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Journal Of Chronic Fatigue Syndrome Volume 5, 1999 - Issue 3-4
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Original Article

Biochemical Dysregulation of the 2-5A Synthetase/RNase L Antiviral Defense Pathway in Chronic Fatigue Syndrome

Robert J. Suhadolnik Temple University School of Medicine, Philadelphia, PA, USAView further author information
,
Vincent Lombardi Temple University School of Medicine, Philadelphia, PA, USA
,
Daniel L. Peterson Sierra Internal Medicine Associates, Incline VillageNV, USA
,
Suzanne Welsch Sierra Nevada College, Incline VillageNV, USA
,
Paul R. Cheney Cheney Clinic, Bald Head, Island, NC
,
Elizabeth G. Furr Cheney Clinic,
,
Susan E. Horvath Temple University School of Medicine, Philadelphia, PA, USA
,
Ramamurthy Charubala Konstanz Universitat, Konstanz, Germany
,
Nancy L. Reichenbach Temple University School of Medicine, Philadelphia, PA, USA
,
Wolfgang Pfleiderer Konstanz Universitat, Konstanz, Germany
&
Karen O'brien Sierra Internal Medicine Associates,
 show all
Pages 223-242 | Published online: 04 Dec 2011

Citations (26)

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Eliza Prangley & Alexei Korennykh. (2022) 2-5A-Mediated decay (2-5AMD): from antiviral defense to control of host RNA. Critical Reviews in Biochemistry and Molecular Biology 57:5-6, pages 477-491.
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Jo Nijs & Marc Frémont. (2008) Intracellular immune dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: state of the art and therapeutic implications. Expert Opinion on Therapeutic Targets 12:3, pages 281-289.
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Kent Holtorf. (2007) Diagnosis and Treatment of Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysfunction in Patients with Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM). Journal Of Chronic Fatigue Syndrome 14:3, pages 59-88.
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Robert J. Suhadolnik, Daniel L. Peterson, Nancy L. Reichenbach, Gail Roen, Melodie Metzger, John McCahan, Karen O'brien, Suzanne Welsch, Jerome Gabriel, John P. Gaughan & Neil R. McGregor. (2004) Clinical and Biochemical Characteristics Differentiating Chronic Fatigue Syndrome from Major Depression and Healthy Control Populations. Journal Of Chronic Fatigue Syndrome 12:1, pages 5-35.
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Jo Nijs, Kenny De Meirleir, Danny Coomans, Pascale De Becker & Garth L. Nicolson. (2003) Deregulation of the 2,5A Synthetase RNase L Antiviral Pathway by Mycoplasma spp. in Subsets of Chronic Fatigue Syndrome. Journal Of Chronic Fatigue Syndrome 11:2, pages 37-50.
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Patrick Englebienne, C. Vincent Herst, Karen De Smet, Anne D'Haese & Kenny De Meirleir. (2001) Interactions Between Rnase L Ankyrin-Like Domain and ABC Transporters as a Possible Origin for Pain, Ion Transport, CNS and Immune Disorders of Chronic Fatigue Immune Dysfunction Syndrome. Journal Of Chronic Fatigue Syndrome 8:3-4, pages 83-102.
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Articles from other publishers (20)

Mateo Cortes Rivera, Claudio Mastronardi, Claudia Silva-Aldana, Mauricio Arcos-Burgos & Brett Lidbury. (2019) Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review. Diagnostics 9:3, pages 91.
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Tom Norris, Kevin Deere, Jon H. Tobias & Esther Crawley. (2017) Chronic Fatigue Syndrome and Chronic Widespread Pain in Adolescence: Population Birth Cohort Study. The Journal of Pain 18:3, pages 285-294.
Crossref
Paul W. Doetsch. (2016) Robert J. Suhadolnik (1925–2016). Journal of Interferon & Cytokine Research 36:5, pages 277-278.
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Michael Maes. (2011) An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways. Progress in Neuro-Psychopharmacology and Biological Psychiatry 35:3, pages 784-794.
Crossref
Judy A Mikovits, Vincent C Lombardi & Francis W Ruscetti. (2010) Xenotropic murine leukemia virus-related virus: current research, disease associations and therapeutic opportunities. Therapy 7:4, pages 377-384.
Crossref
Leon Chaitow, Peter Baldry, Eric Blake, Jan Dommerholt, Rebecca Good, Tamer S. Issa, John C. Lowe, Carolyn McMakin, John M. McPartland, Paul J. Watson, Pat Winstead-Fry, David Peters, Graeme Chambers & Joanna Cameron. 2010. Fibromyalgia Syndrome. Fibromyalgia Syndrome 47 111 .
Mira Meeus, Jo Nijs & Kenny Meirleir. (2007) Chronic musculoskeletal pain in patients with the chronic fatigue syndrome: A systematic review. European Journal of Pain 11:4, pages 377-386.
Crossref
Fumiharu Togo, Benjamin H. Natelson & Neil Cherniack. 2007. Neuroimmunology of Sleep. Neuroimmunology of Sleep 321 335 .
D. Maquet, C. Demoulin & J.-M. Crielaard. (2006) Chronic fatigue syndrome: a systematic review. Annales de Réadaptation et de Médecine Physique 49:6, pages 418-427.
Crossref
D. Maquet, C. Demoulin & J.M. Crielaard. (2006) Le point sur le syndrome de fatigue chronique. Annales de Réadaptation et de Médecine Physique 49:6, pages 337-347.
Crossref
JO NIJS, MIRA MEEUS, NEIL R. MCGREGOR, ROMAIN MEEUSEN, GUY DE SCHUTTER, ELKE VAN HOOF & KENNY DE MEIRLEIR. (2005) Chronic Fatigue Syndrome: Exercise Performance Related to Immune Dysfunction. Medicine & Science in Sports & Exercise 37:10, pages 1647-1654.
Crossref
Jo Nijs, Kenny De Meirleir, Mira Meeus, Neil R McGregor & Patrick Englebienne. (2004) Chronic fatigue syndrome: intracellular immune deregulations as a possible etiology for abnormal exercise response. Medical Hypotheses 62:5, pages 759-765.
Crossref
Jo Nijs, Kenny De Meirleir, Patrick Englebienne & Neil McGregor. (2003) Chronic fatigue syndrome: a risk factor for osteopenia?. Medical Hypotheses 60:1, pages 65-68.
Crossref
Benjamin H Natelson & Gudrun Lange. (2002) A status report on chronic fatigue syndrome.. Environmental Health Perspectives 110:suppl 4, pages 673-677.
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Susan E. Shetzline, Camille Martinand-Mari, Nancy L. Reichenbach, Zivjena Buletic, Bernard Lebleu, Wolfgang Pfleiderer, Ramamurthy Charubala, Kenny De Meirleir, Pascale De Becker, Daniel L. Peterson, C.V.T. Herst, Patrick Englebienne & Robert J. Suhadolnik. (2002) Structural and Functional Features of the 37-kDa 2-5A-Dependent RNase L in Chronic Fatigue Syndrome. Journal of Interferon & Cytokine Research 22:4, pages 443-456.
Crossref
Bernard Lebleu, Kenny De Meirleir, C Vincent Herst, Edith Demettre, Lionel Bastide, Anne D’Haese & Patrick Englebienne. 2002. Chronic Fatigue Syndrome. Chronic Fatigue Syndrome 73 97 .
Robert Suhadolnik, Nancy Reichenbach, Camille Martinand-Mari & Susan Shetzline. 2002. Chronic Fatigue Syndrome. Chronic Fatigue Syndrome 55 72 .
Bernard Lebleu, C Vincent Herst, Karen De Smet, Simon Roelens, Edith Demettre, Karim El Bakkouri, Marc Frémont, Anne D’Haese, Lionel Bastide & Patrick Englebienne. 2002. Chronic Fatigue Syndrome. Chronic Fatigue Syndrome 17 54 .
Susan E. Shetzline & Robert J. Suhadolnik. (2001) Characterization of a 2′,5′-Oligoadenylate (2–5A)-dependent 37-kDa RNase L. Journal of Biological Chemistry 276:26, pages 23707-23711.
Crossref
Fred Friedberg & Leonard A. Jason. (2001) Chronic fatigue syndrome and fibromyalgia: Clinical assessment and treatment. Journal of Clinical Psychology 57:4, pages 433-455.
Crossref

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