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Original Articles

Soy and Isoflavone Intake Are Associated With Reduced Risk of Ovarian Cancer in Southeast China

Pages 125-130 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Maruf Ahmed & Jong-Bang Eun. (2018) Flavonoids in fruits and vegetables after thermal and nonthermal processing: A review. Critical Reviews in Food Science and Nutrition 58:18, pages 3159-3188.
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Susanne Andres, Klaus Abraham, Klaus Erich Appel & Alfonso Lampen. (2011) Risks and benefits of dietary isoflavones for cancer. Critical Reviews in Toxicology 41:6, pages 463-506.
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Marta Rossi, Cristina Bosetti, Eva Negri, Pagona Lagiou & CarloLa Vecchia. (2010) Flavonoids, Proanthocyanidins, and Cancer Risk: A Network of Case-Control Studies From Italy. Nutrition and Cancer 62:7, pages 871-877.
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ElisaV. Bandera, LawrenceH. Kushi & Lorna Rodriguez-Rodriguez. (2009) Nutritional Factors in Ovarian Cancer Survival. Nutrition and Cancer 61:5, pages 580-586.
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Fazlul H. Sarkar, Yiwei Li, Zhiwei Wang & Dejuan Kong. (2008) NF-κB Signaling Pathway and Its Therapeutic Implications in Human Diseases. International Reviews of Immunology 27:5, pages 293-319.
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Fumio Sakauchi, M.M.H. Khan, Mitsuru Mori, Tatsuhiko Kubo, Yoshihisa Fujino, Sadao Suzuki, Shinkan Tokudome, Akiko Tamakoshi & JACC Study Group. (2007) Dietary Habits and Risk of Ovarian Cancer Death in a Large-Scale Cohort Study (JACC Study) in Japan. Nutrition and Cancer 57:2, pages 138-145.
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Eun-Sun Hwang & PhyllisE. Bowen. (2007) DNA Damage, a Biomarker of Carcinogenesis: Its Measurement and Modulation by Diet and Environment. Critical Reviews in Food Science and Nutrition 47:1, pages 27-50.
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Mark Messina, Chisato Nagata & Anna H. Wu. (2006) Estimated Asian Adult Soy Protein and Isoflavone Intakes. Nutrition and Cancer 55:1, pages 1-12.
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Articles from other publishers (45)

E. S. Abdel-Baky, S. A. Radwan, M. F. Ibrahim & O. N. Abdel-Rahman. (2024) Influence of omega- 3 fatty acids, soya isoflavones and their combination for abrogating carbon tetrachloride hazards in male rats. Brazilian Journal of Biology 84.
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Abdelmoneim H. Ali, Basim Abu-Jdayil, Anas Al Nabulsi, Tareq Osaili, Shao-Quan Liu, Afaf Kamal-Eldin & Mutamed Ayyash. (2023) Fermented camel milk influenced by soy extract: Apparent viscosity, viscoelastic properties, thixotropic behavior, and biological activities. Journal of Dairy Science 106:10, pages 6671-6687.
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Fubin Liu, Yu Peng, Yating Qiao, Yubei Huang, Fengju Song, Ming Zhang & Fangfang Song. (2022) Consumption of flavonoids and risk of hormone-related cancers: a systematic review and meta-analysis of observational studies. Nutrition Journal 21:1.
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Yifan Xu, Melanie Le Sayec, Caroline Roberts, Sabine Hein, Ana Rodriguez-Mateos & Rachel Gibson. (2021) Dietary Assessment Methods to Estimate (Poly)phenol Intake in Epidemiological Studies: A Systematic Review. Advances in Nutrition 12:5, pages 1781-1801.
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Junjie Zhu, Qi Zhao, Yun Qiu, Yue Zhang, Shuheng Cui, Yuting Yu, Bo Chen, Meiying Zhu, Na Wang, Xing Liu, Yonggen Jiang, Wanghong Xu & Genming Zhao. (2021) Soy Isoflavones Intake and Obesity in Chinese Adults: A Cross-Sectional Study in Shanghai, China. Nutrients 13:8, pages 2715.
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Farah Abid, Muhammad Saleem, Saleha Yasir, Shumila Arshad, Sundus Qureshi, Mayyda Asif Bajwa, Sana Ashiq, Samreen Tanveer, Mehiwh Qayyum & Kanwal Ashiq. (2020) CANCER EPIGENETICS AND THE ROLE OF DIETARY ELEMENTS. Gomal Journal of Medical Sciences 17:3, pages 96-104.
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Kazim Sahin, Engin Yenice, Birdal Bilir, Cemal Orhan, Mehmet Tuzcu, Nurhan Sahin, Ibrahim H. Ozercan, Nashwa Kabil, Bulent Ozpolat & Omer Kucuk. (2019) Genistein Prevents Development of Spontaneous Ovarian Cancer and Inhibits Tumor Growth in Hen Model. Cancer Prevention Research 12:3, pages 135-146.
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Karen K. L. Chan, Michelle K. Y. Siu, Yu-xin Jiang, Jing-jing Wang, Thomas H. Y. Leung & Hextan Y. S. Ngan. (2018) Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer. Cancer Cell International 18:1.
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Whasun Lim, Soomin Ryu, Fuller W. Bazer, Sung-Man Kim & Gwonhwa Song. (2018) Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction. Journal of Cellular Physiology 233:4, pages 3129-3140.
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Tingting Zheng, Yueqiong Ni, Jun Li, Billy K. C. Chow & Gianni Panagiotou. (2017) Designing Dietary Recommendations Using System Level Interactomics Analysis and Network-Based Inference. Frontiers in Physiology 8.
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Xiaoli Hua, Lili Yu, Ruxu You, Yu Yang, Jing Liao, Dongsheng Chen & Lixiu Yu. (2016) Association among Dietary Flavonoids, Flavonoid Subclasses and Ovarian Cancer Risk: A Meta-Analysis. PLOS ONE 11:3, pages e0151134.
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David Lim & Ian C. Shaw. (2016) Is there a link between dietary phytoestrogens and reproductive health in men? A meta-analysis of data from the USA and China. International Journal of Food Science & Technology 51:1, pages 23-29.
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Seiko Otokozawa, Ryoichi Tanaka, Hiroshi Akasaka, Eiki Ito, Sumiyo Asakura, Hirofumi Ohnishi, Shigeyuki Saito, Tetsuji Miura, Tsuyoshi Saito & Mitsuru Mori. (2015) Associations of Serum Isoflavone, Adiponectin and Insulin Levels with Risk for Epithelial Ovarian Cancer: Results of a Case-control Study. Asian Pacific Journal of Cancer Prevention 16:12, pages 4987-4991.
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Li Tang, Andy H Lee, Fenglian Xu, Taotao Zhang, Jun Lei & Colin W Binns. (2014) Soya and isoflavone intakes associated with reduced risk of oesophageal cancer in north-west China. Public Health Nutrition 18:1, pages 130-134.
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Xin-Lan Qu, Yuan Fang, Ming Zhang & Yuan-Zhen Zhang. (2014) Phytoestrogen Intake and Risk of Ovarian Cancer: a Meta-Analysis of 10 Observational Studies. Asian Pacific Journal of Cancer Prevention 15:21, pages 9085-9091.
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Marta Rossi & Carlo La Vecchia. (2014) Flavonoids and the risk of ovarian cancer. The American Journal of Clinical Nutrition 100:5, pages 1217-1219.
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Nadéra Mansouri-Attia, Rebecca James, Alysse Ligon, Xiaohui Li & Stephanie A. Pangas. (2014) Soy Promotes Juvenile Granulosa Cell Tumor Development in Mice and in the Human Granulosa Cell Tumor-Derived COV434 Cell Line1. Biology of Reproduction 91:4.
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Khoomtong Atcharaporn, Pananun Thawunporn & Buddhi Lamsal. 2014. Functional Foods and Dietary Supplements. Functional Foods and Dietary Supplements 255 293 .
Annette S. Neill, Torukiri I. Ibiebele, Petra H. Lahmann, Maria Celia Hughes, Christina M. Nagle & Penelope M. Webb. (2013) Dietary phyto-oestrogens and the risk of ovarian and endometrial cancers: findings from two Australian case–control studies. British Journal of Nutrition 111:8, pages 1430-1440.
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Andy H. Lee, Dada Su, Maria Pasalich, Li Tang, Colin W. Binns & Liqian Qiu. (2014) Soy and isoflavone intake associated with reduced risk of ovarian cancer in southern Chinese women. Nutrition Research 34:4, pages 302-307.
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Andy H. Lee, Maria Pasalich, Dada Su, Li Tang, Van Dinh Tran & Colin W. Binns. (2013) Mushroom Intake and Risk of Epithelial Ovarian Cancer in Southern Chinese Women. International Journal of Gynecological Cancer 23:8, pages 1400-1405.
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M Rossi, V Edefonti, M Parpinel, P Lagiou, M Franchi, M Ferraroni, A Decarli, A Zucchetto, D Serraino, L Dal Maso, E Negri & C La Vecchia. (2013) Proanthocyanidins and other flavonoids in relation to endometrial cancer risk: a case–control study in Italy. British Journal of Cancer 109:7, pages 1914-1920.
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Seung Hyun Ma, Byoung-Gie Kim, Ji-Yeob Choi, Tae-Joong Kim, Yong-Man Kim, Jae Weon Kim, Sokbom Kang, Daehee Kang, Keun-Young Yoo & Sue K. Park. (2012) Korean Epithelial Ovarian Cancer Study (Ko-EVE): Protocols and Interim Report. Asian Pacific Journal of Cancer Prevention 13:8, pages 3731-3740.
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Jung-Yun Lee, Hee Seung Kim & Yong-Sang Song. (2012) Genistein as a Potential Anticancer Agent against Ovarian Cancer. Journal of Traditional and Complementary Medicine 2:2, pages 96-104.
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Li Zhang, Wenxin Liu, Quan Hao, Lewen Bao & Ke Wang. (2012) Folate Intake and Methylenetetrahydrofolate Reductase Gene Polymorphisms as Predictive and Prognostic Biomarkers for Ovarian Cancer Risk. International Journal of Molecular Sciences 13:4, pages 4009-4020.
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Song Gao, Ning Liu, Yang Ma & Liu Ying. (2012) Methylenetetrahydrofolate Reductase Gene Polymorphisms as Predictive and Prognostic Biomarkers in Ovarian Cancer Risk. Asian Pacific Journal of Cancer Prevention 13:2, pages 569-573.
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Lawrence H. Kushi, Colleen Doyle, Marji McCullough, Cheryl L. Rock, Wendy Demark‐Wahnefried, Elisa V. Bandera, Susan Gapstur, Alpa V. Patel, Kimberly Andrews & Ted Gansler. (2012) American Cancer Society guidelines on nutrition and physical activity for cancer prevention. CA: A Cancer Journal for Clinicians 62:1, pages 30-67.
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Wan-Shui Yang, Puthiery Va, Man-Yu Wong, Huan-Ling Zhang & Yong-Bing Xiang. (2011) Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies. The American Journal of Clinical Nutrition 94:6, pages 1575-1583.
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Elisa V Bandera, Melony King, Urmila Chandran, Lisa E Paddock, Lorna Rodriguez-Rodriguez & Sara H Olson. (2011) Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study. BMC Women's Health 11:1.
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Mi-Kyung Kim, Kidong Kim, Jae Yong Han, Jeong Mook Lim & Yong Sang Song. (2011) Modulation of inflammatory signaling pathways by phytochemicals in ovarian cancer. Genes & Nutrition 6:2, pages 109-115.
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Maria Hedelin, Marie Löf, Therese M.-L. Andersson, Herman Adlercreutz & Elisabete Weiderpass. (2011) Dietary Phytoestrogens and the Risk of Ovarian Cancer in the Women's Lifestyle and Health Cohort Study. Cancer Epidemiology, Biomarkers & Prevention 20:2, pages 308-317.
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Kazuhiro Nara, Ken-ichi Nihei, Yasuo Ogasawara, Hidenori Koga & Yoji Kato. (2011) Novel isoflavone diglycoside in groundnut (Apios americana Medik). Food Chemistry 124:3, pages 703-710.
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Fumi Hirayama, Andy H. Lee, Colin W. Binns, Naoko Hiramatsu, Mitsuru Mori & Koichi Nishimura. (2010) Dietary intake of isoflavones and polyunsaturated fatty acids associated with lung function, breathlessness and the prevalence of chronic obstructive pulmonary disease: Possible protective effect of traditional Japanese diet. Molecular Nutrition & Food Research 54:7, pages 909-917.
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S-K Myung, W Ju, HJ Choi & SC Kim. (2009) Soy intake and risk of endocrine-related gynaecological cancer: a meta-analysis. BJOG: An International Journal of Obstetrics & Gynaecology 116:13, pages 1697-1705.
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Gaoliang Ouyang, Luming Yao, Kai Ruan, Gang Song, Yubin Mao & Shideng Bao. (2013) Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways. Cell Biology International 33:12, pages 1237-1244.
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Marta Rossi, Eva Negri, Cristina Bosetti, Claudio Pelucchi & Carlo La Vecchia. 2009. Plant Phenolics and Human Health. Plant Phenolics and Human Health 471 487 .
Margaret A. Gates, Allison F. Vitonis, Shelley S. Tworoger, Bernard Rosner, Linda Titus-Ernstoff, Susan E. Hankinson & Daniel W. Cramer. (2009) Flavonoid intake and ovarian cancer risk in a population-based case-control study. International Journal of Cancer 124:8, pages 1918-1925.
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Lu Wang, I-Min Lee, Shumin M Zhang, Jeffrey B Blumberg, Julie E Buring & Howard D Sesso. (2009) Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women. The American Journal of Clinical Nutrition 89:3, pages 905-912.
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Leigh A Solomon, Shadan Ali, Sanjeev Banerjee, Adnan R Munkarah, Robert T Morris & Fazlul H Sarkar. (2008) Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB. Journal of Ovarian Research 1:1.
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Keiko Tanaka, Satoshi Sasaki, Kentaro Murakami, Hitomi Okubo, Yoshiko Takahashi & Yoshihiro Miyake. (2008) Relationship between soy and isoflavone intake and periodontal disease: The Freshmen in Dietetic Courses Study II. BMC Public Health 8:1.
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Marta Rossi, Eva Negri, Pagona Lagiou, Renato Talamini, Luigino Dal Maso, Maurizio Montella, Silvia Franceschi & Carlo La Vecchia. (2008) Flavonoids and ovarian cancer risk: A case-control study in Italy. International Journal of Cancer 123:4, pages 895-898.
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Jee-youn ShimYoo Jung KimHye-Sung Lee. (2008) Effects of soybean isoflavone extract on the plasma lipid profiles and antioxidant enzyme activity in streptozotocin-induced diabetic rats. Nutrition Research and Practice 2:4, pages 218.
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Margaret A. Gates, Shelley S. Tworoger, Jonathan L. Hecht, Immaculata De Vivo, Bernard Rosner & Susan E. Hankinson. (2007) A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. International Journal of Cancer 121:10, pages 2225-2232.
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Jee-Youn ShimKwang-Ok KimBo-Hyun SeoHye-Sung Lee. (2007) Soybean isoflavone extract improves glucose tolerance and raises the survival rate in streptozotocin-induced diabetic rats. Nutrition Research and Practice 1:4, pages 266.
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Mao Li, Zhuo Zhang, Donald L. Hill, Xinbin Chen, Hui Wang & Ruiwen Zhang. (2005) Genistein, a Dietary Isoflavone, Down-Regulates the MDM2 Oncogene at Both Transcriptional and Posttranslational Levels. Cancer Research 65:18, pages 8200-8208.
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