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Bioscience, Biotechnology, and Biochemistry Volume 72, 2008 - Issue 5
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Original Articles

Protective Effects of an Extract of Young Radish (Raphanus sativus L) Cultivated with Sulfur (Sulfur-Radish Extract) and of Sulforaphane on Carbon Tetrachloride-Induced Hepatotoxicity

Seung-Hae BAEKDepartment of Biological Sciences and Immunomodulation Research Center, University of Ulsan
,
Min PARKDepartment of Biological Sciences and Immunomodulation Research Center, University of Ulsan
,
Jae-Hee SUHDepartment of Pathology, Ulsan University Hospital
&
Hye-Seon CHOIDepartment of Biological Sciences and Immunomodulation Research Center, University of Ulsan
Pages 1176-1182 | Received 23 Aug 2007, Accepted 21 Jan 2008, Published online: 22 May 2014

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Liang Yan & Yachun Yan. (2023) Therapeutic potential of sulforaphane in liver diseases: a review. Frontiers in Pharmacology 14.
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Shao-yu Chen & Maharajan Kannan. (2023) Neural crest cells and fetal alcohol spectrum disorders: Mechanisms and potential targets for prevention. Pharmacological Research 194, pages 106855.
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Wenjuan Xu, Longde Wang, Yuanyuan Niu, Lanfang Mao, Xiaojuan Du, Ping Zhang, Zhengju Li, Hongfang Li & Ning Li. (2022) A review of edible plant-derived natural compounds for the therapy of liver fibrosis. European Journal of Gastroenterology & Hepatology 35:2, pages 133-152.
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Jinli Tian, Shaohua Yu, Wei Zhao, Lu Wang, Degang Kong, Fujie Cai, Xiaohui Sun, Zhenhua Tian, Liqiao Zhu, Wenru Zhang & Honglei Zhou. (2022) Indole Compounds from Raphanus sativus Seeds. Revista Brasileira de Farmacognosia 32:4, pages 669-672.
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Lei Gao, Huan Li, Bingqian Li, Huili Shao, Xinyue Yu, Zhuang Miao, Lizhen Zhang, Liqiao Zhu & Huagang Sheng. (2022) Traditional uses, phytochemistry, transformation of ingredients and pharmacology of the dried seeds of Raphanus sativus L. (Raphani Semen), A comprehensive review. Journal of Ethnopharmacology 294, pages 115387.
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Kyung-Dong Lee & Sun-Yup Shim. (2022) Anti-Inflammatory Food in Asthma Prepared from Combination of Raphanus sativus L., Allium hookeri, Acanthopanax sessiliflorum, and Dendropanax morbiferus Extracts via Bioassay-Guided Selection. Foods 11:13, pages 1910.
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Meenakshi Gupta & Maryam Sarwat. 2022. Herbal Medicines. Herbal Medicines 609 627 .
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Camelia Ungureanu, Irina Fierascu, Radu Claudiu Fierascu, Teodora Costea, Sorin Marius Avramescu, Mirela Florina Călinescu, Raluca Somoghi & Cristian Pirvu. (2021) In Vitro and In Vivo Evaluation of Silver Nanoparticles Phytosynthesized Using Raphanus sativus L. Waste Extracts. Materials 14:8, pages 1845.
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Koji Ishida, Kosuke Kaji, Shinya Sato, Hiroyuki Ogawa, Hirotetsu Takagi, Hiroaki Takaya, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Takemi Akahane & Hitoshi Yoshiji. (2021) Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway. The Journal of Nutritional Biochemistry 89, pages 108573.
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Qingfeng He, Yunjing Luo & Ziqi Xie. (2021) Sulforaphane ameliorates cadmium induced hepatotoxicity through the up-regulation of /Nrf2/ARE pathway and the inactivation of NF-κB. Journal of Functional Foods 77, pages 104297.
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Shaohua Yu, Shiming Zhang, Chuanhou Li, Yanjun Zhu, Kit-Kay Mak, Mallikarjuna Rao Pichika & Honglei Zhou. (2020) New Alkyl (E)-5-(Methylsulfinyl) Pent-4-Enoates from Raphanus sativus Seeds. Revista Brasileira de Farmacognosia 30:5, pages 715-717.
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Milito, Brancaccio, D’Argenio & Castellano. (2019) Natural Sulfur-Containing Compounds: An Alternative Therapeutic Strategy against Liver Fibrosis. Cells 8:11, pages 1356.
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Dalia O. Saleh, Dina F. Mansour, Ingy M. Hashad & Rofanda M. Bakeer. (2019) Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway.. European Journal of Pharmacology 855, pages 40-49.
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Liang Hu, Houbao Fan, Daishe Wu, Jinbao Wan, Xianglian Wang, Rongzhen Huang, Wenfei Liu & Fangfang Shen. (2019) Assessing bioaccessibility of Se and I in dual biofortified radish seedlings using simulated in vitro digestion. Food Research International 119, pages 701-708.
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Milad Iranshahy, Mehrdad Iranshahi, Seyed Reza Abtahi & Gholamreza Karimi. (2018) The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective activity of natural products: A review. Food and Chemical Toxicology 120, pages 261-276.
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Xiaoping Luo, Haihui Zhang, Yuqing Duan & Guangying Chen. (2018) Protective effects of radish (Raphanus sativus L.) leaves extract against hydrogen peroxide-induced oxidative damage in human fetal lung fibroblast (MRC-5) cells. Biomedicine & Pharmacotherapy 103, pages 406-414.
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Dharmender Sharma & Gurinder Kaur Sangha. (2018) Antioxidative effects of aqueous extract of broccoli sprouts against Triazophos induced hepatic and renal toxicity in female Wistar rats. Journal of Applied Biomedicine 16:2, pages 100-110.
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Sicong Tian, Baolong Li, Peng Lei, Xiuli Yang, Xiaohong Zhang, Yongping Bao & Yujuan Shan. (2018) Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways. Molecular Nutrition & Food Research 62:6, pages 1700737.
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Fuqiang Yuan, Xiaopan Chen, Jie Liu, Wenke Feng, Lu Cai, Xiaoyang Wu & Shao-yu Chen. (2018) Sulforaphane restores acetyl-histone H3 binding to Bcl-2 promoter and prevents apoptosis in ethanol-exposed neural crest cells and mouse embryos. Experimental Neurology 300, pages 60-66.
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Yasemin H Balaban, Ceylan Aka & Ufuk Koca-Caliskan. (2017) Liver immunology and herbal treatment. World Journal of Hepatology 9:17, pages 757.
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Meejung Ahn, Jeongtae Kim, Hyojin Bang, Jihwan Moon, Gi Ok Kim & Taekyun Shin. (2016) Hepatoprotective effects of allyl isothiocyanate against carbon tetrachloride-induced hepatotoxicity in rat. Chemico-Biological Interactions 254, pages 102-108.
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Meejung Ahn, Jihwan Moon, Changnam Park, Hyojin Bang, Gi Ok Kim, Sun-Ju Kim, Ki-heung Kim & Taekyun Shin. (2015) Chungpihongsim radish (Raphanus sativus L. cv. Chungpihongsim) ameliorates ethanol-induced gastric injury in rats. Oriental Pharmacy and Experimental Medicine 16:1, pages 37-43.
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Kazutaka Yoshida, Yusuke Ushida, Tomoko Ishijima, Hiroyuki Suganuma, Takahiro Inakuma, Nobuhiro Yajima, Keiko Abe & Yuji Nakai. (2015) Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury. World Journal of Gastroenterology 21:35, pages 10091-10103.
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Lindsay A. Ambrecht, Jay I. Perlman, James F. McDonnell, Yougang Zhai, Liang Qiao & Ping Bu. (2015) Protection of retinal function by sulforaphane following retinal ischemic injury. Experimental Eye Research 138, pages 66-69.
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Taekyun Shin, Meejung Ahn, Gi Ok Kim & Sang Un Park. (2015) Biological activity of various radish species. Oriental Pharmacy and Experimental Medicine 15:2, pages 105-111.
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Masahiro Kikuchi. (2015) Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. World Journal of Gastroenterology 21:43, pages 12457.
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T. K. LimT. K. Lim. 2015. Edible Medicinal and Non Medicinal Plants. Edible Medicinal and Non Medicinal Plants 829 869 .
Su-Jin Jung, Byung-Ok So, Sang-Wook Shin, Sun-Ok Noh, Eun-Soo Jung & Soo-Wan Chae. (2014) Physiochemical and Quality Characteristics of Young Radish (Yulmoo) Kimchi Cultivated by Organic Farming. Journal of the Korean Society of Food Science and Nutrition 43:8, pages 1197-1206.
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Jia Li, Feihai Shen, Cuiwen Guan, Wenwen Wang, Xiaozhe Sun, Xinlu Fu, Min Huang, Jing Jin & Zhiying Huang. (2014) Activation of Nrf2 Protects against Triptolide-Induced Hepatotoxicity. PLoS ONE 9:7, pages e100685.
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Woo Jin ChoiSeong Keun KimHee Kuk ParkUy Dong SohnWonyong Kim. (2014) Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd's Purse. The Korean Journal of Physiology & Pharmacology 18:1, pages 33.
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Meejung Ahn, RyeoKyeong Koh, Gi Ok Kim & Taekyun Shin. (2013) Aqueous extract of purple Bordeaux radish, Raphanus sativus L. ameliorates ethanol-induced gastric injury in rats. Oriental Pharmacy and Experimental Medicine 13:4, pages 247-252.
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Sikander Pal Choudhary, H. Volkan Oral, Renu Bhardwaj, Jing-Quan Yu & Lam-Son Phan Tran. (2012) Interaction of Brassinosteroids and Polyamines Enhances Copper Stress Tolerance in Raphanus Sativus. Journal of Experimental Botany 63:15, pages 5659-5675.
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Carlos Enrique Guerrero-Beltr?n, Mariel Calder?n-Oliver, Jos? Pedraza-Chaverri & Yolanda Irasema Chirino. (2012) Protective effect of sulforaphane against oxidative stress: Recent advances. Experimental and Toxicologic Pathology 64:5, pages 503-508.
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Sikander Pal Choudhary, Mukesh Kanwar, Renu Bhardwaj, Jing-Quan Yu & Lam-Son Phan Tran. (2012) Chromium Stress Mitigation by Polyamine-Brassinosteroid Application Involves Phytohormonal and Physiological Strategies in Raphanus sativus L.. PLoS ONE 7:3, pages e33210.
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Leobardo Gaona-Gaona, Eduardo Molina-Jijón, Edilia Tapia, Cecilia Zazueta, Rogelio Hernández-Pando, Mariel Calderón-Oliver, Guillermo Zarco-Márquez, Enrique Pinzón & José Pedraza-Chaverri. (2011) Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats. Toxicology 286:1-3, pages 20-27.
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Sikander Pal Choudhary, Mukesh Kanwar, Renu Bhardwaj, B.D. Gupta & R.K. Gupta. (2011) Epibrassinolide ameliorates Cr (VI) stress via influencing the levels of indole-3-acetic acid, abscisic acid, polyamines and antioxidant system of radish seedlings. Chemosphere 84:5, pages 592-600.
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Sikander Pal Choudhary, Renu Bhardwaj, B. D. Gupta, Prabhu Dutt, R. K. Gupta, Mukesh Kanwar & Stefania Biondi. (2010) Enhancing effects of 24-epibrassinolide and Putrescine on the antioxidant capacity and free radical scavenging activity of Raphanus sativus seedlings under Cu ion stress. Acta Physiologiae Plantarum 33:4, pages 1319-1333.
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Shakir Ali, Ram Prasad, Mohammed Naime, Hina Zafar, Amena Mahmood, Indusmita Routray, Mehmet Yalniz, İbrahim H. Bahcecioglu & Kazim Sahin. (2010) Dried peel fraction of Citrus sinensis partially reverses pathological changes in rat model of liver cirrhosis. Mediterranean Journal of Nutrition and Metabolism 4:1, pages 57-67.
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Sikander Pal Choudhary, Renu Bhardwaj, Bishan Datt Gupta, Prabhu Dutt, Rajinder Kumar Gupta, Stefania Biondi & Mukesh Kanwar. (2010) Epibrassinolide induces changes in indole-3-acetic acid, abscisic acid and polyamine concentrations and enhances antioxidant potential of radish seedlings under copper stress. Physiologia Plantarum, pages no-no.
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Sikander P. Choudhary, Renu Bhardwaj, Bishan D. Gupta, Prabhu Dutt, Rajinder K. Gupta, Mukesh Kanwar & Pitamber Dutt. (2010) Changes induced by Cu2+ and Cr6+ metal stress in polyamines, auxins, abscisic acid titers and antioxidative enzymes activities of radish seedlings. Brazilian Journal of Plant Physiology 22:4, pages 263-270.
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Paul R. Hanlon, Melissa G. Robbins, Lori D. Hammon & David M. Barnes. (2009) Aqueous extract from the vegetative portion of Spanish black radish (Raphanus sativus L. var. niger) induces detoxification enzyme expression in HepG2 cells. Journal of Functional Foods 1:4, pages 356-365.
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