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Original Articles

Zerumbone Suppresses Phorbol Ester-Induced Expression of Multiple Scavenger Receptor Genes in THP-1 Human Monocytic Cells

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Pages 935-945 | Received 25 Oct 2006, Accepted 12 Dec 2006, Published online: 22 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Yang Xie, Yuan Jia, Zhanguo Li & Fanlei Hu. (2022) Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy. Expert Opinion on Therapeutic Targets 26:5, pages 461-477.
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Cristian Urla, Matias Julian Stagno, Jörg Fuchs, Steven W. Warmann & Evi Schmid. (2022) Anticancer bioactivity of zerumbone on pediatric rhabdomyosarcoma cells. Journal of Cancer Research and Clinical Oncology 149:7, pages 3313-3323.
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Jie Wang, Yong-Mei Liu, Jun Hu & Cong Chen. (2023) Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease. Frontiers in Pharmacology 14.
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Wei Sheng, Guang Ji & Li Zhang. (2022) Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis. Frontiers in Immunology 13.
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Genoveffa Nuzzo, Giuseppina Senese, Carmela Gallo, Federica Albiani, Lucia Romano, Giuliana d’Ippolito, Emiliano Manzo & Angelo Fontana. (2022) Antitumor Potential of Immunomodulatory Natural Products. Marine Drugs 20:6, pages 386.
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Dongdong Wang, Yang Yang, Yingnan Lei, Nikolay T. Tzvetkov, Xingde Liu, Andy Wai Kan Yeung, Suowen Xu & Atanas G. Atanasov. (2019) Targeting Foam Cell Formation in Atherosclerosis: Therapeutic Potential of Natural Products. Pharmacological Reviews 71:4, pages 596-670.
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Yogendra Prakash Singh, Sosmitha Girisa, Kishore Banik, Sharad Ghosh, Pantheerayil Swathi, Manab Deka, Ganesan Padmavathi, Jibon Kotoky, Gautam Sethi, Lu Fan, Xinliang Mao, Clarissa Esmeralda Halim, Frank Arfuso & Ajaikumar B. Kunnumakkara. (2019) Potential application of zerumbone in the prevention and therapy of chronic human diseases. Journal of Functional Foods 53, pages 248-258.
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Min-Ju KimJung-Mi Yun. (2019) Molecular Mechanism of the Protective Effect of Zerumbone on Lipopolysaccharide-Induced Inflammation of THP-1 Cell-Derived Macrophages. Journal of Medicinal Food 22:1, pages 62-73.
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Sa Hyun Kim, Si Hyun Kim, Sung Ryul Ryu, Pyeongjae Lee & Cheol Moon. (2018) Inhibitory Effects of Zerumbone on MCP-1-Induced THP-1 Migration. The Korean Journal of Clinical Laboratory Science 50:2, pages 177-182.
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Johnna Francis Varghese, Rohit Patel, Mohit Singh & Umesh C. S. Yadav. 2018. Functional Food and Human Health. Functional Food and Human Health 277 296 .
Yung-Chyuan Ho, Shiuan-Shinn Lee, Ming-Ling Yang, Rosa Huang-Liu, Chien-Ying Lee, Yi-Ching Li & Yu-Hsiang Kuan. (2017) Zerumbone reduced the inflammatory response of acute lung injury in endotoxin-treated mice via Akt-NFκB pathway. Chemico-Biological Interactions 271, pages 9-14.
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Min Ho Lee, Sa Hyun Kim, Sung Ryul Ryu, Pyeongjae Lee & Cheol Moon. (2017) Enhancing the Effects of Zerumbone on THP-1 Cell Activation. The Korean Journal of Clinical Laboratory Science 49:1, pages 1-7.
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Laiba Arshad, Ibrahim Jantan, Syed Nasir Abbas Bukhari & Md. Areeful Haque. (2017) Immunosuppressive Effects of Natural α,β-Unsaturated Carbonyl-Based Compounds, and Their Analogs and Derivatives, on Immune Cells: A Review. Frontiers in Pharmacology 8.
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Md. Areeful Haque, Ibrahim Jantan, Laiba Arshad & Syed Nasir Abbas Bukhari. (2017) Exploring the immunomodulatory and anticancer properties of zerumbone. Food & Function 8:10, pages 3410-3431.
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T. K. LimT. K. Lim. 2016. Edible Medicinal and Non-Medicinal Plants. Edible Medicinal and Non-Medicinal Plants 561 576 .
Cheol Moon. (2015) Zerumbone’s Effects on Jurkat Cell Proliferation and Migration. Korean Journal of Clinical Laboratory Science 47:4, pages 182-187.
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Stephanie C. Casey, Amedeo Amedei, Katia Aquilano, Asfar S. Azmi, Fabian Benencia, Dipita Bhakta, Alan E. Bilsland, Chandra S. Boosani, Sophie Chen, Maria Rosa Ciriolo, Sarah Crawford, Hiromasa Fujii, Alexandros G. Georgakilas, Gunjan Guha, Dorota Halicka, William G. Helferich, Petr Heneberg, Kanya Honoki, W. Nicol Keith, Sid P. Kerkar, Sulma I. Mohammed, Elena Niccolai, Somaira Nowsheen, H.P. Vasantha Rupasinghe, Abbas Samadi, Neetu Singh, Wamidh H. Talib, Vasundara Venkateswaran, Richard L. Whelan, Xujuan Yang & Dean W. Felsher. (2015) Cancer prevention and therapy through the modulation of the tumor microenvironment. Seminars in Cancer Biology 35, pages S199-S223.
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Mei-Ling Chan, Jui-Wei Liang, Lih-Ching Hsu, Wei-Ling Chang, Shoei-Sheng Lee & Jih-Hwa Guh. (2015) Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult. Naunyn-Schmiedeberg's Archives of Pharmacology 388:11, pages 1223-1236.
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Shenshen Zhu & Jin-Hua Liu. (2015) Zerumbone, A Natural Cyclic Sesquiterpene, Promotes ABCA1-Dependent Cholesterol Efflux from Human THP-1 Macrophages. Pharmacology 95:5-6, pages 258-263.
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Malla Reddy Gannarapu, Sathish Babu Vasamsetti, Nagender Punna, Naresh Kumar Royya, Shanthan Rao Pamulaparthy, Jagadeesh Babu Nanubolu, Srigiridhar Kotamraju & Narsaiah Banda. (2014) Synthesis of novel 1,2-benzothiazine 1,1-dioxide-3-ethanone oxime N-aryl acetamide ether derivatives as potent anti-inflammatory agents and inhibitors of monocyte-to-macrophage transformation. European Journal of Medicinal Chemistry 75, pages 143-150.
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Heshu Sulaiman Rahman, Abdullah Rasedee, Swee Keong Yeap, Hemn Hassan Othman, Max Stanley Chartrand, Farideh Namvar, Ahmad Bustamam Abdul & Chee Wun How. (2014) Biomedical Properties of a Natural Dietary Plant Metabolite, Zerumbone, in Cancer Therapy and Chemoprevention Trials. BioMed Research International 2014, pages 1-20.
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T. K. LimT. K. Lim. 2014. Edible Medicinal and Non Medicinal Plants. Edible Medicinal and Non Medicinal Plants 857 876 .
Takuya Makino, Toshihiko Otomatsu, Kazutoshi Shindo, Emi Kitamura, Gerhard Sandmann, Hisashi Harada & Norihiko Misawa. (2012) Biocatalytic synthesis of flavones and hydroxyl-small molecules by recombinant Escherichia coli cells expressing the cyanobacterial CYP110E1 gene. Microbial Cell Factories 11:1.
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Remya Prasannan, Karunakaran A. Kalesh, Muthu K. Shanmugam, Alamelu Nachiyappan, Lalitha Ramachandran, An H. Nguyen, Alan Prem Kumar, Manikandan Lakshmanan, Kwang Seok Ahn & Gautam Sethi. (2012) Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer. Biochemical Pharmacology 84:10, pages 1268-1276.
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Yang Qiu, Tomoko Tanaka, Hajime Nawata & Toshihiko Yanase. (2012) Dihydrotestosterone Inhibits Lectin-Like Oxidized-LDL Receptor-1 Expression in Aortic Endothelial Cells via a NF-κB/AP-1-Mediated Mechanism. Endocrinology 153:7, pages 3405-3415.
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C. B. Singh, Kh. Nongalleima, S. Brojendrosingh, Swapana Ningombam, N. Lokendrajit & L. W. Singh. (2011) Biological and chemical properties of Zingiber zerumbet Smith: a review. Phytochemistry Reviews 11:1, pages 113-125.
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Norihiko Misawa. (2011) Pathway engineering for functional isoprenoids. Current Opinion in Biotechnology 22:5, pages 627-633.
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Hisashi Harada, Kazutoshi Shindo, Kanoko Iki, Ayuko Teraoka, Sho Okamoto, Fengnian Yu, Jun-ichiro Hattan, Ryutaro Utsumi & Norihiko Misawa. (2011) Efficient functional analysis system for cyanobacterial or plant cytochromes P450 involved in sesquiterpene biosynthesis. Applied Microbiology and Biotechnology 90:2, pages 467-476.
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Ri-sheng HuangGuan-qiong HuBin LinZhi-yi LinCheng-chao Sun. (2023) MicroRNA-155 Silencing Enhances Inflammatory Response and Lipid Uptake in Oxidized Low-Density Lipoprotein-Stimulated Human THP-1 Macrophages. Journal of Investigative Medicine 58:8, pages 961-967.
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Manal Mohamed Elhassan Taha, Ahmad Bustamam Abdul, Rasedee Abdullah, Tengku Azmi Tengku Ibrahim, Siddig Ibrahim Abdelwahab & Syam Mohan. (2010) Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). Chemico-Biological Interactions 186:3, pages 295-305.
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Uraiwan Panich, Kamolratana Kongtaphan, Tassanee Onkoksoong, Kannika Jaemsak, Rattana Phadungrakwittaya, Athiwat Thaworn, Pravit Akarasereenont & Adisak Wongkajornsilp. (2009) Modulation of antioxidant defense by Alpinia galanga and Curcuma aromatica extracts correlates with their inhibition of UVA-induced melanogenesis. Cell Biology and Toxicology 26:2, pages 103-116.
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S. Fakurazi, I. Hairuszah, J. Mohd Lip, G. Shanthi, U. Nanthini, A.R. Shamima, H. Roslida & Y.H. Tan. (2009) Hepatoprotective Action of Zerumbone Against Paracetamol Induced Hepatotoxicity. Journal of Medical Sciences 9:3, pages 161-164.
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Ahmad B. Abdul, Siddig I. Abdelwahab, Adel S. Al-Zubairi, Manal M. Elhassan & Syam M. Murali. (2008) Anticancer and Antimicrobial Activities of Zerumbone from the Rhizomes of Zingiber zerumbut. International Journal of Pharmacology 4:4, pages 301-304.
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Hirotaka Sekiguchi, Kazuto Washida & Akira Murakami. (2008) Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells. Journal of Clinical Biochemistry and Nutrition 43:2, pages 109-117.
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