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Original Articles

Zyflamend®, a Unique Herbal Preparation With Nonselective OX Inhibitory Activity, Induces Apoptosis of Prostate Cancer Cells That Lack COX-2 Expression

Pages 202-212 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Amin Gasmi, Geir Bjørklund, Sadaf Noor, Yuliya Semenova, Alexandru Dosa, Joeri J. Pen, Alain Menzel, Salva Piscopo, Nicolas Wirth & Daniel-Ovidiu Costea. (2023) Nutritional and surgical aspects in prostate disorders. Critical Reviews in Food Science and Nutrition 63:21, pages 5138-5154.
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Dexter Puckett, Mohammed Alquraishi, Dina S. Alani, Samah Chahed, Victoria D. Frankel, Dallas Donohoe, Brynn Voy, Jay Whelan & Ahmed Bettaieb. (2020) Zyflamend, a unique herbal blend, induces cell death and inhibits adipogenesis through the coordinated regulation of PKA and JNK. Adipocyte 9:1, pages 454-471.
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Yanshi Xue, Lin Yang, Junzun Li, Yilin Yan, Qinghui Jiang, Lan Shen, Shuai Yang, Bing Shen, Ruimin Huang, Jun Yan & Hongqian Guo. (2018) Combination chemotherapy with Zyflamend reduced the acquired resistance of bladder cancer cells to cisplatin through inhibiting NFκB signaling pathway. OncoTargets and Therapy 11, pages 4413-4429.
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E.-Chu Huang, MichaelF. McEntee & Jay Whelan. (2012) Zyflamend, a Combination of Herbal Extracts, Attenuates Tumor Growth in Murine Xenograft Models of Prostate Cancer. Nutrition and Cancer 64:5, pages 749-760.
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E-Chu Huang, Guoxun Chen, Seung Joon Baek, MichaelF. McEntee, J. Jason Collier, Steven Minkin, John Biggerstaff & Jay Whelan. (2011) Zyflamend Reduces the Expression of Androgen Receptor in a Model of Castrate-Resistant Prostate Cancer. Nutrition and Cancer 63:8, pages 1287-1296.
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Suhendan Ekmekcioglu, Chandrani Chattopadhyay , Ugur Akar , Abdul Gabisi$suffix/text()$suffix/text(), RobertA. Newman & ElizabethA. Grimm. (2011) Zyflamend Mediates Therapeutic Induction of Autophagy to Apoptosis in Melanoma Cells. Nutrition and Cancer 63:6, pages 940-949.
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SantoshK. Sandur, Kwang Seok Ahn, Haruyo Ichikawa, Gautam Sethi, Shishir Shishodia, RobertA. Newman & BharatB. Aggarwal. (2007) Zyflamend, a Polyherbal Preparation, Inhibits Invasion, Suppresses Osteoclastogenesis, and Potentiates Apoptosis Through Down-Regulation of NF-κ B Activation and NF-κ B–Regulated Gene Products. Nutrition and Cancer 57:1, pages 78-87.
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Debra L Bemis, Aaron E Katz & Ralph Buttyan. (2006) Clinical trials of natural products as chemopreventive agents for prostate cancer. Expert Opinion on Investigational Drugs 15:10, pages 1191-1200.
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Articles from other publishers (29)

Bingke Bai, Qianbo Chen, Rui Jing, Xuhui He, Hongrui Wang, Yanfei Ban, Qi Ye, Weiheng Xu & Chengjian Zheng. (2021) Molecular Basis of Prostate Cancer and Natural Products as Potential Chemotherapeutic and Chemopreventive Agents. Frontiers in Pharmacology 12.
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Dexter L. Puckett, Mohammed Alquraishi, Dina Alani, Samah Chahed, Dallas Donohoe, Brynn Voy, Jay Whelan & Ahmed Bettaieb. (2020) Zyflamend induces apoptosis in pancreatic cancer cells via modulation of the JNK pathway. Cell Communication and Signaling 18:1.
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Michael R Buckley, Paul D Terry, Stacy S Kirkpatrick, Joshua D Arnold, Michael M McNally, Oscar H Grandas, Michael B Freeman, Mitchell H Goldman, Jay Whelan & Deidra JH Mountain. (2019) Dietary supplementation with Zyflamend poly-herbal extracts and fish oil inhibits intimal hyperplasia development following vascular intervention. Nutrition Research 68, pages 34-44.
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Amber F. MacDonald, Ahmed Bettaieb, Dallas R. Donohoe, Dina S. Alani, Anna Han, Yi Zhao & Jay Whelan. (2018) Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties. BMC Complementary and Alternative Medicine 18:1.
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Eric D. TagueAllen K. BourdonAmber MacDonaldMaggie S. LookadooEdward D. KimWesley M. WhitePaul D. TerryShawn R. CampagnaBrynn H. VoyJay Whelan. (2018) Metabolomics Approach in the Study of the Well-Defined Polyherbal Preparation Zyflamend. Journal of Medicinal Food 21:3, pages 306-316.
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Priyadarshini & Abhishek Negi. 2018. Anticancer plants: Properties and Application. Anticancer plants: Properties and Application 539 558 .
Thierry Roumeguère, Joseph Sfeir, Elie El Rassy, Simone Albisinni, Pierre Van Antwerpen, Karim Zouaoui Boudjeltia, Nassim Farès, Joseph Kattan & Fouad Aoun. (2017) Oxidative stress and prostatic diseases. Molecular and Clinical Oncology 7:5, pages 723-728.
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Michelle Bratton. 2017. Integrating Nutrition Into Practice. Integrating Nutrition Into Practice 231 250 .
Jay Whelan, Yi Zhao, E-Chu Huang, Amber MacDonald & Dallas Donohoe. 2016. Complementary and Alternative Medicines in Prostate Cancer. Complementary and Alternative Medicines in Prostate Cancer 197 220 .
Yi Zhao, Dallas Donohoe, E-Chu Huang & Jay Whelan. (2015) Zyflamend, a polyherbal mixture, inhibits lipogenesis and mTORC1 signalling via activation of AMPK. Journal of Functional Foods 18, pages 147-158.
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Michelle BrattonRDNRDN. 2015. Integrative Nutrition Therapy. Integrative Nutrition Therapy 231 250 .
Mehmet Asim Bilen, Sue-Hwa Lin, Dean G. Tang, Kinjal Parikh, Mong-Hong Lee, Sai-Ching J. Yeung & Shi-Ming Tu. (2015) Maintenance Therapy Containing Metformin and/or Zyflamend for Advanced Prostate Cancer: A Case Series. Case Reports in Oncological Medicine 2015, pages 1-5.
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E-Chu Huang, Yi Zhao, Guoxun Chen, Seung Joon Baek, Michael F McEntee, Steven Minkin, John P Biggerstaff & Jay Whelan. (2014) Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells. BMC Complementary and Alternative Medicine 14:1.
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Yasuhito Funahashi, Katherine J. O'Malley, Naoki Kawamorita, Pradeep Tyagi, Donald B. DeFranco, Ryosuke Takahashi, Momokazu Gotoh, Zhou Wang & Naoki Yoshimura. (2014) Upregulation of androgen-responsive genes and transforming growth factor-β1 cascade genes in a rat model of non-bacterial prostatic inflammation. The Prostate 74:4, pages 337-345.
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Yiannis Philippou, Marios Hadjipavlou, Shahid Khan & Abhay Rane. (2013) Complementary and alternative medicine (CAM) in prostate and bladder cancer. BJU International 112:8, pages 1073-1079.
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Sanjeev Banerjee, Asfar Azmi, Bin Bao & Fazlul H. Sarkar. 2013. Cancer Chemoprevention and Treatment by Diet Therapy. Cancer Chemoprevention and Treatment by Diet Therapy 269 310 .
Philippa J. Cheetham & Aaron E. Katz. 2013. Prostate Cancer: A Comprehensive Perspective. Prostate Cancer: A Comprehensive Perspective 355 367 .
Ajaikumar B. Kunnumakkara, Bokyung Sung, Jayaraj Ravindran, Parmeswaran Diagaradjane, Amit Deorukhkar, Sanjit Dey, Cemile Koca, Zhimin Tong, Juri G. Gelovani, Sushovan Guha, Sunil Krishnan & Bharat B. Aggarwal. (2012) Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. International Journal of Cancer 131:3, pages E292-E303.
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María Gómez-Serranillos Cuadrado, María Ortega Hernández-Agero, Olga Palomino Ruiz-Poveda & María Carretero Accame. 2012. Medicinal Plants. Medicinal Plants 412 471 .
Samuel J. Klempner & Glenn Bubley. (2012) Complementary and Alternative Medicines in Prostate Cancer: From Bench to Bedside?. The Oncologist 17:6, pages 830-837.
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Jun Yan, Bingxian Xie, Jillian L. Capodice & Aaron E. Katz. (2012) Zyflamend inhibits the expression and function of androgen receptor and acts synergistically with bicalutimide to inhibit prostate cancer cell growth. The Prostate 72:3, pages 244-252.
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Xiaoqiang Xu, Xiuhong Gao, Linhong Jin, Pinaki S Bhadury, Kai Yuan, Deyu Hu, Baoan Song & Song Yang. (2011) Antiproliferation and cell apoptosis inducing bioactivities of constituents from Dysosma versipellis in PC3 and Bcap-37 cell lines. Cell Division 6:1.
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Nicole Birgit Arweiler, Gregory Pergola, Jana Kuenz, Elmar Hellwig, Anton Sculean & Thorsten Mathias Auschill. (2010) Clinical and antibacterial effect of an anti-inflammatory toothpaste formulation with Scutellaria baicalensis extract on experimental gingivitis. Clinical Oral Investigations 15:6, pages 909-913.
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Aaron Katz. 2010. Early Diagnosis and Treatment of Cancer Series: Prostate Cancer. Early Diagnosis and Treatment of Cancer Series: Prostate Cancer 207 228 .
Geovanni Espinosa & Aaron Katz. 2009. Food and Nutrients in Disease Management. Food and Nutrients in Disease Management.
Peiying Yang, Zheng Sun, Diana Chan, Carrie A. Cartwright, Mary Vijjeswarapu, Jibin Ding, Xiaoxin Chen & Robert A. Newman. (2008) Zyflamend® reduces LTB 4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[α]anthracene (DMBA)-induced hamster cheek pouch model. Carcinogenesis 29:11, pages 2182-2189.
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James A. (Jim) Duke. (2007) The Garden Pharmacy: Turmeric, the Queen of COX-2-Inhibitors. Alternative and Complementary Therapies 13:5, pages 229-234.
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Chapla Agarwal, Alpna Tyagi, Manjinder Kaur & Rajesh Agarwal. (2007) Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells. Carcinogenesis 28:7, pages 1463-1470.
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Samuil Rafailov, Sam Cammack, Brian A. Stone & Aaron E. Katz. (2016) The Role of Zyflamend, an Herbal Anti-inflammatory, as a Potential Chemopreventive Agent Against Prostate Cancer: A Case Report. Integrative Cancer Therapies 6:1, pages 74-76.
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