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Original Articles

A Pilot Clinical Study of Short-Term Isoflavone Supplements in Breast Cancer Patients

Pages 59-65 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Murphy Lam Yim Wan, Vanessa Anna Co & Hani El-Nezami. (2022) Endocrine disrupting chemicals and breast cancer: a systematic review of epidemiological studies. Critical Reviews in Food Science and Nutrition 62:24, pages 6549-6576.
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Mark Messina, Sonia Blanco Mejia, Aedin Cassidy, Alison Duncan, Mindy Kurzer, Chisato Nagato, Martin Ronis, Ian Rowland, John Sievenpiper & Stephen Barnes. (2022) Neither soyfoods nor isoflavones warrant classification as endocrine disruptors: a technical review of the observational and clinical data. Critical Reviews in Food Science and Nutrition 62:21, pages 5824-5885.
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Susanne Andres, Klaus Abraham, Klaus Erich Appel & Alfonso Lampen. (2011) Risks and benefits of dietary isoflavones for cancer. Critical Reviews in Toxicology 41:6, pages 463-506.
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Mark Messina & Leena Hilakivi-Clarke. (2009) Early Intake Appears to Be the Key to the Proposed Protective Effects of Soy Intake Against Breast Cancer. Nutrition and Cancer 61:6, pages 792-798.
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Articles from other publishers (42)

Melissa D’Ascenzio. 2022. Flavonoids and Phenolics. Flavonoids and Phenolics 384 489 .
Mark Messina, Alison Duncan, Virginia Messina, Heidi Lynch, Jessica Kiel & John W. ErdmanJr.Jr.. (2022) The health effects of soy: A reference guide for health professionals. Frontiers in Nutrition 9.
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Xiaoqi Li, Shuyuan Du, Fangyuan Tian, Minglu Wang, Ying Wang, Hongyan Zhang & Liguo Zang. (2022) Screening of Estrogenic-Disrupting Compounds in Dairy Products Based on the Estrogen Receptor Cocktail. Foods 11:9, pages 1178.
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Maryam Ezzati, Bahman Yousefi, Kobra Velaei & Amin Safa. (2020) A review on anti-cancer properties of Quercetin in breast cancer. Life Sciences 248, pages 117463.
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Jennifer Ahn-Jarvis, Arti Parihar & Andrea Doseff. (2019) Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease. Antioxidants 8:7, pages 202.
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Massimo Romani & Barbara Banelli. 2019. Epigenetics of Cancer Prevention. Epigenetics of Cancer Prevention 395 418 .
Livia S.A. Augustin, Concetta Montagnese, Ilaria Calabrese, Giuseppe Porciello, Elvira Palumbo, Sara Vitale & Stephanie Nishi. 2018. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Rungnapa Boonpawa, Albertus Spenkelink, Ans Punt & Ivonne M C M Rietjens. (2017) In vitro-in silico -based analysis of the dose-dependent in vivo oestrogenicity of the soy phytoestrogen genistein in humans . British Journal of Pharmacology 174:16, pages 2739-2757.
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Mark Messina & Thomas M. Badger. (2017) Health effects of isoflavones misrepresented. Food Chemistry 225, pages 289-292.
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Eric Yarnell. (2017) Phytoestrogens and Estrogen-Sensitive Cancers: Review of the Evidence. Alternative and Complementary Therapies 23:1, pages 25-30.
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Mark Messina. (2016) Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature. Nutrients 8:12, pages 754.
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Andrea Braakhuis, Peta Campion & Karen Bishop. (2016) Reducing Breast Cancer Recurrence: The Role of Dietary Polyphenolics. Nutrients 8:9, pages 547.
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Dominique Chevalier, Christine Debeuf, Gwénaële Joubrel, Martine Kocken & Nadine Planchenault. (2016) Les aliments au soja : consommation en France, qualités nutritionnelles et données scientifiques récentes sur la santé. OCL 23:4, pages D405.
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Mark Messina. (2016) Impact of Soy Foods on the Development of Breast Cancer and the Prognosis of Breast Cancer Patients. Complementary Medicine Research 23:2, pages 75-80.
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P. Kubatka, J. Mojžiš, M. Pilátová, M. Péč & P. Kruzliak. 2016. Critical Dietary Factors in Cancer Chemoprevention. Critical Dietary Factors in Cancer Chemoprevention 213 238 .
Anna H. Wu, Darcy Spicer, Agustin Garcia, Chiu-Chen Tseng, Linda Hovanessian-Larsen, Pulin Sheth, Sue Ellen Martin, Debra Hawes, Christy Russell, Heather MacDonald, Debu Tripathy, Min-Ying Su, Giske Ursin & Malcolm C. Pike. (2015) Double-Blind Randomized 12-Month Soy Intervention Had No Effects on Breast MRI Fibroglandular Tissue Density or Mammographic Density. Cancer Prevention Research 8:10, pages 942-951.
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Maida Taylor. (2015) Complementary and Alternative Approaches to Menopause. Endocrinology and Metabolism Clinics of North America 44:3, pages 619-648.
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A. E Fayed. (2014) Review article: health benefits of some physiologically active ingredients and their suitability as yoghurt fortifiers. Journal of Food Science and Technology 52:5, pages 2512-2521.
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Mark Messina. (2015) Post-Diagnosis Soy Isoflavone Intake Is Not Harmful to Women with Breast Cancer. Breast Diseases: A Year Book Quarterly 26:3, pages 193-197.
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Ifeyinwa E. Obiorah, Ping Fan & V. Craig Jordan. (2014) Breast Cancer Cell Apoptosis with Phytoestrogens Is Dependent on an Estrogen-Deprived State. Cancer Prevention Research 7:9, pages 939-949.
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Mark Messina. (2014) Soy foods, isoflavones, and the health of postmenopausal women. The American Journal of Clinical Nutrition 100, pages 423S-430S.
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Selin Bolca. 2014. Polyphenols in Human Health and Disease. Polyphenols in Human Health and Disease 1241 1256 .
Anna H. WuEunjung LeeCheryl Vigen. (2013) Soy Isoflavones and Breast Cancer. American Society of Clinical Oncology Educational Book:33, pages 102-106.
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Mark Messina, Ian Rowland, Kurt Widhalm, Gwénaële Joubrel, Anna Arnoldi, Nathalie Delzenne & Jean-Michel Lecerf. (2013) Aliments à base de soja et système endocrinien. Pratiques en nutrition 9:34, pages 19-23.
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Ivonne M. C. M. Rietjens, Ana M. Sotoca, Jacques Vervoort & Jochem Louisse. (2012) Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks. Molecular Nutrition & Food Research 57:1, pages 100-113.
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Jae Jeong Yang, Lisa Y. Cho, Kwang-Pil Ko, Seung Hyun Ma, Aesun Shin, Bo Youl Choi, Dong Soo Han, Kyu Sang Song, Yong Sung Kim, Soung-Hoon Chang, Hai-Rim Shin, Daehee Kang, Keun-Young Yoo & Sue K. Park. (2012) Interaction effects between genes involved in the AKT signaling pathway and phytoestrogens in gastric carcinogenesis: A nested case-control study from the Korean Multi-Center Cancer Cohort. Molecular Nutrition & Food Research 56:11, pages 1617-1626.
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Thomas B. Clarkson, Wulf H. Utian, Stephen Barnes, Ellen B. Gold, Shehzad S. Basaria, Takeshi Aso, Fredi Kronenberg, Cara L. Frankenfeld, J. Mark Cline, Britt-Marie Landgren, J. Chris Gallagher, Connie M. Weaver, Howard N. Hodis, Roberta Diaz Brinton & Pauline M. Maki. (2011) The role of soy isoflavones in menopausal health. Menopause 18:7, pages 732-753.
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Dorrah Deeb, Xiaohua Gao, Yongbo Liu, Daniel Jiang, George W. Divine, Ali S. Arbab, Scott A. Dulchavsky & Subhash C. Gautam. (2011) Synthetic triterpenoid CDDO prevents the progression and metastasis of prostate cancer in TRAMP mice by inhibiting survival signaling. Carcinogenesis 32:5, pages 757-764.
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Mark Messina. (2011) Evidence does not support the conclusion that soy is an endocrine disruptor. Journal of Pediatric Endocrinology and Metabolism 24:9-10.
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Jennifer M. Rodenberg & Powel H. Brown. (2009) A Novel Look into Estrogen Receptor–Negative Breast Cancer Prevention with the Natural, Multifunctional Signal Transduction Inhibitor Deguelin. Cancer Prevention Research 2:11, pages 915-918.
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Fazlul H. Sarkar & Yiwei Li. (2009) Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics. Cancer Treatment Reviews 35:7, pages 597-607.
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Christopher K Taylor, Robert M Levy, Jay C Elliott & Bruce P Burnett. (2009) The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies. Nutrition Reviews 67:7, pages 398-415.
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Mark Messina & Anna H Wu. (2009) Perspectives on the soy–breast cancer relation. The American Journal of Clinical Nutrition 89:5, pages 1673S-1679S.
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Mark J Messina & Charles E Wood. (2008) Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary. Nutrition Journal 7:1.
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Marianne Imhof, Sylvia Molzer & Martin Imhof. (2008) Effects of soy isoflavones on 17β-estradiol-induced proliferation of MCF-7 breast cancer cells. Toxicology in Vitro 22:6, pages 1452-1460.
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Louiza S. Velentzis, Jayne V. Woodside, Marie M. Cantwell, Anthony J. Leathem & Mohammed R. Keshtgar. (2008) Do phytoestrogens reduce the risk of breast cancer and breast cancer recurrence? What clinicians need to know. European Journal of Cancer 44:13, pages 1799-1806.
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Mark Messina. (2008) Investigating the Optimal Soy Protein and Isoflavone Intakes for Women: A Perspective. Women's Health 4:4, pages 337-356.
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Gerhard Eisenbrand. (2008) Answer to Dr. Messina's Letter to the Editor. Molecular Nutrition & Food Research 52:6, pages 737-738.
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Mark Messina. (2008) Conclusion that isoflavones exert estrogenic effects on breast tissue and may raise breast cancer risk unfounded. Molecular Nutrition & Food Research 52:2, pages 299-300.
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Krista A. Power & Lilian U. Thompson. (2007) Can the combination of flaxseed and its lignans with soy and its isoflavones reduce the growth stimulatory effect of soy and its isoflavones on established breast cancer?. Molecular Nutrition & Food Research 51:7, pages 845-856.
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Sarah C. Thomasset, David P. Berry, Giuseppe Garcea, Timothy Marczylo, William P. Steward & Andreas J. Gescher. (2007) Dietary polyphenolic phytochemicals—promising cancer chemopreventive agents in humans? A review of their clinical properties. International Journal of Cancer 120:3, pages 451-458.
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Mark Messina. (2006) Resolving the Soy–Breast Cancer Controversy. Journal of the American Dietetic Association 106:3, pages 364.
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