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Original Articles

The Pro-peptide of Streptomyces mobaraensis Transglutaminase Functions in cis and in trans to Mediate Efficient Secretion of Active Enzyme from Methylotrophic Yeasts

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Pages 2058-2069 | Received 06 May 2004, Accepted 02 Jul 2004, Published online: 22 May 2014

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Kosuke Kawaguchi, Hiroya Yurimoto & Yasuyoshi Sakai. (2014) Expression of a codon-optimized Aspergillus niger pectin methylesterase gene in the methylotrophic yeast Candida boidinii. Bioscience, Biotechnology, and Biochemistry 78:4, pages 718-721.
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Dongxu Zhang, Yang Zhu & Jian Chen. (2009) Microbial Transglutaminase Production: Understanding the Mechanism. Biotechnology and Genetic Engineering Reviews 26:1, pages 205-222.
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Articles from other publishers (32)

Zitao Li, Shuang Xing, Jing Liu, Xiaocong Wu, Sichao Zhang, Di Ma & Xianwei Liu. (2023) Chaperonin co-expression and chemical modification enables production of active microbial transglutaminase from E. coli cytoplasm. International Journal of Biological Macromolecules 253, pages 127355.
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Chunxiao Yan, Wei Yu, Lun Yao, Xiaoyu Guo, Yongjin J. Zhou & Jiaoqi Gao. (2022) Expanding the promoter toolbox for metabolic engineering of methylotrophic yeasts. Applied Microbiology and Biotechnology 106:9-10, pages 3449-3464.
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G. Baltulionis, M. Blight, A. Robin, D. Charalampopoulos & K.A. Watson. (2021) The role of propeptide-mediated autoinhibition and intermolecular chaperone in the maturation of cognate catalytic domain in leucine aminopeptidase. Journal of Structural Biology 213:3, pages 107741.
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Nan Zhang, Shan Zhang, Yongzhi He, Xin Chen, Yanfeng Zhang & Zhiyang Dong. (2020) Intein-mediated intracellular production of active microbial transglutaminase in Corynebacterium glutamicum. Enzyme and Microbial Technology 142, pages 109680.
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Shiting Wang, Zhigang Yang, Zhenjiang Li & Yongqiang Tian. (2020) Heterologous Expression of Recombinant Transglutaminase in Bacillus subtilis SCK6 with Optimized Signal Peptide and Codon, and Its Impact on Gelatin Properties . Journal of Microbiology and Biotechnology 30:7, pages 1082-1091.
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A. S. Rozanov, E. G. Pershina, N. V. Bogacheva, V. Shlyakhtun, A. A. Sychev & S. E. Peltek. (2020) Diversity and occurrence of methylotrophic yeasts used in genetic engineering. Vavilov Journal of Genetics and Breeding 24:2, pages 149-157.
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B. Böhme, B. Moritz, J. Wendler, T. C. Hertel, C. Ihling, W. Brandt & M. Pietzsch. (2019) Enzymatic activity and thermoresistance of improved microbial transglutaminase variants. Amino Acids 52:2, pages 313-326.
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Lovaine Duarte, Carla Roberta Matte, Cristiano Valim Bizarro & Marco Antônio Záchia Ayub. (2020) Transglutaminases: part I—origins, sources, and biotechnological characteristics. World Journal of Microbiology and Biotechnology 36:1.
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Lihong Fu, Yu Wang, Jiansong Ju, Lei Cheng, Youqiang Xu, Bo Yu & Limin Wang. (2019) Extracellular production of active-form Streptomyces mobaraensis transglutaminase in Bacillus subtilis. Applied Microbiology and Biotechnology 104:2, pages 623-631.
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Xiaoping Song, Changsheng Shao, Yugang Guo, Yajie Wang & Jingjing Cai. (2019) Improved the expression level of active transglutaminase by directional increasing copy of mtg gene in Pichia pastoris. BMC Biotechnology 19:1.
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A. Türkanoğlu Özçelik. (2019) Comparison of multicopy pro-microbial transglutaminase encoded gene expression in Pichia pastoris . Acta Alimentaria 48:3, pages 375-383.
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Aysun Türkanoğlu Özçelik, Fatma Ersöz & Mehmet İnan. (2019) Extracellular production of the recombinant bacterial transglutaminase in Pichia pastoris. Protein Expression and Purification 159, pages 83-90.
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Aysun TÜRKANOĞLU ÖZÇELİK. (2019) His-etiketli pro-Mikrobiyal Transglutaminaz Enziminin Pichia pastoris’te Üretim Şartlarının OptimizasyonuOptimization of Production Conditions of His-taqqed pro-Microbial Transglutaminase Enzyme in Pichia pastoris. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi 9:2, pages 666-673.
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Ting Xue, Meimei Sun, Duo Chen, Xue Yuan, Kui Liu, Jiannan Chen, Haoying Ye, Jingping Fang, Wenjin He & Youqiang Chen. (2019) Molecular Cloning and Overexpression of the Transglutaminase Gene from <i>Streptomyces mobaraensis</i>. Food Science and Technology Research 25:5, pages 687-694.
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Samuel K. Oteng-Pabi, Christopher M. Clouthier & Jeffrey W. Keillor. (2018) Design of a glutamine substrate tag enabling protein labelling mediated by Bacillus subtilis transglutaminase. PLOS ONE 13:5, pages e0197956.
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Ying Jiang, Yue-Peng Shang, Hao Li, Chao Zhang, Jiang Pan, Yun-Peng Bai, Chun-Xiu Li & Jian-He Xu. (2017) Enhancing transglutaminase production of Streptomyces mobaraensis by iterative mutagenesis breeding with atmospheric and room-temperature plasma (ARTP). Bioresources and Bioprocessing 4:1.
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Hongbing Sun, Olufemi Emmanuel Bankefa, Ijeoma Onyinyechi Ijeoma, Liangtian Miao, Taicheng Zhu & Yin Li. (2017) Systematic assessment of Pichia pastoris system for optimized β -galactosidase production. Synthetic and Systems Biotechnology.
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T Ikezoe, J Yang, C Nishioka, B Pan, K Xu, M Furihata, K Nakamura, H Yurimoto, Y Sakai, G Honda & A Yokoyama. (2016) The fifth epidermal growth factor-like region of thrombomodulin exerts cytoprotective function and prevents SOS in a murine model. Bone Marrow Transplantation 52:1, pages 73-79.
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Oleh Stasyk. 2017. Biotechnology of Yeasts and Filamentous Fungi. Biotechnology of Yeasts and Filamentous Fungi 325 350 .
Song Liu, Miao Wang, Guocheng Du & Jian Chen. (2016) Improving the active expression of transglutaminase in Streptomyces lividans by promoter engineering and codon optimization. BMC Biotechnology 16:1.
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Mathias Rickert, Pavel Strop, Victor Lui, Jody Melton-Witt, Santiago Esteban Farias, Davide Foletti, David Shelton, Jaume Pons & Arvind Rajpal. (2016) Production of soluble and active microbial transglutaminase in Escherichia coli for site-specific antibody drug conjugation . Protein Science 25:2, pages 442-455.
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Song Liu, Dan Wan, Miao Wang, Catherine Madzak, Guocheng Du & Jian Chen. (2015) Overproduction of pro-transglutaminase from Streptomyces hygroscopicus in Yarrowia lipolytica and its biochemical characterization. BMC Biotechnology 15:1.
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H. Handrkova, V. Schroeder & H.P. Kohler. (2015) The activation peptide of coagulation factor XIII is vital for its expression and stability. Journal of Thrombosis and Haemostasis 13:8, pages 1449-1458.
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Yihan Liu, Song Lin, Xiqing Zhang, Xiaoguang Liu, Jianling Wang & Fuping Lu. (2014) A novel approach for improving the yield of Bacillus subtilis transglutaminase in heterologous strains . Journal of Industrial Microbiology and Biotechnology 41:8, pages 1227-1235.
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Kun Du, Zhongmei Liu, Wenjing Cui, Li Zhou, Yi Liu, Guocheng Du, Jian Chen & Zhemin Zhou. (2014) pH-Dependent Activation of Streptomyces hygroscopicus Transglutaminase Mediated by Intein. Applied and Environmental Microbiology 80:2, pages 723-729.
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O. V. Tyurin, I. I. Gubaydullin, S. E. Cheperegin, B. D. Efremov & D. G. Kozlov. (2013) Amplification of leader proregions as a mean to increase the secretion of antibody fragments in the Pichia pastoris yeast. Applied Biochemistry and Microbiology 49:7, pages 656-659.
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Alane Beatriz Vermelho, Eliane Ferreira Noronha, Edivaldo Ximenes Ferreira Filho, Maria Antonieta Ferrara & Elba Pinto S. Bon. 2013. The Prokaryotes. The Prokaryotes 213 240 .
Song Liu, Dongxu Zhang, Miao Wang, Wenjing Cui, Kangkang Chen, Guocheng Du, Jian Chen & Zhemin Zhou. (2011) The order of expression is a key factor in the production of active transglutaminase in Escherichia coli by co-expression with its pro-peptide. Microbial Cell Factories 10:1.
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Song Liu, Dongxu Zhang, Miao Wang, Wenjing Cui, Kangkang Chen, Yi Liu, Guocheng Du, Jian Chen & Zhemin Zhou. (2011) The pro-region of Streptomyces hygroscopicus transglutaminase affects its secretion by Escherichia coli. FEMS Microbiology Letters 324:2, pages 98-105.
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Christian Sommer, Norbert Volk & Markus Pietzsch. (2011) Model based optimization of the fed-batch production of a highly active transglutaminase variant in Escherichia coli. Protein Expression and Purification 77:1, pages 9-19.
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Yu Sasano, Hiroya Yurimoto & Yasuyoshi Sakai. (2007) Gene-tagging mutagenesis in the methylotrophic yeast Candida boidinii. Journal of Bioscience and Bioengineering 104:1, pages 86-89.
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Xiaoqiu Liu, Xiuqing Yang, Fuhong Xie & Shijun Qian. (2006) Cloning of Transglutaminase Gene from Streptomyces fradiae and its Enhanced Expression in the Original Strain. Biotechnology Letters 28:17, pages 1319-1325.
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