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Bioscience, Biotechnology, and Biochemistry Volume 67, 2003 - Issue 7
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Original Articles

Amino Acid Residue Substitution at T-Cell Determinant-flanking Sites in β-Lactoglobulin Modulates Antigen Presentation to T Cells through Subtle Conformational Change

Akio AMETANIDepartment of Applied Biological Chemistry, The University of TokyoTokyo 113-8657, Japan;Present address: Torrey Pines Institute for Molecular StudiesCA 92121, USA
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Toshio SAKURAIDepartment of Applied Biological Chemistry, The University of TokyoTokyo 113-8657, Japan;Technology and Research Institute, Snow Brand Co., Ltd.Kawagoe-city, Saitama 350-1165, Japan
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Yoshinori KATAKURADepartment of Applied Biological Chemistry, The University of TokyoTokyo 113-8657, Japan;Graduate School of Genetic Resources Technology, Kyushu UniversityFukuoka 812-8581, Japan;Present address: Graduate School of Genetic Resources Technology, Kyushu UniversityFukuoka 812-8581, Japan
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Satoru KUHARAGraduate School of Genetic Resources Technology, Kyushu UniversityFukuoka 812-8581, Japan
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Hideki HIRAKAWAGraduate School of Genetic Resources Technology, Kyushu UniversityFukuoka 812-8581, Japan
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Tomohiro HOSOIDepartment of Applied Biological Chemistry, The University of TokyoTokyo 113-8657, Japan;Present address: Tokyo Metropolitan Food Technology Research CenterTokyo 101-0025, Japan
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Shun-ichi DOSAKOTechnology and Research Institute, Snow Brand Co., Ltd.Kawagoe-city, Saitama 350-1165, Japan
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Shuichi KAMINOGAWADepartment of Applied Biological Chemistry, The University of TokyoTokyo 113-8657, Japan;Present address: Department of Food Science and Technology, Nihon University1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan
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Pages 1507-1514 | Received 27 Jan 2003, Accepted 11 Apr 2003, Published online: 22 May 2014

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Ouarda Azdad, Najlae Mejrhit, Mohamed El Kabbaoui, Alae Chda, Ibtissam Ouahidi, Abdelali Tazi, Rachid Bencheikh & Lotfi Aarab. (2018) Effect of heating and enzymatic hydrolysis on casein cow milk sensitivity in Moroccan population. Food and Agricultural Immunology 29:1, pages 424-433.
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Articles from other publishers (11)

Katelyn T. Gause, Yan Yan, Jiwei Cui, Neil M. O’Brien-Simpson, Jason C. Lenzo, Eric C. Reynolds & Frank Caruso. (2015) Physicochemical and Immunological Assessment of Engineered Pure Protein Particles with Different Redox States. ACS Nano 9:3, pages 2433-2444.
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J.Z. Zhong, W. Liu, C.M. Liu, Q.H. Wang, T. Li, Z.C. Tu, S.J. Luo, X.F. Cai & Y.J. Xu. (2012) Aggregation and conformational changes of bovine β-lactoglobulin subjected to dynamic high-pressure microfluidization in relation to antigenicity. Journal of Dairy Science 95:8, pages 4237-4245.
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Xiaoman Li, Wei Xu & Sidong Xiong. (2012) A Novel Tuberculosis DNA Vaccine in an HIV-1 p24 Protein Backbone Confers Protection against Mycobacterium tuberculosis and Simultaneously Elicits Robust Humoral and Cellular Responses to HIV-1. Clinical and Vaccine Immunology 19:5, pages 723-730.
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Katharina Hinz, Paula M O'Connor, Thom Huppertz, R Paul Ross & Alan L Kelly. (2012) Comparison of the principal proteins in bovine, caprine, buffalo, equine and camel milk. Journal of Dairy Research 79:2, pages 185-191.
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P. L. Nilantha Lakshman, Shinjiro Tachibana, Hirohide Toyama, Toki Taira, Toshihiko Suganuma, Worapot Suntornsuk & Masaaki Yasuda. (2011) Application of an acid proteinase from Monascus purpureus to reduce antigenicity of bovine milk whey protein. Journal of Industrial Microbiology & Biotechnology 38:9, pages 1485-1492.
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Junzhen Zhong, Chengmei Liu, Wei Liu, Xiaofei Cai, Zongcai Tu & Jie Wan. (2011) Effect of dynamic high-pressure microfluidization at different temperatures on the antigenic response of bovine β-lactoglobulin. European Food Research and Technology 233:1, pages 95-102.
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Laura J. Peek, Talia T. Martin, Charity Elk Nation, Shannel A. Pegram & C.Russell Middaugh. (2007) Effects of Stabilizers on the Destabilization of Proteins upon Adsorption to Aluminum Salt Adjuvants. Journal of Pharmaceutical Sciences 96:3, pages 547-557.
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Samuel J. Landry. 2006. Food Allergy . Food Allergy 123 159 .
F. Lara-Villoslada, M. Olivares & J. Xaus. (2005) The Balance Between Caseins and Whey Proteins in Cow's Milk Determines its Allergenicity. Journal of Dairy Science 88:5, pages 1654-1660.
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LaToya S. Jones, Laura J. Peek, Jonathan Power, Aaron Markham, Brian Yazzie & C. Russell Middaugh. (2005) Effects of Adsorption to Aluminum Salt Adjuvants on the Structure and Stability of Model Protein Antigens. Journal of Biological Chemistry 280:14, pages 13406-13414.
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Robert Thai, Gervaise Moine, Michel Desmadril, Denis Servent, Jean-Luc Tarride, André Ménez & Michel Léonetti. (2004) Antigen Stability Controls Antigen Presentation. Journal of Biological Chemistry 279:48, pages 50257-50266.
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