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Original Articles

Antitumor Activity of Extract of Zingiber aromaticum and Its Bioactive Sesquiterpenoid Zerumbone

Pages 218-225 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Biswabhusan Dash, Ambika Sahoo, Asit Ray, Sudipta Jena, Sweta Prusty, Javed Akhtar, Pratap Chandra Panda & Sanghamitra Nayak. (2022) Zingiber zerumbet Rhizome Essential Oil Induces Cytotoxicity, Apoptosis and Cell Cycle Arrest in Jurkat Cells. Journal of Essential Oil Bearing Plants 25:3, pages 639-650.
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Wafda Rohhimi, Ji Wei Tan, Kong Yen Liew, Alain Jacquet, Hanis Hazeera Harith, Daud Ahmad Israf & Chau Ling Tham. (2021) Zerumbone attenuates house dust mite extract-induced epithelial barrier dysfunction in 16HBE14o- cells. Immunopharmacology and Immunotoxicology 43:6, pages 813-824.
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Aswani Ravi, Saji Varghese & Radhakrishnan Edayileveetil Krishnankutty. (2017) Biocontrol activity of the extract prepared from Zingiber zerumbet for the management of rhizome rot in Zingiber officinale caused by Pythium myriotylum. Archives of Phytopathology and Plant Protection 50:11-12, pages 555-567.
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Virendra S. Rana, Vivek Ahluwalia, Najam A. Shakil & Lakshman Prasad. (2017) Essential oil composition, antifungal, and seedling growth inhibitory effects of zerumbone from Zingiber zerumbet Smith. Journal of Essential Oil Research 29:4, pages 320-329.
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K.R. Ajish, K.A. Antu, M.P. Riya, M.R. Preetharani, K.G. Raghu, B.P. Dhanya & K.V. Radhakrishnan. (2015) Studies on α-glucosidase, aldose reductase and glycation inhibitory properties of sesquiterpenes and flavonoids of Zingiber zerumbet Smith. Natural Product Research 29:10, pages 947-952.
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Aqeela Afzal, Ghalib Oriqat, M. Akram Khan, Jacquilion Jose & Mohammad Afzal. (2013) Chemistry and Biochemistry of Terpenoids from Curcuma and Related Species. Journal of Biologically Active Products from Nature 3:1, pages 1-55.
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Julie Triolet, Ahmad Ali Shaik, DanielD. Gallaher, MichaelG. O’Sullivan & Chengguo Xing. (2012) Reduction in Colon Cancer Risk by Consumption of Kava or Kava Fractions in Carcinogen-Treated Rats. Nutrition and Cancer 64:6, pages 838-846.
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Bharat B Aggarwal, Haruyo Ichikawa, Prachi Garodia, Priya Weerasinghe, Gautam Sethi, Indra D Bhatt, Manoj K Pandey, Shishir Shishodia & Muraleedharan G Nair. (2006) From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Expert Opinion on Therapeutic Targets 10:1, pages 87-118.
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Articles from other publishers (86)

Muhammed Amanat, Swati Gautam, Rishabh Chalotra, Kanhaiya Lal, Tanya Gupta, Rohini Agrawal, Somdutt Mojwar & Randhir Singh. (2023) Zingiber roseum Roscoe. (Zingiberaceae): Current and future perspective. Pharmacological Research - Modern Chinese Medicine 7, pages 100258.
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N. Divyashree, S. Poojashree, S. Venukumar & Y.C. Vishwanath. 2023. Ginger - Cultivation and Use. Ginger - Cultivation and Use.
Shana Wuken, Junjun Li, Xiaoli Gao, Shungang Jiao, Xiaojing Ma, Suyile Chen, Pengfei Tu, Luqi Huang & Xingyun Chai. (2023) Zerumbone, a major sesquiterpene from Syringa pinnatifolia Hemsl., exerts the sedative effect by regulating GABAergic nervous system. Journal of Ethnopharmacology 301, pages 115813.
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Mity Thambi & Tom Cherian. 2023. Natural Product Experiments in Drug Discovery. Natural Product Experiments in Drug Discovery 505 520 .
Débora Berbel Lirio Rondina, Luan Vitor Alves de Lima, Matheus Felipe da Silva, Thalita Alves Zanetti, Ingrid Felicidade, Lilian Areal Marques, Giuliana Castello Coatti & Mario Sergio Mantovani. (2022) Differential mRNA expression in the induction of DNA damage, G2/M arrest, and cell death by zerumbone in HepG2/C3A cells. Toxicology in Vitro 85, pages 105474.
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Yanling Ai, Ziyi Zhao, Hengyi Wang, Xiaomei Zhang, Weihan Qin, Yanlei Guo, Maoyuan Zhao, Jianyuan Tang, Xiao Ma & Jinhao Zeng. (2022) Pull the plug: Anti‐angiogenesis potential of natural products in gastrointestinal cancer therapy. Phytotherapy Research 36:9, pages 3371-3393.
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Mohanan Biji, Bernard Prabha, Ravi S. Lankalapalli & Kokkuvayil Vasu Radhakrishnan. (2021) Transition Metal/Lewis Acid Catalyzed Reactions of Zerumbone for Diverse Molecular Motifs. The Chemical Record 21:12, pages 3943-3953.
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Janet Jia Yin Tan, Joash Ban Lee Tan & Yau Yan Lim. (2020) Identification of bioactive cytotoxic compound of red button ginger extracted by solvent fractionation. Journal of Food Processing and Preservation 45:2.
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Kumar Rajendran, Divya Dharmaraj, Madhuri Krishnamoorthy, Kannan Karuppiah & Kannapiran Ethiraj. 2021. Nanomedicine Manufacturing and Applications. Nanomedicine Manufacturing and Applications 321 335 .
Margherita Sonnessa, Antonella Cioffi, Oronzo Brunetti, Nicola Silvestris, Francesco A. Zito, Concetta Saponaro & Anita Mangia. (2020) NLRP3 Inflammasome From Bench to Bedside: New Perspectives for Triple Negative Breast Cancer. Frontiers in Oncology 10.
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Irina I. Kapustina, Tatyana N. Makarieva, Alla G. Guzii, Anatoly I. Kalinovsky, Roman S. Popov, Sergey A. Dyshlovoy, Boris B. Grebnev, Gunhild von Amsberg & Valentin A. Stonik. (2020) Leptogorgins A–C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp.. Marine Drugs 18:6, pages 310.
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Mohammad Jalili-Nik, Mohammad Montazami Sadeghi, Elmira Mohtashami, Hamid Mollazadeh, Amir R. Afshari & Amirhossein Sahebkar. (2020) Zerumbone Promotes Cytotoxicity in Human Malignant Glioblastoma Cells through Reactive Oxygen Species (ROS) Generation. Oxidative Medicine and Cellular Longevity 2020, pages 1-9.
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Hai Jiang, Xue-jiao Wang, Liu Yang, Jia-Xu Zhang, A-Jiao Hou, Wen-Jing Man, Song Wang, Bing-You Yang, Kelvin Chan, Qiu-Hong Wang & Hai-Xue Kuang. (2020) The fruits of Xanthium sibiricum Patr: A review on phytochemistry, pharmacological activities, and toxicity. World Journal of Traditional Chinese Medicine 6:4, pages 408.
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Sosmitha Girisa, Bano Shabnam, Javadi Monisha, Lu Fan, Clarissa Halim, Frank Arfuso, Kwang Ahn, Gautam Sethi & Ajaikumar Kunnumakkara. (2019) Potential of Zerumbone as an Anti-Cancer Agent. Molecules 24:4, pages 734.
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Sahba Jafarian, King‐Hwa Ling, Zurina Hassan, Lua Perimal‐Lewis, Mohd Roslan Sulaiman & Enoch Kumar Perimal. (2019) Effect of zerumbone on scopolamine‐induced memory impairment and anxiety‐like behaviours in rats. Alzheimer's & Dementia: Translational Research & Clinical Interventions 5:1, pages 637-643.
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V Kurnianda, A Mardiah, S Karina, S Agustina, M Ulfah, C Octavina, F Syahliza, M R Ramadhan, S Purnawan & V Kurnianda. (2018) Inhibitory of PANC-1 produced by Indonesian’s Marine Sponge Endectyon delaubenfelsi Adapted to Nutrient Starvation. IOP Conference Series: Earth and Environmental Science 216, pages 012032.
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Salam Pradeep Singh, Ningthoujam Indrajit Singh, Khumukcham Nongalleima, Pradip Doley, Chingakham Brajakishor Singh & Dinabandhu Sahoo. (2018) Molecular docking, MD simulation, DFT and ADME-toxicity study on analogs of zerumbone against IKK-β enzyme as anti-cancer agents. Network Modeling Analysis in Health Informatics and Bioinformatics 7:1.
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Hitoshi Nakamoto, Yosuke Amaya, Taiwa Komatsu, Takehiro Suzuki, Naoshi Dohmae, Yusuke Nakamura, Ibrahim Jantan & Yoshihiko Miyata. (2018) Stimulation of the ATPase activity of Hsp90 by zerumbone modification of its cysteine residues destabilizes its clients and causes cytotoxicity. Biochemical Journal 475:15, pages 2559-2576.
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Thomas Sithara, B. P. Dhanya, K. B. Arun, Suresh Sini, Mathew Dan, Radhakrishnan Kokkuvayil Vasu & P. Nisha. (2018) Zerumbone, a Cyclic Sesquiterpene from Zingiber zerumbet Induces Apoptosis, Cell Cycle Arrest, and Antimigratory Effects in SW480 Colorectal Cancer Cells . Journal of Agricultural and Food Chemistry 66:3, pages 602-612.
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Jun-ichiro Hattan, Kazutoshi Shindo, Tetsuya Sasaki & Norihiko Misawa. (2018) Isolation and Functional Characterization of New Terpene Synthase Genes from Traditional Edible Plants. Journal of Oleo Science 67:10, pages 1235-1246.
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Nur Syafinaz Zainal, Chai Phei Gan, Beng Fye Lau, Pei San Yee, Kai Hung Tiong, Zainal Ariff Abdul Rahman, Vyomesh Patel & Sok Ching Cheong. (2018) Zerumbone targets the CXCR4-RhoA and PI3K-mTOR signaling axis to reduce motility and proliferation of oral cancer cells. Phytomedicine 39, pages 33-41.
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Ali Ghasemzadeh, Hawa Z. E. Jaafar, Asmah Rahmat & Mallappa Kumara Swamy. (2017) Optimization of microwave-assisted extraction of zerumbone from Zingiber zerumbet L. rhizome and evaluation of antiproliferative activity of optimized extracts. Chemistry Central Journal 11:1.
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Katayoon Kalantari, Mona Moniri, Amin Boroumand Moghaddam, Raha Abdul Rahim, Arbakariya Bin Ariff, Zahra Izadiyan & Rosfarizan Mohamad. (2017) A Review of the Biomedical Applications of Zerumbone and the Techniques for Its Extraction from Ginger Rhizomes. Molecules 22:10, pages 1645.
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Greeshma Gopalan, Bhandara Purayil Dhanya, Jayaram Saranya, Thankappan Remadevi Reshmitha, Thekke Veettil Baiju, Murugan Thulasi Meenu, Mangalam S. Nair, Prakasan Nisha & Kokkuvayil Vasu Radhakrishnan. (2017) Metal-Free trans -Aziridination of Zerumbone: Synthesis and Biological Evaluation of Aziridine Derivatives of Zerumbone . European Journal of Organic Chemistry 2017:21, pages 3072-3077.
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S.C. Santosh Kumar, P.S. Negi, J.R. Manjunatha & B.K. Bettadaiah. (2017) Synthesis, antibacterial and antimutagenic activity of zerumbone-bicarbonyl analogues. Food Chemistry 221, pages 576-581.
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Md. Areeful Haque, Ibrahim Jantan, Laiba Arshad & Syed Nasir Abbas Bukhari. (2017) Exploring the immunomodulatory and anticancer properties of zerumbone. Food & Function 8:10, pages 3410-3431.
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Marimuthu Govindarajan, Mohan Rajeswary, Subramanian Arivoli, Samuel Tennyson & Giovanni Benelli. (2016) Larvicidal and repellent potential of Zingiber nimmonii (J. Graham) Dalzell (Zingiberaceae) essential oil: an eco-friendly tool against malaria, dengue, and lymphatic filariasis mosquito vectors?. Parasitology Research 115:5, pages 1807-1816.
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Mei-Ling Chan, Jui-Wei Liang, Lih-Ching Hsu, Wei-Ling Chang, Shoei-Sheng Lee & Jih-Hwa Guh. (2015) Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult. Naunyn-Schmiedeberg's Archives of Pharmacology 388:11, pages 1223-1236.
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Louisi de Oliveira, Diogo Tschoeke, Aline de Oliveira, Lilian Hill, Wladimir Paradas, Leonardo Salgado, Cristiane Thompson, Renato Pereira & Fabiano Thompson. (2015) New Insights on the Terpenome of the Red Seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta). Marine Drugs 13:2, pages 879-902.
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Ju-Hyung ParkGeun Mook ParkJin-Kyung Kim. (2015) Zerumbone, Sesquiterpene Photochemical from Ginger, Inhibits Angiogenesis. The Korean Journal of Physiology & Pharmacology 19:4, pages 335.
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Thing-Fong Tzeng, Hung-Jen Lu, Shorong-Shii Liou, Chia Ju Chang & I-Min Liu. (2014) Lipid-lowering effects of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, in high-fat diet-induced hyperlipidemic hamsters. Food and Chemical Toxicology 69, pages 132-139.
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Iyyappan Rajan, Remitha Rabindran, N. Nithya, T. Lakshmipriya, P. R. Jayasree & P. R. M. Kumar. (2014) Assessment of cell cycle phase-specific effects of zerumbone on mitotically synchronous surface cultures of Physarum polycephalum. Protoplasma 251:4, pages 931-941.
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KEN TSUBOI, YOICHI MATSUO, TOMOYA SHAMOTO, TAKAHIRO SHIBATA, SHUJI KOIDE, MAMORU MORIMOTO, SUSHOVAN GUHA, BOKYUNG SUNG, BHARAT B. AGGARWAL, HIROKI TAKAHASHI & HIROMITSU TAKEYAMA. (2014) Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer. Oncology Reports 31:1, pages 57-64.
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Harsh Bhatia, Jaspreet Kaur, Shreya Nandi, Vinita Gurnani, Anushua Chowdhury, P. Hemalatha Reddy, Amit Vashishtha & Brijesh Rathi. (2013) A review on Schleichera oleosa: Pharmacological and environmental aspects. Journal of Pharmacy Research 6:1, pages 224-229.
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Hsing-Yu Weng, Ming-Jen Hsu, Ching-Chung Wang, Bing-Chang Chen, Chuang-Ye Hong, Mei-Chieh Chen, Wen-Ta Chiu & Chien-Huang Lin. (2012) Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells. Journal of Biomedical Science 19:1.
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Songyan Zhang, Qiaojing Liu, Yanju Liu, Hong Qiao & Yu Liu. (2012) Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine 2012, pages 1-8.
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Fengnian Yu, Sho Okamoto, Hisashi Harada, Kazuhisa Yamasaki, Norihiko Misawa & Ryutaro Utsumi. (2010) Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. Cellular and Molecular Life Sciences 68:6, pages 1033-1040.
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Hui-Chun Hsu, Wen-Chia Yang, Wei-Jern Tsai, Chien-Chih Chen, Hui-Yu Huang & Ying-Chieh Tsai. (2006) α-Bulnesene, a novel PAF receptor antagonist isolated from Pogostemon cablin. Biochemical and Biophysical Research Communications 345:3, pages 1033-1038.
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