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Bioscience, Biotechnology, and Biochemistry Volume 74, 2010 - Issue 3
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Original Articles

Fangchinoline Induced G1/S Arrest by Modulating Expression of p27, PCNA, and Cyclin D in Human Prostate Carcinoma Cancer PC3 Cells and Tumor Xenograft

Chang-Dong WANGChina-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory, The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
,
Jian-Guo HUANGChina-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory, The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
,
Xuan GAOChina-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory, The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
,
Yi LIChina-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory, The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
,
Shi-Yi ZHOUChina-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory, The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
,
Xu YANChina-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory, The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
,
An ZOUChina-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory, The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
,
Jun-Li CHANGChina-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory, The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
,
Yue-Sheng WANGChina-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory, The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
,
Guang-Xiao YANGChina-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory, The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
&
Guang-Yuan HEChina-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory, The Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
 show all
Pages 488-493 | Received 09 Jul 2009, Accepted 25 Dec 2009, Published online: 22 May 2014

Citations (28)

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Li-Jun Yang, Zhong-Duo Yang, Zhi-Jie Li, Shu-Hong Yang & Zong-Mei Shu. (2023) Stephtetrandrine A-D, bisbenzylisoquinoline alkaloids from Stephania tetrandra. Natural Product Research 37:2, pages 204-215.
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Bingyu Guo, Jingyuan Su, Tingting Zhang, Kaiwen Wang & Xiaoming Li. (2015) Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549. Journal of Drug Targeting 23:3, pages 266-274.
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Articles from other publishers (26)

Abeer S. Aloufi, Ola A. Habotta, Mohamed S. Abdelfattah, Marina N. Habib, Mohamed M. Omran, Sally A. Ali, Ahmed E. Abdel Moneim, Shereen M. Korany & Aisha M. Alrajhi. (2023) Resistomycin Suppresses Prostate Cancer Cell Growth by Instigating Oxidative Stress, Mitochondrial Apoptosis, and Cell Cycle Arrest. Molecules 28:23, pages 7871.
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Feiyu Chen, Zhangfeng Zhong, Cheng Zhang, Yuanjun Lu, Yau-Tuen Chan, Ning Wang, Di Zhao & Yibin Feng. (2022) Potential Focal Adhesion Kinase Inhibitors in Management of Cancer: Therapeutic Opportunities from Herbal Medicine. International Journal of Molecular Sciences 23:21, pages 13334.
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Taraswi Mitra Ghosh, Teeratas Kansom, Suman Mazumder, Joshua Davis, Ahmed S. Alnaim, Shanese L. Jasper, Chu Zhang, Aedan Bird, Praneet Opanasopit, Amit K. Mitra & Robert D. Arnold. (2022) The Andrographolide Analogue 3A.1 Synergizes with Taxane Derivatives in Aggressive Metastatic Prostate Cancers by Upregulation of Heat Shock Proteins and Downregulation of MAT2A-Mediated Cell Migration and Invasion. Journal of Pharmacology and Experimental Therapeutics 380:3, pages 180-201.
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Daniel Winardi, Pei-Yi Chu, Guan-Yu Chen, Ke Wang, Wei-Yu Hsu, Ching-Liang Hsieh, Yung-Hsiang Chen, Yang-Chang Wu & Juan-Cheng Yang. (2022) Novel Aurora A Kinase Inhibitor Fangchinoline Enhances Cisplatin–DNA Adducts and Cisplatin Therapeutic Efficacy in OVCAR-3 Ovarian Cancer Cells-Derived Xenograft Model. International Journal of Molecular Sciences 23:3, pages 1868.
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Eric Wei Chiang Chan, Siu Kuin Wong & Hung Tuck Chan. (2021) An overview on the chemistry, pharmacology and anticancer properties of tetrandrine and fangchinoline (alkaloids) from Stephania tetrandra roots. Journal of Integrative Medicine 19:4, pages 311-316.
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Yunjing Zhang, Shiwen Wang, Yukun Chen, Junqian Zhang, Jing Yang, Jingrong Xian, Lihui Li, Hu Zhao, Robert M. Hoffman, Yanmei Zhang & Lijun Jia. (2021) Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis. Frontiers in Oncology 11.
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Young Yun Jung, Muthu K. Shanmugam, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H.M. Shair, Jae-Young Um, Gautam Sethi & Kwang Seok Ahn. (2019) Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways. Molecules 24:17, pages 3127.
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Myriam Mérarchi, Gautam Sethi, Lu Fan, Srishti Mishra, Frank Arfuso & Kwang Ahn. (2018) Molecular Targets Modulated by Fangchinoline in Tumor Cells and Preclinical Models. Molecules 23:10, pages 2538.
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Ming He, Linlin Jiang, Bin Li, Guangbin Wang, Jiashi Wang & Yonghui Fu. (2017) Oxymatrine suppresses the growth and invasion of MG63 cells by up-regulating PTEN and promoting its nuclear translocation. Oncotarget 8:39, pages 65100-65110.
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Zhengrong Chen, Tengfei He, Kui Zhao & Chungen Xing. (2017) Anti-metastatic activity of fangchinoline in human gastric cancer AGS cells. Oncology Letters 13:2, pages 655-660.
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Jie Shi, Bingyu Guo, Qiang Hui, Peng Chang & Kai Tao. (2017) Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK. Oncology Reports 38:1, pages 63-70.
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Ming He, Linlin Jiang, Zhaozhou Ren, Guangbin Wang & Jiashi Wang. (2016) Noscapine targets EGFRp-Tyr1068 to suppress the proliferation and invasion of MG63 cells. Scientific Reports 6:1.
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Ting Liu, Xin Liu & Wenhua Li. (2016) Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy. Oncotarget 7:26, pages 40800-40815.
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XUE LUO, JIAN-MING PENG, LAN-DI SU, DONG-YAN WANG & YOU-JIANG YU. (2016) Fangchinoline inhibits the proliferation of SPC-A-1 lung cancer cells by blocking cell cycle progression. Experimental and Therapeutic Medicine 11:2, pages 613-618.
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Bingyu Guo, Peng Xie, Jingyuan Su, Tingting Zhang, Xiaoming Li & Guobiao Liang. (2015) Fangchinoline suppresses the growth and invasion of human glioblastoma cells by inhibiting the kinase activity of Akt and Akt-mediated signaling cascades. Tumor Biology 37:2, pages 2709-2719.
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Shou-song Ren, Fang Yuan, Ying-hong Liu, Le-tian Zhou & Jun Li. (2014) Effect of p27 gene combined with Pientzehuang (片仔癀) on tumor growth in osteosarcoma-bearing nude mice. Chinese Journal of Integrative Medicine 21:11, pages 830-836.
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Dong Li, Yu Lu, Peng Sun, Li-Xing Feng, Miao Liu, Li-Hong Hu, Wan-Ying Wu, Bao-Hong Jiang, Min Yang, Xiao-Bo Qu, De-An Guo & Xuan Liu. (2015) Inhibition on Proteasome β1 Subunit Might Contribute to the Anti-Cancer Effects of Fangchinoline in Human Prostate Cancer Cells. PLOS ONE 10:10, pages e0141681.
Crossref
Zhibo Xing, Youxue Zhang, Xianyu Zhang, Yanmei Yang, Yuyan Ma & Da Pang. (2013) Fangchinoline Induces G1 Arrest in Breast Cancer Cells Through Cell‐Cycle Regulation. Phytotherapy Research 27:12, pages 1790-1794.
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Jun-Chuan Li, Hong-Yu Zhu, Ting-Xuan Chen, Lan-Ying Zou, Xiao-Yan Wang, Hui-Chuan Zhao & Jun Xu. (2013) Roles of mTOR and p-mTOR in Gastrointestinal Stromal Tumors. Asian Pacific Journal of Cancer Prevention 14:10, pages 5925-5928.
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Cheng-Yoong Pang, Sheng-Chun Chiu, Horng-Jyh Harn, Wei-Jun Zhai, Shinn-Zong Lin & Hsueh-Hui Yang. (2013) Proteomic-based identification of multiple pathways underlying n-butylidenephthalide-induced apoptosis in LNCaP human prostate cancer cells. Food and Chemical Toxicology 59, pages 281-288.
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YUPING WANG, JIE CHEN, LIN WANG, YUJI HUANG, YE LENG & GUIYING WANG. (2013) Fangchinoline induces G0/G1 arrest by modulating the expression of CDKN1A and CCND2 in K562 human chronic myelogenous leukemia cells. Experimental and Therapeutic Medicine 5:4, pages 1105-1112.
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Shuhao Yu, Lulu Zheng, Yixue Li, Chunyan Li, Chenchen Ma, Yang Yu, Xuan Li & Pei Hao. (2013) Causal co-expression method with module analysis to screen drugs with specific target. Gene 518:1, pages 145-151.
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Marion Lavergne, Marie-Lise Jourdan, Claire Blechet, Serge Guyetant, Alain Le Pape, Nathalie Heuze-Vourc’h, Yves Courty, Stephanie Lerondel, Julien Sobilo, Sophie Iochmann & Pascale Reverdiau. (2013) Beneficial role of overexpression of TFPI-2 on tumour progression in human small cell lung cancer. FEBS Open Bio 3:1, pages 291-301.
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Dan He, Xiang Luo, Wenjie Wei, Minjie Xie, Wei Wang & Zhiyuan Yu. (2011) DCPIB, A Specific Inhibitor of Volume-Regulated Anion Channels (VRACs), Inhibits Astrocyte Proliferation and Cell Cycle Progression Via G1/S Arrest. Journal of Molecular Neuroscience 46:2, pages 249-257.
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Ning Wang, Weidong Pan, Meifen Zhu, Maosheng Zhang, Xiaojian Hao, Guangyi Liang & Yibin Feng. (2011) Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells. British Journal of Pharmacology 164:2b, pages 731-742.
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Zhi-Bo Xing, Lei Yao, Guo-Qiang Zhang, Xian-Yu Zhang, You-Xue Zhang & Da Pang. (2011) Fangchinoline Inhibits Breast Adenocarcinoma Proliferation by Inducing Apoptosis. Chemical and Pharmaceutical Bulletin 59:12, pages 1476-1480.
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