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Bioscience, Biotechnology, and Biochemistry Volume 75, 2011 - Issue 8
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Original Articles

SNX-2112, a Novel Hsp90 Inhibitor, Induces G2/M Cell Cycle Arrest and Apoptosis in MCF-7 Cells

Shao-Xiang WANGGuangzhoujinan Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center for Genetic Medicine, Jinan University;Institute of Pharmacology Science, Jinan University
,
Huai-Qiang JUGuangzhoujinan Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center for Genetic Medicine, Jinan University
,
Kai-Sheng LIUGuangzhoujinan Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center for Genetic Medicine, Jinan University;Institute of Pharmacology Science, Jinan University
,
Jia-Xuan ZHANGGuangzhoujinan Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center for Genetic Medicine, Jinan University;Institute of Pharmacology Science, Jinan University
,
Xiao WANGSchool of Pharmaceutical Sciences, Sun Yat-sen University
,
Yang-Fei XIANGGuangzhoujinan Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center for Genetic Medicine, Jinan University;Institute of Pharmacology Science, Jinan University
,
Rui WANGGuangzhoujinan Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center for Genetic Medicine, Jinan University
,
Jin-Yun LIUSchool of Pharmaceutical Sciences, Sun Yat-sen University
,
Qiu-Ying LIUGuangzhoujinan Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center for Genetic Medicine, Jinan University;Institute of Pharmacology Science, Jinan University
,
Min XIAInstitute of Pharmacology Science, Jinan University
,
Guo-Wen XINGChemistry College, Beijing Normal University
,
Zhong LIUGuangzhoujinan Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center for Genetic Medicine, Jinan University
&
Yi-Fei WANGGuangzhoujinan Biomedicine Research and Development Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center for Genetic Medicine, Jinan University
 show all
Pages 1540-1545 | Received 22 Mar 2011, Accepted 10 May 2011, Published online: 22 May 2014

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Ting Huyan, Qi Li, Dan-Dan Dong, Hui Yang, Jian Zhang, Qing-Sheng Huang, Da-Chuan Yin & Peng Shang. (2016) Heat shock protein 90 inhibitors induce functional inhibition of human natural killer cells in a dose-dependent manner. Immunopharmacology and Immunotoxicology 38:2, pages 77-86.
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Wei Liu, Hongming Liu, Hua Sun, Dong Dong, Zhiguo Ma, Yifei Wang & Baojian Wu. (2014) Metabolite elucidation of the Hsp90 inhibitor SNX-2112 using ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS). Xenobiotica 44:5, pages 455-464.
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Articles from other publishers (25)

Jaka Dernovšek & Tihomir Tomašič. (2023) Following the design path of isoform-selective Hsp90 inhibitors: Small differences, great opportunities. Pharmacology & Therapeutics 245, pages 108396.
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Simon Mathien, Chloé Tesnière & Sylvain Meloche. (2022) Regulation of Mitogen-Activated Protein Kinase Signaling Pathways by the Ubiquitin-Proteasome System and Its Pharmacological Potential. Pharmacological Reviews 73:4, pages 1434-1467.
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Hamidu Ahmed, Mokrish Ajat, Rana I. Mahmood, Rozaihan Mansor, Intan Shameha Abdul Razak, Jameel R. Al-Obaidi, Nurhanani Razali, Alhaji Zubair Jaji, Abubakar Danmaigoro & Md Zuki Abu Bakar. (2021) LC-MS/MS Proteomic Study of MCF-7 Cell Treated with Dox and Dox-Loaded Calcium Carbonate Nanoparticles Revealed Changes in Proteins Related to Glycolysis, Actin Signalling, and Energy Metabolism. Biology 10:9, pages 909.
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Huaqiang Li, Shuqiang Zhuang, Yang Yang, Fei Zhou, Jianhua Rong & Jianhao Zhao. (2021) ATP/Hyals dually responsive core-shell hyaluronan/chitosan-based drug nanocarrier for potential application in breast cancer therapy. International Journal of Biological Macromolecules 183, pages 839-851.
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Fujun Jin, Rongze Wang, Yexuan Zhu, Jingyi Chen, Wei Cao, Yiliang Wang, Yanting Wu, Xiaowei Song, Yunsheng Huang, Jun Dong & Zhe Ren. (2020) A novel quinolinylmethyl substituted ethylenediamine compound exerts anti-cancer effects via stimulating the accumulation of reactive oxygen species and NO in hepatocellular carcinoma cells. European Journal of Pharmacology 885, pages 173497.
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Akhila Mettu, Venu Talla & Subhashini James Prameela Naikal. (2020) Novel anticancer Hsp90 inhibitor disubstituted pyrazolyl 2-aminopyrimidine compound 7t induces cell cycle arrest and apoptosis via mitochondrial pathway in MCF-7 cells. Bioorganic & Medicinal Chemistry Letters 30:20, pages 127470.
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Liang-Shun Fu, Hong-Hong Qiu, Min Liu, Liu-Bing Hu, Yan Wang, Peng-Chao Zhang, Man-Mei Li, Yi-Fei Wang & Zhong Liu. (2020) SNX-2112, an Hsp90 inhibitor, suppresses cervical cancer cells proliferation, migration, and invasion by inhibiting the Akt/mTOR signaling pathway. Medicinal Chemistry Research 29:6, pages 942-953.
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Kaisheng Liu, Juan Chen, Fang Yang, Zhifan Zhou, Ying Liu, Yaomin Guo, Hong Hu, Hengyuan Gao, Haili Li, Wenbin Zhou, Bo Qin & Yifei Wang. (2019) BJ-B11, an Hsp90 Inhibitor, Constrains the Proliferation and Invasion of Breast Cancer Cells. Frontiers in Oncology 9.
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Kaisheng Liu, Hongtao Jin, Yaomin Guo, Ying Liu, Yong Wan, Pan Zhao, Zhifan Zhou, Jianhong Wang, Maolin Wang, Chang Zou, Weiqing Wu, Zhiqiang Cheng & Yong Dai. (2019) CFTR interacts with Hsp90 and regulates the phosphorylation of AKT and ERK1/2 in colorectal cancer cells. FEBS Open Bio 9:6, pages 1119-1127.
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Liubing Hu, Yan Wang, Zui Chen, Liangshun Fu, Sheng Wang, Xinyue Zhang, Pengchao Zhang, Xueping Lu, Huiyang Jie, Manmei Li, Yifei Wang & Zhong Liu. (2019) Hsp90 Inhibitor SNX-2112 Enhances TRAIL-Induced Apoptosis of Human Cervical Cancer Cells via the ROS-Mediated JNK-p53-Autophagy-DR5 Pathway. Oxidative Medicine and Cellular Longevity 2019, pages 1-26.
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Yan Wu, Xinyue Zhang, Huaqiang Li, Pengfei Deng, Huiru Li, Tianqi He, Jianhua Rong, Jianhao Zhao & Zhong Liu. (2018) A core/shell stabilized polysaccharide-based nanoparticle with intracellular environment-sensitive drug delivery for breast cancer therapy. Journal of Materials Chemistry B 6:41, pages 6646-6659.
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Félix Sauvage, Elias Fattal, Walhan Al-Shaer, Stéphanie Denis, Emilie Brotin, Christophe Denoyelle, Cécile Blanc-Fournier, Balthazar Toussaint, Samir Messaoudi, Mouad Alami, Gillian Barratt & Juliette Vergnaud-Gauduchon. (2018) Antitumor activity of nanoliposomes encapsulating the novobiocin analog 6BrCaQ in a triple-negative breast cancer model in mice. Cancer Letters 432, pages 103-111.
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Félix Sauvage, Samir Messaoudi, Elias Fattal, Gillian Barratt & Juliette Vergnaud-Gauduchon. (2017) Heat shock proteins and cancer: How can nanomedicine be harnessed?. Journal of Controlled Release 248, pages 133-143.
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Patrizio Castagnola, Grazia Bellese, Filippo Birocchi, Maria Cristina Gagliani, Carlo Tacchetti & Katia Cortese. (2016) Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells. Oncotarget 7:51, pages 85411-85429.
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David Montoir, Sophie Barillé-Nion, Alain Tonnerre, Philippe Juin, Muriel Duflos & Marc-Antoine Bazin. (2016) Novel 1,6-naphthyridin-2(1H)-ones as potential anticancer agents targeting Hsp90. European Journal of Medicinal Chemistry 119, pages 17-33.
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Si Hyoung Kim, Jun Goo Kang, Chul Sik Kim, Sung-Hee Ihm, Moon Gi Choi, Hyung Joon Yoo & Seong Jin Lee. (2015) The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells. Endocrine 51:2, pages 274-282.
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Kyoung-Hee Lee, An-Hee Jang & Chul-Gyu Yoo. (2015) 17-Allylamino-17-Demethoxygeldanamycin and the Enhancement of PS-341–Induced Lung Cancer Cell Death by Blocking the NF-κB and PI3K/Akt Pathways. American Journal of Respiratory Cell and Molecular Biology 53:3, pages 412-421.
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Shaoxiang Wang, Zhan Du, Jie Luo, Xiao Wang, Haiying Li, Yuting Liu, Yong Zhang, Jiwei Ma, Weiwei Xiao, Yifei Wang & Xueyun Zhong. (2015) Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer. Journal of Cancer Research and Clinical Oncology 141:8, pages 1405-1416.
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XIAO WANG, SHAOXIANG WANG, YUTING LIU, DANE HUANG, KAI ZHENG, YI ZHANG, XIAOYAN WANG, QIUYING LIU, DEPO YANG & YIFEI WANG. (2015) Comparative effects of SNX-7081 and SNX-2112 on cell cycle, apoptosis and Hsp90 client proteins in human cancer cells. Oncology Reports 33:1, pages 230-238.
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YUTING LIU, XIAO WANG, YING WANG, YI ZHANG, KAI ZHENG, HAIZHAO YAN, LI ZHANG, WENBO CHEN, XIAOYAN WANG, QIUYING LIU, SHAOXIANG WANG & YIFEI WANG. (2015) Combination of SNX-2112 with 5-FU exhibits antagonistic effect in esophageal cancer cells. International Journal of Oncology 46:1, pages 299-307.
Crossref
Xiao Wang, Shaoxiang Wang, Yuting Liu, Weichao Ding, Kai Zheng, Yangfei Xiang, Kaisheng Liu, Dongmei Wang, Yaoying Zeng, Min Xia, Depo Yang & Yifei Wang. (2014) The Hsp90 inhibitor SNX-2112 induces apoptosis of human hepatocellular carcinoma cells: The role of ER stress. Biochemical and Biophysical Research Communications 446:1, pages 160-166.
Crossref
Chunwan Lu, Di Liu, Jing Jin, Hemantkumar Deokar, Yi Zhang, John K. Buolamwini, Xiaoming Yu, Chunhong Yan & Xiaoguang Chen. (2013) Inhibition of gastric tumor growth by a novel Hsp90 inhibitor. Biochemical Pharmacology 85:9, pages 1246-1256.
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Antonino Lauria, Ilenia Abbate, Carla Gentile, Francesca Angileri, Annamaria Martorana & Anna Maria Almerico. (2013) Synthesis and Biological Activities of a New Class of Heat Shock Protein 90 Inhibitors, Designed by Energy-Based Pharmacophore Virtual Screening. Journal of Medicinal Chemistry 56:8, pages 3424-3428.
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Yang-Fei Xiang, Chui-Wen Qian, Guo-Wen Xing, Jing Hao, Min Xia & Yi-Fei Wang. (2012) Anti-herpes simplex virus efficacies of 2-aminobenzamide derivatives as novel HSP90 inhibitors. Bioorganic & Medicinal Chemistry Letters 22:14, pages 4703-4706.
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KAI-SHENG LIU, YI ZHANG, WEI-CHAO DING, SHAO-XIANG WANG, YANG-FEI XIANG, PAN YANG, ZHEN-PING CHEN, KAI ZHENG, ZHONG LIU, MIN XIA & YI-FEI WANG. (2012) The selective Hsp90 inhibitor BJ-B11 exhibits potent antitumor activity via induction of cell cycle arrest, apoptosis and autophagy in Eca-109 human esophageal squamous carcinoma cells. International Journal of Oncology 41:6, pages 2276-2284.
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