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Original Articles

Structurally Related Mycotoxins Ochratoxin A, Ochratoxin B, and Citrinin Differ in Their Genotoxic Activities and in Their Mode of Action in Human-Derived Liver (HepG2) Cells: Implications for Risk Assessment

Pages 190-197 | Published online: 18 Nov 2009

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José Williams Gomes de Oliveira Filho, Teresinha de Jesus Aguiar dos Santos Andrade, Rosália Maria Tôrres de Lima, Dulce Helena Siqueira Silva, Antonielly Campinho dos Reis, José Victor de Oliveira Santos, Ag-Anne Pereira Melo de Meneses, Ricardo Melo de Carvalho, Ana Maria Oliveira da Mata, Marcus Vinícius Oliveira Barros de Alencar, Ana Carolina Soares Dias, Felipe Cavalcanti Carneiro da Silva, Muhammad Torequl Islam, Cain C. T. Clark, João Marcelo de Castro e Sousa & Ana Amélia de Carvalho Melo-Cavalcante. (2022) Cytogenotoxic evaluation of the acetonitrile extract, citrinin and dicitrinin-A from Penicillium citrinum. Drug and Chemical Toxicology 45:2, pages 688-697.
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Mahmoud Sheikh-Zeinoddin & Mohammadreza Khalesi. (2019) Biological detoxification of ochratoxin A in plants and plant products. Toxin Reviews 38:3, pages 187-199.
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Manyu Shao, Li Li, Zuli Gu, Ming Yao, Danning Xu, Wentao Fan, Liping Yan & Suquan Song. (2018) Mycotoxins in commercial dry pet food in China. Food Additives & Contaminants: Part B 11:4, pages 237-245.
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Amal Salah, Chayma Bouaziz, Alexandre Prola, Julie Pires Da Silva, Hassen Bacha, Salwa Abid-Essefi & Christophe Lemaire. (2017) Citrinin induces apoptosis in human HCT116 colon cancer cells through endoplasmic reticulum stress. Journal of Toxicology and Environmental Health, Part A 80:23-24, pages 1230-1241.
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Imourana Alassane-Kpembi, Gerd Schatzmayr, Ionelia Taranu, Daniela Marin, Olivier Puel & Isabelle Paule Oswald. (2017) Mycotoxins co-contamination: Methodological aspects and biological relevance of combined toxicity studies. Critical Reviews in Food Science and Nutrition 57:16, pages 3489-3507.
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Smrati Bhadauria, Rajeev Mishra, Ranjana Kanchan, Chakrapani Tripathi, Anurag Srivastava, Ashutosh Tiwari & Sharad Sharma. (2010) Isoniazid-induced apoptosis in HepG2 cells: Generation of oxidative stress and Bcl-2 down-regulation. Toxicology Mechanisms and Methods 20:5, pages 242-251.
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Articles from other publishers (71)

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Ag-Anne P.M. de Menezes, Raí P.S. Aguiar, José V.O. Santos, Chandan Sarkar, Muhammad T. Islam, Antonio L. Braga, Mohammad M. Hasan, Felipe C.C. da Silva, Javad Sharifi-Rad, Abhijit Dey, Daniela Calina, Ana A.C. Melo-Cavalcante & João M.C. Sousa. (2023) Citrinin as a potential anti-cancer therapy: A comprehensive review. Chemico-Biological Interactions 381, pages 110561.
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Ruíz-Arias Miguel Alfonso, Bernal-Hernández Yael Yvette, Medina-Díaz Irma Martha, González-Arias Cyndia Azucena, Barrón-Vivanco Briscia Socorro, Herrera-Moreno José Francisco, Sordo Monserrat & Rojas-García Aurora Elizabeth. (2022) Genotoxic effects of the ochratoxin A (OTA), its main metabolite (OTα) per se and in combination with fumonisin B1 in HepG2 cells and human lymphocytes. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 878, pages 503482.
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Dubravka Rašić, Srđan Stefanović, Dragan Milićević, Marin Mladinić, Davor Želježić, Alica Pizent, Paško Konjevoda & Maja Peraica. (2022) Ochratoxin A potentiates citrinin accumulation in kidney and liver of rats. Archives of Industrial Hygiene and Toxicology 73:1, pages 43-47.
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Firouz Darroudi. 2022. Ensuring Global Food Safety. Ensuring Global Food Safety 475 488 .
Alfonso Narváez, Luana Izzo, Yelko Rodríguez-Carrasco & Alberto Ritieni. (2021) Citrinin Dietary Exposure Assessment Approach through Human Biomonitoring High-Resolution Mass Spectrometry-Based Data. Journal of Agricultural and Food Chemistry 69:22, pages 6330-6338.
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Michael J. Bradshaw, Holly P. Bartholomew, Jorge M. Fonseca, Verneta L. Gaskins, Dov Prusky & Wayne M. JurickIIII. (2021) Delivering the goods: Fungal secretion modulates virulence during host–pathogen interactions. Fungal Biology Reviews 36, pages 76-86.
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Salma Ouhibi, Arnau Vidal, Carla Martins, Ridha Gali, Abderrazzek Hedhili, Sarah De Saeger & Marthe De Boevre. (2020) LC-MS/MS methodology for simultaneous determination of patulin and citrinin in urine and plasma applied to a pilot study in colorectal cancer patients. Food and Chemical Toxicology 136, pages 110994.
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Kei-ichi Sugiyama, Hiroko Furusawa & Masamitsu Honma. (2019) Detection of epigenetic effects of citrinin using a yeast-based bioassay. Mycotoxin Research 35:4, pages 363-368.
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Imed Maatouk, Amel Mehrez, Aya Ben Amara, Ragoubi Chayma, Salwa Abid, Taieb Jerbi & Ahmed Landoulsi. (2019) Effects of Gamma Irradiation on Ochratoxin A Stability and Cytotoxicity in Methanolic Solutions and Potential Application in Tunisian Millet Samples. Journal of Food Protection 82:8, pages 1433-1439.
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Ana Juan-García, Josefa Tolosa, Cristina Juan & María-José Ruiz. (2019) Cytotoxicity, Genotoxicity and Disturbance of Cell Cycle in HepG2 Cells Exposed to OTA and BEA: Single and Combined Actions. Toxins 11:6, pages 341.
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D. RašićD. ŽelježićN. KopjarD. KiferM. Šegvić KlarićM. Peraica. (2019) DNA damage in rat kidneys and liver upon subchronic exposure to single and combined ochratoxin A and citrinin. World Mycotoxin Journal 12:2, pages 163-172.
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Meng-Wei Xiao, Xiao-Lin Bai, Yi-Ming Liu, Li Yang & Xun Liao. (2018) Simultaneous determination of trace Aflatoxin B1 and Ochratoxin A by aptamer-based microchip capillary electrophoresis in food samples. Journal of Chromatography A 1569, pages 222-228.
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Aori Qileng, Siyuan Yang, Jie Wei, Ning Lu, Hongtao Lei, Yingju Liu & Weipeng Liu. (2018) Construction of CdS/Ag2S-based broad-spectrum photoelectrochemical immunosensor for simultaneous assessment of ochratoxins by multivariable linear regression. Sensors and Actuators B: Chemical 267, pages 216-223.
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Ana Juan-García, Mercedes Taroncher, Guillermina Font & María-José Ruiz. (2018) Micronucleus induction and cell cycle alterations produced by deoxynivalenol and its acetylated derivatives in individual and combined exposure on HepG2 cells. Food and Chemical Toxicology 118, pages 719-725.
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Dubravka Rašić, Marin Mladinić, Davor Želježić, Alica Pizent, Srđan Stefanović, Dragan Milićević, Paško Konjevoda & Maja Peraica. (2018) Effects of combined treatment with ochratoxin A and citrinin on oxidative damage in kidneys and liver of rats. Toxicon 146, pages 99-105.
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