jędrzej Antosiewicz. 2011. Evidence-based Anticancer Materia Medica. Evidence-based Anticancer Materia Medica 193 223 .
Karam El-Bayoumy, Raghu Sinha, Arthur J.L. Cooper & John T. Pinto. 2011. Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention. Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention 91 121 .
Kyeong Lee, Ok-Kyoung Kwon, Yan Xia & Kyung-Seop Ahn. (2010) Effect of AC-264, a Novel Indole Derivative, on Apoptosis in HL-60 Cells. Bulletin of the Korean Chemical Society 31:12, pages 3777-3781.
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Catherine H. Kaschula, Roger Hunter & M. Iqbal Parker. (2010) Garlic‐derived anticancer agents: Structure and biological activity of ajoene. BioFactors 36:1, pages 78-85.
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Bharat B. Aggarwal, Michelle E. Van Kuiken, Laxmi H. Iyer, Kuzhuvelil B. Harikumar & Bokyung Sung. (2009) Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis. Experimental Biology and Medicine 234:8, pages 825-849.
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C. Scherer, C. Jacob, M. Dicato & M. Diederich. (2009) Potential role of organic sulfur compounds from Allium species in cancer prevention and therapy. Phytochemistry Reviews 8:2, pages 349-368.
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Claudia Cerella, Christiane Scherer, Silvia Cristofanon, Estelle Henry, Awais Anwar, Corinna Busch, Mathias Montenarh, Mario Dicato, Claus Jacob & Marc Diederich. (2009) Cell cycle arrest in early mitosis and induction of caspase-dependent apoptosis in U937 cells by diallyltetrasulfide (Al2S4). Apoptosis 14:5, pages 641-654.
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Carmela Fimognari, Monia Lenzi & Patrizia Hrelia. (2009) Apoptosis induction by sulfur‐containing compounds in malignant and nonmalignant human cells. Environmental and Molecular Mutagenesis 50:3, pages 171-189.
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Anna A. Powolny & Shivendra V. Singh. (2008) Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds. Cancer Letters 269:2, pages 305-314.
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Roger Hunter, Catherine H. Kaschula, Iqbal M. Parker, Mino R. Caira, Philip Richards, Susan Travis, Francois Taute & Thozama Qwebani. (2008) Substituted ajoenes as novel anti-cancer agents. Bioorganic & Medicinal Chemistry Letters 18:19, pages 5277-5279.
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Anna HERMAN-ANTOSIEWICZ, Anna A POWOLNY & Shivendra V SINGH. (2007) Molecular targets of cancer chemoprevention by garlic-derived organosulfides. Acta Pharmacologica Sinica 28:9, pages 1355-1364.
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Jerome Terrasson, Bo Xu, Min Li, Sophie Allart, Jean-Luc Davignon, Li-he Zhang, Kui Wang & Christian Davrinche. (2007) Activities of Z-ajoene against tumour and viral spreading in vitro. Fundamental & Clinical Pharmacology 21:3, pages 281-289.
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Bo-Young Park, Byung-Sun Min, Kyung-Seop Ahn, Ok-Kyong Kwon, Hyouk Joung, Ki-Hwan Bae, Hyeong-Kyu Lee & Sei-Ryang Oh. (2007) Daphnane diterpene esters isolated from flower buds of Daphne genkwa induce apoptosis in human myelocytic HL-60 cells and suppress tumor growth in Lewis lung carcinoma (LLC)-inoculated mouse model. Journal of Ethnopharmacology 111:3, pages 496-503.
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Peter Rose, Matt Whiteman, Philip K. Moore & Yi Zhun Zhu. (2005) Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents. Natural Product Reports 22:3, pages 351.
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Anna Herman-Antosiewicz & Shivendra V. Singh. (2004) Signal transduction pathways leading to cell cycle arrest and apoptosis induction in cancer cells by Allium vegetable-derived organosulfur compounds: a review. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 555:1-2, pages 121-131.
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H.T Hassan. (2004) Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy. Leukemia Research 28:7, pages 667-671.
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Bo Xu, Bernard Monsarrat, Jean Edouard Gairin & Elisabeth Girbal-Neuhauser. (2004) Effect of ajoene, a natural antitumor small molecule, on human 20S proteasome activity in vitro and in human leukemic HL60 cells. Fundamental and Clinical Pharmacology 18:2, pages 171-180.
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Eliades Ledezma, Rafael Apitz-Castro & José Cardier. (2004) Apoptotic and anti-adhesion effect of ajoene, a garlic derived compound, on the murine melanoma B16F10 cells: possible role of caspase-3 and the α4β1 integrin. Cancer Letters 206:1, pages 35-41.
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Alexander Gosslau & Kuang Yu Chen. (2004) Nutraceuticals, apoptosis, and disease prevention. Nutrition 20:1, pages 95-102.
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