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Original Articles

Protection Against Esophageal Cancer in Rodents With Lyophilized Berries: Potential Mechanisms

Pages 33-46 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Jillian N. Eskra, Alaina Dodge, Michael J. Schlicht & Maarten C. Bosland. (2020) Effects of Black Raspberries and Their Constituents on Rat Prostate Carcinogenesis and Human Prostate Cancer Cell Growth In Vitro. Nutrition and Cancer 72:4, pages 672-685.
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John David Chetwood, Priya Garg, Peter Finch & Melita Gordon. (2019) Systematic review: the etiology of esophageal squamous cell carcinoma in low-income settings. Expert Review of Gastroenterology & Hepatology 13:1, pages 71-88.
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Anupam Bishayee, Yennie Haskell, Chau Do, Kodappully Sivaraman Siveen, Nima Mohandas, Gautam Sethi & Gary D. Stoner. (2016) Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence. Critical Reviews in Food Science and Nutrition 56:10, pages 1753-1775.
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Marta Kula & Mirosława Krauze-Baranowska. (2016) Rubus occidentalis: The black raspberry—its potential in the prevention of cancer. Nutrition and Cancer 68:1, pages 18-28.
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Sara Zanini, Marta Marzotto, Francesco Giovinazzo, Claudio Bassi & Paolo Bellavite. (2015) Effects of Dietary Components on Cancer of the Digestive System. Critical Reviews in Food Science and Nutrition 55:13, pages 1870-1885.
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Cristina Garcia-Muñoz & Fabrice Vaillant. (2014) Metabolic Fate of Ellagitannins: Implications for Health, and Research Perspectives for Innovative Functional Foods. Critical Reviews in Food Science and Nutrition 54:12, pages 1584-1598.
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Arpita Basu, Angel Nguyen, NancyM. Betts & TimothyJ. Lyons. (2014) Strawberry As a Functional Food: An Evidence-Based Review. Critical Reviews in Food Science and Nutrition 54:6, pages 790-806.
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Arzu Ucar Turker, Arzu Birinci Yildirim & Fatma Pehlivan Karakas. (2012) Antibacterial and Antitumor Activities of Some Wild Fruits Grown in Turkey. Biotechnology & Biotechnological Equipment 26:1, pages 2765-2772.
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HariniS. Aiyer, Yan Li, JackN. Losso, Chenfei Gao, SuzanneC. Schiffman, StephenP. Slone & RobertC.G. Martin. (2011) Effect of Freeze-Dried Berries on the Development of Reflux-Induced Esophageal Adenocarcinoma. Nutrition and Cancer 63:8, pages 1256-1262.
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JohnF. Lechner, RashmeetK. Reen, AlanA. Dombkowski, Daniela Cukovic, Sridevi Salagrama, Li-Shu Wang & GaryD. Stoner. (2008) Effects of a Black Raspberry Diet on Gene Expression in the Rat Esophagus. Nutrition and Cancer 60:sup1, pages 61-69.
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HariniS. Aiyer, Cidambi Srinivasan & RameshC. Gupta. (2008) Dietary Berries and Ellagic Acid Diminish Estrogen-Mediated Mammary Tumorigenesis ∈ ACI rats. Nutrition and Cancer 60:2, pages 227-234.
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Natalia Adamczuk, Justyna Ośko, Małgorzata Grembecka, Paweł Konieczyński, Piotr Migas, Agnieszka Orzeł, Barbara Baj-Wójtowicz & Mirosława Krauze-Baranowska. (2023) Evaluation of the Content of Micro- and Macroelements in Raspberries Depending on the Species, Cultivar Variety, and Geographical Environment. Nutrients 15:17, pages 3782.
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Haoyu Wang, Zhi Wang, Zihui Zhang, Jingchun Liu & Li Hong. (2023) β-Sitosterol as a Promising Anticancer Agent for Chemoprevention and Chemotherapy: Mechanisms of Action and Future Prospects. Advances in Nutrition.
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Dieter Schrenk, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Jesús del Mazo, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean‐Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Heather Wallace, Benigni Romualdo, Cristina Fortes, Stephen Hecht, Marco Iammarino, Olaf Mosbach‐Schulz, Francesca Riolo, Anna Christodoulidou & Bettina Grasl‐Kraupp. (2023) Risk assessment of N‐nitrosamines in food. EFSA Journal 21:3.
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Chen Jin, Rui Li, Tuo Deng, Zixia Lin, Haoqi Li, Yan Yang, Qing Su, Jingxian Wang, Yi Yang, Juejin Wang, Gang Chen & Yi Wang. (2022) Association between dried fruit intake and pan-cancers incidence risk: A two-sample Mendelian randomization study. Frontiers in Nutrition 9.
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Naser Mirazi, Ida Shahabi Baher, Zahra Izadi & Abdolkarim Hosseini. (2021) The protective effect of Rubus fruticosus L. on blood composition in cyclophosphamide treated male rats. Clinical Phytoscience 7:1.
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Jeong Ho Lee, Kyoung Ok Jeong, So Yeon Im & Seung Je Lee. (2021) Analytical method validation of ellagic acid as an antioxidative marker compound of the Rubus occidentalis extract. Korean Journal of Food Preservation 28:5, pages 663-673.
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Koffi Djaman, Soum Sanogo, Komlan Koudahe, Samuel Allen, Aminou Saibou & Samuel Essah. (2021) Characteristics of Organically Grown Compared to Conventionally Grown Potato and the Processed Products: A Review. Sustainability 13:11, pages 6289.
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Ömer İSTEK, Oktay TOMAR & Abdullah ÇAĞLAR. (2021) Orman Meyveli Tarhananın Fonksiyonel Özellikleri. European Journal of Science and Technology.
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K.V. Surangi Dharmawansa, David W. Hoskin & H. P. Vasantha Rupasinghe. (2020) Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives. International Journal of Molecular Sciences 21:18, pages 6555.
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Daniel S Peiffer. (2020) Modulation of the host microbiome by black raspberries or their components and the therapeutic implications in cancer. Food Frontiers 1:3, pages 296-304.
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Stephanie May, Connor Parry & Lee Parry. (2020) Berry chemoprevention: Do berries decrease the window of opportunity for tumorigenesis. Food Frontiers 1:3, pages 260-275.
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Nijolė Vaitkevičienė, Jurgita Kulaitienė, Elvyra Jarienė, Dovilė Levickienė, Honorata Danillčenko, Dominika Średnicka-Tober, Ewa Rembiałkowska & Ewelina Hallmann. (2020) Characterization of Bioactive Compounds in Colored Potato (Solanum Tuberosum L.) Cultivars Grown with Conventional, Organic, and Biodynamic Methods. Sustainability 12:7, pages 2701.
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Valeri V Mossine, Thomas P Mawhinney & Edward L Giovannucci. (2020) Dried Fruit Intake and Cancer: A Systematic Review of Observational Studies. Advances in Nutrition 11:2, pages 237-250.
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Terje Sundstrøm, Lars Prestegarden, Francisco Azuaje, Synnøve Nymark Aasen, Gro Vatne Røsland, Jobin K. Varughese, Marzieh Bahador, Simon Bernatz, Yannick Braun, Patrick N. Harter, Kai Ove Skaftnesmo, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah Tam, Clifford G. Tepper, Kjell Petersen, Katherine W. Ferrara, Karl Johan Tronstad, Morten Lund-Johansen, Rudi Beschorner, Rolf Bjerkvig & Frits Thorsen. (2019) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathologica Communications 7:1.
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Simin Zhao, Yanan Jiang, Tongde Tian, Jimin Zhao, Yifei Xie, Xinhuan Chen, Jing Lu, Feng Yang, Honglin Li, Kangdong Liu & Ziming Dong. (2019) Jie Du Tong Ye San Prevents N-Nitrosomethylbenzylamine-Induced Esophageal Carcinogenesis via Inhibition of Inflammation and Proliferation. Evidence-Based Complementary and Alternative Medicine 2019, pages 1-10.
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Nikolay Goncharov, Vladislav Sobolev, Maxim Terpilowski, Ekaterina Korf & Richard Jenkins. 2019. Nutraceuticals in Veterinary Medicine. Nutraceuticals in Veterinary Medicine 675 684 .
Daniel S. Peiffer. (2018) Preparing black raspberry components for their use as cancer therapeutics. Journal of Berry Research 8:4, pages 297-306.
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Pan Pan, Alan A. Dombkowski, Li-Shu Wang & Gary D. Stoner. (2018) A nutrigenetic approach for investigating the chemopreventive effects of black raspberries during the development of preneoplastic esophagi in rats. Journal of Berry Research 8:4, pages 263-274.
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Hui Yang, Miao Xu, Fang Lu, Qiannan Zhang, Yongquan Feng, Chung S. Yang, Ning Li & Xudong Jia. (2018) Tocopherols inhibit esophageal carcinogenesis through attenuating NF-κB activation and CXCR3-mediated inflammation. Oncogene 37:29, pages 3909-3923.
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Pan Pan, Daniel S. Peiffer, Yi-Wen Huang, Kiyoko Oshima, Gary D. Stoner & Li-Shu Wang. (2018) Inhibition of the development of N-nitrosomethylbenzylamine-induced esophageal tumors in rats by strawberries and aspirin, alone and in combination. Journal of Berry Research 8:2, pages 137-146.
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Sandra N. Jimenez-Garcia, Moises A. Vazquez-Cruz, Lina Garcia-Mier, Luis M. Contreras-Medina, Ramon G. Guevara-González, Juan F. Garcia-Trejo & Ana A. Feregrino-Perez. 2018. Therapeutic Foods. Therapeutic Foods 397 427 .
Shahensha Shaik & Ram Devireddy. 2018. Adipose-Derived Stem Cells. Adipose-Derived Stem Cells 231 259 .
Steve Oghumu, Bruce C. Casto, Jennifer Ahn-Jarvis, Logan C. Weghorst, Jim Maloney, Paul Geuy, Kyle Z. Horvath, Claire E. Bollinger, Blake M. Warner, Kurt F. Summersgill, Christopher M. Weghorst & Thomas J. Knobloch. (2017) Inhibition of Pro-inflammatory and Anti-apoptotic Biomarkers during Experimental Oral Cancer Chemoprevention by Dietary Black Raspberries. Frontiers in Immunology 8.
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Laura A. Kresty, Susan R. Mallery & Gary D. Stoner. (2016) Black raspberries in cancer clinical trials: Past, present and future. Journal of Berry Research 6:2, pages 251-261.
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Ki An Kim, Ji Wung Kwon, Yong-Suk Kim, Pill Jae Park & Kyu Seo Chae. (2015) Antioxidant Activities of Ethanol Extracts from Different Parts of the Black Raspberry (Rubus occidentalis) Obtained Using Ultra-sonication. Korean Journal of Food Science and Technology 47:4, pages 504-510.
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J L Petrick, S E Steck, P T Bradshaw, K F Trivers, P E Abrahamson, L S Engel, K He, W-H Chow, S T Mayne, H A Risch, T L Vaughan & M D Gammon. (2015) Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA). British Journal of Cancer 112:7, pages 1291-1300.
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Blake M. Warner, Bruce C. Casto, Thomas J. Knobloch, Brent T. Accurso & Christopher M. Weghorst. (2014) Chemoprevention of oral cancer by topical application of black raspberries on high at-risk mucosa. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 118:6, pages 674-683.
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Kyu Seo Chae, Rak Ho Son, Song Yie Park, Ki-An Kim, Tae-Bum Lee & Ji-Wung Kwon. (2014) Analytical Method Validation of Ellagic Acid as a Marker Compound for the Standardization of Black Raspberry Extract as a Functional Ingredient. Food Engineering Progress 18:4, pages 355-358.
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Lee Seon Kim, Sang Hyuck Youn & Ji Yeon Kim. (2014) Comparative Study on Antioxidant Effects of Extracts from Rubus coreanus and Rubus occidentalis. Journal of the Korean Society of Food Science and Nutrition 43:9, pages 1357-1362.
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Bo Han, Wei Li, Yulin Sun, Lanping Zhou, Yang Xu & Xiaohang Zhao. (2014) A Prolyl-Hydroxylase Inhibitor, Ethyl-3,4-Dihydroxybenzoate, Induces Cell Autophagy and Apoptosis in Esophageal Squamous Cell Carcinoma Cells via Up-Regulation of BNIP3 and N-myc Downstream-Regulated Gene-1. PLoS ONE 9:9, pages e107204.
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Muhammad Zia-Ul-Haq, Muhammad Riaz, Vincenzo De Feo, Hawa Jaafar & Marius Moga. (2014) Rubus Fruticosus L.: Constituents, Biological Activities and Health Related Uses. Molecules 19:8, pages 10998-11029.
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Srivani Ravoori, Manicka V. Vadhanam, Farrukh Aqil & Ramesh C. Gupta. (2012) Inhibition of Estrogen-Mediated Mammary Tumorigenesis by Blueberry and Black Raspberry. Journal of Agricultural and Food Chemistry 60:22, pages 5547-5555.
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