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Original Articles

Cytotoxicity and DNA Topoisomerase Inhibitory Activity of Benz[f]indole-4,9-dione Analogs

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Pages 1944-1949 | Received 11 Apr 2003, Accepted 02 Jun 2003, Published online: 22 May 2014

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Rayhaneh Alipoor, Mohammad Reza Mohammadizadeh & Dariush Saberi. (2023) New One-Pot Pathway for the Synthesis of 2H–Pyrrolo[2,3-d]Pyrimidine-2,4-(3H)-Diones and 1H-Benzo[f]Indole-4,9-Dione Derivatives Substituted 3-Hydroxy-1,4-Naphthoquinonyl. Polycyclic Aromatic Compounds 43:2, pages 1602-1618.
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Sai Ba, Guangpeng Gao, Tianhu Li & Hao Zhang. (2021) Tricking enzymes in living cells: a mechanism-based strategy for design of DNA topoisomerase biosensors. Journal of Nanobiotechnology 19:1.
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Reyaz Hassan Mir, Roohi Mohi-ud-din, Taha Umair Wani, Mohammad Ovais Dar, Abdul Jaleel Shah, Bashir Lone, Chawla Pooja & Mubashir Hussain Masoodi. (2021) Indole: A Privileged Heterocyclic Moiety in the Management of Cancer. Current Organic Chemistry 25:6, pages 724-736.
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Anoop Kumar Panday, Danish Ali & Lokman H. Choudhury. (2020) One-pot synthesis of pyrimidine linked naphthoquinone-fused pyrroles by iodine-mediated multicomponent reactions. Organic & Biomolecular Chemistry 18:26, pages 4997-5007.
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A.V. Subba Rao, M.V.P.S. Vishnu Vardhan, N.V. Subba Reddy, T. Srinivasa Reddy, Siddiq Pasha Shaik, Chandrakant Bagul & Ahmed Kamal. (2016) Synthesis and biological evaluation of imidazopyridinyl-1,3,4-oxadiazole conjugates as apoptosis inducers and topoisomerase IIα inhibitors. Bioorganic Chemistry 69, pages 7-19.
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Katarzyna Gach, Jakub Modranka, Jacek Szymański, Dorota Pomorska, Urszula Krajewska, Marek Mirowski, Tomasz Janecki & Anna Janecka. (2016) Anticancer properties of new synthetic hybrid molecules combining naphtho[2,3-b]furan-4,9-dione or benzo[f]indole-4,9-dione motif with phosphonate subunit. European Journal of Medicinal Chemistry 120, pages 51-63.
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A. F. M. Motiur Rahman, So-Eun Park, Adnan A. Kadi & Youngjoo Kwon. (2014) Fluorescein Hydrazones as Novel Nonintercalative Topoisomerase Catalytic Inhibitors with Low DNA Toxicity. Journal of Medicinal Chemistry 57:21, pages 9139-9151.
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Mirth T. Hoyt, Rahul Palchaudhuri & Paul J. Hergenrother. (2010) Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism. Investigational New Drugs 29:4, pages 562-573.
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Andrea Defant, Graziano Guella & Ines Mancini. (2009) Synthesis and In‐Vitro Cytotoxicity Evaluation of Novel Naphtindolizinedione Derivatives, Part II: Improved Activity for Aza‐Analogues . Archiv der Pharmazie 342:2, pages 80-86.
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De Qing Shen, Yu Cheng, Lin Kun An, Xian Zhang Bu, Zhi Shu Huang & Lian Quan Gu. (2008) Synthesis of aza-naphthindolizinedione derivatives. Chinese Chemical Letters 19:5, pages 533-536.
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Jin Sung Kim, Hee-Kyung Rhee, Hyen Joo Park, Sang Kook Lee, Chong-Ock Lee & Hea-Young Park Choo. (2008) Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition. Bioorganic & Medicinal Chemistry 16:8, pages 4545-4550.
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Yu Cheng, Lin-Kun An, Ning Wu, Xiao-Dong Wang, Xian-Zhang Bu, Zhi-Shu Huang & Lian-Quan Gu. (2008) Synthesis, cytotoxic activities and structure–activity relationships of topoisomerase I inhibitors: Indolizinoquinoline-5,12-dione derivatives. Bioorganic & Medicinal Chemistry 16:8, pages 4617-4625.
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Andrea Defant, Graziano Guella & Ines Mancini. (2007) Synthesis and In Vitro Cytotoxicity Evaluation of Novel Naphthindolizinedione Derivatives . Archiv der Pharmazie 340:3, pages 147-153.
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Hee-Kyung Rhee, Hyen Joo Park, Sang Kook Lee, Chong-Ock Lee & Hea-Young Park Choo. (2007) Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones. Bioorganic & Medicinal Chemistry 15:4, pages 1651-1658.
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Hyen Joo Park, Hyun-Jung Lee, Hye-Young Min, Hwa-Jin Chung, Myung Eun Suh, Hye-Young Park-Choo, Choonmi Kim, Hwa Jung Kim, Eun-Kyung Seo & Sang Kook Lee. (2005) Inhibitory effects of a benz[f]indole-4,9-dione analog on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells. European Journal of Pharmacology 527:1-3, pages 31-36.
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. (2005) Correlation between the Binding Mode and Inhibitory Activity of Benz[f]indole-4,9-dione Analogs with Human Topoisomerase I-DNA. Journal of the Korean Chemical Society 49:5, pages 449-460.
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Ja-Lok KuJae-Gahb Park. (2005) Biology of SNU Cell Lines. Cancer Research and Treatment 37:1, pages 1.
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Eun-Jin Lee, Hyun-Jung Lee, Hyen Joo Park, Hye-Young Min, Myung-Eun Suh, Hwa-Jin Chung & Sang Kook Lee. (2004) Induction of G2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells. Bioorganic & Medicinal Chemistry Letters 14:20, pages 5175-5178.
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Hyen Joo Park, Young-Shin Kim, Jin Sung Kim, Eun-Jin Lee, You-Jin Yi, Hye Jin Hwang, Myung-Eun Suh, Chung-Kyu Ryu & Sang Kook Lee. (2004) 6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents. Bioorganic & Medicinal Chemistry Letters 14:13, pages 3385-3388.
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