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Original Articles

Effect of Apple Polyphenol Extract on Hepatoma Proliferation and Invasion in Culture and on Tumor Growth, Metastasis, and Abnormal Lipoprotein Profiles in Hepatoma-Bearing Rats

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Pages 2743-2750 | Received 06 Jun 2007, Accepted 03 Aug 2007, Published online: 22 May 2014

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Kumar Ganesan, Muthukumaran Jayachandran & Baojun Xu. (2018) A critical review on hepatoprotective effects of bioactive food components. Critical Reviews in Food Science and Nutrition 58:7, pages 1165-1229.
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Toshiro MATSUI, Sachiko KOREMATSU, Eui-Baek BYUN, Taichi NISHIZUKA, Shunji OHSHIMA & Tomomasa KANDA. (2009) Apple Procyanidins Induced Vascular Relaxation in Isolated Rat Aorta through NO/cGMP Pathway in Combination with Hyperpolarization by Multiple K+ Channel Activations. Bioscience, Biotechnology, and Biochemistry 73:10, pages 2246-2251.
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Articles from other publishers (25)

Joo-Yeon Lee & Choon Young Kim. (2022) Preventive Effects of Thinned Apple Extracts on TNF-α-Induced Intestinal Tight Junction Dysfunction in Caco-2 Cells through Myosin Light Chain Kinase Suppression. Foods 11:12, pages 1714.
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Linda Nezbedova, Tony McGhie, Mark Christensen, Julian Heyes, Noha Ahmed Nasef & Sunali Mehta. (2021) Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds. Nutrients 13:11, pages 4025.
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Estefanny Ruiz García, Eliana Alviárez Gutierrez, Fabiana Cristina Silveira Alves de Melo, Rômulo Dias Novaes & Reggiani Vilela Gonçalves. (2018) Flavonoids Effects on Hepatocellular Carcinoma in Murine Models: A Systematic Review. Evidence-Based Complementary and Alternative Medicine 2018, pages 1-23.
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Paulina Opyd, Adam Jurgoński, Jerzy Juśkiewicz, Joanna Milala, Zenon Zduńczyk & Bogusław Król. (2017) Nutritional and Health-Related Effects of a Diet Containing Apple Seed Meal in Rats: The Case of Amygdalin. Nutrients 9:10, pages 1091.
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Mengfan Jia, Daoyuan Ren, Yan Nie & Xingbin Yang. (2017) Beneficial effects of apple peel polyphenols on vascular endothelial dysfunction and liver injury in high choline-fed mice. Food & Function 8:3, pages 1282-1292.
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Shih-Hsin Tu, Li-Ching Chen & Yuan-Soon Ho. (2017) An apple a day to prevent cancer formation: Reducing cancer risk with flavonoids. Journal of Food and Drug Analysis 25:1, pages 119-124.
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Dai Cheng, Yu Xi, Jiankang Cao, Dongdong Cao, Yuxia Ma & Weibo Jiang. (2014) Protective effect of apple (Ralls) polyphenol extract against aluminum-induced cognitive impairment and oxidative damage in rat. NeuroToxicology 45, pages 111-120.
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Guodong Zheng, Yangyang Qiu, Qing-Feng Zhang & Dongming Li. (2014) Chlorogenic acid and caffeine in combination inhibit fat accumulation by regulating hepatic lipid metabolism-related enzymes in mice. British Journal of Nutrition 112:6, pages 1034-1040.
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Giuliana Noratto, Weston Porter, David Byrne & Luis Cisneros-Zevallos. (2014) Polyphenolics from peach (Prunus persica var. Rich Lady) inhibit tumor growth and metastasis of MDA-MB-435 breast cancer cells in vivo. The Journal of Nutritional Biochemistry 25:7, pages 796-800.
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Dai ChengChunqiu ZhuCuntang WangHuiling XuJiankang CaoWeibo Jiang. (2014) Hepatoprotective effects of apple polyphenol extract on aluminum-induced liver oxidative stress in the rat. Canadian Journal of Physiology and Pharmacology 92:2, pages 109-116.
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Gianna Ferretti, Imma Turco & Tiziana Bacchetti. (2014) Apple as a Source of Dietary Phytonutrients: Bioavailability and Evidence of Protective Effects against Human Cardiovascular Disease. Food and Nutrition Sciences 05:13, pages 1234-1246.
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H.P. Vasantha Rupasinghe, Sandhya V.G. Nair & Robin A. Robinson. 2014. 229 266 .
Myung-Woo Byun. (2013) Immunomodulatory Activities of Apple Seed Extracts on Macrophage. Journal of the Korean Society of Food Science and Nutrition 42:9, pages 1513-1517.
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Nak-Yun Sung, Mi-So Yang, Du-Sup Song, Eui-Baek Byun, Jae-Kyung Kim, Jong-Heum Park, Beom-Seok Song, Ju-Woon Lee, Sang-Hyun Park, Hyun-Jin Park, Myung-Woo Byun, Eui-Hong Byun & Jae-Hun Kim. (2013) The procyanidin trimer C1 induces macrophage activation via NF-κB and MAPK pathways, leading to Th1 polarization in murine splenocytes. European Journal of Pharmacology 714:1-3, pages 218-228.
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S.K. Shukla & V. Kumar. 2013. Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease. Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease 557 567 .
Hyun-Jeong Cho, Hee-Jin Kang, Yun-Jung Kim, Dong-Ha Lee, Hyuk-Woo Kwon, Yun-Yi Kim & Hwa-Jin Park. (2012) Inhibition of platelet aggregation by chlorogenic acid via cAMP and cGMP-dependent manner. Blood Coagulation & Fibrinolysis 23:7, pages 629-635.
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Sheau C. Chai, Shirin Hooshmand, Raz L. Saadat, Mark E. Payton, Kenneth Brummel-Smith & Bahram H. Arjmandi. (2012) Daily Apple versus Dried Plum: Impact on Cardiovascular Disease Risk Factors in Postmenopausal Women. Journal of the Academy of Nutrition and Dietetics 112:8, pages 1158-1168.
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Michaela Dina Stanescu, Simona Gavrilas, Roland Ludwig, Dietmar Haltrich & Vladimir I. Lozinsky. (2012) Preparation of immobilized Trametes pubescens laccase on a cryogel-type polymeric carrier and application of the biocatalyst to apple juice phenolic compounds oxidation. European Food Research and Technology 234:4, pages 655-662.
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Eui-Baek Byun, Sachiko Korematsu, Teruaki Ishikawa, Taichi Nishizuka, Shunji Ohshima, Tomomasa Kanda & Toshiro Matsui. (2012) Apple procyanidins induce hyperpolarization of rat aorta endothelial cells via activation of K+ channels. The Journal of Nutritional Biochemistry 23:3, pages 278-286.
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Zhi-Jun Dai, Jie Gao, Zong-Fang Li, Zong-Zheng Ji, Hua-Feng Kang, Hai-Tao Guan, Yan Diao, Bao-Feng Wang & Xi-Jing Wang. (2011) In Vitro and In Vivo Antitumor Activity of Scutellaria barbate Extract on Murine Liver Cancer. Molecules 16:6, pages 4389-4400.
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Sang-Yoon Choi, Sung-Soo Kim, Yeon-Mi Lee, Bog-Hieu Lee & Chan-Kyu Han. (2010) Phenolic Compounds Content and Tyrosinase Inhibitory Effect of Unripe Apple Extracts. Journal of Applied Biological Chemistry 53:2, pages 87-90.
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Tatiana C. L. Koch, Karlis Briviba, Bernhard Watzl, Christine Fähndrich, Achim Bub, Gerhard Rechkemmer & Stephan W. Barth. (2009) Prevention of colon carcinogenesis by apple juice in vivo : Impact of juice constituents and obesity . Molecular Nutrition & Food Research 53:10, pages 1289-1302.
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Gui-Feng Wang, Li-Ping Shi, Yu-Dan Ren, Qun-Fang Liu, Hou-Fu Liu, Ru-Jun Zhang, Zhuang Li, Feng-Hua Zhu, Pei-Lan He, Wei Tang, Pei-Zhen Tao, Chuan Li, Wei-Min Zhao & Jian-Ping Zuo. (2009) Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Research 83:2, pages 186-190.
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Kazumi Yagasaki. (2008) Nutritional and Bromacological Studies of Food Factors Using In Vitro and In Vivo Disease Models. Nippon Eiyo Shokuryo Gakkaishi 62:2, pages 61-74.
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Zhi-Jun Dai, Xi-Jing Wang, Zong-Fang Li, Zong-Zheng Ji, Hong-Tao Ren, Wei Tang, Xiao-Xu Liu, Hua-Feng Kang, Hai-Tao Guan & Ling-Qin Song. (2008) Scutellaria barbate extract induces apoptosis of hepatoma H22 cells via the mitochondrial pathway involving caspase-3. World Journal of Gastroenterology 14:48, pages 7321.
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