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Original Articles

Inhibition of the Growth of Premalignant and Malignant Human Oral Cell Lines by Extracts and Components of Black Raspberries

Pages 207-217 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Anupam Bishayee, Yennie Haskell, Chau Do, Kodappully Sivaraman Siveen, Nima Mohandas, Gautam Sethi & Gary D. Stoner. (2016) Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence. Critical Reviews in Food Science and Nutrition 56:10, pages 1753-1775.
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Marta Kula & Mirosława Krauze-Baranowska. (2016) Rubus occidentalis: The black raspberry—its potential in the prevention of cancer. Nutrition and Cancer 68:1, pages 18-28.
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Ming-Jen Fan, I-Chen Wang, Yung-Ting Hsiao, Hui-Yi Lin, Nou-Ying Tang, Tzu-Chieh Hung, Christine Quan, Jin-Cherng Lien & Jing-Gung Chung. (2015) Anthocyanins from Black Rice (Oryza sativa L.) Demonstrate Antimetastatic Properties by Reducing MMPs and NF-κB Expressions in Human Oral Cancer CAL 27 Cells. Nutrition and Cancer 67:2, pages 327-338.
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NancyN. Zikri, KennethM. Riedl, Li-Shu Wang, John Lechner, StevenJ. Schwartz & GaryD. Stoner. (2009) Black Raspberry Components Inhibit Proliferation, Induce Apoptosis, and Modulate Gene Expression in Rat Esophageal Epithelial Cells. Nutrition and Cancer 61:6, pages 816-826.
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Essi Päivärinta, Anne-Maria Pajari, Riitta Törrönen & Marja Mutanen. (2006) Ellagic Acid and Natural Sources of Ellagitannins as Possible Chemopreventive Agents Against Intestinal Tumorigenesis in the Min Mouse. Nutrition and Cancer 54:1, pages 79-83.
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Liisa J. Nohynek, Hanna-Leena Alakomi, Marja P Kähkönen, Marina Heinonen, Ilkka M. Helander, Kirsi-Marja Oksman-Caldentey & Riitta H. Puupponen-Pimiä. (2006) Berry Phenolics: Antimicrobial Properties and Mechanisms of Action Against Severe Human Pathogens. Nutrition and Cancer 54:1, pages 18-32.
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Laura A. Kresty, Wendy L. Frankel, Cynthia D. Hammond, Maureen E. Baird, Jennifer M. Mele, Gary D. Stoner & John J. Fromkes. (2006) Transitioning From Preclinical to Clinical Chemopreventive Assessments of Lyophilized Black Raspberries: Interim Results Show Berries Modulate Markers of Oxidative Stress in Barrett's Esophagus Patients. Nutrition and Cancer 54:1, pages 148-156.
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Keun H. Kee, Tae-Bum Lee, Ji W. Kwon & Song Iy Han. (2023) Enhanced Anticancer Effect of Unripe Rubus occidentalis on Gastric Cancer Cells . Natural Product Communications 18:7.
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Haoyu Wang, Zhi Wang, Zihui Zhang, Jingchun Liu & Li Hong. (2023) β-Sitosterol as a Promising Anticancer Agent for Chemoprevention and Chemotherapy: Mechanisms of Action and Future Prospects. Advances in Nutrition.
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Divya Nedungadi, Nathan Ryan, Kelvin Anderson, Felipe F Lamenza, Pete P Jordanides, Michael J Swingler, Liva Rakotondraibe, Kenneth M Riedl, Hans Iwenofu & Steve Oghumu. (2022) Modulation of the oral glucocorticoid system during black raspberry mediated oral cancer chemoprevention. Carcinogenesis 43:1, pages 28-39.
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Hunter Archibald, Seth Buryska & Frank G. Ondrey. (2021) An active surveillance program in oral preneoplasia and translational oncology benefit. Laryngoscope Investigative Otolaryngology 6:4, pages 764-772.
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Matthew D. Teegarden, Thomas J. Knobloch, Christopher M. Weghorst, Jessica L. Cooperstone & Devin G. Peterson. (2018) Storage conditions modulate the metabolomic profile of a black raspberry nectar with minimal impact on bioactivity. Food & Function 9:9, pages 4593-4601.
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Yizhong Shen, Shaopu Liu, Jian Wang, Dan Li & Youqiu He. (2013) Determination of ellagic acid by fluorescence quenching method with glutathione capped CdTe quantum dots as the probe. Analytical Methods 5:13, pages 3228.
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Francesca Giampieri, Sara Tulipani, Josè M. Alvarez-Suarez, Josè L. Quiles, Bruno Mezzetti & Maurizio Battino. (2012) The strawberry: Composition, nutritional quality, and impact on human health. Nutrition 28:1, pages 9-19.
Crossref
T. K. LimT. K. Lim. 2012. Edible Medicinal And Non-Medicinal Plants. Edible Medicinal And Non-Medicinal Plants 570 580 .
Zhaoxia Zhang, Thomas J. Knobloch, Leigh G. Seamon, Gary D. Stoner, David E. Cohn, Electra D. Paskett, Jeffrey M. Fowler & Christopher M. Weghorst. (2011) A black raspberry extract inhibits proliferation and regulates apoptosis in cervical cancer cells. Gynecologic Oncology 123:2, pages 401-406.
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Symone M. San Miguel, Lynne A. Opperman, Edward P. Allen, Jan Zielinski & Kathy K.H. Svoboda. (2011) Bioactive antioxidant mixtures promote proliferation and migration on human oral fibroblasts. Archives of Oral Biology 56:8, pages 812-822.
Crossref
Daniela Monti, Silvia Tampucci, Patrizia Chetoni, Susi Burgalassi, Veronica Saino, Marisanna Centini, Lucia Staltari & Cecilia Anselmi. (2011) Permeation and Distribution of Ferulic Acid and Its α-Cyclodextrin Complex from Different Formulations in Hairless Rat Skin. AAPS PharmSciTech 12:2, pages 514-520.
Crossref
Steven M. D’Ambrosio, Chunhua Han, Li Pan, A. Douglas Kinghorn & Haiming Ding. (2011) Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting the EGFR/RAS/RAF/MEK/ERK1/2 pathway. Biochemical and Biophysical Research Communications 409:3, pages 465-469.
Crossref
Jodee L. Johnson, Joshua A. Bomser, Joseph C. Scheerens & M. Monica Giusti. (2011) Effect of Black Raspberry (Rubus occidentalis L.) Extract Variation Conditioned by Cultivar, Production Site, and Fruit Maturity Stage on Colon Cancer Cell Proliferation. Journal of Agricultural and Food Chemistry 59:5, pages 1638-1645.
Crossref
Thomas J. Knobloch, Bruce C. Casto, Amit Agrawal, Steven K. Clinton & Christopher M. Weghorst. 2011. Berries and Cancer Prevention. Berries and Cancer Prevention 259 280 .
Bruce C. Casto, Thomas J. Knobloch & Christopher M. Weghorst. 2011. Berries and Cancer Prevention. Berries and Cancer Prevention 189 207 .
Pu Jing & M. Monica Giusti. 2011. Berries and Cancer Prevention. Berries and Cancer Prevention 3 40 .
Marcia da Silva Pinto, Joao Ernesto de Carvalho, Franco Maria Lajolo, Maria Inés Genovese & Kalidas Shetty. (2010) Evaluation of Antiproliferative, Anti-Type 2 Diabetes, and Antihypertension Potentials of Ellagitannins from Strawberries ( Fragaria  ×  ananassa Duch.) Using In Vitro Models . Journal of Medicinal Food 13:5, pages 1027-1035.
Crossref
Jia Liu, Wei Zhang, Hao Jing & David G. Popovich. (2010) Bog Bilberry ( Vaccinium uliginosum  L.) Extract Reduces Cultured Hep-G2, Caco-2, and 3T3-L1 Cell Viability, Affects Cell Cycle Progression, and Has Variable Effects on Membrane Permeability . Journal of Food Science 75:3, pages H103-H107.
Crossref
Faith J. Wyzgoski, Liladhar Paudel, Peter L. Rinaldi, R. Neil Reese, Mustafa Ozgen, Artemio Z. TulioJr.Jr., A. Raymond Miller, Joseph C. Scheerens & James K. Hardy. (2010) Modeling Relationships among Active Components in Black Raspberry (Rubus occidentalis L.) Fruit Extracts Using High-Resolution 1 H Nuclear Magnetic Resonance (NMR) Spectroscopy and Multivariate Statistical Analysis . Journal of Agricultural and Food Chemistry 58:6, pages 3407-3414.
Crossref
Michael Kraus, Kathrin Kahle, Friedericke Ridder, Markus Schantz, Wolfgang Scheppach, Peter Schreier & Elke Richling. 2010. Flavor and Health Benefits of Small Fruits. Flavor and Health Benefits of Small Fruits 159 176 .
Gary D. Stoner, Li-Shu Wang, Christine Sardo, Nancy Zikri, Stephen S. Hecht & Susan R. Mallery. 2010. Bioactive Compounds and Cancer. Bioactive Compounds and Cancer 703 723 .
F J. Duncan, Jason R. Martin, Brian C. Wulff, Gary D. Stoner, Kathleen L. Tober, Tatiana M. Oberyszyn, Donna F. Kusewitt & Anne M. Van Buskirk. (2009) Topical Treatment with Black Raspberry Extract Reduces Cutaneous UVB-Induced Carcinogenesis and Inflammation. Cancer Prevention Research 2:7, pages 665-672.
Crossref
Harvey K. Hall, Kim E. Hummer, Andrew R. Jamieson, S. Nikki Jennings & Courtney A. Weber. 2009. Plant Breeding Reviews. Plant Breeding Reviews 39 353 .
Supaluk Prachayasittikul, Saowapa Suphapong, Apilak Worachartcheewan, Ratana Lawung, Somsak Ruchirawat & Virapong Prachayasittikul. (2009) Bioactive Metabolites from Spilanthes acmella Murr.. Molecules 14:2, pages 850-867.
Crossref
Paul E. Milbury. 2009. Complementary and Alternative Therapies and the Aging Population. Complementary and Alternative Therapies and the Aging Population 347 370 .
Haiming Ding, Chunhua Han, Dongmei Guo, Dasheng Wang, Wenrui Duan, Ching-Shih Chen & Steven M. D'Ambrosio. (2008) Sensitivity to the non-COX inhibiting celecoxib derivative, OSU03012, is p21 WAF1/CIP1 dependent . International Journal of Cancer 123:12, pages 2931-2938.
Crossref
R. Paniagua-Pérez, E. Madrigal-Bujaidar, S. Reyes-Cadena, I. Álvarez-González, L. Sánchez-Chapul, J. Pérez-Gallaga, N. Hernández, G. Flores-Mondragón & O. Velasco. (2008) Cell protection induced by beta-sitosterol: inhibition of genotoxic damage, stimulation of lymphocyte production, and determination of its antioxidant capacity. Archives of Toxicology 82:9, pages 615-622.
Crossref
George Notas, Vassiliki Pelekanou, Elias Castanas & Marilena Kampa. 2008. Olive Oil. Olive Oil 129 171 .
G. D. Stoner, L.-S. Wang & B. C. Casto. (2008) Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries. Carcinogenesis 29:9, pages 1665-1674.
Crossref
Gordon J. McDougallHeather A. RossMagnus IkejiDerek Stewart. (2008) Berry Extracts Exert Different Antiproliferative Effects against Cervical and Colon Cancer Cells Grown in Vitro. Journal of Agricultural and Food Chemistry 56:9, pages 3016-3023.
Crossref
Silvia D. Stan, Siddhartha Kar, Gary D. Stoner & Shivendra V. Singh. (2008) Bioactive food components and cancer risk reduction. Journal of Cellular Biochemistry 104:1, pages 339-356.
Crossref
Artemio Z. TulioJr.Jr., R. Neil Reese, Faith J. Wyzgoski, Peter L. Rinaldi, Ruiling Fu, Joseph C. Scheerens & A. Raymond Miller. (2008) Cyanidin 3-Rutinoside and Cyanidin 3-Xylosylrutinoside as Primary Phenolic Antioxidants in Black Raspberry. Journal of Agricultural and Food Chemistry 56:6, pages 1880-1888.
Crossref
Cecilia Anselmi, Marisanna Centini, Maria Maggiore, Nicola Gaggelli, Marco Andreassi, Anna Buonocore, Giangiacomo Beretta & Roberto Maffei Facino. (2008) Non-covalent inclusion of ferulic acid with α-cyclodextrin improves photo-stability and delivery: NMR and modeling studies. Journal of Pharmaceutical and Biomedical Analysis 46:4, pages 645-652.
Crossref
Ranjan Kumar Nanda, Nilmoni Sarkar & Rintu Banerjee. (2007) Probing the interaction of ellagic acid with human serum albumin: A fluorescence spectroscopic study. Journal of Photochemistry and Photobiology A: Chemistry 192:2-3, pages 152-158.
Crossref
Heather A. Ross, Gordon J. McDougall & Derek Stewart. (2007) Antiproliferative activity is predominantly associated with ellagitannins in raspberry extracts. Phytochemistry 68:2, pages 218-228.
Crossref
Mar Larrosa, Francisco A. Tomás-Barberán & Juan Carlos Espín. (2006) The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway. The Journal of Nutritional Biochemistry 17:9, pages 611-625.
Crossref
NAVINDRA P. SEERAM. 2006. Nutritional Oncology. Nutritional Oncology 615 628 .

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