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Bioscience, Biotechnology, and Biochemistry Volume 73, 2009 - Issue 10
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Original Articles

Apple Procyanidins Induced Vascular Relaxation in Isolated Rat Aorta through NO/cGMP Pathway in Combination with Hyperpolarization by Multiple K+ Channel Activations

Toshiro MATSUIDivision of Bioresources and Biosciences, Faculty of Agriculture, Graduate School of Kyushu University
,
Sachiko KOREMATSUDivision of Bioresources and Biosciences, Faculty of Agriculture, Graduate School of Kyushu University
,
Eui-Baek BYUNDivision of Bioresources and Biosciences, Faculty of Agriculture, Graduate School of Kyushu University
,
Taichi NISHIZUKAFundamental Research Laboratory, Asahi Breweries Limited
,
Shunji OHSHIMAFundamental Research Laboratory, Asahi Breweries Limited
&
Tomomasa KANDAFundamental Research Laboratory, Asahi Breweries Limited
Pages 2246-2251 | Received 11 May 2009, Accepted 28 Jun 2009, Published online: 22 May 2014

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Ingrid Beatriz de Melo Morais, Denise Brentan Silva, Carlos Alexandre Carollo, Marcos Luiz Ferreira-Neto, Patrícia Fidelis-de-Oliveira & Luiz Borges Bispo-da-Silva. (2021) Hypotensive activity of Campomanesia xanthocarpa leaf extract: beyond angiotensin II type 1 receptor blockage. Natural Product Research 35:22, pages 4798-4802.
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Aleksandra S. Kristo, Anastasia Z. Kalea, Dale A. Schuschke & Dorothy Klimis-Zacas. (2013) Attenuation of alpha-adrenergic-induced vasoconstriction by dietary wild blueberries (Vaccinium angustifolium) is mediated by the NO-cGMP pathway in spontaneously hypertensive rats (SHRs). International Journal of Food Sciences and Nutrition 64:8, pages 979-987.
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Younghwa KIM, Youngmin CHOI, Junsoo LEE & Yooheon PARK. (2013) Downregulated Lipid Metabolism in Differentiated Murine Adipocytes by Procyanidins from Defatted Grape Seed Meal. Bioscience, Biotechnology, and Biochemistry 77:7, pages 1420-1423.
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Ryo FURUUCHI, Hiroki SAKAI, Naomi HIROKAWA, Yusuke WATANABE, Tadayuki YOKOYAMA & Masao HIRAYAMA. (2012) Antihypertensive Effect of Boysenberry Seed Polyphenols on Spontaneously Hypertensive Rats and Identification of Orally Absorbable Proanthocyanidins with Vasorelaxant Activity. Bioscience, Biotechnology, and Biochemistry 76:9, pages 1694-1701.
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Kayoko KAWAKAMI, Saiko AKETA, Hiroki SAKAI, Yusuke WATANABE, Hiroshi NISHIDA & Masao HIRAYAMA. (2011) Antihypertensive and Vasorelaxant Effects of Water-Soluble Proanthocyanidins from Persimmon Leaf Tea in Spontaneously Hypertensive Rats. Bioscience, Biotechnology, and Biochemistry 75:8, pages 1435-1439.
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Marcela Knox, Raúl Vinet, Lida Fuentes, Bernardo Morales & José L. Martínez. (2019) A Review of Endothelium-Dependent and -Independent Vasodilation Induced by Phytochemicals in Isolated Rat Aorta. Animals 9:9, pages 623.
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Herbert Kolodziej. 2017. Recent Advances in Polyphenol Research. Recent Advances in Polyphenol Research 226 258 .
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Toshiro Matsui. (2015) Condensed catechins and their potential health-benefits. European Journal of Pharmacology 765, pages 495-502.
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Eui-Baek ByunNak-Yun SungMi-So YangDu-Sup SongEui-Hong ByunJae-Kyung KimJong-Heum ParkBeom-Seok SongJu-Woon LeeSang-Hyun ParkMyung-Woo ByunJae-Hun Kim. (2014) Procyanidin C1 Causes Vasorelaxation Through Activation of the Endothelial NO/cGMP Pathway in Thoracic Aortic Rings. Journal of Medicinal Food 17:7, pages 742-748.
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Francisco Luna-Vázquez, César Ibarra-Alvarado, Alejandra Rojas-Molina, Isela Rojas-Molina & Miguel Zavala-Sánchez. (2013) Vasodilator Compounds Derived from Plants and Their Mechanisms of Action. Molecules 18:5, pages 5814-5857.
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Annalisa Aggio, Davide Grassi, Eugenia Onori, Antonio D’Alessandro, Francesco Masedu, Marco Valenti & Claudio Ferri. (2012) Endothelium/nitric oxide mechanism mediates vasorelaxation and counteracts vasoconstriction induced by low concentration of flavanols. European Journal of Nutrition 52:1, pages 263-272.
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Naomi Osakabe. (2013) Flavan 3-ols improve metabolic syndrome risk factors: evidence and mechanisms. Journal of Clinical Biochemistry and Nutrition 52:3, pages 186-192.
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Yasushi Matsuura, Mao Kaneko, Hideaki Hirabaru, Fumie Hidaka, Hiroshi Sakaida, Takanori Kai, Chizuko Yukizaki & Masanobu Sakono. (2013) Antihypertensive Effect of Blueberry Leaves on Spontaneously Hypertensive Rats. Nippon Shokuhin Kagaku Kogaku Kaishi 60:12, pages 689-694.
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Louise A. Horrigan, Catherine A. Holohan, Gráinne A. Lawless, Melissa A. Murtagh, Carmel T. Williams & Christina M. Webster. (2013) Blueberry juice causes potent relaxation of rat aortic rings via the activation of potassium channels and the H 2 S pathway . Food Funct. 4:3, pages 392-400.
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Myung-Woo Byun. (2012) Effect of Procyanidin C1 on Nitric Oxide Production and Hyperpolarization Through Ca 2+ -Dependent Pathway in Endothelial Cells . Journal of Medicinal Food 15:11, pages 1032-1037.
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Shohei Nakashima, Chihiro Oda, Susumu Masuda, Motoyuki Tagashira & Tomomasa Kanda. (2012) Isolation and structure elucidation of tetrameric procyanidins from unripe apples (Malus pumila cv. Fuji) by NMR spectroscopy. Phytochemistry 83, pages 144-152.
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Eui-Baek Byun, Teruaki Ishikawa, Aki Suyama, Masaya Kono, Shohei Nakashima, Tomomasa Kanda, Takahisa Miyamoto & Toshiro Matsui. (2012) A procyanidin trimer, C1, promotes NO production in rat aortic endothelial cells via both hyperpolarization and PI3K/Akt pathways. European Journal of Pharmacology 692:1-3, pages 52-60.
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Eui-Baek Byun, Sachiko Korematsu, Teruaki Ishikawa, Taichi Nishizuka, Shunji Ohshima, Tomomasa Kanda & Toshiro Matsui. (2012) Apple procyanidins induce hyperpolarization of rat aorta endothelial cells via activation of K+ channels. The Journal of Nutritional Biochemistry 23:3, pages 278-286.
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T. K. LimT. K. Lim. 2012. Edible Medicinal And Non-Medicinal Plants. Edible Medicinal And Non-Medicinal Plants 413 436 .
Eberhard P. Scholz, Edgar Zitron, Hugo A. Katus & Christoph A. Karle. (2010) Cardiovascular Ion Channels as a Molecular Target of Flavonoids. Cardiovascular Therapeutics 28:4.
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Valérie B. Schini-Kerth, Cyril Auger, Jong-Hun Kim, Nelly Étienne-Selloum & Thierry Chataigneau. (2010) Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF. Pflügers Archiv - European Journal of Physiology 459:6, pages 853-862.
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Valérie B. Schini-Kerth, Cyril Auger, Nelly Étienne-Selloum & Thierry Chataigneau. 2010. Cardiovascular Pharmacology - Endothelial Control. Cardiovascular Pharmacology - Endothelial Control 133 175 .

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