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Original Articles

Screening for New Hydroxynitrilases from Plants

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Pages 2349-2357 | Received 29 Jun 2005, Accepted 22 Aug 2005, Published online: 22 May 2014

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M. S. Tomescu, D. Davids, M. DuPlessis, B. Darnhofer, R. Birner-Gruenberger, R. Archer, D. Schwendenwein, G. Thallinger, M. Winkler & K. Rumbold. (2020) High-throughput in-field bioprospecting for cyanogenic plants and hydroxynitrile lyases. Biocatalysis and Biotransformation 38:3, pages 234-240.
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Kimiyasu Isobe, Asuka Kitagawa, Kazuma Kanamori, Nozomi Kashiwagi, Daisuke Matsui, Takuya Yamaguchi, Ken-ichi Fuhshuku, Hisashi Semba & Yasuhisa Asano. (2018) Characterization of a novel hydroxynitrile lyase from Nandina domestica Thunb. Bioscience, Biotechnology, and Biochemistry 82:10, pages 1760-1769.
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Aida SOLÍS, Myrna SOLÍS-OBA, Herminia Inés PÉREZ, Norberto MANJARREZ & Julia CASSANI. (2011) Hydroxynitrile Lyases from Prunus Seeds in the Preparation of Cyanohydrins. Bioscience, Biotechnology, and Biochemistry 75:5, pages 985-986.
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Yasuhisa FUKUTA, Samik NANDA, Yasuo KATO, Hiroya YURIMOTO, Yasuyoshi SAKAI, Hidenobu KOMEDA & Yasuhisa ASANO. (2011) Characterization of a New (R)-Hydroxynitrile Lyase from the Japanese Apricot Prunus mume and cDNA Cloning and Secretory Expression of One of the Isozymes in Pichia pastoris . Bioscience, Biotechnology, and Biochemistry 75:2, pages 214-220.
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Articles from other publishers (59)

Yu-Cong Zheng, Hui-Lei Yu & Jian-He Xu. (2023) Recent progress in hydroxynitrile lyases: utilization in the synthetic chemistry. SCIENTIA SINICA Chimica 53:3, pages 300-311.
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Daijun Zheng, Makoto Nakabayashi & Yasuhisa Asano. (2022) Structural characterization of Linum usitatissimum hydroxynitrile lyase: A new cyanohydrin decomposition mechanism involving a cyano-zinc complex. Journal of Biological Chemistry 298:3, pages 101650.
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Pankaj Gupta & Neha Mahajan. 2021. Chemistry of Biologically Potent Natural Products and Synthetic Compounds. Chemistry of Biologically Potent Natural Products and Synthetic Compounds 93 131 .
Yu‐Cong Zheng, Liang‐Yi Ding, Qiao Jia, Zuming Lin, Ran Hong, Hui‐Lei Yu & Jian‐He Xu. (2021) A High‐Throughput Screening Method for the Directed Evolution of Hydroxynitrile Lyase towards Cyanohydrin Synthesis. ChemBioChem 22:6, pages 996-1000.
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Fumihiro Motojima, Atsushi Izumi, Aem Nuylert, Zhenyu Zhai, Mohammad Dadashipour, Sayaka Shichida, Takuya Yamaguchi, Shogo Nakano & Yasuhisa Asano. (2020) R ‐hydroxynitrile lyase from the cyanogenic millipede, Chamberlinius hualienensis —A new entry to the carrier protein family Lipocalines . The FEBS Journal 288:5, pages 1679-1695.
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R. Marlen Martínez-Casares, HerminiaI Pérez, Norberto Manjarrez, Myrna Solís-Oba, Lucia Ortega & Aida Solís. (2020) Pouteria sapota hydroxynitrile lyase catalyzed synthesis of optically active cyanohydrins from ortho-substituted benzaldehydes. Industrial Crops and Products 153, pages 112606.
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Aem Nuylert, Fumihiro Motojima, Chartchai Khanongnuch, Tipparat Hongpattarakere & Yasuhisa Asano. (2019) Stabilization of Hydroxynitrile Lyases from Two Variants of Passion Fruit, Passiflora edulis Sims and Passiflora edulis Forma flavicarpa , by C‐Terminal Truncation . ChemBioChem 21:1-2, pages 181-189.
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Nisha Jangir, Preeti & Santosh Kumar Padhi. (2020) A study on increasing enzymatic stability and activity of Baliospermum montanum hydroxynitrile lyase in biocatalysis. Process Biochemistry 88, pages 78-89.
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Zhenyu Zhai, Aem Nuylert, Kimiyasu Isobe & Yasuhisa Asano. (2019) Effects of codon optimization and glycosylation on the high-level production of hydroxynitrile lyase from Chamberlinius hualienensis in Pichia pastoris . Journal of Industrial Microbiology and Biotechnology 46:7, pages 887-898.
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Peter Lankhorst, Jozef van Rijn & Alexander Duchateau. (2018) One-Dimensional 13C NMR Is a Simple and Highly Quantitative Method for Enantiodiscrimination. Molecules 23:7, pages 1785.
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Takuya Yamaguchi, Aem Nuylert, Atsutoshi Ina, Tsutomu Tanabe & Yasuhisa Asano. (2018) Hydroxynitrile lyases from cyanogenic millipedes: molecular cloning, heterologous expression, and whole-cell biocatalysis for the production of (R)-mandelonitrile. Scientific Reports 8:1.
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Fumihiro Motojima, Aem Nuylert & Yasuhisa Asano. (2017) The crystal structure and catalytic mechanism of hydroxynitrile lyase from passion fruit, Passiflora edulis . The FEBS Journal 285:2, pages 313-324.
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Elisa Lanfranchi, Tea Pavkov-Keller, Eva-Maria Koehler, Matthias Diepold, Kerstin Steiner, Barbara Darnhofer, Jürgen Hartler, Tom Van Den Bergh, Henk-Jan Joosten, Mandana Gruber-Khadjawi, Gerhard G. Thallinger, Ruth Birner-Gruenberger, Karl Gruber, Margit Winkler & Anton Glieder. (2017) Enzyme discovery beyond homology: a unique hydroxynitrile lyase in the Bet v1 superfamily. Scientific Reports 7:1.
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Takuya Yamaguchi, Yasumasa Kuwahara & Yasuhisa Asano. (2017) A novel cytochrome P450, CYP 3201B1, is involved in ( R )‐mandelonitrile biosynthesis in a cyanogenic millipede . FEBS Open Bio 7:3, pages 335-347.
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Aem Nuylert, Yuko Ishida & Yasuhisa Asano. (2017) Effect of Glycosylation on the Biocatalytic Properties of Hydroxynitrile Lyase from the Passion Fruit, Passiflora edulis : A Comparison of Natural and Recombinant Enzymes . ChemBioChem 18:3, pages 257-265.
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Santosh Kumar Padhi. (2017) Modern Approaches to Discovering New Hydroxynitrile Lyases for Biocatalysis. ChemBioChem 18:2, pages 152-160.
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Romana Wiedner, Helmut Schwab & Kerstin Steiner. 2016. Green Biocatalysis. Green Biocatalysis 603 628 .
Yuko Ishida, Yasumasa Kuwahara, Mohammad Dadashipour, Atsutoshi Ina, Takuya Yamaguchi, Masashi Morita, Yayoi Ichiki & Yasuhisa Asano. (2016) A sacrificial millipede altruistically protects its swarm using a drone blood enzyme, mandelonitrile oxidase. Scientific Reports 6:1.
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Mohammad Asif & Tek Chand Bhalla. (2016) Hydroxynitrile Lyase of Wild Apricot (Prunus armeniaca L.): Purification, Characterization and Application in Synthesis of Enantiopure Mandelonitrile. Catalysis Letters 146:6, pages 1118-1127.
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Yasuhisa Asano & Nobuhiro Kawahara. (2016) A New S -Hydroxynitrile Lyase from Baliospermum montanum —Its Structure, Molecular Dynamics Simulation, and Improvement by Protein Engineering . Industrial Biotechnology 12:2, pages 91-97.
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Nobuhiro Kawahara & Yasuhisa Asano. (2015) Mutagenesis of an Asn156 Residue in a Surface Region of S -Selective Hydroxynitrile Lyase from Baliospermum montanum Enhances Catalytic Efficiency and Enantioselectivity . ChemBioChem 16:13, pages 1891-1895.
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Mohammad Dadashipour, Yuko Ishida, Kazunori Yamamoto & Yasuhisa Asano. (2015) Discovery and molecular and biocatalytic properties of hydroxynitrile lyase from an invasive millipede, Chamberlinius hualienensis . Proceedings of the National Academy of Sciences 112:34, pages 10605-10610.
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Manoharan Melvin Joe, Abitha Benson, Muniappan Ayyanar & Tongmin Sa. 2015. Biotechnology of Bioactive Compounds. Biotechnology of Bioactive Compounds 163 193 .
Shogo Nakano, Mohammad Dadashipour & Yasuhisa Asano. (2014) Structural and functional analysis of hydroxynitrile lyase from Baliospermum montanum with crystal structure, molecular dynamics and enzyme kinetics. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1844:12, pages 2059-2067.
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Jan von Langermann & Stefanie Wapenhensch. (2014) Hydroxynitrile Lyase‐Catalyzed Synthesis of Enantiopure Cyanohydrins in Biocatalytic Active Static Emulsions (BASE) with Suppression of the Non‐Enzymatic Side Reaction. Advanced Synthesis & Catalysis 356:14-15, pages 2989-2997.
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Takuya Yamaguchi, Kazunori Yamamoto & Yasuhisa Asano. (2014) Identification and characterization of CYP79D16 and CYP71AN24 catalyzing the first and second steps in l-phenylalanine-derived cyanogenic glycoside biosynthesis in the Japanese apricot, Prunus mume Sieb. et Zucc.. Plant Molecular Biology 86:1-2, pages 215-223.
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Deniz Yildirim, S. Seyhan Tükel & Dilek Alagöz. (2014) Crosslinked enzyme aggregates of hydroxynitrile lyase partially purified from Prunus dulcis seeds and its application for the synthesis of enantiopure cyanohydrins . Biotechnology Progress 30:4, pages 818-827.
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M.A. Kassim, S.A. Sooklal, R. Archer & K. Rumbold. (2014) Screening for hydroxynitrile lyase activity in non-commercialised plants. South African Journal of Botany 93, pages 9-13.
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Dilek Alagöz, S. Seyhan Tükel & Deniz Yildirim. (2014) Purification, immobilization and characterization of (R)-hydroxynitrile lyase from Prunus amygdalus turcomanica seeds and their applicability for synthesis of enantiopure cyanohydrins. Journal of Molecular Catalysis B: Enzymatic 101, pages 40-46.
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Muhammad Arshad Kassim & Karl Rumbold. (2013) HCN production and hydroxynitrile lyase: a natural activity in plants and a renewed biotechnological interest. Biotechnology Letters 36:2, pages 223-228.
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Ulf Hanefeld. (2013) Immobilisation of hydroxynitrile lyases. Chemical Society Reviews 42:15, pages 6308.
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Chen-Sheng Zhang, Zhi-Jun Zhang, Chun-Xiu Li, Hui-Lei Yu, Gao-Wei Zheng & Jian-He Xu. (2012) Efficient production of (R)-o-chloromandelic acid by deracemization of o-chloromandelonitrile with a new nitrilase mined from Labrenzia aggregata. Applied Microbiology and Biotechnology 95:1, pages 91-99.
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Ken-ichi Fuhshuku & Yasuhisa Asano. (2012) Organic Synthesis Catalyzed by Plant Enzyme Hydroxynitrile Lyase. Journal of Synthetic Organic Chemistry, Japan 70:2, pages 102-112.
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Guan-Jie Zhao, Zhi-Qiang Yang & Yang-Hao Guo. (2011) Cloning and expression of hydroxynitrile lyase gene from Eriobotrya japonica in Pichia pastoris. Journal of Bioscience and Bioengineering 112:4, pages 321-325.
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Mohammad Dadashipour & Yasuhisa Asano. (2011) Hydroxynitrile Lyases: Insights into Biochemistry, Discovery, and Engineering. ACS Catalysis 1:9, pages 1121-1149.
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Yasuhisa Asano, Mohammad Dadashipour, Mizue Yamazaki, Nobutaka Doi & Hidenobu Komeda. (2011) Functional expression of a plant hydroxynitrile lyase in Escherichia coli by directed evolution: creation and characterization of highly in vivo soluble mutants. Protein Engineering, Design and Selection 24:8, pages 607-616.
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