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Bioscience, Biotechnology, and Biochemistry Volume 75, 2011 - Issue 8
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Original Articles

Orally Administered Glucosylceramide Improves the Skin Barrier Function by Upregulating Genes Associated with the Tight Junction and Cornified Envelope Formation

Ritsuro IDETAShiseido Functional Food Research and Development Center
,
Tomohiro SAKUTAShiseido Functional Food Research and Development Center
,
Yusuke NAKANOShiseido Functional Food Research and Development Center
&
Taro UCHIYAMAShiseido Functional Food Research and Development Center
Pages 1516-1523 | Received 18 Mar 2011, Accepted 09 May 2011, Published online: 22 May 2014

Citations (36)

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Toshihiko Enomoto, Ayana Kojima-Nakamura, Kazuya Kodaira, Yoshifumi Oguro & Atsushi Kurahashi. (2022) Koji amazake Maintains Water Content in the Left Cheek Skin of Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Comparative Trial. Clinical, Cosmetic and Investigational Dermatology 15, pages 1283-1291.
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Hiroshi Hamajima, Masaru Tanaka, Miyuki Miyagawa, Mayuko Sakamoto, Tsuyoshi Nakamura, Teruyoshi Yanagita, Megumi Nishimukai, Susumu Mitsutake, Jiro Nakayama, Koji Nagao & Hiroshi Kitagaki. (2019) Koji glycosylceramide commonly contained in Japanese traditional fermented foods alters cholesterol metabolism in obese mice. Bioscience, Biotechnology, and Biochemistry 83:8, pages 1514-1522.
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Misho Kawata, Masato Suzuki, Shoko Akutsu, Natsuki Kawahara, Ami Tsukamoto, Shohei Nobukawa, Ryohei Isozaki, Seika Yuyama & Narito Asanuma. (2018) Augmentation of dietary glucosylceramide hydrolysis by the novel bacterium Glucerabacter canisensis NATH-2371T. Bioscience, Biotechnology, and Biochemistry 82:12, pages 2191-2197.
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Yuri Oh, Hye-Won Lim, Kyunghoon Kim & Chang-Jin Lim. (2016) Ginsenoside Re improves skin barrier function in HaCaT keratinocytes under normal growth conditions. Bioscience, Biotechnology, and Biochemistry 80:11, pages 2165-2167.
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Ryo TAKATORI, Phuong LE VU, Taku IWAMOTO, Hideo SATSU, Mamoru TOTSUKA, Kazuhiro CHIDA & Makoto SHIMIZU. (2013) Effects of Oral Administration of Glucosylceramide on Gene Expression Changes in Hairless Mouse Skin: Comparison of Whole Skin, Epidermis, and Dermis. Bioscience, Biotechnology, and Biochemistry 77:9, pages 1882-1887.
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Articles from other publishers (31)

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Kentaro Shoji, Aoi Kameda & Kayo Furuichi. (2023) Effects of Milk Amazake on Skin Elasticity, Hydration, and Transepidermal Water Loss: An 8-Week Double-Blind, Randomized, Controlled Trial. Journal of Oleo Science 72:3, pages 329-335.
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Fang Yang & Guoxun Chen. (2022) The nutritional functions of dietary sphingomyelin and its applications in food. Frontiers in Nutrition 9.
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Tatsuya Sugawara. (2022) Sphingolipids as Functional Food Components: Benefits in Skin Improvement and Disease Prevention. Journal of Agricultural and Food Chemistry 70:31, pages 9597-9609.
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Maya Stoyneva-Gärtner, Blagoy Uzunov & Georg Gärtner. (2022) Aeroterrestrial and Extremophilic Microalgae as Promising Sources for Lipids and Lipid Nanoparticles in Dermal Cosmetics. Cosmetics 9:1, pages 11.
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Kui Ding, Libin Zhang, Da Huo, Xueying Guo, Xiang Liu & Shuangli Zhang. (2021) Metabolomic analysis of coelomic fluids reveals the physiological mechanisms underlying evisceration behavior in the sea cucumber Apostichopus japonicus. Aquaculture 543, pages 736960.
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Kazushi Ohta, Shinobu Hiraki, Masakatsu Miyanabe, Tatsuro Ueki, Yuki Manabe & Tatsuya Sugawara. (2021) Dietary Ceramide Prepared from Soy Sauce Lees Improves Skin Barrier Function in Hairless Mice. Journal of Oleo Science 70:9, pages 1325-1334.
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Nairui Zhang, Kanae Kohama, Miyuki Miyagawa, Moe Mansho, Ryota Sugimoto, Ayaka Nakashima, Kengo Suzuki & Hiroshi Kitagaki. (2020) Identification of Monohexosylceramides From Euglena gracilis by Electrospray Ionization Mass Spectrometry . Natural Product Communications 15:8, pages 1934578X2094235.
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Sakiko Oka, Nobuaki Ohto, Hiroshige Kuwahara & Masashi Mizuno. (2020) Oral administration of pineapple glucosylceramide improves defective epidermal barrier function by restoring diminished level of TGF-β in the skin. European Food Research and Technology 246:5, pages 867-874.
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Shoko Fukunaga, Sayori Wada, Mika Yamashita, Mayuko Morita, Wataru Aoi, Yuji Naito & Akane Higashi. (2019) Torula yeast ( Candida utilis )‐derived glucosylceramide contributes to dermal elasticity in vitro . Journal of Food Biochemistry 43:7.
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Ryosuke Yamaguchi, Yoshimi Kanie, Osamu Kanie & Yoshitaka Shimizu. (2019) A unique structural distribution pattern discovered for the cerebrosides from starfish Asterias amurensis. Carbohydrate Research 473, pages 115-122.
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Misho Kawata, Ami Tsukamoto, Ryohei Isozaki, Shohei Nobukawa, Natsuki Kawahara, Shoko Akutsu, Masato Suzuki & Narito Asanuma. (2017) Glucerabacter canisensis gen. nov., sp. nov., isolated from dog feces and its effect on the hydrolysis of plant glucosylceramide in the intestine of dogs. Archives of Microbiology 200:3, pages 505-515.
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Nami Tomonaga, Yuki Manabe & Tatsuya Sugawara. (2017) Digestion of Ceramide 2-Aminoethylphosphonate, a Sphingolipid from the Jumbo Flying Squid Dosidicus gigas, in Mice. Lipids 52:4, pages 353-362.
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Mayuko SAKAMOTO, Mai SAKATANI, Jannatul FERDOUSE, Hiroshi HAMAJIMA, Keisuke TSUGE, Megumi NISHIMUKAI, Teruyoshi YANAGITA, Koji NAGAO, Susumu MITSUTAKE & Hiroshi KITAGAKI. (2017) Development of a quantitative method for the contents of glycosylceramide contained in Japanese foods brewed with koji and its application.麴で造られる醸造食品のグリコシルセラミド定量手法の検討とそれを用いた定量. JOURNAL OF THE BREWING SOCIETY OF JAPAN 112:9, pages 655-662.
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Efrem N. Tessema, Tsige Gebre-Mariam, Reinhard H.H. Neubert & Johannes Wohlrab. (2017) Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function. Skin Pharmacology and Physiology 30:3, pages 115-138.
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S. Niiyama, T. Yoshino, C. Yasuda, X. Yu, R. Izumi, S. Ishiwatari, S. Matsukuma & H. Mukai. (2016) Galectin-7 in the stratum corneum: a biomarker of the skin barrier function. International Journal of Cosmetic Science 38:5, pages 487-495.
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Daisuke Mikami, Shota Sakai, Shigefumi Sasaki & Yasuyuki Igarashi. (2016) Effects of <i>Asterias amurensis</i>-derived Sphingoid Bases on the <i>de novo</i> Ceramide Synthesis in Cultured Normal Human Epidermal Keratinocytes. Journal of Oleo Science 65:8, pages 671-680.
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Takashi Kida, Akari Kimura, Aoi Ito, Ryouhei Yamashita, Kentaro Kogure, Akira Tokumura & Tamotsu Tanaka. (2016) Quantification of glycosylinositol phosphoceramide and phytoceramide-1-phosphate in foodstuffs. Journal of Lipid Nutrition 25:1, pages 75-85.
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Min Liu, Xia Li, Xiao-Ying Chen, Feng Xue & Jie Zheng. (2015) Topical application of a linoleic acid-ceramide containing moisturizer exhibit therapeutic and preventive benefits for psoriasis vulgaris: a randomized controlled trial. Dermatologic Therapy 28:6, pages 373-382.
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Chisato Oba, Masashi Morifuji, Satomi Ichikawa, Kyoko Ito, Keiko Kawahata, Taketo Yamaji, Yukio Asami, Hiroyuki Itou & Tatsuya Sugawara. (2015) Dietary Milk Sphingomyelin Prevents Disruption of Skin Barrier Function in Hairless Mice after UV-B Irradiation. PLOS ONE 10:8, pages e0136377.
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Hiroaki Yazama, Kazuyuki Kitatani, Kazunori Fujiwara, Misaki Kato, Mayumi Hashimoto-Nishimura, Katsuyuki Kawamoto, Kensaku Hasegawa, Hiroya Kitano, Alicja Bielawska, Jacek Bielawski & Toshiro Okazaki. (2014) Dietary glucosylceramides suppress tumor growth in a mouse xenograft model of head and neck squamous cell carcinoma by the inhibition of angiogenesis through an increase in ceramide. International Journal of Clinical Oncology 20:3, pages 438-446.
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Mijung Yeom, Jinhee Park, Changyong Lim, Bongjun Sur, Bombi Lee, Jeong-Jun Han, Hee-Don Choi, Hyejung Lee & Dae-Hyun Hahm. (2015) Glucosylceramide attenuates the inflammatory mediator expression in lipopolysaccharide-stimulated RAW264.7 cells. Nutrition Research 35:3, pages 241-250.
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Takuto Ogawa, Hikaru Migita, Satoko Shimada, Junji Ichida & Kyoichi Osada. (2014) The Structure and Level of Glucosylceramide in Apple Pomace. Nippon Shokuhin Kagaku Kogaku Kaishi 61:6, pages 251-257.
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Yohei Ishibashi, Ayako Kohyama-Koganeya & Yoshio Hirabayashi. (2013) New insights on glucosylated lipids: Metabolism and functions. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1831:9, pages 1475-1485.
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Allie Cichewicz, Chelsea Pacleb, Ashley Connors, Martha A Hass & Luciana B Lopes. (2013) Cutaneous delivery of α-tocopherol and lipoic acid using microemulsions: influence of composition and charge. Journal of Pharmacy and Pharmacology 65:6, pages 817-826.
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Yoshiyuki Shirakura, Kanako Kikuchi, Kenji Matsumura, Katsuyuki Mukai, Susumu Mitsutake & Yasuyuki Igarashi. (2012) 4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin. Lipids in Health and Disease 11:1.
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Hiroshi ShimodaShuko TerazawaShoketsu HitoeJunji TanakaSeikou NakamuraHisashi MatsudaMasayuki Yoshikawa. (2012) Changes in Ceramides and Glucosylceramides in Mouse Skin and Human Epidermal Equivalents by Rice-Derived Glucosylceramide. Journal of Medicinal Food 15:12, pages 1064-1072.
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Hiroyuki Imai, Hideyasu Hattori & Masayuki Watanabe. (2012) An Improved Method for Analysis of Glucosylceramide Species Having cis-8 and trans-8 Isomers of Sphingoid Bases by LC–MS/MS. Lipids 47:12, pages 1221-1229.
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Yuko Haruta-Ono, Shuichi Setoguchi, Hiroshi M. Ueno, Satoshi Higurashi, Noriko Ueda, Ken Kato, Tadao Saito, Kazuhisa Matsunaga & Jiro Takata. (2012) Orally administered sphingomyelin in bovine milk is incorporated into skin sphingolipids and is involved in the water-holding capacity of hairless mice. Journal of Dermatological Science 68:1, pages 56-62.
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A. Roussel, V. Bruet & P. Bourdeau. (2012) Données actuelles sur la barrière cutanée et implications dans la dermatite atopique canine. Pratique Médicale et Chirurgicale de l'Animal de Compagnie 47:4, pages 101-110.
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