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Original Articles

Anti-Angiogenesis Efficacy of the Garlic Ingredient Alliin and Antioxidants: Role of Nitric Oxide and p53

Pages 104-110 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Tiffany Dennis, Michael Fanous & Shaker Mousa. (2009) Natural Products for Chemopreventive and Adjunctive Therapy in Oncologic Disease. Nutrition and Cancer 61:5, pages 587-597.
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Uri Sela, Alexander Brill, Vyacheslav Kalchenko, Olga Dashevsky & Rami Hershkoviz. (2008) Allicin Inhibits Blood Vessel Growth and Downregulates Akt Phosphorylation and Actin Polymerization. Nutrition and Cancer 60:3, pages 412-420.
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Articles from other publishers (44)

Fatemeh Sanie-Jahromi, Zahra Zia & Mehrdad Afarid. (2023) A review on the effect of garlic on diabetes, BDNF, and VEGF as a potential treatment for diabetic retinopathy. Chinese Medicine 18:1.
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Daniel Ulises Torres-Reyes, Alma Marina Sánchez-Sánchez, Lucrecia Carrera-Quintanar & Daniel Ortuño-Sahagún. (2022) Physiologically Beneficial Actions of Alliin in Health and Disease. Current Nutraceuticals 3:3.
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Asif Khan, Sajid Ali, Waheed Murad, Khizar Hayat, Shumaila Siraj, Muhammad Jawad, Rashid Abbas Khan, Jalal Uddin, Ahmed Al-Harrasi & Ajmal Khan. (2021) Phytochemical and pharmacological uses of medicinal plants to treat cancer: A case study from Khyber Pakhtunkhwa, North Pakistan. Journal of Ethnopharmacology 281, pages 114437.
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Vida Celeste Rosas‐González, Martha Cecilia Téllez‐Bañuelos, Georgina Hernández‐Flores, Alejandro Bravo‐Cuellar, Adriana Aguilar-Lemarroy, Luis Felipe Jave‐Suárez, Jesse Haramati, Fabiola Solorzano‐Ibarra & Pablo Cesar Ortiz‐Lazareno. (2020) Differential effects of alliin and allicin on apoptosis and senescence in luminal A and triple‐negative breast cancer: Caspase, ΔΨm, and pro‐apoptotic gene involvement. Fundamental & Clinical Pharmacology 34:6, pages 671-686.
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Muhammad Torequl Islam. (2020) Angiostatic effects of ascorbic acid: current status and future perspectives. Angiogenesis 23:3, pages 275-277.
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Saleh A. Almatroodi, Mohammed A. Alsahli, Ahmad Almatroudi & Arshad H. Rahmani. (2019) Garlic and its Active Compounds: A Potential Candidate in The Prevention of Cancer by Modulating Various Cell Signalling Pathways. Anti-Cancer Agents in Medicinal Chemistry 19:11, pages 1314-1324.
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Gun-He Nam, Kyung-Jo Jo, Ye-Seul Park, Hye Won Kawk, Sang-Yong Kim & Young-Min Kim. (2019) In vitro and in vivo Induction of p53-Dependent Apoptosis by Extract of Euryale ferox Salisb in A549 Human Caucasian Lung Carcinoma Cancer Cells Is Mediated Through Akt Signaling Pathway. Frontiers in Oncology 9.
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Priyanka Sarkar & Kavitha Thirumurugan. (2019) Modulatory functions of bioactive fruits, vegetables and spices in adipogenesis and angiogenesis. Journal of Functional Foods 53, pages 318-336.
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Pavić Aleksandar, Mitić-Ćulafić Dragana, Jasnić Nebojša, Nikolić Biljana, Simin Nataša, Vasiljević Branka & Knežević-Vukčević Jelena. (2019) Wild edible onions — Allium flavum and Allium carinatum — successfully prevent adverse effects of chemotherapeutic drug doxorubicin. Biomedicine & Pharmacotherapy 109, pages 2482-2491.
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Ahmad Salimzadeh, Elham Alipoor, Sahar Dehghani, Mehdi Yaseri, Mostafa Hosseini, Christine Feinle-Bisset & Mohammad Javad Hosseinzadeh-Attar. (2018) The effect of 12-week garlic supplementation on symptom relief in overweight or obese women with knee osteoarthritis. International Journal of Clinical Practice 72:6, pages e13208.
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E. Chmelíková, D. Němeček, M. Dvořáková, I. Heroutová & M. Sedmíková. (2018) Organo-Sulphur Garlic Compounds Influence Viability of Mammalian Cells: A Review. Scientia Agriculturae Bohemica 49:1, pages 9-16.
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Eric Block, Benjamin Bechand, Sivaji Gundala, Abith Vattekkatte, Kai Wang, Shaymaa Mousa, Kavitha Godugu, Murat Yalcin & Shaker Mousa. (2017) Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies. Molecules 22:12, pages 2081.
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Hamid-Reza Mohammadi-Motlagh, Yalda Shokohinia, Mahdi Mojarrab, Hassan Rasouli & Ali Mostafaie. (2017) 2-Methylpyridine-1-ium-1-sulfonate from Allium hirtifolium: An anti-angiogenic compound which inhibits growth of MCF-7 and MDA-MB-231 cells through cell cycle arrest and apoptosis induction. Biomedicine & Pharmacotherapy 93, pages 117-129.
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Hassan Rasouli, Sharham Parvaneh, Azadeh Mahnam, Mohsen Rastegari-Pouyani, Zohreh Hoseinkhani & Kamran Mansouri. (2017) Anti-angiogenic potential of trypsin inhibitor purified from Cucumis melo seeds: Homology modeling and molecular docking perspective. International Journal of Biological Macromolecules 96, pages 118-128.
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Lucia Morbidelli. (2016) Polyphenol-based nutraceuticals for the control of angiogenesis: Analysis of the critical issues for human use. Pharmacological Research 111, pages 384-393.
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Ajay Bommareddy, Adam L. VanWert, Dan F. McCune, Sarah L. Brozena, Zbigniew Witczak & Shivendra V. Singh. 2016. Critical Dietary Factors in Cancer Chemoprevention. Critical Dietary Factors in Cancer Chemoprevention 111 152 .
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M. Dvořáková, I. Weingartová, J. Nevoral, D. Němeček & T. Krejčová. (2015) Garlic Sulfur Compounds Suppress Cancerogenesis and Oxidative Stress: a Review. Scientia Agriculturae Bohemica 46:2, pages 65-72.
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Wei-Tang Chang, Chi-Hao Wu & Chin-Lin Hsu. (2015) Diallyl trisulphide inhibits adipogenesis in 3T3-L1 adipocytes through lipogenesis, fatty acid transport, and fatty acid oxidation pathways. Journal of Functional Foods 16, pages 414-422.
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Jong Suk Lee, Shruti Shukla, Jung-Ae Kim & Myunghee Kim. (2015) Anti-Angiogenic Effect of Nelumbo nucifera Leaf Extracts in Human Umbilical Vein Endothelial Cells with Antioxidant Potential. PLOS ONE 10:2, pages e0118552.
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Norbert Weiss, Louisa Papatheodorou, Naoaki Morihara, Robert Hilge & Nagatoshi Ide. (2013) Aged garlic extract restores nitric oxide bioavailability in cultured human endothelial cells even under conditions of homocysteine elevation. Journal of Ethnopharmacology 145:1, pages 162-167.
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Ming‐Jie Wang, Wen‐Jie Cai & Yi‐Chun Zhu. (2010) Mechanisms of angiogenesis: Role of hydrogen sulphide. Clinical and Experimental Pharmacology and Physiology 37:7, pages 764-771.
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