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Original Articles

Effects of Bowman-Birk Inhibitor on Rat Colon Carcinogenesis

Pages 174-186 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Blanca Hernández-Ledesma & Chia-Chien Hsieh. (2017) Chemopreventive role of food-derived proteins and peptides: A review. Critical Reviews in Food Science and Nutrition 57:11, pages 2358-2376.
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PamelaJ. Magee, Richard Owusu-Apenten, MarkJ. McCann, ChrisI. Gill & IanR. Rowland. (2012) Chickpea (Cicer arietinum) and Other Plant-Derived Protease Inhibitor Concentrates Inhibit Breast and Prostate Cancer Cell Proliferation In Vitro. Nutrition and Cancer 64:5, pages 741-748.
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Susanne Andres, Klaus Abraham, Klaus Erich Appel & Alfonso Lampen. (2011) Risks and benefits of dietary isoflavones for cancer. Critical Reviews in Toxicology 41:6, pages 463-506.
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BrianD. Kineman, E. Charles Brummer, NancyL. Paiva & DianeF. Birt. (2010) Resveratrol From Transgenic Alfalfa for Prevention of Aberrant Crypt Foci in Mice. Nutrition and Cancer 62:3, pages 351-361.
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Articles from other publishers (46)

M. S. Cid-Gallegos, L. J. Corzo-Ríos, C. Jiménez-Martínez & X. M. Sánchez-Chino. (2022) Protease Inhibitors from Plants as Therapeutic Agents- A Review. Plant Foods for Human Nutrition 77:1, pages 20-29.
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Faruk Toklu, Debjyoti Sen Gupta, Tolga Karaköy & Hakan Özkan. 2021. Breeding for Enhanced Nutrition and Bio-Active Compounds in Food Legumes. Breeding for Enhanced Nutrition and Bio-Active Compounds in Food Legumes 229 245 .
Agata Gitlin-Domagalska, Aleksandra Maciejewska & Dawid Dębowski. (2020) Bowman-Birk Inhibitors: Insights into Family of Multifunctional Proteins and Peptides with Potential Therapeutical Applications. Pharmaceuticals 13:12, pages 421.
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Leydianne Leite de Siqueira Patriota, Dalila de Brito Marques Ramos, Angela Caroline Lima Amorim dos Santos, Yasmym Araújo Silva, Mariana Gama e Silva, Diego José Lira Torres, Thamara Figueiredo Procópio, Alisson Macário de Oliveira, Luana Cassandra Breitenbach Barroso Coelho, Emmanuel Viana Pontual, Diego César Nunes da Silva, Patrícia Maria Guedes Paiva, Vírginia Maria Barros de Lorena, Rosemairy Luciane Mendes & Thiago Henrique Napoleão. (2020) Antitumor activity of Moringa oleifera (drumstick tree) flower trypsin inhibitor (MoFTI) in sarcoma 180-bearing mice. Food and Chemical Toxicology 145, pages 111691.
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Samuel Fernández‐Tomé & Blanca Hernández‐Ledesma. (2020) Gastrointestinal Digestion of Food Proteins under the Effects of Released Bioactive Peptides on Digestive Health. Molecular Nutrition & Food Research 64:21, pages 2000401.
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Xi Chen, Dong Chen, Linyuan Huang, Xiaoling Chen, Mei Zhou, Xinping Xi, Chengbang Ma, Tianbao Chen & Lei Wang. (2020) Identification and Target-Modification of SL-BBI: A Novel Bowman–Birk Type Trypsin Inhibitor from Sylvirana latouchii. Biomolecules 10:9, pages 1254.
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Marcos Aurélio de Santana, William de Castro Borges, Alessandra de Paula Carli, Larissa Lovatto Amorin, Alexandre Gonçalves Santos, Sonaly Cristine Leal & Milton Hércules Guerra de Andrade. 2020. Nuts and Seeds in Health and Disease Prevention. Nuts and Seeds in Health and Disease Prevention 51 65 .
E. I. Finkina, D. N. Melnikova, I. V. Bogdanov & T. V. Ovchinnikova. (2019) Peptides of the Innate Immune System of Plants. Part II. Biosynthesis, Biological Functions, and Possible Practical Applications. Russian Journal of Bioorganic Chemistry 45:2, pages 55-65.
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Diego Elias Honda, João Batista Lopes Martins, Manuel Mateus Ventura, Saltuk Mustafa Eyrilmez, Martin Lepšík, Pavel Hobza, Adam Pecina & Sonia Maria de Freitas. (2018) Interface Interactions of the Bowman-Birk Inhibitor BTCI in a Ternary Complex with Trypsin and Chymotrypsin Evaluated by Semiempirical Quantum Mechanical Calculations. European Journal of Organic Chemistry 2018:37, pages 5203-5211.
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Peng Lyu, Lilin Ge, Rui Ma, Ran Wei, Cian M. McCrudden, Tianbao Chen, Chris Shaw & Hang Fai Kwok. (2018) Identification and pharmaceutical evaluation of novel frog skin-derived serine proteinase inhibitor peptide–PE-BBI (Pelophylax esculentus Bowman-Birk inhibitor) for the potential treatment of cancer. Scientific Reports 8:1.
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Anthony F Juritsch & Régis Moreau. (2018) Role of soybean-derived bioactive compounds in inflammatory bowel disease. Nutrition Reviews 76:8, pages 618-638.
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Taihua Mu, Hongnan Sun, Miao Zhang & Cheng Wang. 2017. Sweet Potato Processing Technology. Sweet Potato Processing Technology 49 119 .
Sandhya Srikanth & Zhong Chen. (2016) Plant Protease Inhibitors in Therapeutics-Focus on Cancer Therapy. Frontiers in Pharmacology 7.
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Caroline M. Forrest, Kara McNair, Maria C. J. Vincenten, L. Gail Darlington & Trevor W. Stone. (2016) Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer. BMC Cancer 16:1.
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A.I.G. Lima, J. Mota, S.A.V.S. Monteiro & R.M.S.B. Ferreira. (2016) Legume seeds and colorectal cancer revisited: Protease inhibitors reduce MMP-9 activity and colon cancer cell migration. Food Chemistry 197, pages 30-38.
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M. Carmen Arques, Silvia Pastoriza, Cristina Delgado-Andrade, Alfonso Clemente & José A. Rufián-Henares. (2016) Relationship between Glycation and Polyphenol Content and the Bioactivity of Selected Commercial Soy Milks. Journal of Agricultural and Food Chemistry 64:8, pages 1823-1830.
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R. P. Srivastava. 2016. Biofortification of Food Crops. Biofortification of Food Crops 333 348 .
M. Carmen Arques, M. Carmen Marín-Manzano, L. Clarissa Brito da Rocha, Blanca Hernandez-Ledesma, Isidra Recio & Alfonso Clemente. (2014) Quantitative determination of active Bowman-Birk isoinhibitors, IBB1 and IBBD2, in commercial soymilks. Food Chemistry 155, pages 24-30.
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Alfonso Clemente. (2014) Bowman-Birk inhibitors from legumes as colorectal chemopreventive agents. World Journal of Gastroenterology 20:30, pages 10305.
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LIQUN XIE, YANMIN ZHENG, XUAN LI, JUNYAN ZHAO, XIAOYI CHEN, LI CHEN, JING ZHOU, OU HAI & FEI LI. (2012) Enhanced proliferation of human hepatoma cells by PAR-2 agonists via the ERK/AP-1 pathway. Oncology Reports 28:5, pages 1665-1672.
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Alfonso Clemente, M. Carmen Marín-Manzano, Elisabeth Jiménez, M. Carmen Arques & Claire Domoney. (2012) The anti-proliferative effect of TI1B, a major Bowman–Birk isoinhibitor from pea ( Pisum sativum L.), on HT29 colon cancer cells is mediated through protease inhibition . British Journal of Nutrition 108:S1, pages S135-S144.
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Mercedes Muzquiz, Alejandro Varela, Carmen Burbano, Carmen Cuadrado, Eva Guillamón & Mercedes M. Pedrosa. (2012) Bioactive compounds in legumes: pronutritive and antinutritive actions. Implications for nutrition and health. Phytochemistry Reviews 11:2-3, pages 227-244.
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Alessandra de Paula Carli, Paula Melo de Abreu Vieira, Karina Taciana Santos Silva, Renata Guerra de Sá Cota, Cláudia Martins Carneiro, William Castro-Borges & Milton Hércules Guerra de Andrade. (2012) Bowman-Birk inhibitors, proteasome peptidase activities and colorectal pre neoplasias induced by 1,2-dimethylhydrazine in Swiss mice. Food and Chemical Toxicology 50:5, pages 1405-1412.
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Vermont P. Dia & Elvira Gonzalez de Mejia. (2010) Lunasin promotes apoptosis in human colon cancer cells by mitochondrial pathway activation and induction of nuclear clusterin expression. Cancer Letters 295:1, pages 44-53.
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Elvira Gonzalez de Mejia & Vermont P. Dia. (2010) The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells. Cancer and Metastasis Reviews 29:3, pages 511-528.
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Pasqua Caccialupi, Luigi R. Ceci, Rosa A. Siciliano, Domenico Pignone, Alfonso Clemente & Gabriella Sonnante. (2010) Bowman-Birk inhibitors in lentil: Heterologous expression, functional characterisation and anti-proliferative properties in human colon cancer cells. Food Chemistry 120:4, pages 1058-1066.
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Lucia Lioi, Incoronata Galasso, Maria Gloria Daminati & Angela Rosa Piergiovanni. (2009) Inhibitory properties and binding loop polymorphism in Bowman-Birk inhibitors from Phaseolus species. Genetic Resources and Crop Evolution 57:4, pages 533-542.
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Alfonso Clemente, Francisco Javier Moreno, Maria del Carmen Marín‐Manzano, Elisabeth Jiménez & Claire Domoney. (2010) The cytotoxic effect of Bowman–Birk isoinhibitors, IBB1 and IBBD2, from soybean ( Glycine max ) on HT29 human colorectal cancer cells is related to their intrinsic ability to inhibit serine proteases . Molecular Nutrition & Food Research 54:3, pages 396-405.
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Ann R. Kennedy. (2009) FACTORS THAT MODIFY RADIATION-INDUCED CARCINOGENESIS. Health Physics 97:5, pages 433-445.
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Incoronata Galasso, Angela Rosa Piergiovanni, Lucia Lioi, Bruno Campion, Roberto Bollini & Francesca Sparvoli. (2009) Genome organization of Bowman–Birk inhibitor in common bean (Phaseolus vulgaris L.). Molecular Breeding 23:4, pages 617-624.
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M. Carmen Marín-Manzano, Raquel Ruiz, Elisabeth Jiménez, Luis A. Rubio & Alfonso Clemente. (2008) Anti-carcinogenic soyabean Bowman–Birk inhibitors survive faecal fermentation in their active form and do not affect the microbiota composition in vitro . British Journal of Nutrition 101:7, pages 967-971.
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Bradley W. Bolling & Kirk L. Parkin. (2008) Phenolic Derivatives from Soy Flour Ethanol Extract Are Potent In Vitro Quinone Reductase (QR) Inducing Agents. Journal of Agricultural and Food Chemistry 56:22, pages 10473-10480.
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Alfonso Clemente, Elisabeth Jimenez, M Carmen Marin-Manzano & Luis A Rubio. (2008) Active Bowman–Birk inhibitors survive gastrointestinal digestion at the terminal ileum of pigs fed chickpea-based diets. Journal of the Science of Food and Agriculture 88:3, pages 513-521.
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Kentaro Iwaki, Kohei Shibata, Masayuki Ohta, Yuichi Endo, Hiroki Uchida, Masayuki Tominaga, Ryoki Okunaga, Seiichiro Kai & Seigo Kitano. (2007) A small interfering RNA targeting proteinase‐activated receptor‐2 is effective in suppression of tumor growth in a Panc1 xenograft model. International Journal of Cancer 122:3, pages 658-663.
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Blanca Hernández-LedesmaBen O. De Lumen. (2008) Lunasin: A Novel Cancer Preventive Seed Peptide. Perspectives in Medicinal Chemistry 2, pages PMC.S372.
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Alfonso Clemente, Jennifer M. Gee, Ian T. Johnson, Donald A. MacKenzie & Claire Domoney. (2005) Pea ( Pisum sativum L.) Protease Inhibitors from the Bowman−Birk Class Influence the Growth of Human Colorectal Adenocarcinoma HT29 Cells in Vitro . Journal of Agricultural and Food Chemistry 53:23, pages 8979-8986.
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Wenyi Wang & Elvira Gonzalez de Mejia. (2005) A New Frontier in Soy Bioactive Peptides that May Prevent Age-related Chronic Diseases. Comprehensive Reviews in Food Science and Food Safety 4:4, pages 63-78.
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Yifan Mao, Cindy Lai, Gudrun Vogtentanz, Brian Schmidt, Tony Day, Jeff Miller, David L. Brandon & Dan Chen. (2005) Monoclonal Antibodies Against Soybean Bowman-Birk Inhibitor Recognize the Protease-Reactive Loops. The Protein Journal 24:5, pages 275-282.
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Hiroshi Kobayashi, Yoichi Fukuda, Ryuji Yoshida, Yasufumi Kanada, Setsuko Nishiyama, Mika Suzuki, Naohiro Kanayama & Toshihiko Terao. (2004) Suppressing effects of dietary supplementation of soybean trypsin inhibitor on spontaneous, experimental and peritoneal disseminated metastasis in mouse model. International Journal of Cancer 112:3, pages 519-524.
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Hiba A. Bawadi, Tania Maria Antunes, Fred Shih & Jack N. Losso. (2004) In Vitro Inhibition of the Activation of Pro-matrix Metalloproteinase 1 (Pro-MMP-1) and Pro-matrix Metalloproteinase 9 (Pro-MMP-9) by Rice and Soybean Bowman−Birk Inhibitors. Journal of Agricultural and Food Chemistry 52:15, pages 4730-4736.
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Dalila Darmoul, Valérie Gratio, Hélène Devaud & Marc Laburthe. (2004) Protease-activated Receptor 2 in Colon Cancer. Journal of Biological Chemistry 279:20, pages 20927-20934.
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Ju-Yuan Guo, Xiaosong Li, Jimmy D. BrowningJr.Jr., Ruth S. MacDonald, George E. Rottinghaus, Dennis B. Lubahn, Andreas Constantinou & Maurice Bennink. (2004) Dietary Soy Isoflavones and Estrone Protect Ovariectomized ERαKO and Wild-Type Mice from Carcinogen-Induced Colon Cancer. The Journal of Nutrition 134:1, pages 179-182.
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