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Original Articles

Expression Level of ABCG2 in the Placenta Decreases from the Mid Stage to the End of Gestation

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Pages 1871-1876 | Received 19 Apr 2005, Accepted 13 Jul 2005, Published online: 22 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Lyrialle W. Han, Chunying Gao & Qingcheng Mao. (2018) An update on expression and function of P-gp/ABCB1 and BCRP/ABCG2 in the placenta and fetus. Expert Opinion on Drug Metabolism & Toxicology 14:8, pages 817-829.
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Frantisek Staud & Martina Ceckova. (2015) Regulation of drug transporter expression and function in the placenta. Expert Opinion on Drug Metabolism & Toxicology 11:4, pages 533-555.
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Frantisek Staud, Lukas Cerveny & Martina Ceckova. (2012) Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure. Journal of Drug Targeting 20:9, pages 736-763.
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Lenka Hahnova-Cygalova, Martina Ceckova & Frantisek Staud. (2011) Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancy. Drug Metabolism Reviews 43:1, pages 53-68.
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Päivi Myllynen, Maria Kummu & Elina Sieppi. (2010) ABCB1 and ABCG2 expression in the placenta and fetus: an interspecies comparison. Expert Opinion on Drug Metabolism & Toxicology 6:11, pages 1385-1398.
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Päivi Myllynen, Elina Immonen, Maria Kummu & Kirsi Vähäkangas. (2009) Developmental expression of drug metabolizing enzymes and transporter proteins in human placenta and fetal tissues. Expert Opinion on Drug Metabolism & Toxicology 5:12, pages 1483-1499.
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Javad Behravan & Micheline Piquette-Miller. (2007) Drug transport across the placenta, role of the ABC drug efflux transporters. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 819-830.
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Päivi Myllynen, Markku Pasanen & Kirsi Vähäkangas. (2007) The fate and effects of xenobiotics in human placenta. Expert Opinion on Drug Metabolism & Toxicology 3:3, pages 331-346.
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Articles from other publishers (34)

Péter Szatmári & Eszter Ducza. (2023) Changes in Expression and Function of Placental and Intestinal P-gp and BCRP Transporters during Pregnancy. International Journal of Molecular Sciences 24:17, pages 13089.
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Rafael Mineiro, Cecília Santos, Isabel Gonçalves, Manuel Lemos, José Eduardo B. Cavaco & Telma Quintela. (2023) Regulation of ABC transporters by sex steroids may explain differences in drug resistance between sexes. Journal of Physiology and Biochemistry.
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Ali Mustafa Mohammed, Heidi Sahlman & Kirsi H. Vähäkangas. 2022. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 1355 1371 .
Ludwik Gorczyca, Jianyao Du, Kristin M. Bircsak, Xia Wen, Anna M. Vetrano & Lauren M. Aleksunes. (2020) Low oxygen tension differentially regulates the expression of placental solute carriers and ABC transporters. FEBS Letters 595:6, pages 811-827.
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Danyi Lu, Huan Zhao & Baojian Wu. 2020. Circadian Pharmacokinetics. Circadian Pharmacokinetics 159 186 .
María Paula Ceballos, Juan Pablo Rigalli, Lucila Inés Ceré, Mariana Semeniuk, Viviana Alicia Catania & María Laura Ruiz. (2019) ABC Transporters: Regulation and Association with Multidrug Resistance in Hepatocellular Carcinoma and Colorectal Carcinoma. Current Medicinal Chemistry 26:7, pages 1224-1250.
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Li Liu & Xiaodong Liu. 2019. Drug Transporters in Drug Disposition, Effects and Toxicity. Drug Transporters in Drug Disposition, Effects and Toxicity 505 548 .
Lukas Cerveny, Zuzana Ptackova, Marketa Durisova & Frantisek Staud. (2018) Interactions of protease inhibitors atazanavir and ritonavir with ABCB1, ABCG2, and ABCC2 transporters: Effect on transplacental disposition in rats. Reproductive Toxicology 79, pages 57-65.
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P. Jungsuwadee & M. Vore. 2018. Comprehensive Toxicology. Comprehensive Toxicology 617 666 .
María Fernanda Filia, Timoteo Marchini, Juan Mauricio Minoia, Martín Ignacio Roma, Fernanda Teresa De Fino, Modesto Carlos Rubio, Guillermo J. Copello, Pablo A. Evelson & Roxana Noemí Peroni. (2017) Induction of ABCG2/BCRP restricts the distribution of zidovudine to the fetal brain in rats. Toxicology and Applied Pharmacology 330, pages 74-83.
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Vesa Karttunen, Ali Mustafa Mohammed & Kirsi Vähäkangas. 2017. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 1275 1300 .
Anand A. Joshi, Soniya S. Vaidya, Marie V. St-Pierre, Andrei M. Mikheev, Kelly E. Desino, Abner N. Nyandege, Kenneth L. Audus, Jashvant D. Unadkat & Phillip M. Gerk. (2016) Placental ABC Transporters: Biological Impact and Pharmaceutical Significance. Pharmaceutical Research 33:12, pages 2847-2878.
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Jeyan S. Kumar, Bih-Rong Wei, James P. Madigan, R. Mark Simpson, Matthew D. Hall & Michael M. Gottesman. (2016) Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier. Scientific Reports 6:1.
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Qingcheng Mao & Jashvant D. Unadkat. (2014) Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update. The AAPS Journal 17:1, pages 65-82.
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Márton Jani, Csilla Ambrus, Rémi Magnan, Katalin Tauberné Jakab, Erzsébet Beéry, Joseph K. Zolnerciks & Péter Krajcsi. (2014) Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics. Archives of Toxicology 88:6, pages 1205-1248.
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Sarabjit S. Gahir & Micheline Piquette-Miller. (2011) Gestational and Pregnane X Receptor-Mediated Regulation of Placental ATP-Binding Cassette Drug Transporters in Mice. Drug Metabolism and Disposition 39:3, pages 465-471.
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Kirsi H. Vähäkangas, Jenni Veid, Vesa Karttunen, Heidi Partanen, Elina Sieppi, Maria Kummu, Päivi Myllynen & Jarkko Loikkanen. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 1051 1065 .
Henriette E. Meyer zu Schwabedissen & Heyo K. Kroemer. 2011. Drug Transporters. Drug Transporters 325 371 .
Caroline Prouillac & Sylvaine Lecoeur. (2010) The Role of the Placenta in Fetal Exposure to Xenobiotics: Importance of Membrane Transporters and Human Models for Transfer Studies. Drug Metabolism and Disposition 38:10, pages 1623-1635.
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Valeria Feinshtein, Gershon Holcberg, Alaa Amash, Noam Erez, Mazal Rubin, Eyal Sheiner, Hana Polachek & Zvi Ben-Zvi. (2009) Nitrofurantoin transport by placental choriocarcinoma JAr cells: involvement of BCRP, OATP2B1 and other MDR transporters. Archives of Gynecology and Obstetrics 281:6, pages 1037-1044.
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P. Jungsuwadee & M.E. Vore. 2010. Comprehensive Toxicology. Comprehensive Toxicology 557 601 .
Satoru Yasuda, Masaki Kobayashi, Shirou Itagaki, Takeshi Hirano & Ken Iseki. (2008) Response of the ABCG2 promoter in T47D cells and BeWo cells to sex hormone treatment. Molecular Biology Reports 36:7, pages 1889-1896.
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Abhishek Gulati & Phillip M. Gerk. (2009) Role of placental ATP-binding cassette (ABC) transporters in antiretroviral therapy during pregnancy. Journal of Pharmaceutical Sciences 98:7, pages 2317-2335.
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Elvis Terci Valera, Maria Angélica Abdalla de Freitas Cortez, Rosane Gomes de Paula Queiroz, Fabio Morato de Oliveira, María Sol Brassesco, Nada Jabado, Damien Faury, Michael S. Bobola, Hélio Rubens Machado, Carlos Alberto Scrideli & Luiz Gonzaga Tone. (2008) Pediatric glioblastoma cell line shows different patterns of expression of transmembrane ABC transporters after in vitro exposure to vinblastine. Child's Nervous System 25:1, pages 39-45.
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Gergely Szakács, Kenneth Kin Wah, Orsolya Polgár, Robert W. Robey & Susan E. Bates. 2009. Drug Resistance in Cancer Cells. Drug Resistance in Cancer Cells 1 20 .
Lauren M. Aleksunes, Yue Cui & Curtis D. Klaassen. (2008) Prominent Expression of Xenobiotic Efflux Transporters in Mouse Extraembryonic Fetal Membranes Compared with Placenta. Drug Metabolism and Disposition 36:9, pages 1960-1970.
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Qingcheng Mao. (2008) BCRP/ABCG2 in the Placenta: Expression, Function and Regulation. Pharmaceutical Research 25:6, pages 1244-1255.
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Lenka Cygalova, Martina Ceckova, Petr Pavek & Frantisek Staud. (2008) Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat. Toxicology Letters 178:3, pages 176-180.
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Mary Vore & Markos Leggas. (2008) Progesterone Acts via Progesterone Receptors A and B to Regulate Breast Cancer Resistance Protein Expression: Fig. 1.. Molecular Pharmacology 73:3, pages 613-615.
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Honggang Wang, Jashvant D. Unadkat & Qingcheng Mao. (2007) Hormonal Regulation of BCRP Expression in Human Placental BeWo Cells. Pharmaceutical Research 25:2, pages 444-452.
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Fanfan Zhou, Mei Hong & Guofeng You. (2007) Regulation of human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells. American Journal of Physiology-Endocrinology and Metabolism 293:1, pages E57-E61.
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Robert W. Robey, Orsolya Polgar, John Deeken, Kin Wah To & Susan E. Bates. (2007) ABCG2: determining its relevance in clinical drug resistance. Cancer and Metastasis Reviews 26:1, pages 39-57.
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Honggang Wang, Xiaohui Wu, Kelly Hudkins, Andrei Mikheev, Huixia Zhang, Anshul Gupta, Jashvant D. Unadkat & Qingcheng Mao. (2006) Expression of the breast cancer resistance protein (Bcrp1/Abcg2) in tissues from pregnant mice: effects of pregnancy and correlations with nuclear receptors. American Journal of Physiology-Endocrinology and Metabolism 291:6, pages E1295-E1304.
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Henriette E. Meyer zu Schwabedissen, Markus Grube, Annette Dreisbach, Gabriele Jedlitschky, Konrad Meissner, Knud Linnemann, Christoph Fusch, Christoph A. Ritter, Uwe Völker & Heyo K. Kroemer. (2006) EPIDERMAL GROWTH FACTOR-MEDIATED ACTIVATION OF THE MAP KINASE CASCADE RESULTS IN ALTERED EXPRESSION AND FUNCTION OF ABCG2 (BCRP). Drug Metabolism and Disposition 34:4, pages 524-533.
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