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Original Articles

Transport Mechanisms for Soy Isoflavones and Microbial Metabolites Dihydrogenistein and Dihydrodaidzein Across Monolayers and Membranes

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Pages 2210-2217 | Received 21 May 2013, Accepted 07 Aug 2013, Published online: 22 May 2014

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Vaishnavi S. Shete, Darshan R. Telange, Nilesh M. Mahajan, Anil M. Pethe & Debarshi K. Mahapatra. (2023) Development of phospholipon®90H complex nanocarrier with enhanced oral bioavailability and anti-inflammatory potential of genistein. Drug Delivery 30:1.
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Young Sung Jung, Hyunbin Seong, Nam Soo Han & Dae-Ok Kim. (2023) Bioaccessibility and Bioavailability of Soybean Isoflavones: An In Vitro Study. Food Reviews International 0:0, pages 1-18.
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Thiécla Katiane Osvaldt Rosales, Fábio Fernando Alves da Silva, Emerson Soares Bernardes & João Paulo Fabi. (2023) Plant-derived polyphenolic compounds: nanodelivery through polysaccharide-based systems to improve the biological properties. Critical Reviews in Food Science and Nutrition 0:0, pages 1-25.
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Articles from other publishers (32)

Ewa Garbiec, Natalia Rosiak, Przemysław Zalewski, Lidia Tajber & Judyta Cielecka-Piontek. (2023) Genistein Co-Amorphous Systems with Amino Acids: An Investigation into Enhanced Solubility and Biological Activity. Pharmaceutics 15:12, pages 2653.
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Joaquim Bié, Bruno Sepodes, Pedro C. B. Fernandes & Maria H. L. Ribeiro. (2023) Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability. Compounds 3:1, pages 40-72.
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Natalia Drabińska & Elżbieta Jarocka-Cyrta. (2022) Crosstalk between Resveratrol and Gut Barrier: A Review. International Journal of Molecular Sciences 23:23, pages 15279.
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Giulia Magni, Benedetta Riboldi, Katia Petroni & Stefania Ceruti. (2022) Flavonoids bridging the gut and the brain: Intestinal metabolic fate, and direct or indirect effects of natural supporters against neuroinflammation and neurodegeneration. Biochemical Pharmacology 205, pages 115257.
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Rongzi Li, Megan Robinson, Xiaowen Ding, Thangiah Geetha, Layla Al‐Nakkash, Tom L. Broderick & Jeganathan Ramesh Babu. (2022) Genistein: A focus on several neurodegenerative diseases. Journal of Food Biochemistry 46:7.
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Shenglin Hou. (2022) Genistein: Therapeutic and Preventive Effects, Mechanisms, and Clinical Application in Digestive Tract Tumor. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-10.
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Cristina Mas- Bargues, Consuelo Borrás & José Viña. (2022) Genistein, a tool for geroscience. Mechanisms of Ageing and Development 204, pages 111665.
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Mi-Seon Kim, Young Sung Jung, Davin Jang, Chi Heung Cho, Sang-Hoon Lee, Nam Soo Han & Dae-Ok Kim. (2022) Antioxidant capacity of 12 major soybean isoflavones and their bioavailability under simulated digestion and in human intestinal Caco-2 cells. Food Chemistry 374, pages 131493.
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Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka & Tamihide Matsunaga. (2022) Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells. Drug Metabolism and Disposition 50:1, pages 17-23.
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B. Shain Zuñiga-Martínez, J. Abraham Domínguez-Avila, Abraham Wall-Medrano, J. Fernando Ayala-Zavala, Javier Hernández-Paredes, Norma J. Salazar-López, Mónica A. Villegas-Ochoa & Gustavo A. González-Aguilar. (2021) Avocado paste from industrial byproducts as an unconventional source of bioactive compounds: characterization, in vitro digestion and in silico interactions of its main phenolics with cholesterol. Journal of Food Measurement and Characterization 15:6, pages 5460-5476.
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Francesca Truzzi, Camilla Tibaldi, Yanxin Zhang, Giovanni Dinelli & Eros D′Amen. (2021) An Overview on Dietary Polyphenols and Their Biopharmaceutical Classification System (BCS). International Journal of Molecular Sciences 22:11, pages 5514.
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Adrià Botet-Carreras, Cristina Tamames-Tabar, Fabrice Salles, Sara Rojas, Edurne Imbuluzqueta, Hugo Lana, María José Blanco-Prieto & Patricia Horcajada. (2021) Improving the genistein oral bioavailability via its formulation into the metal–organic framework MIL-100(Fe) . Journal of Materials Chemistry B 9:9, pages 2233-2239.
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Tai L. Guo, Yingjia Chen, Hannah Shibo Xu, Callie M. McDonough & Guannan Huang. (2020) Gut microbiome in neuroendocrine and neuroimmune interactions: The case of genistein. Toxicology and Applied Pharmacology 402, pages 115130.
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Iichiro Kawahara, Satoyo Nishikawa, Akira Yamamoto, Yusuke Kono & Takuya Fujita. (2020) The Impact of Breast Cancer Resistance Protein (BCRP/ABCG2) on Drug Transport Across Caco-2 Cell Monolayers. Drug Metabolism and Disposition 48:6, pages 491-498.
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Katarzyna Papaj, Anna Kasprzycka, Artur Góra, Aniela Grajoszek, Grażyna Rzepecka, Jerzy Stojko, Jarosław-Jerzy Barski, Wiesław Szeja & Aleksandra Rusin. (2020) Structure–bioavailability relationship study of genistein derivatives with antiproliferative activity on human cancer cell. Journal of Pharmaceutical and Biomedical Analysis 185, pages 113216.
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Qianrui Wang, Bert Spenkelink, Rungnapa Boonpawa, Ivonne M. C. M. Rietjens & Karsten Beekmann. (2020) Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S ‐Equol and Its Consequences for ERα Activation . Molecular Nutrition & Food Research 64:6.
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Muhammad Bilal Hussain, Sadia Hassan, Marwa Waheed, Ahsan Javed, Muhammad Adil Farooq & Ali Tahir. 2019. Plant Physiological Aspects of Phenolic Compounds. Plant Physiological Aspects of Phenolic Compounds.
Mina FUJITANI, Takafumi MIZUSHIGE, Keshab BHATTARAI, Sudhashree ADHIKARI, Junji ISHIKAWATaro KISHIDA. (2019) Dietary daidzein induces accumulation of <i>S</i>-equol in enterohepatic circulation to far higher levels than that of daidzein in female rats with and without ovariectomy. Biomedical Research 40:3, pages 97-105.
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Taka-aki Inui, Makoto Yasuda, Shigeru Hirano, Yukiko Ikeuchi, Haruka Kogiso, Toshio Inui, Yoshinori Marunaka & Takashi Nakahari. (2018) Daidzein-Stimulated Increase in the Ciliary Beating Amplitude via an [Cl−]i Decrease in Ciliated Human Nasal Epithelial Cells. International Journal of Molecular Sciences 19:12, pages 3754.
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Zhong-Wen Yuan, Ya-Zhuo Li, Zhong-Qiu Liu, Sen-ling Feng, Hua Zhou, Chang-Xiao Liu, Liang Liu & Ying Xie. (2018) Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies. Pharmacological Research 128, pages 153-166.
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Jovana Čvorović, Lovro Ziberna, Stefano Fornasaro, Federica Tramer & Sabina Passamonti. 2018. Polyphenols: Mechanisms of Action in Human Health and Disease. Polyphenols: Mechanisms of Action in Human Health and Disease 295 320 .
Marc Maresca, Philippe Pinton, El Hassan Ajandouz, Sandrine Menard, Laurent Ferrier & Isabelle P. Oswald. 2021. Three Dimensional Human Organotypic Models for Biomedical Research. Three Dimensional Human Organotypic Models for Biomedical Research 247 264 .
A.D. Eaton, C. Zimmermann, B. Delaney & B.P. Hurley. (2017) Primary human polarized small intestinal epithelial barriers respond differently to a hazardous and an innocuous protein. Food and Chemical Toxicology 106, pages 70-77.
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Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 203 267 .
J. Abraham Domínguez-Avila, Abraham Wall-Medrano, Gustavo R. Velderrain-Rodríguez, C.-Y. Oliver Chen, Norma Julieta Salazar-López, Maribel Robles-Sánchez & Gustavo A. González-Aguilar. (2017) Gastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds. Food & Function 8:1, pages 15-38.
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Bryan P. Hurley, Alex D. Eaton, Cindi Zimmermann & Bryan Delaney. (2016) Polarized monolayer cultures of human intestinal epithelial cell lines exposed to intractable proteins - In vitro hazard identification studies. Food and Chemical Toxicology 98, pages 262-268.
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Marcos Roberto de Oliveira. (2016) Evidence for genistein as a mitochondriotropic molecule. Mitochondrion 29, pages 35-44.
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Bryan P. Hurley, Waheed Pirzai, Alex D. Eaton, Marc Harper, Jason Roper, Cindi Zimmermann, Gregory S. Ladics, Raymond J. Layton & Bryan Delaney. (2016) An experimental platform using human intestinal epithelial cell lines to differentiate between hazardous and non-hazardous proteins. Food and Chemical Toxicology 92, pages 75-87.
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Mihyang Kim, Nayoung Kim & Jaehong Han. (2016) Deglycosylation of flavonoid O-glucosides by human intestinal bacteria Enterococcus sp. MRG-2 and Lactococcus sp. MRG-IF-4. Applied Biological Chemistry 59:3, pages 443-449.
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. (2015) Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones. EFSA Journal 13:10, pages 4246.
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Carmela Spagnuolo, Gian Luigi Russo, Ilkay Erdogan Orhan, Solomon Habtemariam, Maria Daglia, Antoni Sureda, Seyed Fazel Nabavi, Kasi Pandima Devi, Monica Rosa Loizzo, Rosa Tundis & Seyed Mohammad Nabavi. (2015) Genistein and Cancer: Current Status, Challenges, and Future Directions. Advances in Nutrition 6:4, pages 408-419.
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Tomoko Tamura, Megumi Ozawa, Shoko Kobayashi, Hirohito Watanabe, Soichi Arai & Kiyoshi Mura. (2015) Inhibitory Effect of Oligomeric Polyphenols from Peanut-skin on Sugar Digestion Enzymes and Glucose Transport. Food Science and Technology Research 21:1, pages 111-115.
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