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Bioscience, Biotechnology, and Biochemistry Volume 74, 2010 - Issue 5
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Original Articles

Advances in the Production of Various Polyunsaturated Fatty Acids through Oleaginous Fungus Mortierella alpina Breeding

Eiji SAKURADANIDivision of Applied Life Sciences, Graduate School of Agriculture, Kyoto University
Pages 908-917 | Published online: 22 May 2014

Citations (46)

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Yu-Lei Jia, Shan-Shan Geng, Fei Du, Ying-Shuang Xu, Ling-Ru Wang, Xiao-Man Sun, Qing-Zhuo Wang & Qi Li. (2022) Progress of metabolic engineering for the production of eicosapentaenoic acid. Critical Reviews in Biotechnology 42:6, pages 838-855.
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Xiao-Jun Ji, Lu-Jing Ren, Zhi-Kui Nie, He Huang & Ping-Kai Ouyang. (2014) Fungal arachidonic acid-rich oil: research, development and industrialization. Critical Reviews in Biotechnology 34:3, pages 197-214.
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Articles from other publishers (44)

Hiroshi Kikukawa, Akinori Ando, Asuka Hannya, Mohd Fazli Farida Asras, Tomoyo Okuda, Takaiku Sakamoto, Kiyotaka Y. Hara, Eiji Sakuradani & Jun Ogawa. (2023) Mead acid production by disruption of Δ12-desaturase gene in Mortierella alpina 1S-4. Journal of Bioscience and Bioengineering 136:5, pages 353-357.
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Xin Tang, Fengzhu Ling, Jianxin Zhao, Haiqin Chen & Wei Chen. (2023) Overexpression of Citrate-Malate Carrier Promoted Lipid Accumulation in Oleaginous Filamentous Fungus Mortierella alpina . Journal of Agricultural and Food Chemistry 71:19, pages 7468-7476.
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Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong & Reeta Rani Singhania. (2022) Emerging prospects of microbial production of omega fatty acids: Recent updates. Bioresource Technology 360, pages 127534.
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Hiroshi Kikukawa, Kenshi Watanabe, Shigenobu Kishino, Michiki Takeuchi, Akinori Ando, Yoshihiro Izumi & Eiji Sakuradani. (2022) Recent trends in the field of lipid engineering. Journal of Bioscience and Bioengineering 133:5, pages 405-413.
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Guoxiang Chi, Yiyuan Xu, Xingyu Cao, Zhipeng Li, Mingfeng Cao, Yusuf Chisti & Ning He. (2022) Production of polyunsaturated fatty acids by Schizochytrium (Aurantiochytrium) spp.. Biotechnology Advances 55, pages 107897.
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Carlos Ricardo Soccol, Brigitte Sthepani Orozco Colonia, Gilberto Vinícius de Melo Pereira, Luis Daniel Goyzueta Mamani, Susan Grace Karp, Vanete Thomaz Soccol, Rafaela de Oliveira Penha, Carlos José Dalmas Neto & Júlio César de Carvalho. (2022) Bioprospecting lipid-producing microorganisms: From metagenomic-assisted isolation techniques to industrial application and innovations. Bioresource Technology 346, pages 126455.
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Guyu Hao & Guy C Barker. (2022) Fatty acid secretion by the white-rot fungus, Trametes versicolor . Journal of Industrial Microbiology and Biotechnology 49:1.
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Lulu Chang, Hengqian Lu, Haiqin Chen, Xin Tang, Jianxin Zhao, Hao Zhang, Yong Q. Chen & Wei Chen. (2022) Lipid metabolism research in oleaginous fungus Mortierella alpina: Current progress and future prospects. Biotechnology Advances 54, pages 107794.
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Hassan Mohamed, Tahira Naz, Junhuan Yang, Aabid Manzoor Shah, Yusuf Nazir & Yuanda Song. (2021) Recent Molecular Tools for the Genetic Manipulation of Highly Industrially Important Mucoromycota Fungi. Journal of Fungi 7:12, pages 1061.
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Heng Zhao, Meilin Lv, Ze Liu, Mingzhe Zhang, Yaning Wang, Xiao Ju, Zhen Song, Liying Ren, Bisi Jia, Min Qiao & Xiaoyong Liu. (2020) High-yield oleaginous fungi and high-value microbial lipid resources from Mucoromycota. BioEnergy Research 14:4, pages 1196-1206.
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Xin Tang, Xiaoqi Sun, Xuxu Wang, Hao Zhang, Yong Q. Chen, Jianxin Zhao, Haiqin Chen & Wei Chen. (2021) Characterization of NAD+/NADP+-Specific Isocitrate Dehydrogenases From Oleaginous Fungus Mortierella alpina Involved in Lipid Accumulation. Frontiers in Nutrition 8.
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Hanqin Chen, Haiqin Chen, Hengqian Lu, Xin Tang, Hao Zhang, Yong Q. Chen & Wei Chen. (2021) Carbohydrate analysis of Mortierella alpina by colorimetry and HPLC–ELSD to reveal accumulation differences of sugar and lipid. Biotechnology Letters 43:7, pages 1289-1301.
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Hengqian Lu, Haiqin Chen, Xin Tang, Qin Yang, Hao Zhang, Yong Q. Chen & Wei Chen. (2021) Metabolomics analysis reveals the role of oxygen control in the nitrogen limitation induced lipid accumulation in Mortierella alpina. Journal of Biotechnology 325, pages 325-333.
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Huidan Zhang, Qiu Cui & Xiaojin Song. (2021) Research advances on arachidonic acid production by fermentation and genetic modification of Mortierella alpina. World Journal of Microbiology and Biotechnology 37:1.
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Ruma Dutta, D. K. Bhattacharyya & Jayati Bhowal. 2021. Advances in Bioprocess Engineering and Technology. Advances in Bioprocess Engineering and Technology 51 65 .
Km Sartaj & R. Prasad. 2020. Nutraceutical Fatty Acids from Oleaginous Microalgae. Nutraceutical Fatty Acids from Oleaginous Microalgae 187 207 .
Huidan Zhang, Zhuojun Wang, Yingang Feng, Qiu Cui & Xiaojin Song. (2019) Phytohormones as stimulators to improve arachidonic acid biosynthesis in Mortierella alpina. Enzyme and Microbial Technology 131, pages 109381.
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Hengqian Lu, Haiqin Chen, Xin Tang, Qin Yang, Hao Zhang, Yong Q. Chen & Wei Chen. (2019) Ultra Performance Liquid Chromatography–Q Exactive Orbitrap/Mass Spectrometry-Based Lipidomics Reveals the Influence of Nitrogen Sources on Lipid Biosynthesis of Mortierella alpina . Journal of Agricultural and Food Chemistry 67:39, pages 10984-10993.
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Yung-Yu Tsai, Takao Ohashi, Chih-Chan Wu, Dolgormaa Bataa, Ryo Misaki, Savitree Limtong & Kazuhito Fujiyama. (2019) Delta-9 fatty acid desaturase overexpression enhanced lipid production and oleic acid content in Rhodosporidium toruloides for preferable yeast lipid production. Journal of Bioscience and Bioengineering 127:4, pages 430-440.
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Joy Michal JohnsonAnatoli LudwigAlexandra C. U. FurchAxel MithöferSandra Scholz, Michael Reichelt & Ralf Oelmüller. (2019) The Beneficial Root-Colonizing Fungus Mortierella hyalina Promotes the Aerial Growth of Arabidopsis and Activates Calcium-Dependent Responses That Restrict Alternaria brassicae –Induced Disease Development in Roots . Molecular Plant-Microbe Interactions® 32:3, pages 351-363.
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Yan Yang, Fatemeh Heidari & Bo Hu. 2019. Microbial Lipid Production. Microbial Lipid Production 51 89 .
Huidan Zhang, Dong Lu, Xin Li, Yingang Feng, Qiu Cui & Xiaojin Song. (2018) Heavy ion mutagenesis combined with triclosan screening provides a new strategy for improving the arachidonic acid yield in Mortierella alpina. BMC Biotechnology 18:1.
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Pablo Villarreal, Mario Carrasco, Salvador Barahona, Jennifer Alcaíno, Víctor Cifuentes & Marcelo Baeza. (2018) Antarctic yeasts: analysis of their freeze-thaw tolerance and production of antifreeze proteins, fatty acids and ergosterol. BMC Microbiology 18:1.
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Rani J. Qasem. (2018) Single-tube biosynthesis and extraction of U-13C and U-14C arachidonic acid from microcultures of Mortierella alpina for in vivo pharmacology and metabolic tracing studies. Journal of Pharmacological and Toxicological Methods 92, pages 1-12.
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Hiroshi Kikukawa, Eiji Sakuradani, Akinori Ando, Sakayu Shimizu & Jun Ogawa. (2018) Arachidonic acid production by the oleaginous fungus Mortierella alpina 1S-4: A review. Journal of Advanced Research 11, pages 15-22.
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Alexander L. Rabinovich, Alexander P. Lyubartsev & Dmitrii V. Zhurkin. (2017) Unperturbed hydrocarbon chains and liquid phase bilayer lipid chains: a computer simulation study. European Biophysics Journal 47:2, pages 109-130.
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Chengfeng Ge, Haiqin Chen, Tiantian Mei, Xin Tang, Lulu Chang, Zhennan Gu, Hao Zhang, Wei Chen & Yong Q. Chen. (2018) Application of a ω-3 Desaturase with an Arachidonic Acid Preference to Eicosapentaenoic Acid Production in Mortierella alpina. Frontiers in Bioengineering and Biotechnology 5.
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Huidan Zhang, Yingang Feng, Qiu Cui & Xiaojin Song. (2017) Expression of Vitreoscilla hemoglobin enhances production of arachidonic acid and lipids in Mortierella alpina. BMC Biotechnology 17:1.
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Takaiku Sakamoto, Eiji Sakuradani, Tomoyo Okuda, Hiroshi Kikukawa, Akinori Ando, Shigenobu Kishino, Yoshihiro Izumi, Takeshi Bamba, Jun Shima & Jun Ogawa. (2017) Metabolic engineering of oleaginous fungus Mortierella alpina for high production of oleic and linoleic acids. Bioresource Technology 245, pages 1610-1615.
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Arun Chand Rayaroth, Rajesh Singh Tomar & Raghavendra Kumar Mishra. (2016) Arachidonic Acid Synthesis in Mortierella alpina: Origin, Evolution and Advancements. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences 87:4, pages 1053-1066.
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Xiaojin Song, Zengxin Ma, Yanzhen Tan, Huidan Zhang & Qiu Cui. (2017) Wastewater recycling technology for fermentation in polyunsaturated fatty acid production. Bioresource Technology 235, pages 79-86.
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Hiroshi Kikukawa, Eiji Sakuradani, Akinori Ando, Tomoyo Okuda, Sakayu Shimizu & Jun Ogawa. (2016) Microbial production of dihomo-γ-linolenic acid by Δ5-desaturase gene-disruptants of Mortierella alpina 1S-4. Journal of Bioscience and Bioengineering 122:1, pages 22-26.
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Tomoyo Okuda, Akinori Ando, Hiroaki Negoro, Tatsuya Muratsubaki, Hiroshi Kikukawa, Takaiku Sakamoto, Eiji Sakuradani, Sakayu Shimizu & Jun Ogawa. (2015) Eicosapentaenoic acid (EPA) production by an oleaginous fungus Mortierella alpina expressing heterologous the Δ17‐desaturase gene under ordinary temperature . European Journal of Lipid Science and Technology 117:12, pages 1919-1927.
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Hiroshi Kikukawa, Eiji Sakuradani, Masato Nakatani, Akinori Ando, Tomoyo Okuda, Takaiku Sakamoto, Misa Ochiai, Sakayu Shimizu & Jun Ogawa. (2015) Gene targeting in the oil-producing fungus Mortierella alpina 1S-4 and construction of a strain producing a valuable polyunsaturated fatty acid. Current Genetics 61:4, pages 579-589.
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Tayvich Vorapreeda, Chinae Thammarongtham, Supapon Cheevadhanarak & Kobkul Laoteng. (2015) Genome mining of fungal lipid-degrading enzymes for industrial applications. Microbiology 161:8, pages 1613-1626.
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Hiroshi Kikukawa, Eiji Sakuradani, Akinori Ando, Tomoyo Okuda, Misa Ochiai, Sakayu Shimizu & Jun Ogawa. (2015) Disruption of lig4 improves gene targeting efficiency in the oleaginous fungus Mortierella alpina 1S-4. Journal of Biotechnology 208, pages 63-69.
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Alessandro Luis Venega Coradini, Andréia Anschau, Annamaria Dória Souza Vidotti, Érika Marques Reis, Michelle da Cunha Abreu Xavier, Renato Sano Coelho & Telma Teixeira Franco. 2015. Microorganisms in Biorefineries. Microorganisms in Biorefineries 51 78 .
Yuhui Zhao, Hui Wang, Tianxing Liu & Zhihong Xin. (2013) The individual lipid compositions produced by Cunninghamella sp. Salicorn 5, an endophytic oleaginous fungus from Salicornia bigelovii Torr.. European Food Research and Technology 238:4, pages 621-633.
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Jun Ogawa, Eiji Sakuradani, Shigenobu Kishino, Akinori Ando, Kenzo Yokozeki & Sakayu Shimizu. 2014. Microbial Production. Microbial Production 207 218 .
Hiroshi Kikukawa, Eiji Sakuradani, Shigenobu Kishino, Si-Bum Park, Akinori Ando, Jun Shima, Misa Ochiai, Sakayu Shimizu & Jun Ogawa. (2013) Characterization of a trifunctional fatty acid desaturase from oleaginous filamentous fungus Mortierella alpina 1S-4 using a yeast expression system. Journal of Bioscience and Bioengineering 116:6, pages 672-676.
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Jun Ogawa, Eiji Sakuradani, Shigenobu Kishino, Akinori Ando, Kenzo Yokozeki & Sakayu Shimizu. (2012) Polyunsaturated fatty acids production and transformation by Mortierella alpina and anaerobic bacteria . European Journal of Lipid Science and Technology 114:10, pages 1107-1113.
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Yujin Cao, Yugang Cao & Min’an Zhao. (2012) Biotechnological production of eicosapentaenoic acid: From a metabolic engineering point of view. Process Biochemistry 47:9, pages 1320-1326.
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A. Nisha, K. Udaya Sankar & G. Venkateswaran. (2012) Supercritical CO2 extraction of Mortierella alpina single cell oil: Comparison with organic solvent extraction. Food Chemistry 133:1, pages 220-226.
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L.F. Bautista, G. Vicente & V. Garre. 2012. Advances in Biodiesel Production. Advances in Biodiesel Production 179 203 .

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