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Bioscience, Biotechnology, and Biochemistry Volume 64, 2000 - Issue 4
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Original Articles

Identification and Characterization of a Potent Antibacterial Agent, NH125 against Drug-resistant Bacteria

Kaneyoshi YAMAMOTODepartment of Agricultural Chemistry, Kinki University
,
Takashi KITAYAMADepartment of Agricultural Chemistry, Kinki University
,
Noriyasu ISHIDADepartment of Agricultural Chemistry, Kinki University
,
Takafumi WATANABEDepartment of Agricultural Chemistry, Kinki University
,
Hiroyuki TANABEDepartment of Agricultural Chemistry, Kinki University
,
Masahiro TAKATANIDepartment of Agricultural Chemistry, Kinki University
,
Tadashi OKAMOTODepartment of Agricultural Chemistry, Kinki University
&
Ryutaro UTSUMIDepartment of Agricultural Chemistry, Kinki University
 show all
Pages 919-923 | Received 22 Nov 1999, Accepted 27 Dec 1999, Published online: 22 May 2014

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Wooseong Kim, Gabriel Lambert Hendricks, Kiho Lee & Eleftherios Mylonakis. (2017) An update on the use of C. elegans for preclinical drug discovery: screening and identifying anti-infective drugs. Expert Opinion on Drug Discovery 12:6, pages 625-633.
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Mark J Macielag & Raul Goldschmidt. (2000) Inhibitors of bacterial two-component signalling systems. Expert Opinion on Investigational Drugs 9:10, pages 2351-2369.
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Articles from other publishers (27)

Shrijan Bhattarai, Lane Marsh, Kelsey Knight, Liaqat Ali, Antonio Gomez, Allison Sunderhaus & May H. Abdel Aziz. (2023) NH125 Sensitizes Staphylococcus aureus to Cell Wall-Targeting Antibiotics through the Inhibition of the VraS Sensor Histidine Kinase. Microbiology Spectrum 11:3.
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Donghee Lee, Yunmi Lee, Son Hye Shin, Su Min Choi, Shin Hyeon Lee, Seonghun Jeong, Soojin Jang & Jung-Min Kee. (2023) A simple protein histidine kinase activity assay for high-throughput inhibitor screening. Bioorganic Chemistry 130, pages 106232.
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Haotian Li, Tingting Li, Qiao Hu, Zhiming Yao, Lu Li, Qi Huang & Rui Zhou. (2022) Inhibitors targeting the autophosphorylation of serine/threonine kinase of Streptococcus suis show potent antimicrobial activity. Frontiers in Microbiology 13.
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Sabeeha Ali, Manzar Alam, Gulam Mustafa Hasan & Md Imtaiyaz Hassan. (2022) Potential therapeutic targets of Klebsiella pneumoniae : a multi-omics review perspective . Briefings in Functional Genomics 21:2, pages 63-77.
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Bin Zhang, Jiamei Zou, Qiting Zhang, Ze Wang, Ning Wang, Shan He, Yufen Zhao & C. Benjamin Naman. (2021) Progress in the Development of Eukaryotic Elongation Factor 2 Kinase (eEF2K) Natural Product and Synthetic Small Molecule Inhibitors for Cancer Chemotherapy. International Journal of Molecular Sciences 22:5, pages 2408.
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Miyanou Rosales‐Hurtado, Patrick Meffre, Hendrik Szurmant & Zohra Benfodda. (2019) Synthesis of histidine kinase inhibitors and their biological properties. Medicinal Research Reviews 40:4, pages 1440-1495.
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Soo Min Kim, Iliana Escorbar, Kiho Lee, Beth Burgwyn Fuchs, Eleftherios Mylonakis & Wooseong Kim. (2020) Anti-MRSA agent discovery using Caenorhabditis elegans-based high-throughput screening. Journal of Microbiology 58:6, pages 431-444.
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Hermann AM Mucke. (2019) Patent Highlights December 2018–January 2019. Pharmaceutical Patent Analyst 8:3, pages 73-80.
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Wooseong Kim, Iliana Escobar, Beth Burgwyn Fuchs & Eleftherios Mylonakis. 2019. Persister Cells and Infectious Disease. Persister Cells and Infectious Disease 273 295 .
Sarah Moeschler, Samira Locher & Gert Zimmer. (2018) 1-Benzyl-3-cetyl-2-methylimidazolium Iodide (NH125) Is a Broad-Spectrum Inhibitor of Virus Entry with Lysosomotropic Features. Viruses 10:6, pages 306.
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Qingzhong Liu, Zhaojun Zheng, Wooseong Kim, Beth Burgwyn Fuchs & Eleftherios Mylonakis. (2018) Influence of subinhibitory concentrations of NH125 on biofilm formation & virulence factors of Staphylococcus aureus . Future Medicinal Chemistry 10:11, pages 1319-1331.
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Wooseong Kim, Gabriel L Hendricks, Katerina Tori, Beth B Fuchs & Eleftherios Mylonakis. (2018) Strategies against methicillin-resistant Staphylococcus aureus persisters . Future Medicinal Chemistry 10:7, pages 779-794.
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Silvia T. Cardona, Matthew Choy & Andrew M. Hogan. (2017) Essential Two-Component Systems Regulating Cell Envelope Functions: Opportunities for Novel Antibiotic Therapies. The Journal of Membrane Biology 251:1, pages 75-89.
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Cin Kong, Su-Anne Eng, Mei-Perng Lim & Sheila Nathan. (2016) Beyond Traditional Antimicrobials: A Caenorhabditis elegans Model for Discovery of Novel Anti-infectives. Frontiers in Microbiology 7.
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Kenneth P. SmithJames E. Kirby. (2016) Validation of a High-Throughput Screening Assay for Identification of Adjunctive and Directly Acting Antimicrobials Targeting Carbapenem-Resistant Enterobacteriaceae. ASSAY and Drug Development Technologies 14:3, pages 194-206.
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Wooseong Kim, Nico Fricke, Annie L Conery, Beth Burgwyn Fuchs, Rajmohan Rajamuthiah, Elamparithi Jayamani, Petia M Vlahovska, Frederick M Ausubel & Eleftherios Mylonakis. (2016) NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption . Future Medicinal Chemistry 8:3, pages 257-269.
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Wooseong Kim, Annie L. Conery, Rajmohan Rajamuthiah, Beth Burgwyn Fuchs, Frederick M. Ausubel & Eleftherios Mylonakis. (2015) Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy. PLOS ONE 10:6, pages e0127640.
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Xing Hua Tang, Xun Yi Wu, Lan Xu, You Xin Fang, Ping Wang, Guo Xing Zhu & Zhen Hong. (2015) eEF-2 Phosphorylation Down-Regulates P-Glycoprotein Over-Expression in Rat Brain Microvessel Endothelial Cells. PLOS ONE 10:5, pages e0125389.
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Jacqueline W. Njoroge & Vanessa Sperandio. 2013. Antibiotics. Antibiotics 241 261 .
Roberta J Worthington, Meghan S Blackledge & Christian Melander. (2013) Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence. Future Medicinal Chemistry 5:11, pages 1265-1284.
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Ashwini K. Devkota, Clint D. J. Tavares, Mangalika Warthaka, Olga Abramczyk, Kyle D. Marshall, Tamer S. Kaoud, Kivanc Gorgulu, Bulent Ozpolat & Kevin N. Dalby. (2012) Investigating the Kinetic Mechanism of Inhibition of Elongation Factor 2 Kinase by NH125: Evidence of a Common in Vitro Artifact. Biochemistry 51:10, pages 2100-2112.
Crossref
Zehan Chen, Sujatha M. Gopalakrishnan, Mai-Ha Bui, Niru B. Soni, Usha Warrior, Eric F. Johnson, Jennifer B. Donnelly & Keith B. Glaser. (2011) 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) Induces Phosphorylation of Eukaryotic Elongation Factor-2 (eEF2). Journal of Biological Chemistry 286:51, pages 43951-43958.
Crossref
Noritaka Iwai, Kyosuke Nakayama & Tomoya Kitazume. (2011) Antibacterial activities of imidazolium, pyrrolidinium and piperidinium salts. Bioorganic & Medicinal Chemistry Letters 21:6, pages 1728-1730.
Crossref
Ario Okada, Yasuhiro Gotoh, Takafumi Watanabe, Eiji Furuta, Kaneyoshi Yamamoto & Ryutaro Utsumi. 2007. Two‐Component Signaling Systems, Part A. Two‐Component Signaling Systems, Part A 386 395 .
Kaneyoshi Yamamoto, Hiroshi Ogasawara, Nobuyuki Fujita, Ryutaro Utsumi & Akira Ishihama. (2002) Novel mode of transcription regulation of divergently overlapping promoters by PhoP, the regulator of two-component system sensing external magnesium availability. Molecular Microbiology 45:2, pages 423-438.
Crossref
Keith Stephenson & James A Hoch. (2002) Virulence- and antibiotic resistance-associated two-component signal transduction systems of Gram-positive pathogenic bacteria as targets for antimicrobial therapy. Pharmacology & Therapeutics 93:2-3, pages 293-305.
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Ryutaro Utsumi. (2002) Bacterial Signal Transduction Systems for Environmental Adaptation and Their Inhibitors.. Microbes and Environments 17:1, pages 1-5.
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