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Bioscience, Biotechnology, and Biochemistry Volume 76, 2012 - Issue 5
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Original Articles

ε-Viniferin Is More Effective Than Its Monomer Resveratrol in Improving the Functions of Vascular Endothelial Cells and the Heart

Nahla ZGHONDAGraduate School of Life and Environmental Sciences, Tsukuba University
,
Shigeki YOSHIDAGraduate School of Life and Environmental Sciences, Tsukuba University
,
Shoji EZAKIGraduate School of Life and Environmental Sciences, Tsukuba University
,
Yoshie OTAKEGraduate School of Life and Environmental Sciences, Tsukuba University
,
Chie MURAKAMIGraduate School of Life and Environmental Sciences, Tsukuba University
,
Ahmed MLIKILaboratory of Molecular Physiology of Grapevine, CBBC
,
Abdelwahed GHORBELLaboratory of Molecular Physiology of Grapevine, CBBC
&
Hitoshi MIYAZAKIGraduate School of Life and Environmental Sciences, Tsukuba University
 show all
Pages 954-960 | Received 21 Dec 2011, Accepted 25 Jan 2012, Published online: 22 May 2014

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Dongtao Li, Yan Liu, Rong Xu, Xin Jia, Xing Li, Cong Huo & Xiaoming Wang. (2019) RETRACTED ARTICLE: Astragalus polysaccharide alleviates H2O2-triggered oxidative injury in human umbilical vein endothelial cells via promoting KLF2. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 2188-2195.
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Articles from other publishers (41)

Veronica D’Eusanio, Lorenzo Morelli, Andrea Marchetti & Lorenzo Tassi. (2023) Polyphenolic Compounds in Extracts from Roasted Grapevine Canes: An Investigation for a Circular Approach to Increase Sustainability in the Viticulture Sectors. Molecules 28:22, pages 7676.
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Yuanyuan Liu, Haidong Wei & Jianhong Li. (2023) A review on SIRT3 and its natural small molecule activators as a potential Preventive and therapeutic target. European Journal of Pharmacology, pages 176155.
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Susana Ferreyra, Rubén Bottini & Ariel Fontana. (2023) Background and Perspectives on the Utilization of Canes’ and Bunch Stems’ Residues from Wine Industry as Sources of Bioactive Phenolic Compounds. Journal of Agricultural and Food Chemistry 71:23, pages 8699-8730.
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Veronica D’Eusanio, Francesco Genua, Andrea Marchetti, Lorenzo Morelli & Lorenzo Tassi. (2023) Characterization of Some Stilbenoids Extracted from Two Cultivars of Lambrusco—Vitis vinifera Species: An Opportunity to Valorize Pruning Canes for a More Sustainable Viticulture. Molecules 28:10, pages 4074.
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Saioa Gómez-Zorita, Iñaki Milton-Laskibar, Itziar Eseberri, Pauline Beaumont, Arnaud Courtois, Stéphanie Krisa & María P. Portillo. (2023) Beneficial Effects of ε-Viniferin on Obesity and Related Health Alterations. Nutrients 15:4, pages 928.
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Roxana Pop, Adela Daescu, Dumitrita Rugina & Adela Pintea. (2022) Resveratrol: Its Path from Isolation to Therapeutic Action in Eye Diseases. Antioxidants 11:12, pages 2447.
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Shivkanya Fuloria, Mahendran Sekar, Farrah Syazana Khattulanuar, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Subban Ravi, Vetriselvan Subramaniyan, Srikanth Jeyabalan, M. Yasmin Begum, Kumarappan Chidambaram, Kathiresan V. Sathasivam, Sher Zaman Safi, Yuan Seng Wu, Rusli Nordin, Mohammad Nazmul Hasan Maziz, Vinoth Kumarasamy, Pei Teng Lum & Neeraj Kumar Fuloria. (2022) Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy. Molecules 27:16, pages 5072.
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Fubao Su, Qibin Zhu, Ying Chen, Yanqiu Li, Qingyun Yang & Chunsuo Yao. (2022) Practical and efficient total synthetic route of the resveratrol dimer (±)-ε-viniferin. Tetrahedron Letters 97, pages 153775.
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Pauline Beaumont, Arnaud Courtois, Claude Atgié, Tristan Richard & Stéphanie Krisa. (2022) In the shadow of resveratrol: biological activities of epsilon-viniferin. Journal of Physiology and Biochemistry 78:2, pages 465-484.
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Ru Wang, Varun Kumar, Noga Sikron-Persi, Irena Dynkin, David Weiss, Avichai Perl, Aaron Fait & Michal Oren-Shamir. (2022) Over 1000-Fold Synergistic Boost in Viniferin Levels by Elicitation of Vitis vinifera cv. Gamay Red Cell Cultures over Accumulating Phenylalanine . Journal of Agricultural and Food Chemistry 70:16, pages 5049-5056.
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Biswanath Dinda, Subhajit Dinda & Mithun Chakraborty. 2022. Natural Products in Obesity and Diabetes. Natural Products in Obesity and Diabetes 277 467 .
Pauline Beaumont, Chrystel Faure, Arnaud Courtois, Michael Jourdes, Axel Marchal, Pierre-Louis Teissedre, Tristan Richard, Claude Atgié & Stéphanie Krisa. (2021) Trans-ε-Viniferin Encapsulation in Multi-Lamellar Liposomes: Consequences on Pharmacokinetic Parameters, Biodistribution and Glucuronide Formation in Rats. Nutrients 13:12, pages 4212.
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Susana Ferreyra, Carolina Torres-Palazzolo, Rubén Bottini, Alejandra Camargo & Ariel Fontana. (2021) Assessment of in-vitro bioaccessibility and antioxidant capacity of phenolic compounds extracts recovered from grapevine bunch stem and cane by-products. Food Chemistry 348, pages 129063.
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Su Jin Lee, Ji Eun Kim, Yun Ju Choi, Jeong Eun Gong, So Hae Park, Bounleuane Douangdeuane, Onevilay Souliya, Ju Min Park, Hee Seob Lee, Bae-Hwan Kim & Dae Youn Hwang. (2021) Therapeutic Effects of Dipterocarpus tuberculatus with High Antioxidative Activity Against UV-Induced Photoaging of NHDF Cells and Nude Mice. Antioxidants 10:5, pages 791.
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Concepción Medrano-Padial, María Puerto, Tristan Richard, Emma Cantos-Villar & Silvia Pichardo. (2021) Protection and reversion role of a pure stilbene extract from grapevine shoot and its major compounds against an induced oxidative stress. Journal of Functional Foods 79, pages 104393.
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Ru Wang, Sangram Keshari Lenka, Varun Kumar, Kelem Gashu, Noga Sikron-Persi, Irena Dynkin, David Weiss, Avichai Perl, Aaron Fait & Michal Oren-Shamir. (2021) Metabolic Engineering Strategy Enables a Hundred-Fold Increase in Viniferin Levels in Vitis vinifera cv. Gamay Red Cell Culture . Journal of Agricultural and Food Chemistry 69:10, pages 3124-3133.
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Julien Gabaston, Josep Valls Fonayet, Céline Franc, Pierre Waffo-Teguo, Gilles de Revel, Ghislaine Hilbert, Eric Gomès, Tristan Richard & Jean-Michel Mérillon. (2020) Characterization of Stilbene Composition in Grape Berries from Wild Vitis Species in Year-To-Year Harvest . Journal of Agricultural and Food Chemistry 68:47, pages 13408-13417.
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Concepción Medrano-Padial, María Puerto, María del Mar Merchán-Gragero, Francisco Javier Moreno, Tristan Richard, Emma Cantos-Villar & Silvia Pichardo. (2020) Cytotoxicity studies of a stilbene extract and its main components intended to be used as preservative in the wine industry. Food Research International 137, pages 109738.
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Che Wei Wu, Yoshihiro Nakamoto, Takumaru Hisatome, Shigeki Yoshida & Hitoshi Miyazaki. (2020) Resveratrol and its dimers ε‐viniferin and δ‐viniferin in red wine protect vascular endothelial cells by a similar mechanism with different potency and efficacy. The Kaohsiung Journal of Medical Sciences 36:7, pages 535-542.
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Ema Kosović, Martin Topiař, Petra Cuřínová & Marie Sajfrtová. (2020) Stability testing of resveratrol and viniferin obtained from Vitis vinifera L. by various extraction methods considering the industrial viewpoint. Scientific Reports 10:1.
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Susana G Ferreyra, Andrea Antoniolli, Rubén Bottini & Ariel Fontana. (2019) Bioactive compounds and total antioxidant capacity of cane residues from different grape varieties. Journal of the Science of Food and Agriculture 100:1, pages 376-383.
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Shuo Zhang, Yan Ma & Juan Feng. (2020) Neuroprotective mechanisms of ε-viniferin in a rotenone-induced cell model of Parkinson's disease: significance of SIRT3-mediated FOXO3 deacetylation. Neural Regeneration Research 15:11, pages 2143.
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Carole Lambert, Julien Lemaire, Hélène Auger, Arnaud Guilleret, Romain Reynaud, Christophe Clément, Eric Courot & Behnam Taidi. (2019) Optimize, Modulate, and Scale-up Resveratrol and Resveratrol Dimers Bioproduction in Vitis labrusca L. Cell Suspension from Flasks to 20 L Bioreactor. Plants 8:12, pages 567.
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Bo Yu, Ruifang Xie, Lingling Jin, Xiangge Tian, Yang Niu, Tonghui Ma & Hong Yang. (2019) trans-δ-Viniferin inhibits Ca2+-activated Cl− channels and improves diarrhea symptoms. Fitoterapia 139, pages 104367.
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Ibrahim Abdelgawad, Marianne Grant & Beshay Zordoky. (2019) Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology. Nutrients 11:3, pages 627.
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Ming-Wei Hung, Che-Wei Wu, Daichi Kokubu, Shigeki Yoshida & Hitoshi Miyazaki. (2019) ε-Viniferin is More Effective than Resveratrol in Promoting Favorable Adipocyte Differentiation with Enhanced Adiponectin Expression and Decreased Lipid Accumulation. Food Science and Technology Research 25:6, pages 817-826.
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Arnaud Courtois, Claude Atgié, Axel Marchal, Ruth Hornedo-Ortega, Caroline Lapèze, Chrystel Faure, Tristan Richard & Stéphanie Krisa. (2018) Tissular Distribution and Metabolism of trans-ε-Viniferin after Intraperitoneal Injection in Rat. Nutrients 10:11, pages 1660.
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Ruth Hornedo-Ortega, Ana B. Cerezo, Rocío M. de Pablos, Stéphanie Krisa, Tristan Richard, M. Carmen García-Parrilla & Ana M. Troncoso. (2018) Phenolic Compounds Characteristic of the Mediterranean Diet in Mitigating Microglia-Mediated Neuroinflammation. Frontiers in Cellular Neuroscience 12.
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Bo Yu, Yu Jiang, Bo Zhang, Hong Yang & Tonghui Ma. (2018) Resveratrol dimer trans-ε -viniferin prevents rotaviral diarrhea in mice by inhibition of the intestinal calcium-activated chloride channel. Pharmacological Research 129, pages 453-461.
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Zhuofu Wu, Heng Li, XueJun Zhu, Shuai Li, Zhi Wang, Lei Wang, Zhengqiang Li & Guang Chen. (2017) Using Laccases in the Nanoflower to Synthesize Viniferin. Catalysts 7:6, pages 188.
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Joydip Das, Rashmi Ramani & M. Olufemi Suraju. (2016) Polyphenol compounds and PKC signaling. Biochimica et Biophysica Acta (BBA) - General Subjects 1860:10, pages 2107-2121.
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Kazuaki Ohara, Kaori Kusano, Sayoko Kitao, Takaaki Yanai, Ryoji Takata & Osamu Kanauchi. (2015) ε-Viniferin, a resveratrol dimer, prevents diet-induced obesity in mice. Biochemical and Biophysical Research Communications 468:4, pages 877-882.
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Seok-Jo Kim, Paul Cheresh, Renea Jablonski, David Williams & David Kamp. (2015) The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis. International Journal of Molecular Sciences 16:9, pages 21486-21519.
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Qingwang Liu, Xiaolin Liao, Jie Xu, Jie Zhao, Jianguang Luo & Lingyi Kong. (2014) Development and validation of a sensitive and selective LC–MS/MS method for the determination of trans δ-veniferin, a resveratrol dehydrodimer, in rat plasma and its application to pharmacokinetics and bioavailability studies. Journal of Chromatography B 958, pages 124-129.
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Ching-Fent TsaiKun-Teng WangLih-Geeng ChenChia-Jung LeeSung-Hui TsengChing-Chiung Wang. (2014) Anti-Inflammatory Effects of Vitis thunbergii var. taiwaniana on Knee Damage Associated with Arthritis . Journal of Medicinal Food 17:4, pages 479-486.
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Henry Tran, Benjamin D. Dickson & David Barker. (2013) Unexpected O-alkylation and ester migration in phenolic 2,3-diaryl-2,3-dihydrobenzo[b]furans. Tetrahedron Letters 54:16, pages 2093-2096.
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