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Bioscience, Biotechnology, and Biochemistry Volume 72, 2008 - Issue 7
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Original Articles

The Biosynthetic Pathway of Curcuminoid in Turmeric (Curcuma longa) as Revealed by 13C-Labeled Precursors

Tomoko KITASomatech Center, House Foods Corporation
,
Shinsuke IMAISomatech Center, House Foods Corporation
,
Hiroshi SAWADASomatech Center, House Foods Corporation
,
Hidehiko KUMAGAIResearch Institute for Bioresources and Biotechnology, Ishikawa Prefectural University
&
Haruo SETODepartment of Applied Biology and Chemistry, Tokyo University of Agriculture
Pages 1789-1798 | Received 01 Feb 2008, Accepted 03 Apr 2008, Published online: 22 May 2014

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Muhammad Imran, Farhan Saeed, Suliman A. Alsagaby, Ali Imran, Ishtiaque Ahmad, Ahmad H. El Ghorab, Mohamed A. Abdelgawad, Tahira Batool Qaisrani, Tahir Mehmood, Maryam Umar, Muhammad Arslan Mumtaz, Arfaa Sajid, Qaisar Manzoor, Muzzamal Hussain, Waleed Al Abdulmonem & Entessar Al Jbawi. (2023) Curcumin: recent updates on gastrointestinal cancers. CyTA - Journal of Food 21:1, pages 502-513.
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Wen Sun, Sheng Wang, Wenwen Zhao, Chuanhong Wu, Shuhui Guo, Hongwei Gao, Hongxun Tao, Jinjian Lu, Yitao Wang & Xiuping Chen. (2017) Chemical constituents and biological research on plants in the genus Curcuma. Critical Reviews in Food Science and Nutrition 57:7, pages 1451-1523.
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Ke Wu, Xiaoxia Zhang, Shulan Sun & Xiaojing Wang. (2015) Factors Affecting the Accumulation of Curcumin in Microrhizomes of Curcuma aromatica Salisb . BioMed Research International 2015, pages 1-10.
Crossref
W. Elaine Hardman. (2014) Diet components can suppress inflammation and reduce cancer risk. Nutrition Research and Practice 8:3, pages 233.
Crossref
Rakesh Sharma & Dipti Jani. (2013) Interaction of Cationic CTAB Surfactant with Curcumin, an Anticarcinogenic Drug: Spectroscopic Investigation. Tenside Surfactants Detergents 50:4, pages 283-288.
Crossref
K.P. Prabhakaran Nair. 2013. The Agronomy and Economy of Turmeric and Ginger. The Agronomy and Economy of Turmeric and Ginger 47 59 .
Itay Presiado, Yuval Erez, Rinat Gepshtein, Naum Koifman & Dan Huppert. (2012) Pressure effect on the excited-state proton transfer from curcumin to monols. Journal of Photochemistry and Photobiology A: Chemistry 247, pages 42-51.
Crossref
Laura Pistelli, Alessandra Bertoli, Federica Gelli, Laura Bedini, Barbara Ruffoni & Luisa Pistelli. (2012) Production of Curcuminoids in Different in vitro Organs of Curcuma longa . Natural Product Communications 7:8, pages 1934578X1200700.
Crossref
Tuba Esatbeyoglu, Patricia Huebbe, Insa M. A. Ernst, Dawn Chin, Anika E. Wagner & Gerald Rimbach. (2012) Curcumin-From Molecule to Biological Function. Angewandte Chemie International Edition 51:22, pages 5308-5332.
Crossref
Tuba Esatbeyoglu, Patricia Huebbe, Insa M. A. Ernst, Dawn Chin, Anika E. Wagner & Gerald Rimbach. (2012) Curcumin – vom Molekül zur biologischen Wirkung. Angewandte Chemie 124:22, pages 5402-5427.
Crossref
Yuval Erez, Itay Presiado, Rinat Gepshtein & Dan Huppert. (2012) The Effect of a Mild Base on Curcumin in Methanol and Ethanol. The Journal of Physical Chemistry A 116:9, pages 2039-2048.
Crossref
Yuval Erez, Itay Presiado, Rinat Gepshtein & Dan Huppert. (2011) Temperature Dependence of the Fluorescence Properties of Curcumin. The Journal of Physical Chemistry A 115:40, pages 10962-10971.
Crossref
Glen R.B. Irving, Ankur Karmokar, David P. Berry, Karen Brown & William P. Steward. (2011) Curcumin: The potential for efficacy in gastrointestinal diseases. Best Practice & Research Clinical Gastroenterology 25:4-5, pages 519-534.
Crossref
Rakesh Sharma & Jose Katz. 2010. Bioactive Foods and Extracts. Bioactive Foods and Extracts 143 180 .
Thomas Vogt. (2010) Phenylpropanoid Biosynthesis. Molecular Plant 3:1, pages 2-20.
Crossref
Yohei Katsuyama, Tomoko Kita & Sueharu Horinouchi. (2009) Identification and characterization of multiple curcumin synthases from the herb Curcuma longa . FEBS Letters 583:17, pages 2799-2803.
Crossref
Tanya Renner, Jennifer Bragg, Heather E. Driscoll, Juliana Cho, Andrew O. Jackson & Chelsea D. Specht. (2009) Virus-Induced Gene Silencing in the Culinary Ginger (Zingiber officinale): An Effective Mechanism for Down-Regulating Gene Expression in Tropical Monocots. Molecular Plant 2:5, pages 1084-1094.
Crossref
Timothy L Dawson. (2009) Biosynthesis and synthesis of natural colours. Coloration Technology 125:2, pages 61-73.
Crossref
Yohei Katsuyama, Tomoko Kita, Nobutaka Funa & Sueharu Horinouchi. (2009) Curcuminoid Biosynthesis by Two Type III Polyketide Synthases in the Herb Curcuma longa. Journal of Biological Chemistry 284:17, pages 11160-11170.
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