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Original Articles

Acyclic Carotenoids and Their Oxidation Mixtures Inhibit the Growth of HL-60 Human Promyelocytic Leukemia Cells

Pages 273-283 | Published online: 18 Nov 2009

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Eiichi Kotake-Nara & Megumi Hase. (2020) Effect of dispersed form on the bioavailability of β-carotene from daily intake in humans. Bioscience, Biotechnology, and Biochemistry 84:12, pages 2545-2557.
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Mareike Kelkel, Marc Schumacher, Mario Dicato & Marc Diederich. (2011) Antioxidant and anti-proliferative properties of lycopene. Free Radical Research 45:8, pages 925-940.
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NikkiA. Ford, AmyC. Elsen, Krystle Zuniga, BrianL. Lindshield & JohnW. Erdman. (2011) Lycopene and Apo-12′-Lycopenal Reduce Cell Proliferation and Alter Cell Cycle Progression in Human Prostate Cancer Cells. Nutrition and Cancer 63:2, pages 256-263.
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Nilesh M. Kalariya, Kota V. Ramana, Satish K. Srivastava & Frederik J. G. M. van Kuijk. (2009) Genotoxic Effects of Carotenoid Breakdown Products in Human Retinal Pigment Epithelial Cells. Current Eye Research 34:9, pages 737-747.
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RichardS. Gunasekera, Kiran Sewgobind, Smruti Desai, Larry Dunn, HomerS. Black, WallaceL. McKeehan & Bhimanagouda Patil. (2007) Lycopene and Lutein Inhibit Proliferation in Rat Prostate Carcinoma Cells. Nutrition and Cancer 58:2, pages 171-177.
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ConradO. Perera & Gan Mei Yen. (2007) Functional Properties of Carotenoids in Human Health. International Journal of Food Properties 10:2, pages 201-230.
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Hyung-Sook Kim, Phyllis Bowen, Longwen Chen, Claudine Duncan, Luna Ghosh, Roohollah Sharifi & Konstantin Christov. (2003) Effects of Tomato Sauce Consumption on Apoptotic Cell Death in Prostate Benign Hyperplasia and Carcinoma. Nutrition and Cancer 47:1, pages 40-47.
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Articles from other publishers (75)

Elena Rodríguez-Rodríguez, Rocío Estévez-Santiago, Milagros Sánchez-Prieto & Begoña Olmedilla-Alonso. (2022) Status and Dietary Intake of Phytoene and Phytofluene in Spanish Adults and the Effect of a Four-Week Dietary Intervention with Lutein-Rich Fruits or Vegetables. Nutrients 14:14, pages 2922.
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Tiago Linus Silva Coelho, Darlisson Slag Neri Silva, Jedaias Marreiros dos Santos Junior, Clecio Dantas, Ana Rita de Araujo Nogueira, Cícero Alves Lopes Júnior & Edivan Carvalho Vieira. (2022) Multivariate optimization and comparison between conventional extraction (CE) and ultrasonic-assisted extraction (UAE) of carotenoid extraction from cashew apple. Ultrasonics Sonochemistry 84, pages 105980.
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Andrew J. Simkin. (2021) Carotenoids and Apocarotenoids in Planta: Their Role in Plant Development, Contribution to the Flavour and Aroma of Fruits and Flowers, and Their Nutraceutical Benefits. Plants 10:11, pages 2321.
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Shlomit Odes-Barth, Marina Khanin, Karin Linnewiel-Hermoni, Yifat Miller, Karina Abramov, Joseph Levy & Yoav Sharoni. (2020) Inhibition of Osteoclast Differentiation by Carotenoid Derivatives through Inhibition of the NF-κB Pathway. Antioxidants 9:11, pages 1167.
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Junrui Cheng, Baxter Miller, Emilio Balbuena & Abdulkerim Eroglu. (2020) Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair. Antioxidants 9:7, pages 643.
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Shenghui Wu, Yanning Liu, Joel E Michalek, Ruben A Mesa, Dorothy Long Parma, Ronald Rodriguez, Ahmed M Mansour, Robert Svatek, Thomas C Tucker & Amelie G Ramirez. (2020) Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis. Advances in Nutrition 11:3, pages 630-643.
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J. Madureira, A. Severino, M. Cojocaru, S. Garofalide, P.M.P. Santos, M.M. Carolino, F.M.A. Margaça & S. Cabo Verde. (2019) E-beam treatment to guarantee the safety and quality of cherry tomatoes. Innovative Food Science & Emerging Technologies 55, pages 57-65.
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Daniela Ribeiro, Marisa Freitas, Artur M.S. Silva, Félix Carvalho & Eduarda Fernandes. (2018) Antioxidant and pro-oxidant activities of carotenoids and their oxidation products. Food and Chemical Toxicology 120, pages 681-699.
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Antonio J. Meléndez-Martínez, Paula Mapelli-Brahm & Carla M. Stinco. (2018) The colourless carotenoids phytoene and phytofluene: From dietary sources to their usefulness for the functional foods and nutricosmetics industries. Journal of Food Composition and Analysis 67, pages 91-103.
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Fabien Havas, Shlomo Krispin, Antonio J. Meléndez-Martínez & Liki von Oppen-Bezalel. (2018) Preliminary Data on the Safety of Phytoene- and Phytofluene-Rich Products for Human Use including Topical Application. Journal of Toxicology 2018, pages 1-8.
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K. Shemesh, M. Zohar, I. Bar-Ya’akov, K. Hatib, D. Holland & T. Isaacson. (2017) Analysis of carotenoids in fruit of different apricot accessions reveals large variability and highlights apricot as a rich source of phytoene and phytofluene. Fruits 72:4, pages 185-202.
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Paula Mapelli-Brahm, Joana Corte-Real, Antonio J. Meléndez-Martínez & Torsten Bohn. (2017) Bioaccessibility of phytoene and phytofluene is superior to other carotenoids from selected fruit and vegetable juices. Food Chemistry 229, pages 304-311.
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Tim J. Wooster, Sean C. Moore, Wei Chen, Helen Andrews, Rama Addepalli, Robert B. Seymour & Simone A. Osborne. (2017) Biological fate of food nanoemulsions and the nutrients they carry – internalisation, transport and cytotoxicity of edible nanoemulsions in Caco-2 intestinal cells. RSC Advances 7:64, pages 40053-40066.
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Bangalore Prabhashankar Arathi, Poorigali Raghavendra-Rao Sowmya, Gini Chempakathinal Kuriakose, Kariyappa Vijay, Vallikannan Baskaran, Chelliah Jayabaskaran & Rangaswamy Lakshminarayana. (2016) Enhanced cytotoxic and apoptosis inducing activity of lycopene oxidation products in different cancer cell lines. Food and Chemical Toxicology 97, pages 265-276.
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Ana Martínez & Antonio J. Melendez-Martínez. (2016) Lycopene, oxidative cleavage derivatives and antiradical activity. Computational and Theoretical Chemistry 1077, pages 92-98.
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Delia B. Rodriguez‐Amaya. 2015. Food Carotenoids. Food Carotenoids 174 198 .
Poorigali Raghavendra-Rao Sowmya, Bangalore Prabhashankar Arathi, Kariyappa Vijay, Vallikannan Baskaran & Rangaswamy Lakshminarayana. (2015) Role of different vehicles in carotenoids delivery and their influence on cell viability, cell cycle progression, and induction of apoptosis in HeLa cells. Molecular and Cellular Biochemistry 406:1-2, pages 245-253.
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Antonio J. Meléndez-Martínez, Paula Mapelli-Brahm, Ana Benítez-González & Carla M. Stinco. (2015) A comprehensive review on the colorless carotenoids phytoene and phytofluene. Archives of Biochemistry and Biophysics 572, pages 188-200.
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Jo-Won Lee, Jihye Son, Kyung-Mi Yoo, Y. Martin Lo & BoKyung Moon. (2014) Characterization of the antioxidant activity of gold@platinum nanoparticles. RSC Advances 4:38, pages 19824.
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Luisa Pozzo, Martina Tarantola, Elena Biasibetti, Maria Teresa Capucchio, Maddalena Pagella, Elisabetta Mellia, Stefania Bergagna, Maria Silvia Gennero, Giuseppe Strazzullo & Achille Schiavone. (2013) Adverse effects in broiler chickens fed a high lycopene concentration supplemented diet. Canadian Journal of Animal Science 93:2, pages 231-241.
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Rangaswamy Lakshminarayana, Gorusupudi Aruna, Upparahalli V. Sathisha, Shylaja M. Dharmesh & Vallikannan Baskaran. (2013) Structural elucidation of possible lutein oxidation products mediated through peroxyl radical inducer 2,2′-Azobis (2-methylpropionamidine) dihydrochloride: Antioxidant and cytotoxic influence of oxidized lutein in HeLa cells. Chemico-Biological Interactions 203:2, pages 448-455.
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John T. Landrum. 2013. Carotenoids and Human Health. Carotenoids and Human Health 57 101 .
Nikki Ford & John W. ErdmanJr.Jr.. 2013. Carotenoids and Human Health. Carotenoids and Human Health 193 214 .
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Yoav Sharoni, Karin Linnewiel-Hermoni, Marina Khanin, Hagar Salman, Anna Veprik, Michael Danilenko & Joseph Levy. (2012) Carotenoids and apocarotenoids in cellular signaling related to cancer: A review. Molecular Nutrition & Food Research 56:2, pages 259-269.
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Nilesh M. Kalariya, Kota V. Ramana, Satish K. Srivastava & Frederik J.G.M. van Kuijk. (2011) Post‐translational protein modification by carotenoid cleavage products. BioFactors 37:2, pages 104-116.
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U Gupta. 2011. What's New About Crop Plants. What's New About Crop Plants 345 377 .
Nancy J. Engelmann, Steven K. Clinton & John W. ErdmanJrJr. (2011) Nutritional Aspects of Phytoene and Phytofluene, Carotenoid Precursors to Lycopene. Advances in Nutrition 2:1, pages 51-61.
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Hsueh-Li Tan, Jennifer M. Thomas-Ahner, Elizabeth M. Grainger, Lei Wan, David M. Francis, Steven J. Schwartz, John W. ErdmanJr.Jr. & Steven K. Clinton. (2010) Tomato-based food products for prostate cancer prevention: what have we learned?. Cancer and Metastasis Reviews 29:3, pages 553-568.
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Subramaniam Pennathur, Dhiman Maitra, Jaeman Byun, Inga Sliskovic, Ibrahim Abdulhamid, Ghassan M. Saed, Michael P. Diamond & Husam M. Abu-Soud. (2010) Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid. Free Radical Biology and Medicine 49:2, pages 205-213.
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Lloyd D. Graham, Stephen J. Danon, Graham Johnson, Carl Braybrook, Noel K. Hart, Russell J. Varley, Margaret D. M. Evans, Gail A. McFarland, Michael J. Tyler, Jerome A. Werkmeister & John A. M. Ramshaw. (2009) Biocompatibility and modification of the protein‐based adhesive secreted by the Australian frog Notaden bennetti . Journal of Biomedical Materials Research Part A 93A:2, pages 429-441.
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Michal Vinkler & Tomáš Albrecht. (2009) Carotenoid maintenance handicap and the physiology of carotenoid-based signalisation of health. Naturwissenschaften 97:1, pages 19-28.
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Nikki Ford & John Erdman. 2009. Lycopene. Lycopene 37 63 .
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Jonathan R Mein, Fuzhi Lian & Xiang-Dong Wang. (2008) Biological activity of lycopene metabolites: implications for cancer prevention. Nutrition Reviews 66:12, pages 667-683.
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Aviv Shaish, Ayelet Harari, Yehuda Kamari, Etienne Soudant, Dror Harats & Ami Ben-Amotz. (2008) A Carotenoid Algal Preparation Containing Phytoene and Phytofluene Inhibited LDL Oxidation In Vitro. Plant Foods for Human Nutrition 63:2, pages 83-86.
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Henry Jackson, Cristi L. Braun & Hansgeorg Ernst. (2008) The Chemistry of Novel Xanthophyll Carotenoids. The American Journal of Cardiology 101:10, pages S50-S57.
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Nilesh M. Kalariya, Kota V. Ramana, Satish K. Srivastava & Frederik J.G.M. van Kuijk. (2008) Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells. Experimental Eye Research 86:1, pages 70-80.
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Delphine Gitenay, Bernard Lyan, Mathieu Rambeau, Andrzej Mazur & Edmond Rock. (2007) Comparison of lycopene and tomato effects on biomarkers of oxidative stress in vitamin E deficient rats. European Journal of Nutrition 46:8, pages 468-475.
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Paola Palozza, Simona Serini, Alma Boninsegna, Diana Bellovino, Massimo Lucarini, Giovanni Monastra & Sancia Gaetani. (2007) The growth-inhibitory effects of tomatoes digested in vitro in colon adenocarcinoma cells occur through down regulation of cyclin D1, Bcl-2 and Bcl-xL. British Journal of Nutrition 98:04.
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Brian L. Lindshield, Kirstie Canene-Adams & John W. ErdmanJr.Jr.. (2007) Lycopenoids: Are lycopene metabolites bioactive?. Archives of Biochemistry and Biophysics 458:2, pages 136-140.
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Eszter Hazai, Zsolt Bikádi, Ferenc Zsila & Samuel F. Lockwood. (2006) Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase. Bioorganic & Medicinal Chemistry 14:20, pages 6859-6867.
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Jessica K. Campbell, Randy B. Rogers, Mary Ann Lila & John W. Erdman. (2006) Biosynthesis of 14 C-Phytoene from Tomato Cell Suspension Cultures ( Lycopersicon esculentum ) for Utilization in Prostate Cancer Cell Culture Studies . Journal of Agricultural and Food Chemistry 54:3, pages 747-755.
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Annika Lindqvist, Yu-Guang He & Stefan Andersson. (2005) Cell Type-specific Expression of β-Carotene 9', 10'-Monooxygenase in Human Tissues. Journal of Histochemistry & Cytochemistry 53:11, pages 1403-1412.
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Ana Lucia dos Anjos Ferreira, Kyung-Jin Yeum, Robert M. Russell, Norman I. Krinsky & Guangwen Tang. (2003) Enzymatic and oxidative metabolites of lycopene☆☆Supported in part by a grant from BASF, by Fundacao para o Desenvolvimento da Unesp, FUNDUNESP, Sao Paulo, SP, Brazil under a contract number 111/2000-DFP, and by the U.S. Department of Agriculture, under agreement No. 581950-9-001. Any opinions, findings, conclusion, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the U.S. Dept of Agriculture.. The Journal of Nutritional Biochemistry 14:9, pages 531-540.
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