Advanced search
Publication Cover
Bioscience, Biotechnology, and Biochemistry Volume 67, 2003 - Issue 6
Journal homepage
335
Views
42
CrossRef citations to date
0
Altmetric
Original Articles

Promoting Effect of Kaempferol on the Differentiation and Mineralization of Murine Pre-osteoblastic Cell Line MC3T3-E1

Masaki MIYAKEFujisaki Institute, Hayashibara Biochemical Laboratories Inc.675-1 Fujisaki, Okayama 702-8006, Japan
,
Norie ARAIFujisaki Institute, Hayashibara Biochemical Laboratories Inc.675-1 Fujisaki, Okayama 702-8006, Japan
,
Shimpei USHIOFujisaki Institute, Hayashibara Biochemical Laboratories Inc.675-1 Fujisaki, Okayama 702-8006, Japan
,
Kanso IWAKIFujisaki Institute, Hayashibara Biochemical Laboratories Inc.675-1 Fujisaki, Okayama 702-8006, Japan
,
Masao IKEDAFujisaki Institute, Hayashibara Biochemical Laboratories Inc.675-1 Fujisaki, Okayama 702-8006, Japan
&
Masashi KURIMOTOFujisaki Institute, Hayashibara Biochemical Laboratories Inc.675-1 Fujisaki, Okayama 702-8006, Japan
Pages 1199-1205 | Received 12 Aug 2002, Accepted 16 Jan 2003, Published online: 22 May 2014

Citations (42)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Sok Kuan Wong, Kok-Yong Chin & Soelaiman Ima-Nirwana. (2019) The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies. Drug Design, Development and Therapy 13, pages 3497-3514.
Read now
Shuhei Tsuchiya, Keisuke Sugimoto, Hisanobu Kamio, Kazuto Okabe, Kensuke Kuroda, Masazumi Okido & Hideharu Hibi. (2018) Kaempferol-immobilized titanium dioxide promotes formation of new bone: effects of loading methods on bone marrow stromal cell differentiation in vivo and in vitro. International Journal of Nanomedicine 13, pages 1665-1676.
Read now
Ryohei KONO, Yoshiharu OKUNO, Ken-ichi INADA, Akihiko TOKUDA, Hiroshi HASHIZUME, Munehito YOSHIDA, Misa NAKAMURA & Hirotoshi UTSUNOMIYA. (2011) A Prunus mume Extract Stimulated the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells. Bioscience, Biotechnology, and Biochemistry 75:10, pages 1907-1911.
Read now

Articles from other publishers (39)

Wenkui Qiu, Zhenghui Li, Zhenyan Su, Lichao Cao, Lei Li, Xi Chen, Wanhong Zhang & Yanqing Li. (2023) Kaempferol prevents aseptic loosening via enhance the Wnt/β-catenin signaling pathway in vitro and in vivo. European Journal of Medical Research 28:1.
Crossref
Kalpana Patel, SVVS Ravi Mangu, Shinde Vijay Sukhdeo & Kunal Sharan. (2022) Ethanolic extract from the root and leaf of Sida cordifolia promotes osteoblast activity and prevents ovariectomy-induced bone loss in mice. Phytomedicine 99, pages 154024.
Crossref
Edward J. Calabrese. (2021) Human periodontal ligament stem cells and hormesis: Enhancing cell renewal and cell differentiation. Pharmacological Research 173, pages 105914.
Crossref
Nilkantha Gupta, Manjunath Kamath S, Subha Krishna Rao, Jaison D, Shantanu Patil, Neha Gupta & Kantha Deivi Arunachalam. (2021) Kaempferol loaded albumin nanoparticles and dexamethasone encapsulation into electrospun polycaprolactone fibrous mat – Concurrent release for cartilage regeneration. Journal of Drug Delivery Science and Technology 64, pages 102666.
Crossref
Tuğba Demir, Özlem Akpınar, Haki Kara & Hüseyin Güngör. (2020) Cherry stem phenolic compounds: Optimization of extraction conditions and in vitro evaluations of antioxidant, antimicrobial, antidiabetic, anti‐inflammatory, and cytotoxic activities. Journal of Food Processing and Preservation 44:10.
Crossref
Fujiao Nie, Wenjuan Zhang, Qun Cui, Yajing Fu, Hongkun Li & Jun Zhang. (2020) Kaempferol promotes proliferation and osteogenic differentiation of periodontal ligament stem cells via Wnt/β-catenin signaling pathway. Life Sciences 258, pages 118143.
Crossref
Ji Yeon Lee, Jeong-Yong Park, Dong Hwi Kim, Hyung Don Kim, Yun-Jeong Ji & Kyung Hye Seo. (2020) Erigeron annuus Protects PC12 Neuronal Cells from Oxidative Stress Induced by ROS-Mediated Apoptosis . Evidence-Based Complementary and Alternative Medicine 2020, pages 1-10.
Crossref
Didem Şöhretoğlu & Gülin Renda. 2020. Medicinal Natural Products: A Disease-Focused Approach. Medicinal Natural Products: A Disease-Focused Approach 327 372 .
Ashish Ranjan Sharma & Ju-Suk Nam. (2019) Kaempferol stimulates WNT/β-catenin signaling pathway to induce differentiation of osteoblasts. The Journal of Nutritional Biochemistry 74, pages 108228.
Crossref
Nazario Russo, Clara Cassinelli, Elisa Torre, Marco Morra & Giorgio Iviglia. (2019) Improvement of the Physical Properties of Guided Bone Regeneration Membrane from Porcine Pericardium by Polyphenols-Rich Pomace Extract. Materials 12:16, pages 2564.
Crossref
Sara Zadegan, Jhamak Nourmohammadi, Bahman Vahidi & Nooshin Haghighipour. (2019) An investigation into osteogenic differentiation effects of silk fibroin-nettle (Urtica dioica L.) nanofibers. International Journal of Biological Macromolecules 133, pages 795-803.
Crossref
Rabail Hassan Toor, Raazia Tasadduq, Achyut Adhikari, Muhammad Iqbal Chaudhary, Jane B. Lian, Janet L. Stein, Gary S. Stein & Abdul Rauf Shakoori. (2018) Ethyl acetate and n‐butanol fraction of Cissus quadrangularis promotes the mineralization potential of murine pre‐osteoblast cell line MC3T3‐E1 (sub‐clone 4) . Journal of Cellular Physiology 234:7, pages 10300-10314.
Crossref
Sulekha Adhikary, Dharmendra Choudhary, Naseer Ahmad, Anirudha Karvande, Avinash Kumar, Venkatesh Teja Banala, Prabhat Ranjan Mishra & Ritu Trivedi. (2018) Dietary flavonoid kaempferol inhibits glucocorticoid-induced bone loss by promoting osteoblast survival. Nutrition 53, pages 64-76.
Crossref
Chang-Ju Kim, Sang-Hun Shin, Bok-Joo Kim, Chul-Hoon Kim, Jung-Han Kim, Hae-Mi Kang, Bong-Soo Park & In-Ryoung Kim. (2018) The Effects of Kaempferol-Inhibited Autophagy on Osteoclast Formation. International Journal of Molecular Sciences 19:1, pages 125.
Crossref
Raazia Tasadduq, Jonathan Gordon, Khalid A. Al-Ghanim, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein & Abdul Rauf Shakoori. (2017) Ethanol Extract of Cissus quadrangularis Enhances Osteoblast Differentiation and Mineralization of Murine Pre-Osteoblastic MC3T3-E1 Cells . Journal of Cellular Physiology 232:3, pages 540-547.
Crossref
Nor Aijratul Asikin Mohd Shalan, Noordin M. Mustapha & Suhaila Mohamed. (2017) Noni leaf and black tea enhance bone regeneration in estrogen-deficient rats. Nutrition 33, pages 42-51.
Crossref
In-Ryoung Kim, Seong-Eon Kim, Hyun-Su Baek, Bok-Joo Kim, Chul-Hoon Kim, In-Kyo Chung, Bong-Soo Park & Sang-Hun Shin. (2016) The role of kaempferol-induced autophagy on differentiation and mineralization of osteoblastic MC3T3-E1 cells. BMC Complementary and Alternative Medicine 16:1.
Crossref
Yuri Lee, Jisun Oh, Hyeji Lee, Nam Keun Lee, Do-Youn Jeong & Yong-Seob Jeong. (2015) Lactic acid bacteria-mediated fermentation of Cudrania tricuspidata leaf extract improves its antioxidative activity, osteogenic effects, and anti-adipogenic effects. Biotechnology and Bioprocess Engineering 20:5, pages 861-870.
Crossref
Emily E Hohman & Connie M Weaver. (2015) A Grape-Enriched Diet Increases Bone Calcium Retention and Cortical Bone Properties in Ovariectomized Rats. The Journal of Nutrition 145:2, pages 253-259.
Crossref
Tetsuro Mazaki, Takashi Kitajima, Yasuyuki Shiozaki, Miwa Sato, Megumi Mino, Aki Yoshida, Mariko Nakamura, Yasuhiro Yoshida, Masato Tanaka, Toshifumi Ozaki, Akihiro Matsukawa & Yoshihiro Ito. (2014) In vitro and in vivo enhanced osteogenesis by kaempferol found by a high-throughput assay using human mesenchymal stromal cells. Journal of Functional Foods 6, pages 241-247.
Crossref
Ava Jiangyang Guo, Roy Chiyan Choi, Ken Yuzhong Zheng, Vicky Ping Chen, Tina Tingxia Dong, Zheng-Tao Wang, Günter Vollmer, David Taiwai Lau & Karl Wah-keung Tsim. (2012) Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. Chinese Medicine 7:1.
Crossref
C. Bessa Pereira, P. S. Gomes, J. Costa‐Rodrigues, R. Almeida Palmas, L. Vieira, M. P. Ferraz, M. A. Lopes & M. H. Fernandes. (2012) Equisetum arvense hydromethanolic extracts in bone tissue regeneration: in vitro osteoblastic modulation and antibacterial activity . Cell Proliferation 45:4, pages 386-396.
Crossref
J. A. Siddiqui, G. Swarnkar, K. Sharan, B. Chakravarti, A. K. Gautam, P. Rawat, M. Kumar, V. Gupta, L. Manickavasagam, A. K. Dwivedi, R. Maurya & N. Chattopadhyay. (2011) A naturally occurring rare analog of quercetin promotes peak bone mass achievement and exerts anabolic effect on osteoporotic bone. Osteoporosis International 22:12, pages 3013-3027.
Crossref
Eun Mi Choi. (2011) Kaempferol protects MC3T3-E1 cells through antioxidant effect and regulation of mitochondrial function. Food and Chemical Toxicology 49:8, pages 1800-1805.
Crossref
Lijuan Yang, Qianfeng Chen, Fei Wang & Guolin Zhang. (2011) Antiosteoporotic compounds from seeds of Cuscuta chinensis. Journal of Ethnopharmacology 135:2, pages 553-560.
Crossref
Wen-Fei Chiou, Chia-Hsin Lee, Jyh-Fei Liao & Chien-Chih Chen. (2011) 8-Prenylkaempferol accelerates osteoblast maturation through bone morphogenetic protein-2/p38 pathway to activate Runx2 transcription. Life Sciences 88:7-8, pages 335-342.
Crossref
Jun Lin, Yi-jing Fan, Christian Mehl, Jia-jun Zhu, Hong Chen, Ling-yan Jin, Jing-hong Xu & Hui-ming Wang. (2011) Eucommia ulmoides Oliv. antagonizes H2O2-induced rat osteoblastic MC3T3-E1 apoptosis by inhibiting expressions of caspases 3, 6, 7, and 9. Journal of Zhejiang University SCIENCE B 12:1, pages 47-54.
Crossref
Avinash Kumar, Anand K. Singh, Abnish K. Gautam, Deepak Chandra, Divya Singh, Bendangla Changkija, Mahendra Pratap Singh & Ritu Trivedi. (2010) Identification of kaempferol‐regulated proteins in rat calvarial osteoblasts during mineralization by proteomics. PROTEOMICS 10:9, pages 1730-1739.
Crossref
Min-Hsiung Pan, Ching-Shu Lai & Chi-Tang Ho. (2010) Anti-inflammatory activity of natural dietary flavonoids. Food & Function 1:1, pages 15.
Crossref
Kwang Sik Suh, Eun-Mi Choi, Mikwang Kwon, Suk Chon, Seungjoon Oh, Jeong-Taek Woo, Sung Woon Kim, Jin-Woo Kim & Young Seol Kim. (2009) Kaempferol Attenuates 2-Deoxy-D-ribose-Induced Oxidative Cell Damage in MC3T3-E1 Osteoblastic Cells. Biological and Pharmaceutical Bulletin 32:4, pages 746-749.
Crossref
Véronique Habauzit & Marie-Noëlle Horcajada. (2007) Phenolic phytochemicals and bone. Phytochemistry Reviews 7:2, pages 313-344.
Crossref
Seung Min Oh, Ha Ryong Kim & Kyu Hyuck Chung. (2008) Effects of ginkgo biloba on in vitro osteoblast cells and ovariectomized rat osteoclast cells. Archives of Pharmacal Research 31:2, pages 216-224.
Crossref
Eun‐Mi Choi. (2013) Modulatory effects of luteolin on osteoblastic function and inflammatory mediators in osteoblastic MC3T3‐E1 cells. Cell Biology International 31:9, pages 870-877.
Crossref
I.R. Garrett. 2007. 127 171 .
Yeon Jeong Kim, Yong Chan Bae, Kuen Taek Suh & Jin Sup Jung. (2006) Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells. Biochemical Pharmacology 72:10, pages 1268-1278.
Crossref
Yu Zhong, Yoshiyuki Yoshinaka, Tadahiro Takeda, Noriko Shimizu, Sayaka Yoshizaki, Yoshio Inagaki, Shinobu Matsuda, Gisho Honda, Nobutaka Fujii & Naoki Yamamoto. (2005) Highly potent anti-HIV-1 activity isolated from fermented Polygonum tinctorium Aiton. Antiviral Research 66:2-3, pages 119-128.
Crossref
Satoru Kawaii & Ephraim P. Lansky. (2004) Differentiation-Promoting Activity of Pomegranate ( Punica granatum ) Fruit Extracts in HL-60 Human Promyelocytic Leukemia Cells . Journal of Medicinal Food 7:1, pages 13-18.
Crossref
Christophe Prouillet, Jean-Claude Mazière, Cécile Mazière, Alice Wattel, Michel Brazier & Saı&#x;d Kamel. (2004) Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. Biochemical Pharmacology 67:7, pages 1307-1313.
Crossref
Marine-Noëlle Horcajada & Véronique Coxam. 2004. Nutritional Aspects of Osteoporosis. Nutritional Aspects of Osteoporosis 109 126 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.