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Bioscience, Biotechnology, and Biochemistry Volume 68, 2004 - Issue 1
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Original Articles

Cloning of a Gene Cluster Responsible for the Biosynthesis of Diterpene Aphidicolin, a Specific Inhibitor of DNA Polymerase α

Tomonobu TOYOMASUDepartment of Bioresource Engineering, Faculty of Agriculture, Yamagata University
,
Kentaro NAKAMINAMIDepartment of Bioresource Engineering, Faculty of Agriculture, Yamagata University
,
Hiroaki TOSHIMADepartment of Bioresource Science, College of Agriculture, Ibaraki University
,
Takashi MIEDivision of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
,
Kenji WATANABEDivision of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
,
Hiroyuki ITODivision of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
,
Hirokazu MATSUIDivision of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
,
Wataru MITSUHASHIDepartment of Bioresource Engineering, Faculty of Agriculture, Yamagata University
,
Takeshi SASSADepartment of Bioresource Engineering, Faculty of Agriculture, Yamagata University
&
Hideaki OIKAWADivision of Chemistry, Graduate School of Science, Hokkaido University
 show all
Pages 146-152 | Received 23 Jul 2003, Accepted 10 Sep 2003, Published online: 22 May 2014

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Akihiko Ban, Mizuki Tanaka, Ryuya Fujii, Atsushi Minami, Hideaki Oikawa, Takahiro Shintani & Katsuya Gomi. (2018) Subcellular localization of aphidicolin biosynthetic enzymes heterologously expressed in Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry 82:1, pages 139-147.
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Ryuya FUJII, Atsushi MINAMI, Tae TSUKAGOSHI, Natsuko SATO, Takehiko SAHARA, Satoru OHGIYA, Katsuya GOMI & Hideaki OIKAWA. (2011) Total Biosynthesis of Diterpene Aphidicolin, a Specific Inhibitor of DNA Polymerase α: Heterologous Expression of Four Biosynthetic Genes in Aspergillus oryzae . Bioscience, Biotechnology, and Biochemistry 75:9, pages 1813-1817.
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Hiroshi KAWAIDE. (2006) Biochemical and Molecular Analyses of Gibberellin Biosynthesis in Fungi. Bioscience, Biotechnology, and Biochemistry 70:3, pages 583-590.
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Juan He, Jiao-Xian Du, Qian-Ru Zhao, Ya-Pei Liu, Yan-Long Yang, Ji-Kai Liu & Tao Feng. (2023) Biochemical and Genetic Basis of Guanacastane Diterpene Biosynthesis in Basidiomycete Fungi. Organic Letters 25:28, pages 5345-5349.
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Alexander A. Zhgun. (2023) Fungal BGCs for Production of Secondary Metabolites: Main Types, Central Roles in Strain Improvement, and Regulation According to the Piano Principle. International Journal of Molecular Sciences 24:13, pages 11184.
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Ayousha Shahi, Houlin Yu & Sibongile Mafu. (2022) Diterpene Biosynthesis in Rice Blast Fungus Magnaporthe. Frontiers in Fungal Biology 3.
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Prema S. Karunanithi & Philipp Zerbe. (2019) Terpene Synthases as Metabolic Gatekeepers in the Evolution of Plant Terpenoid Chemical Diversity. Frontiers in Plant Science 10.
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Hiroshi Ogawara. (2018) Comparison of Strategies to Overcome Drug Resistance: Learning from Various Kingdoms. Molecules 23:6, pages 1476.
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Yi He, Bin Wang, Wanping Chen, Russell J. Cox, Jingren He & Fusheng Chen. (2018) Recent advances in reconstructing microbial secondary metabolites biosynthesis in Aspergillus spp.. Biotechnology Advances 36:3, pages 739-783.
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Indu Kumari, Mushtaq Ahmed & Yusuf Akhter. (2018) Evolution of catalytic microenvironment governs substrate and product diversity in trichodiene synthase and other terpene fold enzymes. Biochimie 144, pages 9-20.
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Momoka Yamane, Atsushi Minami, Chengwei Liu, Taro Ozaki, Ichiro Takeuchi, Tae Tsukagoshi, Tetsuo Tokiwano, Katsuya Gomi & Hideaki Oikawa. (2017) Biosynthetic Machinery of Diterpene Pleuromutilin Isolated from Basidiomycete Fungi. ChemBioChem 18:23, pages 2317-2322.
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Günter Speit, Petra Schütz & Julia Bausinger. (2016) Different sensitivities of cultured mammalian cells towards aphidicolin-enhanced DNA effects in the comet assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 803-804, pages 22-26.
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Andy M. Bailey, Fabrizio Alberti, Sreedhar Kilaru, Catherine M. Collins, Kate de Mattos-Shipley, Amanda J. Hartley, Patrick Hayes, Alison Griffin, Colin M. Lazarus, Russell J. Cox, Christine L. Willis, Karen O’Dwyer, David W. Spence & Gary D. Foster. (2016) Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production. Scientific Reports 6:1.
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Bettina Tudzynski, Lena Studt & María Cecilia Rojas. 2016. Annual Plant Reviews, Volume 49. Annual Plant Reviews, Volume 49 121 152 .
B.G.G. Donzelli & S.B. Krasnoff. 2016. Genetics and Molecular Biology of Entomopathogenic Fungi. Genetics and Molecular Biology of Entomopathogenic Fungi 365 436 .
Marc JC Fischer, Camille Rustenhloz, Véronique Leh-Louis & Guy Perrière. (2015) Molecular and functional evolution of the fungal diterpene synthase genes. BMC Microbiology 15:1.
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Grayson T. Wawrzyn, Mark A. Held, Sarah E. Bloch & Claudia Schmidt-Dannert. 2015. Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2. Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2 43 65 .
Maureen B. Quin, Christopher M. Flynn & Claudia Schmidt-Dannert. (2014) Traversing the fungal terpenome. Nat. Prod. Rep. 31:10, pages 1449-1473.
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Dietmar Schomburg & Ida Schomburg. 2013. Class 3.4–6 Hydrolases, Lyases, Isomerases, Ligases. Class 3.4–6 Hydrolases, Lyases, Isomerases, Ligases 568 569 .
Grayson T. Wawrzyn, Sarah E. Bloch & Claudia Schmidt-Dannert. 2012. Natural Product Biosynthesis by Microorganisms and Plants, Part A. Natural Product Biosynthesis by Microorganisms and Plants, Part A 83 105 .
Claudia Leoni, Mariateresa Volpicella, Francesca De Leo, Raffaele Gallerani & Luigi R. Ceci. (2011) Genome walking in eukaryotes. The FEBS Journal 278:21, pages 3953-3977.
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Chen-Hsien Lee, Keng-Hao Hsu, Sheng-Yang Wang, Tun-Tschu Chang, Fang-Hua Chu & Jei-Fu Shaw. (2010) Cloning and Characterization of the Lanosterol 14α-Demethylase Gene from Antrodia cinnamomea. Journal of Agricultural and Food Chemistry 58:8, pages 4800-4807.
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István Molnár, Donna M. Gibson & Stuart B. Krasnoff. (2010) Secondary metabolites from entomopathogenic Hypocrealean fungi. Natural Product Reports 27:9, pages 1241.
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Shohei Sakuda & Makoto Kimura. 2010. Comprehensive Natural Products II. Comprehensive Natural Products II 411 455 .
Tomonobu Toyomasu & Takeshi Sassa. 2010. Comprehensive Natural Products II. Comprehensive Natural Products II 643 672 .
Christiane Bömke & Bettina Tudzynski. (2009) Diversity, regulation, and evolution of the gibberellin biosynthetic pathway in fungi compared to plants and bacteria. Phytochemistry 70:15-16, pages 1876-1893.
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Sean Agger, Fernando Lopez-Gallego & Claudia Schmidt-Dannert. (2009) Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus . Molecular Microbiology 72:5, pages 1181-1195.
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Tomonobu Toyomasu, Akane Kaneko, Tetsuo Tokiwano, Yuya Kanno, Yuri Kanno, Rie Niida, Shigeyoshi Miura, Taiki Nishioka, Chiho Ikeda, Wataru Mitsuhashi, Tohru Dairi, Tomikazu Kawano, Hideaki Oikawa, Nobuo Kato & Takeshi Sassa. (2009) Biosynthetic Gene-Based Secondary Metabolite Screening: A New Diterpene, Methyl Phomopsenonate, from the Fungus Phomopsis amygdali . The Journal of Organic Chemistry 74:4, pages 1541-1548.
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Kazunori OKADA. (2009) . KAGAKU TO SEIBUTSU 47:1, pages 43-50.
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Christiane Bömke, Maria Cecilia Rojas, Fan Gong, Peter Hedden & Bettina Tudzynski. (2008) Isolation and Characterization of the Gibberellin Biosynthetic Gene Cluster in Sphaceloma manihoticola . Applied and Environmental Microbiology 74:17, pages 5325-5339.
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Kazuhiro Shimura, Atsushi Okada, Kazunori Okada, Yusuke Jikumaru, Kwang-Wook Ko, Tomonobu Toyomasu, Takeshi Sassa, Morifumi Hasegawa, Osamu Kodama, Naoto Shibuya, Jinichiro Koga, Hideaki Nojiri & Hisakazu Yamane. (2007) Identification of a Biosynthetic Gene Cluster in Rice for Momilactones. Journal of Biological Chemistry 282:47, pages 34013-34018.
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Tomonobu ToyomasuMai TsukaharaAkane KanekoRie NiidaWataru MitsuhashiTohru Dairi, Nobuo Kato & Takeshi Sassa. (2007) Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi. Proceedings of the National Academy of Sciences 104:9, pages 3084-3088.
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Dirk Hoffmeister & Nancy P. Keller. (2007) Natural products of filamentous fungi: enzymes, genes, and their regulation. Nat. Prod. Rep. 24:2, pages 393-416.
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Punyasloke Bhadury, Balsam T. Mohammad & Phillip C. Wright. (2006) The current status of natural products from marine fungi and their potential as anti-infective agents. Journal of Industrial Microbiology & Biotechnology 33:5, pages 325-337.
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S. Malonek, M. C. Rojas, P. Hedden, P. Hopkins & B. Tudzynski. (2005) Restoration of Gibberellin Production in Fusarium proliferatum by Functional Complementation of Enzymatic Blocks . Applied and Environmental Microbiology 71:10, pages 6014-6025.
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Takeshi Tokai, Hiroyuki Koshino, Tsuneomi Kawasaki, Tomoko Igawa, Yoshikatsu Suzuki, Masayuki Sato, Makoto Fujimura, Takayoshi Eizuka, Hidenori Watanabe, Takeshi Kitahara, Kunihiro Ohta, Takehiko Shibata, Toshiaki Kudo, Hirokazu Inoue, Isamu Yamaguchi & Makoto Kimura. (2005) Screening of putative oxygenase genes in the Fusarium graminearum genome sequence database for their role in trichothecene biosynthesis . FEMS Microbiology Letters 251:2, pages 193-201.
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C. A. Young, M. K. Bryant, M. J. Christensen, B. A. Tapper, G. T. Bryan & B. Scott. (2005) Molecular cloning and genetic analysis of a symbiosis-expressed gene cluster for lolitrem biosynthesis from a mutualistic endophyte of perennial ryegrass. Molecular Genetics and Genomics 274:1, pages 13-29.
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Shuguang Zhang, Brendon J. Monahan, Jan S. Tkacz & Barry Scott. (2004) Indole-Diterpene Gene Cluster from Aspergillus flavus . Applied and Environmental Microbiology 70:11, pages 6875-6883.
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