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Original Articles

Anti-angiogenic Activity of Tocotrienol

, , , , &
Pages 1623-1627 | Received 07 Apr 2003, Accepted 19 May 2003, Published online: 22 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Louise Raunkilde, Torben Frøstrup Hansen, Birgitte Mayland Havelund, Caroline Brenner Thomsen, Søren Rafael Rafaelsen, Jan Lindebjerg & Lars Henrik Jensen. (2023) Delta tocotrienol as a supplement to FOLFOXIRI in first-line treatment of metastatic colorectal cancer. A randomized, double-blind, placebo-controlled phase II study. Acta Oncologica 62:9, pages 1066-1075.
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Annette Abraham, Ajoe John Kattoor, Tom Saldeen & Jawahar L. Mehta. (2019) Vitamin E and its anticancer effects. Critical Reviews in Food Science and Nutrition 59:17, pages 2831-2838.
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Tsuyoshi TSUZUKI, Akira SHIBATA, Yuki KAWAKAMI, Kiyotaka NAKAGAYA & Teruo MIYAZAWA. (2007) Anti-Angiogenic Effects of Conjugated Docosahexaenoic Acid in Vitro and in Vivo . Bioscience, Biotechnology, and Biochemistry 71:8, pages 1902-1910.
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Yuki KAWAKAMI, Tsuyoshi TSUZUKI, Kiyotaka NAKAGAWA & Teruo MIYAZAWA. (2007) Distribution of Tocotrienols in Rats Fed a Rice Bran Tocotrienol Concentrate. Bioscience, Biotechnology, and Biochemistry 71:2, pages 464-471.
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Viren Patel, Savita Khanna, Sashwati Roy, Omar Ezziddin & Chandan K. Sen. (2006) Natural vitamin E α-tocotrienol: Retention in vital organs in response to long-term oral supplementation and withdrawal. Free Radical Research 40:7, pages 763-771.
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Articles from other publishers (56)

Torben Frøstrup Hansen, Camilla Qvortrup & Per Pfeiffer. (2021) Angiogenesis Inhibitors for Colorectal Cancer. A Review of the Clinical Data. Cancers 13:5, pages 1031.
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Sasadhar Majhi & Debjit Das. (2021) Chemical derivatization of natural products: Semisynthesis and pharmacological aspects- A decade update. Tetrahedron 78, pages 131801.
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Shi Wei Tan, Daud Ahmad bin Israf Ali, Huzwah Khaza'ai, Jia Woei Wong & Sharmili Vidyadaran. (2020) Cellular uptake and anti-inflammatory effects of palm oil-derived delta (δ)-tocotrienol in microglia. Cellular Immunology 357, pages 104200.
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Janam K. Pandya, Maryssa DeBonee, Maria G. Corradini, Mary Ellen Camire, David Julian McClements & Amanda J. Kinchla. (2019) Development of vitamin E‐enriched functional foods: stability of tocotrienols in food systems. International Journal of Food Science & Technology 54:12, pages 3196-3204.
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Beatriz Martínez-Poveda, José Antonio Torres-Vargas, María del Carmen Ocaña, Melissa García-Caballero, Miguel Ángel Medina & Ana R. Quesada. (2019) The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer. Nutrients 11:9, pages 2036.
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Kai Tang, Ji Liu, Pamela Russell, Judith Clements & Ming-Tat Ling. (2019) Gamma-Tocotrienol Induces Apoptosis in Prostate Cancer Cells by Targeting the Ang-1/Tie-2 Signalling Pathway. International Journal of Molecular Sciences 20:5, pages 1164.
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Caroline Brenner Thomsen, Rikke Fredslund Andersen, Karina Dahl Steffensen, Parvin Adimi & Anders Jakobsen. (2019) Delta tocotrienol in recurrent ovarian cancer. A phase II trial. Pharmacological Research 141, pages 392-396.
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Guillaume Viault, Jean-Jacques Helesbeux, Pascal Richomme & Denis Séraphin. (2018) Concise semisynthesis of novel phenazine-vitamin E hybrids via regioselective tocopheryl ortho -quinone formation. Tetrahedron Letters 59:27, pages 2627-2630.
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Nor Nor Azman, Jo Goon, Siti Abdul Ghani, Zalina Hamid & Wan Wan Ngah. (2018) Comparing Palm Oil, Tocotrienol-Rich Fraction and α-Tocopherol Supplementation on the Antioxidant Levels of Older Adults. Antioxidants 7:6, pages 74.
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Kazim Husain & Mokenge P. Malafa. 2018. Role of Nutraceuticals in Chemoresistance to Cancer. Role of Nutraceuticals in Chemoresistance to Cancer 77 97 .
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Malinee Neelamegam, Irene Looi, Kee Sing Ng & Sharad Suryakant Malavade. (2017) Vitamin E supplementation for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack. Cochrane Database of Systematic Reviews.
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Kok-Yong Chin, Kok-Lun Pang & Ima-Nirwana Soelaiman. 2016. Anti-inflammatory Nutraceuticals and Chronic Diseases. Anti-inflammatory Nutraceuticals and Chronic Diseases 97 130 .
Farahani Abdul Rahman Sazli, Zakiah Jubri, Mariati Abdul Rahman, Saiful Anuar Karsani, Abdul Gapor Md Top & Wan Zurinah Wan Ngah. (2015) Gamma-tocotrienol treatment increased peroxiredoxin-4 expression in HepG2 liver cancer cell line. BMC Complementary and Alternative Medicine 15:1.
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Minar M. M. Hassanien, Adel G. Abdel‐Razek, Magdalena Rudzińska, Aleksander Siger, Katarzyna Ratusz & Roman Przybylski. (2014) Phytochemical contents and oxidative stability of oils from non‐traditional sources. European Journal of Lipid Science and Technology 116:11, pages 1563-1571.
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Lan-Feng Dong & Jiri Neuzil. 2014. Mitochondria: The Anti- cancer Target for the Third Millennium. Mitochondria: The Anti- cancer Target for the Third Millennium 151 181 .
Malinee Neelamegam, Irene Looi, Kee Sing Ng & Sharad Suryakant Malavade. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Kazim Husain, Barbara A. Centeno, Dung-Tsa Chen, Sunil R. Hingorani, Said M. Sebti & Mokenge P. Malafa. (2013) Vitamin E δ-Tocotrienol Prolongs Survival in the LSL-KrasG12D /+; LSL-Trp53R172H /+; Pdx-1-Cre (KPC) Transgenic Mouse Model of Pancreatic Cancer . Cancer Prevention Research 6:10, pages 1074-1083.
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M. T. Ling, S. U. Luk, F. Al-Ejeh & K. K. Khanna. (2011) Tocotrienol as a potential anticancer agent. Carcinogenesis 33:2, pages 233-239.
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Kouji ITOU. (2012) Hypotensive Effect of Rice Bran Discarded after Heshiko Processing. Food Science and Technology Research 18:1, pages 99-105.
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Hannah R. Vasanthi, R. P. Parameswari & Dipak K. Das. (2011) Multifaceted role of tocotrienols in cardioprotection supports their structure: function relation. Genes & Nutrition 7:1, pages 19-28.
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Kanga Rani Selvaduray, Ammu K. Radhakrishnan, Methil Kannan Kutty & Kalanithi Nesaretnam. (2011) Palm tocotrienols decrease levels of pro-angiogenic markers in human umbilical vein endothelial cells (HUVEC) and murine mammary cancer cells. Genes & Nutrition 7:1, pages 53-61.
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Ramaswamy Kannappan, Subash C. Gupta, Ji Hye Kim & Bharat B. Aggarwal. (2011) Tocotrienols fight cancer by targeting multiple cell signaling pathways. Genes & Nutrition 7:1, pages 43-52.
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Lim T. K.T. K. Lim. 2012. Edible Medicinal and Non-Medicinal Plants. Edible Medicinal and Non-Medicinal Plants 335 392 .
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Byungrok Min, Anna M. McClung & Ming-Hsuan Chen. (2011) Phytochemicals and Antioxidant Capacities in Rice Brans of Different Color. Journal of Food Science 76:1, pages C117-C126.
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Bharat B. Aggarwal, Chitra Sundaram, Seema Prasad & Ramaswamy Kannappan. (2010) Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases. Biochemical Pharmacology 80:11, pages 1613-1631.
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Zhihong Ren, Munkyong Pae, Maria Carlota Dao, Donald Smith, Simin Nikbin Meydani & Dayong Wu. (2010) Dietary Supplementation with Tocotrienols Enhances Immune Function in C57BL/6 Mice. The Journal of Nutrition 140:7, pages 1335-1341.
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Phumon Sookwong, Kiyotaka Nakagawa, Yasuhiro Yamaguchi, Taiki Miyazawa, Shunji Kato, Fumiko Kimura & Teruo Miyazawa. (2010) Tocotrienol Distribution in Foods: Estimation of Daily Tocotrienol Intake of Japanese Population. Journal of Agricultural and Food Chemistry 58:6, pages 3350-3355.
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Tomoko Kayashima, Masaharu Mori, Hiromi Yoshida, Yoshiyuki Mizushina & Kiminori Matsubara. (2009) 1,4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis. Cancer Letters 278:1, pages 34-40.
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Teruo Miyazawa, Akira Shibata, Phumon Sookwong, Yuki Kawakami, Takahiro Eitsuka, Akira Asai, Shinichi Oikawa & Kiyotaka Nakagawa. (2009) Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol). The Journal of Nutritional Biochemistry 20:2, pages 79-86.
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