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Original Articles

Conjugated Linoleic Acid Reduces Body Fats and Cytokine Levels of Mice

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Pages 916-920 | Received 26 Oct 2001, Accepted 17 Dec 2001, Published online: 22 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Allison Dilzer & Yeonhwa Park. (2012) Implication of Conjugated Linoleic Acid (CLA) in Human Health. Critical Reviews in Food Science and Nutrition 52:6, pages 488-513.
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Mitsuo Namiki. (2007) Nutraceutical Functions of Sesame: A Review. Critical Reviews in Food Science and Nutrition 47:7, pages 651-673.
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Articles from other publishers (51)

Poliana C. Martins, Januária S. Santos, Pedro M. Rezende, Ana F.B. Royer, Lais M. Montel, Fabyola B. Carvalho, Maria A. Andrade, Itallo C.S. Araújo & José H. Stringhini. (2023) Cellular and humoral immunity of broilers subjected to posthatch fasting and a prestarter diet containing conjugated linoleic acid. Poultry Science 102:12, pages 103167.
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Xin-Xin Liu, Hong-Yun Zhang, Xin Song, Ying Yang, Zhi-Qiang Xiong, Yong-Jun Xia & Lian-Zhong Ai. (2021) Reasons for the differences in biotransformation of conjugated linoleic acid by Lactobacillus plantarum. Journal of Dairy Science 104:11, pages 11466-11473.
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Rakesh Kapoor & Martin Reaney. 2005. Bailey's Industrial Oil and Fat Products. Bailey's Industrial Oil and Fat Products 1 30 .
Rakesh Kapoor & Harikumar Nair. 2005. Bailey's Industrial Oil and Fat Products. Bailey's Industrial Oil and Fat Products 1 45 .
Maressa C. Morzelle, Bruce A. Watkins, Yong Li, Bernhard Hennig & Michal Toborek. 2005. Bailey's Industrial Oil and Fat Products. Bailey's Industrial Oil and Fat Products 1 27 .
Guang-Cheng Wu, Shyr-Yi Lin, Hong-Jen Liang & Wen-Chi Hou. (2018) 135-Day Interventions of Yam Dioscorin and the Dipeptide Asn-Trp (NW) To Reduce Weight Gains and Improve Impaired Glucose Tolerances in High-Fat Diet-Induced C57BL/6 Mice. Journal of Agricultural and Food Chemistry 66:3, pages 645-652.
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Susan Q. Yang, Jason R. DeGuire, Paula Lavery, Ivy L. Mak, Hope A. Weiler & Sylvia Santosa. (2016) Conjugated linoleic acid mitigates testosterone-related changes in body composition in male guinea pigs. Nutrition Research 36:5, pages 408-417.
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Bo Yang, Haiqin Chen, Catherine Stanton, R. Paul Ross, Hao Zhang, Yong Q. Chen & Wei Chen. (2015) Review of the roles of conjugated linoleic acid in health and disease. Journal of Functional Foods 15, pages 314-325.
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A. Pinelli-Saavedra, J.R. Peralta-Quintana, J. Sosa-Castañeda, S.Y. Moya-Camarena, A. Burgara-Estrella & J. Hernández. (2015) Dietary conjugated linoleic acid and its effect on immune response in pigs infected with the porcine reproductive and respiratory syndrome virus. Research in Veterinary Science 98, pages 30-38.
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A. Makol, S. Torrecillas, M.J. Caballero, A. Fernández-Vaquero & M.S. Izquierdo. (2012) Effect of long term feeding with conjugated linoleic acid (CLA) in growth performance and lipid metabolism of European sea bass (Dicentrarchus labrax). Aquaculture 368-369, pages 129-137.
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Yeonhwa Park & Yooheon Park. 2012. Emerging Trends in Dietary Components for Preventing and Combating Disease. Emerging Trends in Dietary Components for Preventing and Combating Disease 393 405 .
Mitsuo Namiki. 2010. Functional Foods of the East. Functional Foods of the East 215 262 .
Rui Rosa, Ana M. Andrade, Narcisa M. Bandarra & Maria L. Nunes. (2010) Physiological and biochemical effects of conjugated linoleic acid and its use in aquaculture. Reviews in Aquaculture 2:2, pages 59-72.
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Ganesh V. Halade, Md M. Rahman & Gabriel Fernandes. (2010) Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57Bl/6J mice. The Journal of Nutritional Biochemistry 21:4, pages 332-337.
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Yeonhwa Park. (2009) Conjugated linoleic acid (CLA): Good or bad trans fat?. Journal of Food Composition and Analysis 22, pages S4-S12.
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Yunkyoung Lee, Jerry T. Thompson, Angel R. de Lera & John P. Vanden Heuvel. (2009) Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7. The Journal of Nutritional Biochemistry 20:11, pages 848-859.e5.
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Ganesh V. Halade, Md. M. Rahman & Gabriel Fernandes. (2009) Effect of CLA isomers and their mixture on aging C57Bl/6J mice. European Journal of Nutrition 48:7, pages 409-418.
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Sevil Kurban, Figen Erkoç & Şakir Erkoç. (2009) Quantum‐chemical treatment of the linoleic acid molecule and two of its conjugated isomers. European Journal of Lipid Science and Technology 111:10, pages 1035-1041.
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Rebecca Wall, R Paul Ross, Fergus Shanahan, Liam O’Mahony, Caitlin O’Mahony, Mairead Coakley, Orla Hart, Peadar Lawlor, Eamonn M Quigley, Barry Kiely, Gerald F Fitzgerald & Catherine Stanton. (2009) Metabolic activity of the enteric microbiota influences the fatty acid composition of murine and porcine liver and adipose tissues. The American Journal of Clinical Nutrition 89:5, pages 1393-1401.
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Anu M. Turpeinen, Niina Ylönen, Eva von Willebrand, Samar Basu & Antti Aro. (2008) Immunological and metabolic effects of cis -9, trans -11-conjugated linoleic acid in subjects with birch pollen allergy . British Journal of Nutrition 100:1, pages 112-119.
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Paula A. Lopes, Susana V. Martins, Mário S. Pinho, Cristina M. Alfaia, Carlos M.G.A. Fontes, Pedro O. Rodrigues, Graça S.L. Morais, Matilde F. Castro, Rui Pinto & José A.M. Prates. (2008) Diet supplementation with the cis-9,trans-11 conjugated linoleic acid isomer affects the size of adipocytes in Wistar rats. Nutrition Research 28:7, pages 480-486.
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Jing‐Jing Li, Chang J. Huang & Dong Xie. (2008) Anti‐obesity effects of conjugated linoleic acid, docosahexaenoic acid, and eicosapentaenoic acid. Molecular Nutrition & Food Research 52:6, pages 631-645.
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Rebecca Wall, R. Paul Ross, Gerald F. Fitzgerald & Catherine Stanton. (2008) Microbial conjugated linoleic acid production - a novel probiotic trait?. Food Science & Technology Bulletin: Functional Foods 4:8, pages 87-97.
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Klaus W.J. Wahle, Marie Goua, Simona D'Urso & Steven D. Heys. 2008. Trans Fatty Acids. Trans Fatty Acids 54 101 .
Sun Jin Hur & Yeonhwa Park. (2007) Effect of conjugated linoleic acid on bone formation and rheumatoid arthritis. European Journal of Pharmacology 568:1-3, pages 16-24.
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YEONHWA PARK, MINGDER YANG, JAYNE M. STORKSON, KAREN J. ALBRIGHT, WEI LIU, MARK E. COOK & MICHAEL W. PARIZA. (2007) EFFECTS OF CONJUGATED LINOLEIC ACID ISOMERS ON SERUM TUMOR NECROSIS FACTOR-A CONCENTRATION IN MICE. Journal of Food Biochemistry 31:2, pages 252-265.
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Yeonhwa Park & Michael W. Pariza. (2007) Mechanisms of body fat modulation by conjugated linoleic acid (CLA). Food Research International 40:3, pages 311-323.
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Jean-Michel Gaullier, Johan Halse, Hans Olav Høivik, Kjetil Høye, Christian Syvertsen, Minna Nurminiemi, Cecilie Hassfeld, Alexandra Einerhand, Marianne O'Shea & Ola Gudmundsen. (2007) Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese. British Journal of Nutrition 97:3, pages 550-560.
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Yoshikazu YONEI, Yoko TAKAHASHI, Miwako WATANABE & Toshito YOSHIOKA. (2007) A double-blind, randomized controlled trial (RCT) of L-carnitine and conjugated linoleic acid-based health food with health claims. ANTI-AGING MEDICINE 4:1, pages 19-27.
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Arunabh Bhattacharya, Jameela Banu, Mizanur Rahman, Jennifer Causey & Gabriel Fernandes. (2006) Biological effects of conjugated linoleic acids in health and disease. The Journal of Nutritional Biochemistry 17:12, pages 789-810.
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V. Navarro, A. Fernández-Quintela, I. Churruca & M. P. Portillo. (2006) The body fat-lowering effect of conjugated linoleic acid: a comparison between animal and human studies. Journal of Physiology and Biochemistry 62:2, pages 137-147.
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Arunabh Bhattacharya, M. Mizanur Rahman, Roger McCarter, Marianne O'Shea & Gabriel Fernandes. (2006) Conjugated linoleic acid and chromium lower body weight and visceral fat mass in high-fat-diet-fed mice. Lipids 41:5, pages 437-444.
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Angela A. Wendel & Martha A. Belury. (2006) Effects of conjugated linoleic acid and troglitazone on lipid accumulation and composition in lean and Zucker diabetic fatty (fa/fa) rats. Lipids 41:3, pages 241-247.
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M. A. Zulet, A. Marti, M. D. Parra & J. A. Martínez. (2005) Inflammation and conjugated linoleic acid: mechanisms of action and implications for human healthInflamación y ácido linoleico conjugado: mecanismos de acción e implicaciones para la salud(minirrevisión). Journal of Physiology and Biochemistry 61:3, pages 483-494.
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Rakesh Kapoor, Martin Reaney & Neil D. Westcott. 2005. Bailey's Industrial Oil and Fat Products. Bailey's Industrial Oil and Fat Products.
Rakesh Kapoor & Harikumar Nair. 2005. Bailey's Industrial Oil and Fat Products. Bailey's Industrial Oil and Fat Products.
Bruce A. Watkins, Yong Li, Bernhard Hennig & Michal Toborek. 2005. Bailey's Industrial Oil and Fat Products. Bailey's Industrial Oil and Fat Products.
Mohamed Labib Salem. (2005) Systemic treatment with n-6 polyunsaturated fatty acids attenuates EL4 thymoma growth and metastasis through enhancing specific and non-specific anti-tumor cytolytic activities and production of TH1 cytokines. International Immunopharmacology 5:6, pages 947-960.
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Jean-Michel Gaullier, Johan Halse, Kjetil Høye, Knut Kristiansen, Hans Fagertun, Hogne Vik & Ola Gudmundsen. (2005) Supplementation with Conjugated Linoleic Acid for 24 Months Is Well Tolerated by and Reduces Body Fat Mass in Healthy, Overweight Humans. The Journal of Nutrition 135:4, pages 778-784.
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H-J Song, I Grant, D Rotondo, I Mohede, N Sattar, S D Heys & K W J Wahle. (2005) Effect of CLA supplementation on immune function in young healthy volunteers. European Journal of Clinical Nutrition 59:4, pages 508-517.
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Lai Changhua, Yin Jindong, Li Defa, Zhao Lidan, Qiao Shiyan & Xing Jianjun. (2005) Conjugated Linoleic Acid Attenuates the Production and Gene Expression of Proinflammatory Cytokines in Weaned Pigs Challenged with Lipopolysaccharide. The Journal of Nutrition 135:2, pages 239-244.
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Erin Graves, Andrew Hitt, Michael W. Pariza, Mark E. Cook & Donna O. McCarthy. (2004) Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon‐26 adenocarcinoma. Research in Nursing & Health 28:1, pages 48-55.
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Klaus W.J. Wahle, Steven D. Heys & Dino Rotondo. (2004) Conjugated linoleic acids: are they beneficial or detrimental to health?. Progress in Lipid Research 43:6, pages 553-587.
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Y W Wang & P J H Jones. (2004) Conjugated linoleic acid and obesity control: efficacy and mechanisms. International Journal of Obesity 28:8, pages 941-955.
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Bruce A Watkins, Yong Li, Hugh E Lippman, Susan Reinwald & Mark F Seifert. (2004) A test of Ockham's razor: implications of conjugated linoleic acid in bone biology. The American Journal of Clinical Nutrition 79:6, pages 1175S-1185S.
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Jean-Michel Gaullier, Johan Halse, Kjetil Høye, Knut Kristiansen, Hans Fagertun, Hogne Vik & Ola Gudmundsen. (2004) Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. The American Journal of Clinical Nutrition 79:6, pages 1118-1125.
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Patricia A. Masso-Welch, Danilo Zangani, Mary M. Vaughan, Suzanne F. Shoemaker, Sibel Oflazoglu McGee, Margot M. Ip & Clement Ip. (2004) Isomers of Conjugated Linoleic Acid Differ in Their Effects on Angiogenesis and Survival of Mouse Mammary Adipose Vasculature. The Journal of Nutrition 134:2, pages 299-307.
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Asuka Akahoshi, Kazunori Koba, Fumika Ichinose, Mai Kaneko, Asako Shimoda, Kikuko Nonaka, Masao Yamasaki, Toshio Iwata, Yoshie Yamauchi, Kentaro Tsutsumi & Michihiro Sugano. (2004) Dietary protein modulates the effect of CLA on lipid metabolism in rats. Lipids 39:1, pages 25-30.
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Asuka Akahoshi, Kazunori Koba, Shihoko Ohkura-Kaku, Naoko Kaneda, Chikage Goto, Hiroe Sano, Toshio Iwata, Yoshie Yamauchi, Kentaro Tsutsumi & Michihiro Sugano. (2003) Metabolic effects of dietary conjugated linoleic acid (CLA) isomers in rats. Nutrition Research 23:12, pages 1691-1701.
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Ronald L. McNeel & Harry J. Mersmann. (2003) Effects of isomers of conjugated linoleic acid on porcine adipocyte growth and differentiation11This work is a publication of the USDA/ARS Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030-2600. This project has been funded in part with federal funds from the USDA/ARS under Cooperative Agreement No. 58-6250-6001. The contents of this publication do not necessarily reflect the views or policies of the USDA, nor does mention of trade names, commercial products, or organizations imply endorsement from the U.S. government.. The Journal of Nutritional Biochemistry 14:5, pages 266-274.
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Kyoko Ishiguro, Hisae Oku, Akiko SuitaniYoshikuni Yamamoto. (2002) Effects of Conjugated Linoleic Acid on Anaphylaxis and Allergic Pruritus.. Biological and Pharmaceutical Bulletin 25:12, pages 1655-1657.
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