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Journal of Musculoskeletal Pain Volume 4, 1996 - Issue 3
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Original Article

A Randomized Placebo-Controlled Trial of Sustained-Release Amitriptyline in Primary Fibromyalgia

Francis Ginsberg Consultant of Rheumatolgy, University Hospital Erasme, Polyclinique du Lothier, Brussels, Belgium
,
Andre Mancaux Head, Department of Physical Medicine and Rheumatology, Centre Hospitalier J. Bracops, Brussels, Belgium
,
Erika Joos Assistant Professor, University of Brussels, VUB, Hopital Universitaire Saint-Pierre, Department of Rheumatology and Physical Medicine, Brussels, Belgium
,
Philippe Vanhove Assistant to the Medical Department, Sanofi-Winthrop SA, Brussels, Belgium
&
Jean-Pierre Famaey Professor of Physical Medicine, University of Brussels, and Member of the Board, Therabel Research SA, B-1150 Brussels, Belgium
Pages 37-47 | Published online: 16 Jan 2010

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Fernando Rico-Villademoros, Mahmoud Slim & Elena P Calandre. (2015) Amitriptyline for the treatment of fibromyalgia: a comprehensive review. Expert Review of Neurotherapeutics 15:10, pages 1123-1150.
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Elena P Calandre, Fernando Rico-Villademoros & Mahmoud Slim. (2015) An update on pharmacotherapy for the treatment of fibromyalgia. Expert Opinion on Pharmacotherapy 16:9, pages 1347-1368.
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Adam Lloyd, Chad S. Boomershine, Ernest H. Choy, Arthi Chandran & Gergana Zlateva. (2012) The cost-effectiveness of pregabalin in the treatment of fibromyalgia: US perspective. Journal of Medical Economics 15:3, pages 481-492.
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Matthias F Seidel & Wolfgang Müller. (2011) Differential pharmacotherapy for subgroups of fibromyalgia patients with specific consideration of 5-HT3 receptor antagonists. Expert Opinion on Pharmacotherapy 12:9, pages 1381-1391.
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Ernest Choy, Selwyn Richards, Kevin Bowrin, Penny Watson, Adam Lloyd, Alesia Sadosky & Gergana Zlateva. (2010) Cost effectiveness of pregabalin in the treatment of fibromyalgia from a UK perspective. Current Medical Research and Opinion 26:4, pages 965-975.
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Chantal Moret & Mike Briley. (2006) Antidepressants in the treatment of fibromyalgia. Neuropsychiatric Disease and Treatment 2:4, pages 537-548.
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David Fishbain. (2000) Evidence-based data on pain relief with antidepressants. Annals of Medicine 32:5, pages 305-316.
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Francis Ginsberg, Erika Joos, Joseph Géczy, Jacques Brahwyler, Kristof Vandekerckhove & Jean-Pierre Famaey. (1998) A Pilot Randomized Placebo-Controlled Study of Pirlindole in the Treatment of Primary Fibromyalgia. Journal of Musculoskeletal Pain 6:2, pages 5-17.
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Articles from other publishers (29)

Hollie Birkinshaw, Claire M Friedrich, Peter Cole, Christopher Eccleston, Marc Serfaty, Gavin Stewart, Simon White, R Andrew Moore, David Phillippo & Tamar Pincus. (2023) Antidepressants for pain management in adults with chronic pain: a network meta-analysis. Cochrane Database of Systematic Reviews 2023:5.
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Fernanda Fávero Alberti, Matheus William Becker, Carine Raquel Blatt, Patricia Klarmann Ziegelmann, Tatiane da Silva Dal Pizzol & Diogo Pilger. (2022) Comparative efficacy of amitriptyline, duloxetine and pregabalin for treating fibromyalgia in adults: an overview with network meta-analysis. Clinical Rheumatology 41:7, pages 1965-1978.
Crossref
Hussein M. Farag, Ismaeel Yunusa, Hardik Goswami, Ihtisham Sultan, Joanne A. Doucette & Tewodros Eguale. (2022) Comparison of Amitriptyline and US Food and Drug Administration–Approved Treatments for Fibromyalgia. JAMA Network Open 5:5, pages e2212939.
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Kim Lawson. (2017) A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia. Biomedicines 5:4, pages 24.
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Sanam Kia & Ernet Choy. (2017) Update on Treatment Guideline in Fibromyalgia Syndrome with Focus on Pharmacology. Biomedicines 5:4, pages 20.
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Akiko Okifuji, Jeff Gao, Christina Bokat & Bradford D Hare. (2016) Management of fibromyalgia syndrome in 2016. Pain Management 6:4, pages 383-400.
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R Andrew Moore, Sheena Derry, Dominic Aldington, Peter Cole & Philip J Wiffen. (2015) Amitriptyline for fibromyalgia in adults. Cochrane Database of Systematic Reviews 2019:5.
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S. Perrot & I.J. Russell. (2014) More ubiquitous effects from non-pharmacologic than from pharmacologic treatments for fibromyalgia syndrome: A meta-analysis examining six core symptoms. European Journal of Pain 18:8, pages 1067-1080.
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Claudia Sommer, Winfried Häuser, Rieke H. F. Alten, Franz Petzke, Michael Späth, Thomas Tölle, Nurcan Üçeyler, Andreas Winkelmann, Eva Winter & Karl-Jürgen Bär. (2013) Das Fibromyalgiesyndrom: Was hilft wirklich?. CME 10:6, pages 61-74.
Crossref
R Andrew Moore, Sheena Derry, Dominic Aldington, Peter Cole & Philip J Wiffen. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
C. Sommer, W. Häuser, R. Alten, F. Petzke, M. Späth, T. Tölle, N. Üçeyler, A. Winkelmann, E. Winter & K.J. Bär. (2012) Medikamentöse Therapie des FibromyalgiesyndromsDrug therapy of fibromyalgia syndrome. Der Schmerz 26:3, pages 297-310.
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Pinky Dharmshaktu, Vandana Tayal & Bhupinder Singh Kalra. (2013) Efficacy of Antidepressants as Analgesics: A Review. The Journal of Clinical Pharmacology 52:1, pages 6-17.
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Ernest Choy, David Marshall, Zahava L. Gabriel, Stephen A. Mitchell, Elizabeth Gylee & Helen A. Dakin. (2011) A Systematic Review and Mixed Treatment Comparison of the Efficacy of Pharmacological Treatments for Fibromyalgia. Seminars in Arthritis and Rheumatism 41:3, pages 335-345.e6.
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Nathan L. Kleinman, Robert J. Sanchez, Wendy D. Lynch, Joseph C. Cappelleri, Ian A. Beren & Ashish V. Joshi. (2011) Health Outcomes and Costs among Employees with Fibromyalgia Treated with Pregabalin vs. Standard of Care. Pain Practice 11:6, pages 540-551.
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Thiru Mandyam Annaswamy, Arthur J. De Luigi, Bryan J. O'Neill, Nandita Keole & David Berbrayer. (2011) Emerging Concepts in the Treatment of Myofascial Pain: A Review of Medications, Modalities, and Needle-based Interventions. PM&R 3:10, pages 940-961.
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W. Hauser, F. Petzke, N. Uceyler & C. Sommer. (2010) Comparative efficacy and acceptability of amitriptyline, duloxetine and milnacipran in fibromyalgia syndrome: a systematic review with meta-analysis. Rheumatology 50:3, pages 532-543.
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Philip J. Mease. (2014) Fibromyalgia: Key Clinical Domains, Comorbidities, Assessment, And Treatment . CNS Spectrums 14:S16, pages 6-9.
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B. Nishishinya, G. Urrutia, B. Walitt, A. Rodriguez, X. Bonfill, C. Alegre & G. Darko. (2008) Amitriptyline in the treatment of fibromyalgia: a systematic review of its efficacy. Rheumatology 47:12, pages 1741-1746.
Crossref
Nurcan Üçeyler, Winfried Häuser & Claudia Sommer. (2008) A systematic review on the effectiveness of treatment with antidepressants in fibromyalgia syndrome. Arthritis & Rheumatism 59:9, pages 1279-1298.
Crossref
C. Sommer, W. Häuser, M. Berliner, W. Brückle, S. Ehlers, K. Mönkemöller, B. Moradi, F. Petzke, N. Üçeyler, R. Wörz, E. Winter & D.O. Nutzinger. (2008) Medikamentöse Therapie des FibromyalgiesyndromsPharmacological treatment of fibromyalgia syndrome. Der Schmerz 22:3, pages 313-323.
Crossref
Serge Perrot, Rose-Marie Javier, Marc Marty, Claire Le Jeunne & Françoise Laroche. (2008) Antidepressant Use in Painful Rheumatic Conditions. Rheumatic Disease Clinics of North America 34:2, pages 433-453.
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S. Perrot, R.-M. Javier, M. Marty, C. Le Jeunne & F. Laroche. (2008) Is there any evidence to support the use of anti-depressants in painful rheumatological conditions? Systematic review of pharmacological and clinical studies. Rheumatology 47:8, pages 1117-1123.
Crossref
Lesley M. Arnold. (2007) Duloxetine and Other Antidepressants in the Treatment of Patients with Fibromyalgia. Pain Medicine 8:suppl 2, pages S63-S74.
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Heather V. Krell, Andrew F. Leuchter, Ian A. Cook & Michelle Abrams. (2005) Evaluation of Reboxetine, a Noradrenergic Antidepressant, for the Treatment of Fibromyalgia and Chronic Low Back Pain. Psychosomatics 46:5, pages 379-384.
Crossref
Martin Offenbaecher & Manfred Ackenheil. (2014) Current Trends in Neuropathic Pain Treatments with Special Reference to Fibromyalgia. CNS Spectrums 10:4, pages 285-297.
Crossref
Karen Moore Schaefer. (2003) Sleep Disturbances Linked to Fibromyalgia. Holistic Nursing Practice 17:3, pages 120-127.
Crossref
Eric Thomas & Francis Blotman. (2002) Are antidepressants effective in fibromyalgia?. Joint Bone Spine 69:6, pages 531-533.
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Éric Thomas & Francis Blotman. (2002) Les traitements antidépresseurs améliorent-ils vraiment la fibromyalgie ?. Revue du Rhumatisme 69:12, pages 1165-1167.
Crossref
Patrick G. O’Malley, Erin Balden, Glen Tomkins, James Santoro, Kurt Kroenke & Jeffrey L. Jackson. (2000) Treatment of fibromyalgia with antidepressants. Journal of General Internal Medicine 15:9, pages 659-666.
Crossref

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