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Bioscience, Biotechnology, and Biochemistry Volume 62, 1998 - Issue 12
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Original Articles

Substrate Specificity of 2-Deoxy-scyllo-inosose Synthase, the Starter Enzyme for 2-Deoxystreptamine Biosynthesis, toward Deoxyglucose-6-phosphates and Proposed Mechanism

Noriaki IWASEDepartment of Chemistry, Tokyo Institute of Technology
,
Fumitaka KUDODepartment of Chemistry, Tokyo Institute of Technology
,
Noriaki YAMAUCHIDepartment of Chemistry, Tokyo Institute of Technology
&
Katsumi KAKINUMADepartment of Chemistry, Tokyo Institute of Technology
Pages 2396-2407 | Received 29 Jul 1998, Accepted 25 Aug 1998, Published online: 22 May 2014

Citations (14)

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Read on this site (2)

C. Kumar, M. Himabindu & Annapurna Jetty. (2008) Microbial Biosynthesis and Applications of Gentamicin: A Critical Appraisal. Critical Reviews in Biotechnology 28:3, pages 173-212.
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Kenji WATANABE, Takashi MIE, Akitami ICHIHARA, Hideaki OIKAWA & Mamoru HONMA. (2000) Substrate Diversity of Macrophomate Synthase Catalyzing an Unusual Multistep Transformation from 2-Pyrones to Benzoates. Bioscience, Biotechnology, and Biochemistry 64:3, pages 530-538.
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Articles from other publishers (12)

Atsushi Sudo, Taichi Sano, Makoto Harada & Dai Ishida. (2014) Synthesis of Oligo(spiroketal)s from Naturally Occurring myo -Inositol . ACS Macro Letters 3:8, pages 808-812.
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Stuart W. McCombieWilliam B. MotherwellMatthew J. Tozer. 2004. Organic Reactions. Organic Reactions 161 432 .
Donald J. AbrahamLester A. Mitscher. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 403 480 .
Fumitaka Kudo & Tadashi Eguchi. 2009. Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates. Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates 493 519 .
Eriko Nango, Takashi Kumasaka, Toshifumi Hirayama, Nobuo Tanaka & Tadashi Eguchi. (2007) Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+. Proteins: Structure, Function, and Bioinformatics 70:2, pages 517-527.
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Zhen Huang, Katsumi Kakinuma & Tadashi Eguchi. (2005) Stereospecificity of hydride transfer in NAD+-catalyzed 2-deoxy-scyllo-inosose synthase, the key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminocyclitol antibiotics. Bioorganic Chemistry 33:2, pages 82-89.
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Mai Le Thuy, Madan Kumar Kharel, Rajan Lamichhane, Hei Chan Lee, Joo-Won Suh, Kwangkyoung Liou & Jae Kyung Sohng. (2005) Expression of 2-deoxy-scyllo-inosose synthase (kanA) from kanamycin gene cluster in Streptomyces lividans. Biotechnology Letters 27:7, pages 465-470.
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Guuske F. Busscher, Floris P. J. T. Rutjes & Floris L. van Delft. (2005) 2-Deoxystreptamine:  Central Scaffold of Aminoglycoside Antibiotics. Chemical Reviews 105:3, pages 775-792.
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Noriaki Yamauchi, Hideyoshi Ueoka, Norisuke Kamada & Tatsushi Murae. (2004) Resemblance of Carbocycle Formation from Carbohydrates between Archaea and Eucarya/Eubacteria. Biosynthesis of Calditol, the Characteristic Lipid-Content Molecule in Sulfolobus acidocaldarius . Bulletin of the Chemical Society of Japan 77:4, pages 771-778.
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Tadashi Eguchi, Satoko Sasaki, Zhen Huang & Katsumi Kakinuma. (2002) Importance of Specific Hydrogen-Bond Donor−Acceptor Interactions for the Key Carbocycle-Forming Reaction Catalyzed by 2-Deoxy- scyllo -inosose Synthase in the Biosynthesis of 2-Deoxystreptamine-Containing Aminocyclitol Antibiotics . The Journal of Organic Chemistry 67:12, pages 3979-3984.
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Kenji Watanabe, Takashi Mie, Akitami Ichihara, Hideaki Oikawa & Mamoru Honma. (2000) Reaction mechanism of the macrophomate synthase: experimental evidence on intermediacy of a bicyclic compound. Tetrahedron Letters 41:9, pages 1443-1446.
Crossref
Hideaki Oikawa, Kenji Watanabe, Kenji Yagi, Satoshi Ohashi, Takashi Mie, Akitami Ichihara & Mamoru Honma. (1999) Macrophomate synthase: unusual enzyme catalyzing multiple reactions from pyrones to benzoates. Tetrahedron Letters 40:38, pages 6983-6986.
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