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Original Articles

Soyasaponins: The Relationship Between Chemical Structure and Colon Anticarcinogenic Activity

Pages 24-33 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Yu Zhang, Ruojie Hao, Junda Chen, Sen Li, Kai Huang, Hongwei Cao, Mohamed A. Farag, Maurizio Battino, Maria Daglia, Esra Capanoglu, Fan Zhang, Qiqi Sun, Jianbo Xiao, Zhenliang Sun & Xiao Guan. (2023) Health benefits of saponins and its mechanisms: perspectives from absorption, metabolism, and interaction with gut. Critical Reviews in Food Science and Nutrition 0:0, pages 1-22.
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Tingna Li, Xiaorui Zhang, Yijia Zeng, Yuanyuan Ren, Jilin Sun, Renchuan Yao, Yijie Wang, Jin Wang & Qinwan Huang. (2023) Semen Sojae Preparatum as a Traditional Chinese Medicine: Manufacturing Technology, Bioactive Compounds, Microbiology and Medicinal Function. Food Reviews International 39:2, pages 896-921.
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Xariss Sánchez-Chino, Cristian Jiménez-Martínez, Gloria Dávila-Ortiz, Isela Álvarez-González & Eduardo Madrigal-Bujaidar. (2015) Nutrient and Nonnutrient Components of Legumes, and Its Chemopreventive Activity: A Review. Nutrition and Cancer 67:3, pages 401-410.
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Jiading Chen, Suxia Sun, Dingsheng Zha, Jiguo Wu, Limei Mao, Hong Deng, Xinwei Chu, Haiji Luo & Longying Zha. (2014) Soyasaponins Prevent H2O2-Induced Inhibition of Gap Junctional Intercellular Communication by Scavenging Reactive Oxygen Species in Rat Liver Cells. Nutrition and Cancer 66:8, pages 1342-1351.
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Hala Abdel Salam Amin, Atef G. Hanna & Sayeda Saleh Mohamed. (2011) Comparative studies of acidic and enzymatic hydrolysis for production of soyasapogenols from soybean saponin. Biocatalysis and Biotransformation 29:6, pages 311-319.
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Jayadev Raju & Rekha Mehta. (2008) Cancer Chemopreventive and Therapeutic Effects of Diosgenin, a Food Saponin. Nutrition and Cancer 61:1, pages 27-35.
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Theodouli Stergiopoulou, Anthony J De Lucca, Joseph Meletiadis, Tin Sein, Stephen M. Boue, Robert Schaufele, Emmanuel Roilides, Mahmoud Ghannoum & Thomas J. Walsh. (2008) In vitro activity of CAY-1, a saponin from Capsicum frutescens, against Microsporum and Trichophyton species. Medical Mycology 46:8, pages 805-810.
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Özlem Güçlü-Üstündağ & Giuseppe Mazza. (2007) Saponins: Properties, Applications and Processing. Critical Reviews in Food Science and Nutrition 47:3, pages 231-258.
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Manabu WATANABE, Naomi SUMIDA, Koji YANAI & Takeshi MURAKAMI. (2005) Cloning and Characterization of Saponin Hydrolases from Aspergillus oryzae and Eupenicillium brefeldianum . Bioscience, Biotechnology, and Biochemistry 69:11, pages 2178-2185.
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Xuewei Xia, Qianmin Lin, Ning Zhao, Jinzi Zeng, Jiajia Yang, Zhiyuan Liu & Riming Huang. (2022) Anti-Colon Cancer Activity of Dietary Phytochemical Soyasaponin I and the Induction of Metabolic Shifts in HCT116. Molecules 27:14, pages 4382.
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Phillip Johnson, Anna Trybala, Victor Starov & Valerie J. Pinfield. (2021) Effect of synthetic surfactants on the environment and the potential for substitution by biosurfactants. Advances in Colloid and Interface Science 288, pages 102340.
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Javier Donoso-Quezada, Daniel Guajardo-Flores & José González-Valdéz. (2019) Exosomes as nanocarriers for the delivery of bioactive compounds from black bean extract with antiproliferative activity in cancer cell lines. Materials Today: Proceedings 13, pages 362-369.
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Yavuz Yagiz & Liwei Gu. 2019. Health Benefits of Pulses. Health Benefits of Pulses 109 127 .
Zofia Nizioł-Łukaszewska & Tomasz Bujak. (2018) Saponins as Natural Raw Materials for Increasing the Safety of Bodywash Cosmetic Use. Journal of Surfactants and Detergents 21:6, pages 767-776.
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Qunying Xie, Xiangfu Gu, Junbin Chen, Minshun Liu, Fei Xiong, Xinglong Wu, Yajie Zhang, Fengping Chen, Honger Chen, Meijuan Li, Suxia Sun, Xinwei Chu & Longying Zha. (2018) Soyasaponins Reduce Inflammation and Improve Serum Lipid Profiles and Glucose Homeostasis in High Fat Diet‐Induced Obese Mice. Molecular Nutrition & Food Research 62:19.
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Hafiz Mamoon Rehman, Muhammad Amjad Nawaz, Zahid Hussain Shah, Seung Hwan Yang & Gyuhwa Chung. (2018) Functional characterization of naturally occurring wild soybean mutant (sg-5) lacking astringent saponins using whole genome sequencing approach. Plant Science 267, pages 148-156.
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Mo'ez Al-Islam Ezzat Faris & Amita Attlee. 2018. Food Science and Nutrition. Food Science and Nutrition 361 391 .
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Balwinder Singh, Jatinder Pal Singh, Narpinder Singh & Amritpal Kaur. (2017) Saponins in pulses and their health promoting activities: A review. Food Chemistry 233, pages 540-549.
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Dorota Kregiel, Joanna Berlowska, Izabela Witonska, Hubert Antolak, Charalampos Proestos, Mirko Babic, Ljiljana Babic & Bolin Zhang. 2017. Application and Characterization of Surfactants. Application and Characterization of Surfactants.
Ana Lima, Jennifer Oliveira, Filipe Saúde, Joana Mota & Ricardo Ferreira. (2017) Proteins in Soy Might Have a Higher Role in Cancer Prevention than Previously Expected: Soybean Protein Fractions Are More Effective MMP-9 Inhibitors Than Non-Protein Fractions, Even in Cooked Seeds. Nutrients 9:3, pages 201.
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Mo'ez Al-Islam Ezzat Faris & Amita Attlee. 2017. Exploring the Nutrition and Health Benefits of Functional Foods. Exploring the Nutrition and Health Benefits of Functional Foods 42 72 .
Masayoshi Teraishi, Yuka Tojo, Naohiro Yamada & Yutaka Okumoto. (2017) Identification of environmentally stable QTLs controlling Saponin content in <i>Glycine max</i>. Breeding Science 67:2, pages 123-128.
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M. Neacsu, D. McBey & A.M. Johnstone. 2017. Sustainable Protein Sources. Sustainable Protein Sources 359 375 .
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Sachiko Ogasawara, Jun Akiba, Masamichi Nakayama, Hironori Kusano & Hirohisa Yano. (2016) Antiproliferative effect of ME3738, a derivative of soyasapogenol, on hepatocellular carcinoma cell lines in vitro and in vivo. Biomedical Reports 5:6, pages 731-736.
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Vasudeva Reddy Netala, Venkata Subbaiah Kotakadi, Susmila Aparna Gaddam, Sukhendu Bikash Ghosh & Vijaya Tartte. (2016) Elicitation of gymnemic acid production in cell suspension cultures of Gymnema sylvestre R.Br. through endophytic fungi. 3 Biotech 6:2.
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Jang-Eun Lee, So Rim Park & Seong Il Lim. (2016) Mass spectrometry-based metabolomic study of traditional Doenjang effects against hepatic fibrosis. Applied Biological Chemistry 59:5, pages 775-780.
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Zheng Guo, Wei Cao, Shifeng Zhao, Zengtai Han & Boxiang Han. (2016) Protection against 1-methyl-4-phenyl pyridinium-induced neurotoxicity in human neuroblastoma SH-SY5Y cells by Soyasaponin I by the activation of the phosphoinositide 3-kinase/AKT/GSK3β pathway. NeuroReport 27:10, pages 730-736.
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Yajie Zhang, Fengping Chen, Jiading Chen, Suqun Huang, Junbin Chen, Jian Huang, Nan Li, Suxia Sun, Xinwei Chu & Longying Zha. (2016) Soyasaponin Bb inhibits the recruitment of toll-like receptor 4 (TLR4) into lipid rafts and its signaling pathway by suppressing the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent generation of reactive oxygen species. Molecular Nutrition & Food Research 60:7, pages 1532-1543.
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Dayun Zhao. (2016) Challenges associated with elucidating the mechanisms of the hypocholesterolaemic activity of saponins. Journal of Functional Foods 23, pages 52-65.
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Manish K. Patel, Avinash Mishra & Bhavanath Jha. (2016) Non-targeted Metabolite Profiling and Scavenging Activity Unveil the Nutraceutical Potential of Psyllium (Plantago ovata Forsk). Frontiers in Plant Science 7.
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Farhaneen Afzal Mazlan, M. Suffian M. Annuar & Yusrizam Sharifuddin. (2015) Biotransformation of Momordica charantia fresh juice by Lactobacillus plantarum BET003 and its putative anti-diabetic potential . PeerJ 3, pages e1376.
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Isil Yildir&#;m & Turkan Kutlu. (2015) Anticancer Agents: Saponin and Tannin. International Journal of Biological Chemistry 9:6, pages 332-340.
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Pilar Vila-Donat, Celia Fernández-Blanco, Gianni Sagratini, Guillermina Font & María-José Ruiz. (2015) Effects of soyasaponin I and soyasaponins-rich extract on the Alternariol-induced cytotoxicity on Caco-2 cells. Food and Chemical Toxicology 77, pages 44-49.
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Reham Hassan Mekky, María del Mar Contreras, Mohamed Roshdi El-Gindi, Azza R. Abdel-Monem, Essam Abdel-Sattar & Antonio Segura-Carretero. (2015) Profiling of phenolic and other compounds from Egyptian cultivars of chickpea (Cicer arietinum L.) and antioxidant activity: a comparative study. RSC Advances 5:23, pages 17751-17767.
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Cuie Guang, Jie Chen, Shangyuan Sang & Shuiyuan Cheng. (2014) Biological Functionality of Soyasaponins and Soyasapogenols. Journal of Agricultural and Food Chemistry 62:33, pages 8247-8255.
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Mohamed Elbandy, Jung Rae Rho & Raffat Afifi. (2014) Analysis of saponins as bioactive zoochemicals from the marine functional food sea cucumber Bohadschia cousteaui. European Food Research and Technology 238:6, pages 937-955.
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Na Qiao, Qi Liu, He Meng & Dayun Zhao. (2014) Haemolytic activity and adjuvant effect of soyasaponins and some of their derivatives on the immune responses to ovalbumin in mice. International Immunopharmacology 18:2, pages 333-339.
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Nívea D. Fonseca, Marcos Paulo Melo Villar, Carmen Marino Donangelo & Daniel Perrone. (2014) Isoflavones and soyasaponins in soy infant formulas in Brazil: Profile and estimated consumption. Food Chemistry 143, pages 492-498.
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Xiushi Yang, Chuan Dong & Guixing Ren. (2011) Effect of Soyasaponins-Rich Extract from Soybean on Acute Alcohol-Induced Hepatotoxicity in Mice. Journal of Agricultural and Food Chemistry 59:4, pages 1138-1144.
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Simone Rochfort, Vilnis Ezernieks, Nathan Neumann & Joe Panozzo. (2011) Pulses for Human Health: Changes in Isoflavone and Saponin Content with Preparation and Cooking. Australian Journal of Chemistry 64:6, pages 790.
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Wei Zhang & David G. Popovich. (2010) Group B Oleanane Triterpenoid Extract Containing Soyasaponins I and III from Soy Flour Induces Apoptosis in Hep-G2 Cells. Journal of Agricultural and Food Chemistry 58:9, pages 5315-5319.
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John Shi, Sophia Jun Xue, Ying Ma, Dong Li, Yukio Kakuda & Yubin Lan. (2009) Kinetic study of saponins B stability in navy beans under different processing conditions. Journal of Food Engineering 93:1, pages 59-65.
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Jane Hubert, Monique Berger, Françoise Nepveu, François Paul & Jean Daydé. (2008) Effects of fermentation on the phytochemical composition and antioxidant properties of soy germ. Food Chemistry 109:4, pages 709-721.
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Wei Zhang & David G. Popovich. (2008) Effect of Soyasapogenol A and Soyasapogenol B Concentrated Extracts on Hep-G2 Cell Proliferation and Apoptosis. Journal of Agricultural and Food Chemistry 56:8, pages 2603-2608.
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Jie Wu & Tie-qiao Wen. (2008) Evaluating effects of gypenosides and soyasaponins on differentiation of neural stem cells as an in vitro model. Journal of Shanghai University (English Edition) 12:1, pages 91-94.
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Simone Rochfort & Joe Panozzo. (2007) Phytochemicals for Health, the Role of Pulses. Journal of Agricultural and Food Chemistry 55:20, pages 7981-7994.
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Jun-Xia Xiao, Guo-Qing Huang & Sheng-Hua Zhang. (2007) Soyasaponins inhibit the proliferation of Hela cells by inducing apoptosis. Experimental and Toxicologic Pathology 59:1, pages 35-42.
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Jun-Xia Xiao, Guo-Qing Huang, Cai-Ping Zhu, Dan-Dan Ren & Sheng-Hua Zhang. (2007) Morphological study on apoptosis Hela cells induced by soyasaponins. Toxicology in Vitro 21:5, pages 820-826.
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Yiwen Yang, Micong Jin, Mei Huang, Baogen Su & Qilong Ren. (2007) Ultrasound-Assisted Extraction of Soyasaponins from Hypocotyls, and Analysis by LC-ESI-MS. Chromatographia 65:9-10, pages 555-560.
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T.C. JYOTHI, T.C. SINDHU KANYA & A.G. APPU RAO. (2007) INFLUENCE OF GERMINATION ON SAPONINS IN SOYBEAN AND RECOVERY OF SOY SAPOGENOL I. Journal of Food Biochemistry 31:1, pages 1-13.
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Karel Decroos, Jean-Paul Vincken, Gerrit A. van Koningsveld, Harry Gruppen & Willy Verstraete. (2007) Preparative chromatographic purification and surfactant properties of individual soyasaponins from soy hypocotyls. Food Chemistry 101:1, pages 324-333.
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Mark MessinaGeoffrey Redmond. (2006) Effects of Soy Protein and Soybean Isoflavones on Thyroid Function in Healthy Adults and Hypothyroid Patients: A Review of the Relevant Literature. Thyroid 16:3, pages 249-258.
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