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Original Article

Lipid Replacement and Antioxidant Nutritional Therapy for Restoring Mitochondrial Function and Reducing Fatigue in Chronic Fatigue Syndrome and Other Fatiguing Illnesses

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Pages 57-68 | Received 26 May 2004, Accepted 26 Jul 2004, Published online: 04 Dec 2011

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Doaa A. Ghareeb, Hend M. Hussien, Ashraf A. Khalil, Mohamod A. El-Saadani & Asmaa N. Ali. (2010) Toxic effects of lead exposure on the brain of rats: Involvement of oxidative stress, inflammation, acetylcholinesterase, and the beneficial role of flaxseed extract. Toxicological & Environmental Chemistry 92:1, pages 187-195.
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Articles from other publishers (25)

Gül Akduman, Emine Kurtbeyoğlu & Fatma Esra Güneş. (2023) Can we Reduce the Symptoms of Chronic Fatigue Syndrome by Regulating Micronutrients? A Review. Current Nutrition & Food Science 19:5, pages 509-518.
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Garth L. Nicolson & Gonzalo Ferreira de Mattos. (2022) Fifty Years of the Fluid–Mosaic Model of Biomembrane Structure and Organization and Its Importance in Biomedicine with Particular Emphasis on Membrane Lipid Replacement. Biomedicines 10:7, pages 1711.
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Garth L. Nicolson, Gonzalo Ferreira de Mattos, Michael Ash, Robert Settineri & Pablo V. Escribá. (2021) Fundamentals of Membrane Lipid Replacement: A Natural Medicine Approach to Repairing Cellular Membranes and Reducing Fatigue, Pain, and Other Symptoms While Restoring Function in Chronic Illnesses and Aging. Membranes 11:12, pages 944.
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Geir Bjørklund, Maryam Dadar, Lyudmila Pivina, Monica Daniela Doşa, Yuliya Semenova & Michael Maes. (2020) Environmental, Neuro-immune, and Neuro-oxidative Stress Interactions in Chronic Fatigue Syndrome. Molecular Neurobiology 57:11, pages 4598-4607.
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Arttatrana Pal & Pramod C. Rath. 2020. Models, Molecules and Mechanisms in Biogerontology. Models, Molecules and Mechanisms in Biogerontology 347 391 .
Geir Bjørklund, Maryam Dadar, Joeri J. Pen, Salvatore Chirumbolo & Jan Aaseth. (2019) Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach. Biomedicine & Pharmacotherapy 109, pages 1000-1007.
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Asuka Hirose, Masakazu Terauchi, Yurika Osaka, Mihoko Akiyoshi, Kiyoko Kato & Naoyuki Miyasaka. (2018) Effect of soy lecithin on fatigue and menopausal symptoms in middle-aged women: a randomized, double-blind, placebo-controlled study. Nutrition Journal 17:1.
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Gonzalo Ferreira, Carlos Costa, Verónica Bassaizteguy, Marcelo Santos, Romina Cardozo, José Montes, Robert Settineri & Garth L. Nicolson. (2018) Incubation of human sperm with micelles made from glycerophospholipid mixtures increases sperm motility and resistance to oxidative stress. PLOS ONE 13:6, pages e0197897.
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Luciana L. Ferreira, Ana Raquel Coelho, Paulo J. Oliveira & Teresa Cunha-Oliveira. 2018. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants 593 612 .
Garth L. Nicolson, Gonzalo Ferreira, Robert Settineri, Rita R. Ellithorpe, Paul Breeding & Michael E. Ash. 2018. Mitochondrial Biology and Experimental Therapeutics. Mitochondrial Biology and Experimental Therapeutics 499 522 .
Garth L. Nicolson & Michael E. Ash. (2017) Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phospholipid function in cellular membranes, organelles, cells and tissues. Biochimica et Biophysica Acta (BBA) - Biomembranes 1859:9, pages 1704-1724.
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Arnaud Germain, David Ruppert, Susan M. Levine & Maureen R. Hanson. (2017) Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism. Molecular BioSystems 13:2, pages 371-379.
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Rekik A. Muluye, Yuhong Bian, Li Wang, Paulos N. Alemu, Huantian Cui, Xiaofei Peng & Shanshan Li. (2016) Placenta Peptide Can Protect Mitochondrial Dysfunction through Inhibiting ROS and TNF-α Generation, by Maintaining Mitochondrial Dynamic Network and by Increasing IL-6 Level during Chronic Fatigue. Frontiers in Pharmacology 7.
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Pablo V. Escribá, Xavier Busquets, Jin-ichi Inokuchi, Gábor Balogh, Zsolt Török, Ibolya Horváth, John L. Harwood & László Vígh. (2015) Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment. Progress in Lipid Research 59, pages 38-53.
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Mariana Barbosa, Patrícia Valentão & Paula Andrade. (2014) Bioactive Compounds from Macroalgae in the New Millennium: Implications for Neurodegenerative Diseases. Marine Drugs 12:9, pages 4934-4972.
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Garth L. Nicolson & Michael E. Ash. (2014) Lipid Replacement Therapy: A natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838:6, pages 1657-1679.
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Gerwyn Morris & Michael Maes. (2013) Mitochondrial dysfunctions in Myalgic Encephalomyelitis / chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways. Metabolic Brain Disease 29:1, pages 19-36.
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W.N. Marsden. (2013) Synaptic plasticity in depression: Molecular, cellular and functional correlates. Progress in Neuro-Psychopharmacology and Biological Psychiatry 43, pages 168-184.
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Garth L. Nicolson, Robert Settineri & Rita Ellithorpe. (2012) Lipid Replacement Therapy with a Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Fatigue in Intractable Chronic Fatiguing Illnesses and Chronic Lyme Disease Patients. International Journal of Clinical Medicine 03:03, pages 163-170.
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Enno FreyeEnno Freye. 2012. Acquired Mitochondropathy – A New Paradigm in Western Medicine explaining Chronic Diseases. Acquired Mitochondropathy – A New Paradigm in Western Medicine explaining Chronic Diseases 217 370 .
Garth L. Nicolson. (2010) Lipid replacement therapy: a nutraceutical approach for reducing cancer-associated fatigue and the adverse effects of cancer therapy while restoring mitochondrial function. Cancer and Metastasis Reviews 29:3, pages 543-552.
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Garth L. Nicolson & Kenneth A. Conklin. (2007) Reversing mitochondrial dysfunction, fatigue and the adverse effects of chemotherapy of metastatic disease by molecular replacement therapy. Clinical & Experimental Metastasis 25:2, pages 161-169.
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. (2013) Chronic fatigue syndrome. Arbor Clinical Nutrition Updates 278, pages 1-3.
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Garth L. Nicolson. (2007) Metabolic syndrome and mitochondrial function: Molecular replacement and antioxidant supplements to prevent membrane peroxidation and restore mitochondrial function. Journal of Cellular Biochemistry 100:6, pages 1352-1369.
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Garth L. Nicolson. (2005) Lipid replacement/antioxidant therapy as an adjunct supplement to reduce the adverse effects of cancer therapy and restore mitochondrial function. Pathology & Oncology Research 11:3, pages 139-144.
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