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Original Articles

Depressive Effects on the Central Nervous System and Underlying Mechanism of the Enzymatic Extract and Its Phlorotannin-Rich Fraction from Ecklonia cava Edible Brown Seaweed

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Pages 163-168 | Received 21 Sep 2011, Accepted 12 Oct 2011, Published online: 22 May 2014

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Minseok Yoon, Jin-Soo Kim, Min Young Um, Hyejin Yang, Jiyoung Kim, Yun Tai Kim, Changho Lee, Seon-Bong Kim, Sangoh Kwon & Suengmok Cho. (2017) Extraction Optimization for Phlorotannin Recovery from the Edible Brown Seaweed Ecklonia Cava. Journal of Aquatic Food Product Technology 26:7, pages 801-810.
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Articles from other publishers (27)

Yoon Ji Kwon, Oh Ig Kwon, Hye Jeong Hwang, Hyeon-Cheol Shin & Sungchil Yang. (2023) Therapeutic effects of phlorotannins in the treatment of neurodegenerative disorders. Frontiers in Molecular Neuroscience 16.
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Seonghui Kim, Duhyeon Kim, Min Young Um, Minseok Yoon, Jae-Suk Choi, Yung Hyun Choi & Suengmok Cho. (2022) Marine Polyphenol Phlorotannins as a Natural Sleep Aid for Treatment of Insomnia: A Review of Sedative–Hypnotic Effects and Mechanism of Action. Marine Drugs 20:12, pages 774.
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José-Luis Ríos, Guillermo R. Schinella & Inés Moragrega. (2022) Phenolics as GABAA Receptor Ligands: An Updated Review. Molecules 27:6, pages 1770.
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Durairaj Karthick Rajan, Kannan Mohan, Shubing Zhang & Abirami Ramu Ganesan. (2021) Dieckol: a brown algal phlorotannin with biological potential. Biomedicine & Pharmacotherapy 142, pages 111988.
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Farid Menaa, Udari Wijesinghe, Gobika Thiripuranathar, Norah A. Althobaiti, Aishah E. Albalawi, Barkat Ali Khan & Bouzid Menaa. (2021) Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs?. Marine Drugs 19:9, pages 484.
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Leonel Pereira & Ana Valado. (2021) The Seaweed Diet in Prevention and Treatment of the Neurodegenerative Diseases. Marine Drugs 19:3, pages 128.
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Nolwenn Terme, Kévin Hardouin, Hugo Pliego Cortès, Ana Peñuela, Yolanda Freile-Pelegrín, Daniel Robledo, Gilles Bedoux & Nathalie Bourgougnon. 2020. Sustainable Seaweed Technologies. Sustainable Seaweed Technologies 225 256 .
Sangeeta Saikia, Nikhil Kumar Mahnot, Ravi Kumar Sahu & Jatin Kalita. 2020. Marine Niche: Applications in Pharmaceutical Sciences. Marine Niche: Applications in Pharmaceutical Sciences 183 201 .
Dool-Ri Oh, Yujin Kim, Ara Jo, Eun Jin Choi, Kyo-Nyeo Oh, Jaeyong Kim, Huwon Kang, Young Ran Kim & Chul yung Choi. (2019) Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABAA-ergic systems: Involvement of 5-HT1A receptor agonistic activity. Biomedicine & Pharmacotherapy 109, pages 2218-2227.
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Eun-Jeong Yang, Usman Mahmood, Hyunju Kim, Moonseok Choi, Yunjung Choi, Jean-Pyo Lee, Joo-Youn Cho, Jin Won Hyun, Yong Sik Kim, Moon-Jeong Chang & Hye-Sun Kim. (2018) Phloroglucinol ameliorates cognitive impairments by reducing the amyloid β peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice. Free Radical Biology and Medicine 126, pages 221-234.
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Min Young Um, Jin Young Kim, Jin Kyu Han, Jinkyung Kim, Hyejin Yang, Minseok Yoon, Jiyoung Kim, Seung Wan Kang & Suengmok Cho. (2018) Phlorotannin supplement decreases wake after sleep onset in adults with self-reported sleep disturbance: A randomized, controlled, double-blind clinical and polysomnographic study. Phytotherapy Research 32:4, pages 698-704.
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Suvimol Charoensiddhi, Michael A. Conlon, Christopher M.M. Franco & Wei Zhang. (2017) The development of seaweed-derived bioactive compounds for use as prebiotics and nutraceuticals using enzyme technologies. Trends in Food Science & Technology 70, pages 20-33.
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A. Leyton, J.R. Vergara-Salinas, J.R. Pérez-Correa & M.E. Lienqueo. (2017) Purification of phlorotannins from Macrocystis pyrifera using macroporous resins. Food Chemistry 237, pages 312-319.
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Alejandro Mayer, Abimael Rodríguez, Orazio Taglialatela-Scafati & Nobuhiro Fusetani. (2017) Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action. Marine Drugs 15:9, pages 273.
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Kenneth Lundstrom, Huyen Pham & Long Dinh. (2017) Interaction of Plant Extracts with Central Nervous System Receptors. Medicines 4:1, pages 12.
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Hyun Jung Son, Min Young Um, Inho Kim, Suengmok Cho, Daeseok Han & Changho Lee. (2016) In Vitro Screening for Anti-Dementia Activities of Seaweed Extracts. Journal of the Korean Society of Food Science and Nutrition 45:7, pages 966-972.
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Seon-Heui Cha, Soo-Jin Heo, You-Jin Jeon & Sang Myun Park. (2016) Dieckol, an edible seaweed polyphenol, retards rotenone-induced neurotoxicity and α-synuclein aggregation in human dopaminergic neuronal cells. RSC Advances 6:111, pages 110040-110046.
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P. Déléris, H. Nazih & J.-M. Bard. 2016. Seaweed in Health and Disease Prevention. Seaweed in Health and Disease Prevention 319 367 .
Issa Bangoura, Muhammad Tanvir Hossain Chowdhury, Paulos Getachew, Ji-Young Cho & Yong-Ki Hong. (2015) Feeding the Abalone Haliotis discus hannai with the Seaweed Eisenia bicyclis Allows the Accumulation of Phlorotannins. Fisheries and aquatic sciences 18:2, pages 165-171.
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Suengmok Cho & Makoto Shimizu. 2015. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease 141 151 .
Jiyoung Kim, Minseok Yoon, Hyejin Yang, Jinho Jo, Daeseok Han, You-Jin Jeon & Suengmok Cho. (2014) Enrichment and purification of marine polyphenol phlorotannins using macroporous adsorption resins. Food Chemistry 162, pages 135-142.
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Hyejin Yang, Minseok Yoon, Jiyoung Kim & Suengmok Cho. (2014) Acute Oral Toxicity of Phlorotannins in Beagle Dogs. Korean Journal of Fisheries and Aquatic Sciences 47:4, pages 356-362.
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Jae Kim, Dong Lim, Suengmok Cho, Daeseok Han & Yun Kim. (2014) The Edible Brown Seaweed Ecklonia cava Reduces Hypersensitivity in Postoperative and Neuropathic Pain Models in Rats. Molecules 19:6, pages 7669-7678.
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Minseok Yoon, Jin Soo Kim, Jinho Jo, Daeseok Han & Suengmok Cho. (2014) Sleep-Promoting Effect of Ecklonia cava: Ethanol Extract Promotes Non-rapid Eye Movement Sleep in C57BL/6N Mice. Fisheries and aquatic sciences 17:1, pages 19-25.
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Suengmok Cho, Hyejin Yang, Minseok Yoon, Jiyoung Kim, Dongsoo Kim, Jinkyung Kim & Seon-Bong Kim. (2014) Arousal Inhibitory Effect of Phlorotannins on Caffeine in Pentobarbital-Induced Mice. Fisheries and aquatic sciences 17:1, pages 13-18.
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Sang Mi Lee, Ho Hyun Jeong, Jong Cheol Lee, Man Yong Park & Sung Chul Kim. (2013) A Clinical Case Study on the Effects of Acupuncture Therapy and Ecklonia Cava Extract on Sleep Disturbances in ALS Patients. The Acupuncture 30:5, pages 247-252.
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Se-Kwon KimSuengmok Cho & Se-Kwon Kim. 2012. Marine Pharmacognosy. Marine Pharmacognosy 355 372 .

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