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Original Articles

Validation of an Ion Trap Tandem Mass Spectrometric Analysis of Mulberry 1-Deoxynojirimycin in Human Plasma: Application to Pharmacokinetic Studies

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Pages 2210-2213 | Received 01 Apr 2008, Accepted 08 May 2008, Published online: 22 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Isabella Supardi Parida, Soo Takasu & Kiyotaka Nakagawa. (2023) A comprehensive review on the production, pharmacokinetics and health benefits of mulberry leaf iminosugars: Main focus on 1-deoxynojirimycin, d-fagomine, and 2-O-ɑ-d-galactopyranosyl-DNJ. Critical Reviews in Food Science and Nutrition 63:19, pages 3468-3496.
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Kun-Qiang Hong, Xiao-Meng Fu, Hao Yin, Shu-Ting Li, Tao Chen & Zhi-Wen Wang. (2021) Advances in the Extraction, Purification and Detection of the Natural Product 1-Deoxynojirimycin. Critical Reviews in Analytical Chemistry 51:3, pages 246-257.
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Articles from other publishers (30)

Masaki Takahashi, Yui Mineshita, Jumpei Yamagami, Chunyi Wang, Kyoko Fujihira, Yu Tahara, Hyeon-Ki Kim, Takashi Nakaoka & Shigenobu Shibata. (2023) Effects of the timing of acute mulberry leaf extract intake on postprandial glucose metabolism in healthy adults: a randomised, placebo-controlled, double-blind study. European Journal of Clinical Nutrition 77:4, pages 468-473.
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Soo Takasu, Isabella Supardi Parida, Yoshihiro Kojima, Toshiyuki Kimura & Kiyotaka Nakagawa. (2021) Evaluation and development of a novel pre-treatment method for mulberry leaves to enhance their bioactivity via enzymatic degradation of GAL-DNJ to DNJ . Food & Function 12:24, pages 12250-12255.
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Yue-sheng Dong, Na Yu, Xia Li, Bowei Zhang, Yan Xing, Chunlin Zhuang & Zhi-long Xiu. (2020) Dietary 5,6,7-Trihydroxy-flavonoid Aglycones and 1-Deoxynojirimycin Synergistically Inhibit the Recombinant Maltase–Glucoamylase Subunit of α-Glucosidase and Lower Postprandial Blood Glucose. Journal of Agricultural and Food Chemistry 68:33, pages 8774-8787.
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Isabella Supardi Parida, Soo Takasu, Junya Ito, Ryoichi Ikeda, Kenji Yamagishi, Toshiyuki Kimura, Takahiro Eitsuka & Kiyotaka Nakagawa. (2020) Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder containing 1-deoxynojirimycin in a high-fat diet altered the gene expressions related to lipid metabolism and insulin signaling in mice epididymal white adipose tissue . Food & Function 11:5, pages 3926-3940.
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Amira R. Amin, Rami B. Kassab, Ahmed E. Abdel Moneim & Hatem K. Amin. (2020) Comparison Among Garlic, Berberine, Resveratrol, Hibiscus sabdariffa , Genus Zizyphus , Hesperidin, Red Beetroot, Catha edulis , Portulaca oleracea , and Mulberry Leaves in the Treatment of Hypertension and Type 2 DM: A Comprehensive Review . Natural Product Communications 15:4, pages 1934578X2092162.
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Yanfen Li, Ziqiang Li, Ruihua Wang, Bo Mi, Ting Jiang, Meijuan Lu, Jia Liu, Baohe Wang, Deqin Zhang, Qiang Xu & Yuhong Huang. (2020) Alleviating the Hydrolysis of Carbohydrates, Tangzhiqing (TZQ) Decreased the Postprandial Glycemia in Healthy Volunteers: An Eight-Period Crossover Study. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-12.
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Kiran Thakur, Yuan-Yuan Zhang, Andrei Mocan, Fang Zhang, Jian-Guo Zhang & Zhao-Jun Wei. (2019) 1-Deoxynojirimycin, its potential for management of non-communicable metabolic diseases. Trends in Food Science & Technology 89, pages 88-99.
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Isabella Supardi PARIDA, Soo TAKASU, Junya ITO, Ryoichi IKEDAKenji YAMAGISHIToshiyuki KIMURATeruo MIYAZAWA, Takahiro EITSUKA & Kiyotaka NAKAGAWA. (2019) Physiological Effects and Organ Distribution of <i>Bacillus amyloliquefaciens</i> AS385 Culture Broth Powder Containing 1-Deoxynojirimycin in C57BL/6J Mice. Journal of Nutritional Science and Vitaminology 65:2, pages 157-163.
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Hao Wu, Wei Zeng, Lei Chen, Bo Yu, Ye Guo, Guiguang Chen & Zhiqun Liang. (2018) Integrated multi-spectroscopic and molecular docking techniques to probe the interaction mechanism between maltase and 1-deoxynojirimycin, an α-glucosidase inhibitor. International Journal of Biological Macromolecules 114, pages 1194-1202.
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Soo Takasu, Isabella Supardi Parida, Shinji Onose, Junya Ito, Ryoichi Ikeda, Kenji Yamagishi, Oki Higuchi, Fukuyo Tanaka, Toshiyuki Kimura, Teruo Miyazawa & Kiyotaka Nakagawa. (2018) Evaluation of the anti-hyperglycemic effect and safety of microorganism 1-deoxynojirimycin. PLOS ONE 13:6, pages e0199057.
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Weili Han, Xiangxiang Chen, Huimin Yu, Lingyun Chen & Mei Shen. (2018) Seasonal variations of iminosugars in mulberry leaves detected by hydrophilic interaction chromatography coupled with tandem mass spectrometry. Food Chemistry 251, pages 110-114.
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Chun-Fang, Bo-Bo Zhang, Lin-Han, Cai-Feng Gao & Min-Wang. (2018) d -Fagomine Attenuates High Glucose-Induced Endothelial Cell Oxidative Damage by Upregulating the Expression of PGC-1α . Journal of Agricultural and Food Chemistry 66:11, pages 2758-2764.
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Susana Amézqueta, Sara Ramos-Romero, Carolina Martínez-Guimet, Albert Moreno, Mercè Hereu & Josep Lluís Torres. (2017) Fate of d -Fagomine after Oral Administration to Rats . Journal of Agricultural and Food Chemistry 65:22, pages 4414-4420.
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Susana Amézqueta & Josep Lluís Torres. (2016) Advances in the analysis of iminocyclitols: Methods, sources and bioavailability. Talanta 151, pages 157-171.
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Gui-Hai Chen, Jing-Jing Tong, Fang Wang, Xue-Qin Hu, Xue-Wei Li, Fei Tao & Zhao-Jun Wei. (2015) Chronic adjunction of 1-deoxynojirimycin protects from age-related behavioral and biochemical changes in the SAMP8 mice. AGE 37:5.
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Shuang Yang, Baolian Wang, Xuejun Xia, Xue Li, Renyun Wang, Li Sheng, Dan Li, Yuling Liu & Yan Li. (2015) Simultaneous quantification of three active alkaloids from a traditional Chinese medicine Ramulus Mori (Sangzhi) in rat plasma using liquid chromatography?tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 109, pages 177-183.
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Masatoshi Hori, Shigeto Komatsubara, Kiyotaka Nakagawa, Oki Higuchi, Shinji Onose & Teruo Miyazawa. (2014) Comparisons of accumulation and excretion of iminosugars among mulberry-feeding specialist Bombyx larvae and non-specialist larvae. Applied Entomology and Zoology 49:4, pages 571-578.
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Shuang E.Ryo Kijima, Taro Honma, Kazushi Yamamoto, Yu Hatakeyama, Yasuna Kitano, Toshiyuki Kimura, Kiyotaka Nakagawa, Teruo Miyazawa & Tsuyoshi Tsuduki. (2014) 1-Deoxynojirimycin attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells. Experimental Gerontology 55, pages 63-69.
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Bing-Xin Xiao, Qian Wang, Li-Qing Fan, Ling-Ti Kong, Shu-Ren Guo & Qi Chang. (2014) Pharmacokinetic mechanism of enhancement by Radix Pueraria flavonoids on the hyperglycemic effects of Cortex Mori extract in rats. Journal of Ethnopharmacology 151:2, pages 846-851.
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Tsuyoshi Tsuduki, Ikuko Kikuchi, Toshiyuki Kimura, Kiyotaka Nakagawa & Teruo Miyazawa. (2013) Intake of mulberry 1-deoxynojirimycin prevents diet-induced obesity through increases in adiponectin in mice. Food Chemistry 139:1-4, pages 16-23.
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Shinji Onose, Ryoichi Ikeda, Kiyotaka Nakagawa, Toshiyuki Kimura, Kenji Yamagishi, Ohki Higuchi & Teruo Miyazawa. (2013) Production of the ?-glycosidase inhibitor 1-deoxynojirimycin from Bacillus species. Food Chemistry 138:1, pages 516-523.
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Stephen G. DaviesAude L. A. FigucciaAi M. FletcherPaul M. RobertsJames E. Thomson. (2013) Asymmetric Syntheses of (−)-1-Deoxymannojirimycin and (+)-1-Deoxyallonojirimycin via a Ring-Expansion Approach. Organic Letters 15:8, pages 2042-2045.
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Ning Zhang, Yafeng Li, Yueming Zhou, Jian Hou, Qing He, Xiang-Guo Hu, Yue-Mei Jia, Chu-Yi Yu & Zongxiu Nie. (2013) Rapid detection of polyhydroxylated alkaloids in mulberry using leaf spray mass spectrometry. Analytical Methods 5:10, pages 2455.
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Chaluntorn Vichasilp, Kiyotaka Nakagawa, Phumon Sookwong, Ohki Higuchi, Fumiko Kimura & Teruo Miyazawa. (2012) A novel gelatin crosslinking method retards release of mulberry 1-deoxynojirimycin providing a prolonged hypoglycaemic effect. Food Chemistry 134:4, pages 1823-1830.
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Chaluntorn Vichasilp, Kiyotaka Nakagawa, Phumon Sookwong, Ohki Higuchi, Somchai Luemunkong & Teruo Miyazawa. (2012) Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction. LWT - Food Science and Technology 45:2, pages 226-232.
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Kazuhisa Yatsunami, Kohji Murata & Tsutomu Kamei. (2011) 1-Deoxynojirimycin Content and Alfa-Glucosidase Inhibitory Activity and Heat Stability of 1-Deoxynojirimycin in Silkworm Powder. Food and Nutrition Sciences 02:02, pages 87-89.
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Sharan K. BagalStephen G. DaviesJames A. LeePaul M. RobertsPhilip M. ScottJames E. Thomson. (2010) Syntheses of the Enantiomers of 1-Deoxynojirimycin and 1-Deoxyaltronojirimycin via Chemo- and Diastereoselective Olefinic Oxidation of Unsaturated Amines. The Journal of Organic Chemistry 75:23, pages 8133-8146.
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Kiyotaka Nakagawa, Kenta Ogawa, Ohki Higuchi, Toshiyuki Kimura, Teruo Miyazawa & Masatoshi Hori. (2010) Determination of iminosugars in mulberry leaves and silkworms using hydrophilic interaction chromatography?tandem mass spectrometry. Analytical Biochemistry 404:2, pages 217-222.
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Toshiyuki Kimura. (2010) Development of Mulberry Leaf Product with .ALPHA.-Glucosidase Inhibitor for the Prevention of Type 2 Diabetes Mellitus. Nippon Shokuhin Kagaku Kogaku Kaishi 57:2, pages 57-62.
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. (2009) Current literature in mass spectrometry. Journal of Mass Spectrometry 44:2, pages 288-299.
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