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Original Articles

Diet-Induced Obesity and Mammary Tumor Development in MMTV-neu Female Mice

Pages 174-180 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Laura Scolaro, Marco Cassone, Jerzy W Kolaczynski, Laszlo Otvos Jr & Eva Surmacz. (2010) Leptin-based therapeutics. Expert Review of Endocrinology & Metabolism 5:6, pages 875-889.
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Amitbha Ray & Margot P Cleary. (2010) Leptin as a potential therapeutic target for breast cancer prevention and treatment. Expert Opinion on Therapeutic Targets 14:4, pages 443-451.
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Articles from other publishers (48)

Ho Lee. (2022) Obesity-Associated Cancers: Evidence from Studies in Mouse Models. Cells 11:9, pages 1472.
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Brett L. Ecker, Jun Y. Lee, Christopher J. Sterner, Aaron C. Solomon, Dhruv K. Pant, Fei Shen, Javier Peraza, Lauren Vaught, Samyukta Mahendra, George K. Belka, Tien-chi Pan, Kathryn H. Schmitz & Lewis A. Chodosh. (2019) Impact of obesity on breast cancer recurrence and minimal residual disease. Breast Cancer Research 21:1.
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Amitabha Ray. (2017) Tumor-linked HER2 expression: association with obesity and lipid-related microenvironment. Hormone Molecular Biology and Clinical Investigation 32:3.
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Martin P. Ogrodzinski, Jamie J. Bernard & Sophia Y. Lunt. (2017) Deciphering metabolic rewiring in breast cancer subtypes. Translational Research 189, pages 105-122.
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Emily L. Rossi, Sarah M. Dunlap, Laura W. Bowers, Subreen A. Khatib, Steven S. Doerstling, Laura A. Smith, Nikki A. Ford, Darcy Holley, Powel H. Brown, Marcos R. Estecio, Donna F. Kusewitt, Linda A. deGraffenried, Scott J. Bultman & Stephen D. Hursting. (2017) Energy Balance Modulation Impacts Epigenetic Reprogramming, ERα and ERβ Expression, and Mammary Tumor Development in MMTV-neu Transgenic Mice. Cancer Research 77:9, pages 2500-2511.
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Atilla Engin. 2017. Obesity and Lipotoxicity. Obesity and Lipotoxicity 571 606 .
Yirong Zhu, Mark D. Aupperlee, Yong Zhao, Ying Siow Tan, Erin L. Kirk, Xuezheng Sun, Melissa A. Troester, Richard C. Schwartz & Sandra Z. Haslam. (2016) Pubertal and adult windows of susceptibility to a high animal fat diet in Trp53-null mammary tumorigenesis . Oncotarget 7:50, pages 83409-83423.
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Shawna Matthews & Henry Thompson. (2016) The Obesity-Breast Cancer Conundrum: An Analysis of the Issues. International Journal of Molecular Sciences 17:6, pages 989.
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Emma H Allott & Stephen D Hursting. (2015) Obesity and cancer: mechanistic insights from transdisciplinary studies. Endocrine-Related Cancer 22:6, pages R365-R386.
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Laetitia Delort, Adrien Rossary, Marie-Chantal Farges, Marie-Paule Vasson & Florence Caldefie-Chézet. (2015) Leptin, adipocytes and breast cancer: Focus on inflammation and anti-tumor immunity. Life Sciences 140, pages 37-48.
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Emily Jane Gallagher, Ruslan Novosyadlyy & Derek LeRoith. 2015. International Textbook of Diabetes Mellitus. International Textbook of Diabetes Mellitus 306 315 .
Shawna B. Matthews, Zongjian Zhu, Weiqin Jiang, John N. McGinley, Elizabeth S. Neil & Henry J. Thompson. (2014) Excess Weight Gain Accelerates 1-Methyl-1-Nitrosourea–Induced Mammary Carcinogenesis in a Rat Model of Premenopausal Breast Cancer. Cancer Prevention Research 7:3, pages 310-318.
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Zhao He & Gen-Sheng Feng. (2013) Control of body weight versus tumorigenesis by concerted action of leptin and estrogen. Reviews in Endocrine and Metabolic Disorders 14:4, pages 339-345.
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Neeraj K. Saxena & Dipali Sharma. (2013) Multifaceted Leptin Network: The Molecular Connection Between Obesity and Breast Cancer. Journal of Mammary Gland Biology and Neoplasia 18:3-4, pages 309-320.
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Nikki A. Ford, Kaylyn L. Devlin, Laura M. Lashinger & Stephen D. Hursting. (2013) Deconvoluting the Obesity and Breast Cancer Link: Secretome, Soil and Seed Interactions. Journal of Mammary Gland Biology and Neoplasia 18:3-4, pages 267-275.
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Margot P. Cleary. (2013) Impact of Obesity on Development and Progression of Mammary Tumors in Preclinical Models of Breast Cancer. Journal of Mammary Gland Biology and Neoplasia 18:3-4, pages 333-343.
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Yong Zhao, Ying Siow Tan, Mark D Aupperlee, Ingeborg M Langohr, Erin L Kirk, Melissa A Troester, Richard C Schwartz & Sandra Z Haslam. (2013) Pubertal high fat diet: effects on mammary cancer development. Breast Cancer Research 15:5.
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Florence Caldefie-Chézet, Virginie Dubois, Laetitia Delort, Adrien Rossary & Marie-Paule Vasson. (2013) Leptine : implication dans la physiopathologie du cancer du sein. Annales d'Endocrinologie 74:2, pages 90-101.
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Nikki A Ford, Nomeli P Nunez, Valerie B Holcomb & Stephen D Hursting. (2013) IGF1 dependence of dietary energy balance effects on murine Met1 mammary tumor progression, epithelial-to-mesenchymal transition, and chemokine expression. Endocrine-Related Cancer 20:1, pages 39-51.
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Samar BasuRachida Nachat-KappesFlorence Caldefie-ChézetMarie-Paule Vasson. (2013) Eicosanoids and Adipokines in Breast Cancer: From Molecular Mechanisms to Clinical Considerations. Antioxidants & Redox Signaling 18:3, pages 323-360.
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Amitabha Ray & Margot P. Cleary. 2013. Adipose Tissue and Cancer. Adipose Tissue and Cancer 99 119 .
Dara Hope Cohen & Derek LeRoith. (2012) Obesity, type 2 diabetes, and cancer: the insulin and IGF connection. Endocrine-Related Cancer 19:5, pages F27-F45.
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Michael E. Grossmann & Margot P. Cleary. (2012) The balance between leptin and adiponectin in the control of carcinogenesis – Focus on mammary tumorigenesis. Biochimie 94:10, pages 2164-2171.
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Britnie R. James, Ann Tomanek-Chalkley, Eric J. Askeland, Tamara Kucaba, Thomas S. Griffith & Lyse A. Norian. (2012) Diet-Induced Obesity Alters Dendritic Cell Function in the Presence and Absence of Tumor Growth. The Journal of Immunology 189:3, pages 1311-1321.
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Sebastiano Andò & Stefania Catalano. (2011) The multifactorial role of leptin in driving the breast cancer microenvironment. Nature Reviews Endocrinology 8:5, pages 263-275.
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Amitabha Ray & Margot P. Cleary. (2012) Obesity and breast cancer: A clinical biochemistry perspective. Clinical Biochemistry 45:3, pages 189-197.
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Melissa J. L. Bonorden, Michael E. Grossmann, Sarah A. Ewing, Olga P. Rogozina, Amitabha Ray, Katai J. Nkhata, D. Joshua Liao, Joseph P. Grande & Margot P. Cleary. (2012) Growth and Progression of TRAMP Prostate Tumors in Relationship to Diet and Obesity. Prostate Cancer 2012, pages 1-13.
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Rosalyn D. Ferguson & Derek LeRoith. 2012. Insulin-like Growth Factors and Cancer. Insulin-like Growth Factors and Cancer 37 72 .
Zhao He, Andy B. Chen & Gen-Sheng Feng. (2011) Deciphering the molecular and physiological connections between obesity and breast cancer. Frontiers in Biology 6:3.
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Olga P. Rogozina, Melissa J.L. Bonorden, Christine N. Seppanen, Joseph P. Grande & Margot P. Cleary. (2011) Effect of Chronic and Intermittent Calorie Restriction on Serum Adiponectin and Leptin and Mammary Tumorigenesis. Cancer Prevention Research 4:4, pages 568-581.
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Thierry Jardé, Stéphane Perrier, Marie-Paule Vasson & Florence Caldefie-Chézet. (2011) Molecular mechanisms of leptin and adiponectin in breast cancer. European Journal of Cancer 47:1, pages 33-43.
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Ruslan Novosyadlyy, Archana Vijayakumar, Yvonne Fierz & Derek LeRoith. 2011. Insulin Resistance and Cancer. Insulin Resistance and Cancer 141 157 .
Michael E. Grossmann, Amitabha Ray, Katai J. Nkhata, Dmitry A. Malakhov, Olga P. Rogozina, Soner Dogan & Margot P. Cleary. (2010) Obesity and breast cancer: status of leptin and adiponectin in pathological processes. Cancer and Metastasis Reviews 29:4, pages 641-653.
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Kathryn N. Phoenix, Frank Vumbaca, Melissa M. Fox, Rebecca Evans & Kevin P. Claffey. (2009) Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy. Breast Cancer Research and Treatment 123:2, pages 333-344.
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Sarah Khalid, David Hwang, Yael Babichev, Rani Kolli, Svetlana Altamentova, Shlomit Koren, Pamela J. Goodwin, Marguerite Ennis, Michael Pollak, Nahum Sonenberg & I. George Fantus. (2009) Evidence for a tumor promoting effect of high-fat diet independent of insulin resistance in HER2/Neu mammary carcinogenesis. Breast Cancer Research and Treatment 122:3, pages 647-659.
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Nadine A. Binai, Annette Damert, Gert Carra, Stephan Steckelbroeck, Johannes Löwer, Roswitha Löwer & Silja Wessler. (2010) Expression of estrogen receptor alpha increases leptin-induced STAT3 activity in breast cancer cells. International Journal of Cancer 127:1, pages 55-66.
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Paul S. MacLean, Erin D. Giles, Ginger C. Johnson, Shauntae M. McDaniel, Brooke K. Fleming‐Elder, Kaite A. Gilman, Anna G. Andrianakos, Matthew R. Jackman, Kenneth R. Shroyer & Pepper J. Schedin. (2012) A Surprising Link Between the Energetics of Ovariectomy‐induced Weight Gain and Mammary Tumor Progression in Obese Rats. Obesity 18:4, pages 696-703.
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M. P. ClearyM. E. GrossmannA. Ray. (2010) Effect of Obesity on Breast Cancer Development. Veterinary Pathology 47:2, pages 202-213.
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SONER DOGAN, OLGA P. ROGOZINA, ANNA E. LOKSHIN, JOSEPH P. GRANDE & MARGOT P. CLEARY. (2010) Effects of chronic vs. intermittent calorie restriction on mammary tumor incidence and serum adiponectin and leptin levels in MMTV-TGF-α mice at different ages. Oncology Letters 1:1, pages 167-176.
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Margot P. Cleary & Michael E. Grossmann. (2009) Obesity and Breast Cancer: The Estrogen Connection. Endocrinology 150:6, pages 2537-2542.
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Katai J. Nkhata, Amitabha Ray, Soner Dogan, Joseph P. Grande & Margot P. Cleary. (2008) Mammary tumor development from T47-D human breast cancer cells in obese ovariectomized mice with and without estradiol supplements. Breast Cancer Research and Treatment 114:1, pages 71-83.
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Michele La Merrill, David S. Baston, Michael S. Denison, Linda S. Birnbaum, Daniel Pomp & David W. Threadgill. (2009) Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. American Journal of Physiology-Endocrinology and Metabolism 296:1, pages E203-E210.
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Amitabha Ray, Katai J. Nkhata, Joseph P. Grande & Margot P. Cleary. (2007) Diet-induced obesity and mammary tumor development in relation to estrogen receptor status. Cancer Letters 253:2, pages 291-300.
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Claudia Bocca, Francesca Bozzo, Simona Francica, Sebastiano Colombatto & Antonella Miglietta. (2007) Involvement of PPARγ and E-cadherin/β-catenin pathway in the antiproliferative effect of conjugated linoleic acid in MCF-7 cells. International Journal of Cancer 121:2, pages 248-256.
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Ruben R. Gonzalez, Salandre Cherfils, Maria Escobar, Jin H. Yoo, Cecilia Carino, Aaron K. Styer, Brian T. Sullivan, Hideo Sakamoto, Alex Olawaiye, Takehiro Serikawa, Maureen P. Lynch & Bo R. Rueda. (2006) Leptin Signaling Promotes the Growth of Mammary Tumors and Increases the Expression of Vascular Endothelial Growth Factor (VEGF) and Its Receptor Type Two (VEGF-R2). Journal of Biological Chemistry 281:36, pages 26320-26328.
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Mariola Sulkowska, Jolanta Golaszewska, Andrzej Wincewicz, Mariusz Koda, Marek Baltaziak & Stanislaw Sulkowski. (2006) Leptin — From regulation of fat metabolism to stimulation of breast cancer growth. Pathology & Oncology Research 12:2, pages 69-72.
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Cecilia Garofalo & Eva Surmacz. (2006) Leptin and cancer. Journal of Cellular Physiology 207:1, pages 12-22.
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Delia-Marina Alexe & Eleni Petridou. 2006. Leptin. Leptin 201 223 .

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