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Original Articles

Cocaine Abuse Sharply Reduced in an Effective Methadone Maintenance Program

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Pages 63-75 | Published online: 12 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Mary Jeanne Kreek, Lisa Borg, Elizabeth Ducat & Brenda Ray. (2010) Pharmacotherapy in the Treatment of Addiction: Methadone. Journal of Addictive Diseases 29:2, pages 200-216.
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Albert M. Woodward, Ira E. Raskin & Beatrice Blacklow. (2008) A Profile of the Substance Abuse Treatment Industry: Organization, Costs, and Treatment Completion. Substance Use & Misuse 43:5, pages 647-679.
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Mary Jeanne Kreek. (2007) Opioids, dopamine, stress, and the addictions. Dialogues in Clinical Neuroscience 9:4, pages 363-378.
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Scott Kellogg, Dorothy Melia, Elizabeth Khuri, Amy Lin, Ann Ho & Mary Jeanne Kreek. (2006) Adolescent and Young Adult Heroin Patients. Journal of Addictive Diseases 25:3, pages 15-25.
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Einat Peles, Mary Jeanne Kreek, Scott Kellogg & Miriam Adelson. (2006) High Methadone Dose Significantly Reduces Cocaine Use in Methadone Maintenance Treatment (MMT) Patients. Journal of Addictive Diseases 25:1, pages 43-50.
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Markus Backmund, Kirsten Meyer, Kirsten Meyer, Michael Soyka, Jens Reimer & ChristianG. Schütz. (2006) Co-Consumption of Benzodiazepines in Heroin Users, Methadone-Substituted and Codeine-Substituted Patients. Journal of Addictive Diseases 24:4, pages 17-29.
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MoriJ. Krantz, ShaneB. Rowan & PhilipS. Mehler. (2005) Cocaine-Related Torsade de Pointes in a Methadone Maintenance Patient. Journal of Addictive Diseases 24:1, pages 53-60.
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Stephen Magura, Andrew Rosenblum, Chunki Fong, Cherie Villano & Beverly Richman. (2002) TREATING COCAINE-USING METHADONE PATIENTS: PREDICTORS OF OUTCOMES IN A PSYCHOSOCIAL CLINICAL TRIAL. Substance Use & Misuse 37:14, pages 1927-1955.
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Articles from other publishers (41)

Stefano Errico, Davide Bedocchi, Martina Drommi, Rosario Barranco, Alessandro Bonsignore & Francesco Ventura. (2021) Forensic pathological study of methadone-related deaths in the Genoa (Italy) district: A six-year study. Journal of Forensic and Legal Medicine 79, pages 102149.
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Thomas Julian. (2020) Long-Term Efficacy of Medication-Assisted Treatment of Opioid Addiction: A Systematic Literature Review—Part 1. Topics in Pain Management 35:6, pages 1-9.
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Einat Peles, Orna Levran, Matthew Randesi, Jurg Ott, Mary Jeanne Kreek & Miriam Adelson. (2019) Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated With Cessation of Cocaine Use in Methadone Maintenance Patients With Opioid Addiction. Journal of Addiction Medicine 13:6, pages 430-435.
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Eduardo R. Butelman, Angelo G. I. Maremmani, Silvia Bacciardi, Carina Y. Chen, Joel Correa da Rosa & Mary Jeanne Kreek. (2018) Non-medical Cannabis Self-Exposure as a Dimensional Predictor of Opioid Dependence Diagnosis: A Propensity Score Matched Analysis. Frontiers in Psychiatry 9.
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Marcus Herdener, Kenneth M Dürsteler, Erich Seifritz & Carlos Nordt. (2017) Changes in substance use in patients receiving opioid substitution therapy and resulting clinical challenges: a 17-year treatment case register analysis. The Lancet Psychiatry 4:4, pages 302-309.
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Boris B. Quednow & Marcus Herdener. 2016. Neuroscience for Addiction Medicine: From Prevention to Rehabilitation - Methods and Interventions. Neuroscience for Addiction Medicine: From Prevention to Rehabilitation - Methods and Interventions 227 250 .
Armin Claus, Manfred Gerlach, Rudolf Stohler & Gerhard Wiesbeck. 2016. Neuro-/Psychopharmaka im Kindes- und Jugendalter. Neuro-/Psychopharmaka im Kindes- und Jugendalter 575 597 .
Marcus Baumeister, Marc Vogel, Kenneth M Dürsteler-MacFarland, Urs Gerhard, Johannes Strasser, Marc Walter, Gerhard A Wiesbeck & Sylvie A Petitjean. (2014) Association between methadone dose and concomitant cocaine use in methadone maintenance treatment: a register-based study. Substance Abuse Treatment, Prevention, and Policy 9:1.
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Sebastian Winklhofer, Eddie Surer, Garyfalia Ampanozi, Thomas Ruder, Paul Stolzmann, Marina Elliott, Andrea Oestreich, Thomas Kraemer, Michael Thali, Hatem Alkadhi & Wolf Schweitzer. (2014) Post-mortem whole body computed tomography of opioid (heroin and methadone) fatalities: frequent findings and comparison to autopsy. European Radiology 24:6, pages 1276-1282.
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Rudolf Stohler, Manfred Gerlach & Gerhard A. Wiesbeck. 2014. Psychiatric Drugs in Children and Adolescents. Psychiatric Drugs in Children and Adolescents 417 427 .
Francesco Leri, Yan Zhou, Brendan Carmichael, Erin Cummins & Mary Jeanne Kreek. (2012) Treatment-like steady-state methadone in rats interferes with incubation of cocaine sensitization and associated alterations in gene expression. European Neuropsychopharmacology 22:2, pages 143-152.
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Mary Jeanne Kreek. (2011) Extreme marginalization: addiction and other mental health disorders, stigma, and imprisonment. Annals of the New York Academy of Sciences 1231:1, pages 65-72.
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Melinda Campopiano. (2010) Methadone maintenance therapy in the United States: a case example of dual diagnosis. Advances in Dual Diagnosis 3:3, pages 11-16.
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Francesco Leri, Yan Zhou, Benjamin Goddard, AnneMarie Levy, Derek Jacklin & Mary Jeanne Kreek. (2009) Steady-state methadone blocks cocaine seeking and cocaine-induced gene expression alterations in the rat brain. European Neuropsychopharmacology 19:4, pages 238-249.
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Mary Jeanne Kreek, Yan Zhou, Eduardo R Butelman & Orna Levran. (2009) Opiate and cocaine addiction: from bench to clinic and back to the bench. Current Opinion in Pharmacology 9:1, pages 74-80.
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R. Stohler & G. A. Wiesbeck. 2009. Neuro-Psychopharmaka im Kindes- und Jugendalter. Neuro-Psychopharmaka im Kindes- und Jugendalter 405 414 .
Erik W Gunderson & David A Fiellin. (2008) Office-Based Maintenance Treatment of Opioid Dependence. CNS Drugs 22:2, pages 99-111.
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Francesco Leri, Robert E Sorge, Erin Cummins, David Woehrling, James G Pfaus & Jane Stewart. (2007) High-Dose Methadone Maintenance in Rats: Effects on Cocaine Self-Administration and Behavioral Side Effects. Neuropsychopharmacology 32:11, pages 2290-2300.
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Andrew Byrne & Barry Stimmel. (2007) Methadone and QTc prolongation. The Lancet 369:9559, pages 366.
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John C.M. Brust. 2007. Aspects neurologiques de l'addiction. Aspects neurologiques de l'addiction 171 243 .
Albert Woodward, Abhik Das, Ira E. Raskin & Antonio A. Morgan-Lopez. (2006) An exploratory analysis of treatment completion and client and organizational factors using hierarchical linear modeling. Evaluation and Program Planning 29:4, pages 335-351.
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Mori J. Krantz, William A. Baker & John Schmittner. (2006) Cocaine and Methadone: Parallel Effects on the QTc Interval. The American Journal of Cardiology 98:8, pages 1121.
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Francesco Leri, Yan Zhou, Benjamin Goddard, Erin Cummins & Mary Jeanne Kreek. (2005) Effects of High-Dose Methadone Maintenance on Cocaine Place Conditioning, Cocaine Self-Administration, and Mu-Opioid Receptor mRNA Expression in the Rat Brain. Neuropsychopharmacology 31:7, pages 1462-1474.
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James L. Sorensen, Carmen L. Masson, Kevin Delucchi, Karl Sporer, Paul G. Barnett, Fumi Mitsuishi, Christine Lin, Yong Song, TeChieh Chen & Sharon M. Hall. (2005) Randomized Trial of Drug Abuse Treatment-Linkage Strategies.. Journal of Consulting and Clinical Psychology 73:6, pages 1026-1035.
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Anja Dobler-Mikola, Josef Hättenschwiler, Daniel Meili, Thilo Beck, Edi Böni & Jiri Modestin. (2005) Patterns of heroin, cocaine, and alcohol abuse during long-term methadone maintenance treatment. Journal of Substance Abuse Treatment 29:4, pages 259-265.
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Thomas Kerr, David Marsh, Kathy Li, Julio Montaner & Evan Wood. (2005) Factors associated with methadone maintenance therapy use among a cohort of polysubstance using injection drug users in Vancouver. Drug and Alcohol Dependence 80:3, pages 329-335.
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Fabian Termorshuizen, Anneke Krol, Maria Prins, Ronald Geskus, Wim van den Brink & Erik J.C. van Ameijden. (2005) Prediction of relapse to frequent heroin use and the role of methadone prescription: An analysis of the Amsterdam Cohort Study among drug users. Drug and Alcohol Dependence 79:2, pages 231-240.
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Francesco Leri, Jane Stewart, Benedikt Fischer, Rehm Jürgen, David C. Marsh, Suzanne Brissette, Julie Bruneau, Nady El-Guebaly, Lina Noël, Mark W. Tyndall & T. Cameron Wild. (2005) Patterns of opioid and cocaine co-use: A descriptive study in a Canadian sample of untreated opioid-dependent individuals.. Experimental and Clinical Psychopharmacology 13:4, pages 303-310.
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Francesco Leri, Annie Tremblay, Robert E Sorge & Jane Stewart. (2004) Methadone Maintenance Reduces Heroin- and Cocaine-Induced Relapse without Affecting Stress-Induced Relapse in a Rodent Model of Poly-Drug Use. Neuropsychopharmacology 29:7, pages 1312-1320.
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S.Stevens Negus & Nancy K Mello. (2004) Effects of chronic methadone treatment on cocaine- and food-maintained responding under second-order, progressive-ratio and concurrent-choice schedules in rhesus monkeys. Drug and Alcohol Dependence 74:3, pages 297-309.
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John C.M. Brust. 2004. Neurological Aspects of Substance Abuse. Neurological Aspects of Substance Abuse 139 199 .
Wim van den Brink & Jan M. van Ree. (2003) Pharmacological treatments for heroin and cocaine addiction. European Neuropsychopharmacology 13:6, pages 476-487.
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Fabrizio Faggiano, Federica Vigna-Taglianti, Elisabetta Versino & Patrizia Lemma. (2003) Methadone maintenance at different dosages for opioid dependence. Cochrane Database of Systematic Reviews.
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Francesco Leri, Julie Bruneau & Jane Stewart. (2002) Understanding polydrug use: review of heroin and cocaine co‐use. Addiction 98:1, pages 7-22.
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Mary Jeanne Kreek, K. Steven LaForge & Eduardo Butelman. (2002) Pharmacotherapy of addictions. Nature Reviews Drug Discovery 1:9, pages 710-726.
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Mary Jeanne Kreek & Frank J. Vocci. (2002) History and current status of opioid maintenance treatments: blending conference session. Journal of Substance Abuse Treatment 23:2, pages 93-105.
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S. Stevens Negus & Nancy K. Mello. (2002) Effects of μ-Opioid Agonists on Cocaine- and Food-Maintained Responding and Cocaine Discrimination in Rhesus Monkeys: Role of μ-Agonist Efficacy. Journal of Pharmacology and Experimental Therapeutics 300:3, pages 1111-1121.
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Franziska Liechti, Luis Falcato, Kenneth M. D�rsteler-Mac Farland, Wulf R�ssler & Rudolf Stohler. (2002) Psychosoziale Charakteristika, Methadondosierung und Heroinkonsum in ambulaten Methadonbehandlungen: einMatched-pair-Design. Sozial- und Pr�ventivmedizin SPM 47:1, pages 44-47.
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Chin B. Eap, Thierry Buclin & Pierre Baumann. (2002) Interindividual Variability of the Clinical Pharmacokinetics of Methadone. Clinical Pharmacokinetics 41:14, pages 1153-1193.
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S S Shreeram & Sylvia J Dennison. (2001) The Future of Pharmacologic Interventions for Addictive Disorders. Psychiatric Annals 31:12, pages 723-728.
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MARY JEANNE KREEK. (2006) Drug Addictions. Annals of the New York Academy of Sciences 937:1, pages 27-49.
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