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Bioscience, Biotechnology, and Biochemistry Volume 69, 2005 - Issue 1
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Original Articles

Modulating Effect of Sesamin, a Functional Lignan in Sesame Seeds, on the Transcription Levels of Lipid- and Alcohol-Metabolizing Enzymes in Rat Liver: A DNA Microarray Study

Nobuo TSURUOKASuntory Institute for Health Care Science
,
Ayako KIDOKOROSuntory Institute for Health Care Science
,
Ichiro MATSUMOTODepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
,
Keiko ABEDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
&
Yoshinobu KISOSuntory Institute for Health Care Science
Pages 179-188 | Received 14 Sep 2004, Accepted 23 Oct 2004, Published online: 22 May 2014

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Haohai Huang, Guanghui Zhou, Rong Pu, Yejia Cui & Dan Liao. (2022) Clinical evidence of dietary supplementation with sesame on cardiovascular risk factors: An updated meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition 62:20, pages 5592-5602.
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Amin F. Majdalawieh, Sarah M. Yousef, Imad A. Abu-Yousef & Gheyath K. Nasrallah. (2022) Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions. Critical Reviews in Food Science and Nutrition 62:18, pages 5081-5112.
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Kuo-Ching Jan, Binghuei-Barry Yang & Tristan C. Liu. (2014) Gene expression profiling of sesaminol triglucoside and its tetrahydrofuranoid metabolites in primary rat hepatocytes. International Journal of Food Sciences and Nutrition 65:8, pages 981-988.
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Kaori Yasuda & Toshiyuki Sakaki. (2012) How is sesamin metabolised in the human liver to show its biological effects?. Expert Opinion on Drug Metabolism & Toxicology 8:1, pages 93-102.
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Si-Hyung Park, Su-Noh Ryu, Youngmin Bu, Hocheol Kim, James E. Simon & Kwan-Su Kim. (2010) Antioxidant Components as Potential Neuroprotective Agents in Sesame (Sesamum indicum L.). Food Reviews International 26:2, pages 103-121.
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Mitsuo Namiki. (2007) Nutraceutical Functions of Sesame: A Review. Critical Reviews in Food Science and Nutrition 47:7, pages 651-673.
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Fumiki AOKI, Shinichi HONDA, Hideyuki KISHIDA, Mitsuaki KITANO, Naoki ARAI, Hozumi TANAKA, Shinichi YOKOTA, Kaku NAKAGAWA, Tomiko ASAKURA, Yuji NAKAI & Tatsumasa MAE. (2007) Suppression by Licorice Flavonoids of Abdominal Fat Accumulation and Body Weight Gain in High-Fat Diet-Induced Obese C57BL/6J Mice. Bioscience, Biotechnology, and Biochemistry 71:1, pages 206-214.
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Articles from other publishers (49)

Andrés Alexis Ramírez‐Coronel, Khetam Abdalsada Ali Alhilali, Yasmin Basheer Ahmed, Sami G. Almalki & Jahangir Karimian. (2023) Effect of sesame ( Sesamum indicum L .) consumption on glycemic control in patients with type 2 diabetes: A systematic review and meta‐analysis of randomized controlled trials . Phytotherapy Research.
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Masoumeh Atefi, Mohammad Hassan Entezari, Hamid Vahedi & Akbar Hassanzadeh. (2022) Sesame Oil Ameliorates Alanine Aminotransferase, Aspartate Aminotransferase, and Fatty Liver Grade in Women with Nonalcoholic Fatty Liver Disease Undergoing Low-Calorie Diet: A Randomized Double-Blind Controlled Trial. International Journal of Clinical Practice 2022, pages 1-11.
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Haiyang Zhang, D. Ray Langham & Hongmei Miao. 2021. The Sesame Genome. The Sesame Genome 1 18 .
Keiko Abe, Shinji Okada & Tomoko Ishijima. (2020) The activities of the ILSI Japan endowed chair, at the University of Tokyo, regarding functional food genomics. Nutrition Reviews 78:Supplement_3, pages 35-39.
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T. Gayatri & Asitava Basu. (2020) Development of reproducible regeneration and transformation system for Sesamum indicum. Plant Cell, Tissue and Organ Culture (PCTOC) 143:2, pages 441-456.
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Amin F. Majdalawieh, Sarah Dalibalta & Sarah M. Yousef. (2020) Effects of sesamin on fatty acid and cholesterol metabolism, macrophage cholesterol homeostasis and serum lipid profile: A comprehensive review. European Journal of Pharmacology 885, pages 173417.
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Dilipkumar Pal, Phool Chandra & Neetu Sachan. 2020. Nuts and Seeds in Health and Disease Prevention. Nuts and Seeds in Health and Disease Prevention 183 210 .
Tran Duong Thuy, Nam Nhut Phan, Chih-Yang Wang, Han-Gang Yu, Shu-Yin Wang, Pung-Ling Huang, Yi-Yin Do & Yen-Chang Lin. (2017) Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction. Molecular Medicine Reports 15:5, pages 2949-2956.
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Ruijuan Zhang, Yan Yu, Senke Hu, Jinghua Zhang, Haixia Yang, Bei Han, Yue Cheng & Xiaoqin Luo. (2016) Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXRα and PPARα. Nutrition Research 36:9, pages 1022-1030.
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Takuto Kumano, Etsuko Fujiki, Yoshiteru Hashimoto & Michihiko Kobayashi. (2016) Discovery of a sesamin-metabolizing microorganism and a new enzyme. Proceedings of the National Academy of Sciences 113:32, pages 9087-9092.
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Saman Khalesi, Ernesta Paukste, Elham Nikbakht & Hossein Khosravi-Boroujeni. (2016) Sesame fractions and lipid profiles: a systematic review and meta-analysis of controlled trials. British Journal of Nutrition 115:5, pages 764-773.
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Shuichi SEGAWA, Takahito TAKASE, Koji TAKAZUMI, Takayuki KOSUGI & Takeshi NAKAMURA. (2016) α-glucosylglycerol contained in Japanese sake : inhibitory effect on ALDH activity清酒に含まれるα-グルコシルグリセロールによるアセトアルデヒドデヒドロゲナーゼ阻害作用. JOURNAL OF THE BREWING SOCIETY OF JAPAN 111:2, pages 107-116.
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Kyu-Ho Han. (2016) Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes. World Journal of Gastroenterology 22:1, pages 37.
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Vinay K. Singh, Krishna Pramanik, Sirsendu S. Ray & Kunal Pal. (2014) Development and Characterization of Sorbitan Monostearate and Sesame Oil-Based Organogels for Topical Delivery of Antimicrobials. AAPS PharmSciTech 16:2, pages 293-305.
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Chandrakala Aluganti NarasimhuluKrithika SelvarajanDmitry LitvinovSampath Parthasarathy. (2015) Anti-Atherosclerotic and Anti-Inflammatory Actions of Sesame Oil. Journal of Medicinal Food 18:1, pages 11-20.
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Takashi Ide. (2014) Effect of dietary α-lipoic acid on the mRNA expression of genes involved in drug metabolism and antioxidation system in rat liver. British Journal of Nutrition 112:3, pages 295-308.
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Sachie Horii & Takaaki Ishii. (2014) Effect of Arbuscular Mycorrhizal Fungi and Their Partner Bacteria on the Growth of Sesame Plants and the Concentration of Sesamin in the Seeds. American Journal of Plant Sciences 05:20, pages 3066-3072.
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N.E. Mohamed & M.M. Wakwak. (2014) Effect of sesame seeds or oil supplementation to the feed on some physiological parameters in Japanese Quail. Journal of Radiation Research and Applied Sciences 7:1, pages 101-109.
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Satoshi Fukumitsu, Myra O. Villareal, Shoko Onaga, Kazuhiko Aida, Junkyu Han & Hiroko Isoda. (2012) ?-Linolenic acid suppresses cholesterol and triacylglycerol biosynthesis pathway by suppressing SREBP-2, SREBP-1a and -1c expression. Cytotechnology 65:6, pages 899-907.
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Jesús Osada. (2013) The Use of Transcriptomics to Unveil the Role of Nutrients in Mammalian Liver. ISRN Nutrition 2013, pages 1-19.
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Lei Hong, Wang Yi, Cai Liangliang, Han Juncheng, Wang Qin & Zhang Xiaoxiang. (2012) Hypoglycaemic and hypolipidaemic activities of sesamin from sesame meal and its ability to ameliorate insulin resistance in KK ‐Ay mice . Journal of the Science of Food and Agriculture 93:8, pages 1833-1838.
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Chan-Min Liu, Gui-Hong Zheng, Qing-Lei Ming, Cheng Chao & Jian-Mei Sun. (2013) Sesamin Protects Mouse Liver against Nickel-Induced Oxidative DNA Damage and Apoptosis by the PI3K-Akt Pathway. Journal of Agricultural and Food Chemistry 61:5, pages 1146-1154.
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Hong Lei, Juncheng Han, Qin Wang, Shuzhen Guo, Hanju Sun & Xiaoxiang Zhang. (2012) Effects of Sesamin on Streptozotocin (STZ)-Induced NIT-1 Pancreatic β-Cell Damage. International Journal of Molecular Sciences 13:12, pages 16961-16970.
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A. Schiller Vestergren, L. Wagner, J. Pickova, G. Rosenlund, A. Kamal‐Eldin & S. Trattner. (2012) Sesamin Modulates Gene Expression Without Corresponding Effects on Fatty acids in Atlantic Salmon ( Salmo salar L.) . Lipids 47:9, pages 897-911.
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Suman Lakhanpaul, Vibhuti Singh, Sachin Kumar, Deepak Bhardwaj & Kangila Venkataramana Bhat. 2012. Improving Crop Resistance to Abiotic Stress. Improving Crop Resistance to Abiotic Stress 1251 1283 .
Naoki Hata, Yoshinori Hayashi, Atsushi Okazawa, Eiichiro Ono, Honoo Satake & Akio Kobayashi. (2012) Effect of photoperiod on growth of the plants, and sesamin content and CYP81Q1 gene expression in the leaves of sesame (Sesamum indicum L.). Environmental and Experimental Botany 75, pages 212-219.
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T. K. LimT. K. Lim. 2012. Edible Medicinal And Non-Medicinal Plants. Edible Medicinal And Non-Medicinal Plants 187 219 .
Ryoichi Izuchi, Yuji Nakai, Hidehito Takahashi, Shota Ushiama, Shinji Okada, Takumi Misaka & Keiko Abe. (2011) Hepatic Gene Expression of the Insulin Signaling Pathway Is Altered by Administration of Persimmon Peel Extract: A DNA Microarray Study Using Type 2 Diabetic Goto-Kakizaki Rats. Journal of Agricultural and Food Chemistry 59:7, pages 3320-3329.
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Tomohiro Rogi, Namino Tomimori, Yoshiko Ono & Yoshinobu Kiso. (2011) The Mechanism Underlying the Synergetic Hypocholesterolemic Effect of Sesamin and α-Tocopherol in Rats Fed a High-Cholesterol Diet. Journal of Pharmacological Sciences 115:3, pages 408-416.
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Mohamed Elleuch, Dorothea Bedigian & Adel Zitoun. 2011. Nuts and Seeds in Health and Disease Prevention. Nuts and Seeds in Health and Disease Prevention 1029 1036 .
Kaori Yasuda, Shinichi Ikushiro, Masaki Kamakura, Miho Ohta & Toshiyuki Sakaki. (2010) Metabolism of Sesamin by Cytochrome P450 in Human Liver Microsomes. Drug Metabolism and Disposition 38:12, pages 2117-2123.
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Mitsuo Namiki. 2010. Functional Foods of the East. Functional Foods of the East 215 262 .
Naoki Hata, Yoshinori Hayashi, Atsushi Okazawa, Eiichiro Ono, Honoo Satake & Akio Kobayashi. (2010) Comparison of sesamin contents and CYP81Q1 gene expressions in aboveground vegetative organs between two Japanese sesame (Sesamum indicum L.) varieties differing in seed sesamin contents. Plant Science 178:6, pages 510-516.
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Harukazu Fukami. 2010. Biotechnology in Functional Foods and Nutraceuticals. Biotechnology in Functional Foods and Nutraceuticals 29 50 .
Motoko IRIE. (2010) Effects of Sake Lees on Reducing Ethanol Concentration in the Blood after Alcohol Intake. JOURNAL OF THE BREWING SOCIETY OF JAPAN 105:7, pages 440-446.
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Yoshihiko Tokuji, Kyoko Akiyama, Keita Yunoki, Mikio Kinoshita, Keiko Sasaki, Hitoshi Kobayashi, Masahiro Wada & Masao Ohnishi. (2009) Screening for Beneficial Effects of Oral Intake of Sweet Corn by DNA Microarray Analysis. Journal of Food Science 74:7, pages H197-H203.
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Takashi IDE, Jin Seon LIM, Tseye-Oidov ODBAYAR & Yasutaka NAKASHIMA. (2009) Comparative Study of Sesame Lignans (Sesamin, Episesamin and Sesamolin) Affecting Gene Expression Profile and Fatty Acid Oxidation in Rat Liver. Journal of Nutritional Science and Vitaminology 55:1, pages 31-43.
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André B Konan, Jacques Y Datté & Paul A Yapo. (2008) Nitric oxide pathway-mediated relaxant effect of aqueous sesame leaves extract (Sesamum radiatum Schum. & Thonn.) in the guinea-pig isolated aorta smooth muscle. BMC Complementary and Alternative Medicine 8:1.
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Kelly S. Williamson, J. Brad Morris, Quentin N. Pye, Chandrashekhar D. Kamat & Kenneth Hensley. (2008) A survey of sesamin and composition of tocopherol variability from seeds of eleven diverse sesame ( Sesamum indicum L.) genotypes using HPLC‐PAD‐ECD . Phytochemical Analysis 19:4, pages 311-322.
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Bikesh Dongol, Yatrik Shah, Insook Kim, Frank J. Gonzalez & Mary C. Hunt. (2007) The acyl-CoA thioesterase I is regulated by PPARα and HNF4α via a distal response element in the promoter. Journal of Lipid Research 48:8, pages 1781-1791.
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Soichi Arai & Akiko Shimizu-Ibuka. (2007) . Japanese Journal of Lactic Acid Bacteria 18:1, pages 2-6.
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Saiko IKEDA, Chisato ABE, Tomono UCHIDA, Tomio ICHIKAWA, Fumihiko HORIO & Kanae YAMASHITA. (2007) Dietary Sesame Seed and Its Lignan Increase Both Ascorbic Acid Concentration in Some Tissues and Urinary Excretion by Stimulating Biosynthesis in Rats. Journal of Nutritional Science and Vitaminology 53:5, pages 383-392.
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Shylesh BhaskaranNalini SantanamMeera PenumetchaSampath Parthasarathy. (2006) Inhibition of Atherosclerosis in Low-Density Lipoprotein Receptor-Negative Mice by Sesame Oil. Journal of Medicinal Food 9:4, pages 487-490.
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José L. Peñalvo, Anu Hopia & Herman Adlercreutz. (2006) Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient mice. European Journal of Nutrition 45:8.
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Shinichi Honda, Fumiki Aoki, Hozumi Tanaka, Hideyuki Kishida, Tozo Nishiyama, Shinji Okada, Ichiro Matsumoto, Keiko Abe & Tatsumasa Mae. (2006) Effects of Ingested Turmeric Oleoresin on Glucose and Lipid Metabolisms in Obese Diabetic Mice:  A DNA Microarray Study. Journal of Agricultural and Food Chemistry 54:24, pages 9055-9062.
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Eiichiro OnoMasaaki Nakai, Yuko Fukui, Namino Tomimori, Masako Fukuchi-MizutaniMasayuki SaitoHonoo SatakeTakaharu TanakaMasumi Katsuta, Toshiaki Umezawa & Yoshikazu Tanaka. (2006) Formation of two methylenedioxy bridges by a Sesamum CYP81Q protein yielding a furofuran lignan, (+)-sesamin . Proceedings of the National Academy of Sciences 103:26, pages 10116-10121.
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Kiyoto Motojima & Toshitake Hirai. (2005) Peroxisome proliferator‐activated receptor α plays a vital role in inducing a detoxification system against plant compounds with crosstalk with other xenobiotic nuclear receptors. The FEBS Journal 273:2, pages 292-300.
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Yoshinobu Kiso, Nobuo Tsuruoka, Ayako Kidokoro, Ichiro Matsumoto & Keiko Abe. (2005) Sesamin Ingestion Regulates the Transcription Levels of Hepatic Metabolizing Enzymes for Alcohol and Lipids in Rats. Alcoholism: Clinical and Experimental Research 29, pages 116S-120S.
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Hisanori Kato, Kenji Saito & Takeshi Kimura. (2005) A perspective on DNA microarray technology in food and nutritional science. Current Opinion in Clinical Nutrition & Metabolic Care 8:5, pages 516-522.
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