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Original Articles

HIV Pharmacology: Barriers to the Eradication of HIV from the CNS

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Pages 142-153 | Published online: 02 Feb 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Babita Garg, Sarwar Beg, Ranjot Kaur, Rajendra Kumar, Om Prakash Katare & Bhupinder Singh. (2018) Long-chain triglycerides-based self-nanoemulsifying oily formulations (SNEOFs) of darunavir with improved lymphatic targeting potential. Journal of Drug Targeting 26:3, pages 252-266.
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Maria João Gomes, José das Neves & Bruno Sarmento. (2014) Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system. International Journal of Nanomedicine 9, pages 1757-1769.
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Matthias Mehling, Henning Drechsler, Jens Kuhle, Martin Hardmeier, Ruediger Doerries, Stephan Ruegg & Achim Gass. (2008) Adaptation of antiretroviral therapy in human immunodeficiency virus infection with central nervous system involvement. Journal of Neurovirology 14:1, pages 78-84.
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Articles from other publishers (44)

Leila Fotooh Abadi, Fouad Damiri, Mehrukh Zehravi, Rohit Joshi, Rohan Pai, Mohammed Berrada, Ehab El Sayed Massoud, Md. Habibur Rahman, Satish Rojekar & Simona Cavalu. (2022) Novel Nanotechnology-Based Approaches for Targeting HIV Reservoirs. Polymers 14:15, pages 3090.
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Siddhesh Jadhav, Nikhil Yenorkar, Ruchika Bondre, Megha Karemore & Nikhil Bali. (2022) Nanomedicines encountering HIV dementia: A guiding star for neurotherapeutics. Journal of Drug Delivery Science and Technology 71, pages 103315.
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Divya Soundararajan, Lakshmi Narashimhan Ramana, Prakash Shankaran & Uma Maheswari Krishnan. (2022) Nanoparticle-based strategies to target HIV-infected cells. Colloids and Surfaces B: Biointerfaces 213, pages 112405.
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Hang Su, Sruthi Sravanam, Brady Sillman, Emiko Waight, Edward Makarov, Saumi Mathews, Larisa Y. Poluektova, Santhi Gorantla, Howard E. Gendelman & Prasanta K. Dash. (2021) Recovery of Latent HIV-1 from Brain Tissue by Adoptive Cell Transfer in Virally Suppressed Humanized Mice. Journal of Neuroimmune Pharmacology 16:4, pages 796-805.
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Rohini Kharwade, Sachin More, Nilesh Mahajan & Pratibha Agrawal. (2020) Functionalised Dendrimers: Potential Tool for Antiretroviral Therapy. Current Nanoscience 16:5, pages 708-722.
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Babita Garg, Sarwar Beg, Rajendra Kumar, O.P. Katare & Bhupinder Singh. (2019) Nanostructured lipidic carriers of lopinavir for effective management of HIV-associated neurocognitive disorder. Journal of Drug Delivery Science and Technology 53, pages 101220.
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Shijie Cao & Kim A. Woodrow. (2019) Nanotechnology approaches to eradicating HIV reservoirs. European Journal of Pharmaceutics and Biopharmaceutics 138, pages 48-63.
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Aarti Belgamwar, Shagufta Khan & Pramod Yeole. 2019. Nanobiotechnology in Neurodegenerative Diseases. Nanobiotechnology in Neurodegenerative Diseases 241 266 .
Jason D. Graci, Daniel Michaels, Guangming Chen, Gillian M. Schiralli Lester, Sarah Nodder, Marla Weetall, Gary M. Karp, Zhengxian Gu, Joseph M. Colacino & Andrew J. Henderson. (2017) Identification of benzazole compounds that induce HIV-1 transcription. PLOS ONE 12:6, pages e0179100.
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Debasis Nayak, Ankita Boxi, Sarbani Ashe, Neethi Chandra Thathapudi & Bismita Nayak. (2017) Stavudine loaded gelatin liposomes for HIV therapy: Preparation, characterization and in vitro cytotoxic evaluation. Materials Science and Engineering: C 73, pages 406-416.
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Madhavan Nair, Rahul Dev Jayant, Ajeet Kaushik & Vidya Sagar. (2016) Getting into the brain: Potential of nanotechnology in the management of NeuroAIDS. Advanced Drug Delivery Reviews 103, pages 202-217.
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Sudheesh Pilakka-Kanthikeel, Andrea Raymond, Venkata Subba Rao Atluri, Vidya Sagar, Shailendra K Saxena, Patricia Diaz, Semithe Chevelon, Michael Concepcion & Madhavan Nair. (2015) Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1)-facilitated HIV restriction in astrocytes is regulated by miRNA-181a. Journal of Neuroinflammation 12:1.
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Brigid K. Jensen, Hubert Monnerie, Maggie V. Mannell, Patrick J. Gannon, Cagla Akay Espinoza, Michelle A. Erickson, Annadora J. Bruce-Keller, Benjamin B. Gelman, Lisa A. Briand, R. Christopher Pierce, Kelly L. Jordan-Sciutto & Judith B. Grinspan. (2015) Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders. Journal of Neuropathology & Experimental Neurology 74:11, pages 1093-1118.
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Manuela Prato, Elisabetta Venturini, Elena Chiappini, Maurizio de Martino & Luisa Galli. (2015) Starting Treatment in Pediatric HIV Infection. Pediatric Infectious Disease Journal 34:5, pages S31-S35.
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Maria Ferrara, Ignacio P. Valero, David J. Moore, Adam F. Knight, Nichole A. Duarte & J. Hampton Atkinson. 2014. HIV and Psychiatry. HIV and Psychiatry 157 210 .
Vidya Sagar, Sudheesh Pilakka-Kanthikeel, Ravi Pottathil, Shailendra K. Saxena & Madhavan Nair. (2014) Towards nanomedicines for neuroAIDS. Reviews in Medical Virology 24:2, pages 103-124.
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Kevin R. Robillard, Md Tozammel Hoque & Reina Bendayan. (2014) Expression of ATP-binding cassette membrane transporters in a HIV-1 transgenic rat model. Biochemical and Biophysical Research Communications 444:4, pages 531-536.
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Frank BoehmRose Hayeshi, Boitumelo Semete, Lonji Kalombo, Yolandy Lemmer, Lebogang Katata & Hulda Swai. 2013. Nanomedical Device and Systems Design. Nanomedical Device and Systems Design 491 516 .
Renan Domingues. 2013. Neuroviral Infections. Neuroviral Infections 129 142 .
V. Le Douce, A. Janossy, H. Hallay, S. Ali, R. Riclet, O. Rohr & C. Schwartz. (2012) Achieving a cure for HIV infection: do we have reasons to be optimistic?. Journal of Antimicrobial Chemotherapy 67:5, pages 1063-1074.
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Ik L. Tan & Justin C. McArthur. (2012) HIV-Associated Neurological Disorders. CNS Drugs 26:2, pages 123-134.
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María Palacio, Susana Álvarez & Mª Ángeles Muñoz‐Fernández. (2011) HIV‐1 infection and neurocognitive impairment in the current era. Reviews in Medical Virology 22:1, pages 33-45.
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Thomas Cherrier, Mikael Elias, Alicia Jeudy, Guillaume Gotthard, Valentin Le Douce, Houda Hallay, Patrick Masson, Andrea Janossy, Ermanno Candolfi, Olivier Rohr, Eric Chabrière & Christian Schwartz. (2011) Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication. Virology Journal 8:1.
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Wen Huang, Ibolya E. András, Geun Bae Rha, Bernhard Hennig & Michal Toborek. (2011) PPARα and PPARγ protect against HIV‐1‐induced MMP‐9 overexpression via caveolae‐associated ERK and Akt signaling . The FASEB Journal 25:11, pages 3979-3988.
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Maile AY Karris & Davey M Smith. (2011) Tissue-specific HIV-1 infection: why it matters. Future Virology 6:7, pages 869-882.
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Alexander G Holman, Megan E Mefford, Niall O'Connor & Dana Gabuzda. (2010) HIVBrainSeqDB: a database of annotated HIV envelope sequences from brain and other anatomical sites. AIDS Research and Therapy 7:1.
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Valentin Le Douce, Georges Herbein, Olivier Rohr & Christian Schwartz. (2010) Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage. Retrovirology 7:1.
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Ethan Will Taylor. (2010) The oxidative stress-induced niacin sink (OSINS) model for HIV pathogenesis. Toxicology 278:1, pages 124-130.
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Serguei V Vinogradov, Larisa Y Poluektova, Edward Makarov, Trevor Gerson & Madapathage T Senanayake. (2010) Nano-NRTIs: Efficient Inhibitors of HIV Type-1 in Macrophages with a Reduced Mitochondrial Toxicity. Antiviral Chemistry and Chemotherapy 21:1, pages 1-14.
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Christopher J Destache, Michael Goede & Todd Belgum. (2010) Research Spotlight: Antiretroviral nanoparticles: an extended drug delivery modality. Therapeutic Delivery 1:3, pages 383-386.
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FT Aweeka, A Stek, BM Best, C Hu, D Holland, A Hermes, SK Burchett, J Read, M Mirochnick & EV Capparelli. (2010) Lopinavir protein binding in HIV-1-infected pregnant women. HIV Medicine 11:4, pages 232-238.
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Stephanie D. Kraft-Terry, Andrew R. Stothert, Shilpa Buch & Howard E. Gendelman. (2010) HIV-1 neuroimmunity in the era of antiretroviral therapy. Neurobiology of Disease 37:3, pages 542-548.
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Ho Lun Wong, Niladri Chattopadhyay, Xiao Yu Wu & Reina Bendayan. (2010) Nanotechnology applications for improved delivery of antiretroviral drugs to the brain. Advanced Drug Delivery Reviews 62:4-5, pages 503-517.
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Tewodros Mamo, E Ashley Moseman, Nagesh Kolishetti, Carolina Salvador-Morales, Jinjun Shi, Daniel R Kuritzkes, Robert Langer, Ulrich von Andrian & Omid C Farokhzad. (2010) Emerging nanotechnology approaches for HIV/AIDS treatment and prevention. Nanomedicine 5:2, pages 269-285.
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Jürgen K Rockstroh, Jose Gatell, Roland Landman & Andrea Antinori. (2010) Management of Late-presenting Patients with HIV Infection. Antiviral Therapy 15:1_suppl, pages 25-30.
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Olena Kis, Kevin Robillard, Gary N.Y. Chan & Reina Bendayan. (2010) The complexities of antiretroviral drug–drug interactions: role of ABC and SLC transporters. Trends in Pharmacological Sciences 31:1, pages 22-35.
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Laetitia Redel, Valentin Le Douce, Thomas Cherrier, Céline Marban, Andrea Janossy, Dominique Aunis, Carine Van Lint, Olivier Rohr & Christian Schwartz. (2010) HIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytes. Journal of Leukocyte Biology 87:4, pages 575-588.
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Christina Gavegnano & Raymond F Schinazi. (2009) Antiretroviral Therapy in Macrophages: Implication for HIV Eradication. Antiviral Chemistry and Chemotherapy 20:2, pages 63-78.
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Ari NowacekHoward E Gendelman. (2009) NanoART, neuroAIDS and CNS drug delivery. Nanomedicine 4:5, pages 557-574.
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Patrick T. Ronaldson, Yuri Persidsky & Reina Bendayan. (2008) Regulation of ABC membrane transporters in glial cells: Relevance to the pharmacotherapy of brain HIV‐1 infection. Glia 56:16, pages 1711-1735.
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Lola C. Hudson, Mary B. Tompkins & Rick B. Meeker. (2008) Endothelial cell suppression of peripheral blood mononuclear cell trafficking in vitro during acute exposure to feline immunodeficiency virus. Cell and Tissue Research 334:1, pages 55-65.
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Katrina L. Mealey, Stephen Greene, Rodney Bagley, John Gay, Russ Tucker, Patrick Gavin, Kari Schmidt & Frederick Nelson. (2008) P-Glycoprotein Contributes to the Blood-Brain, but Not Blood-Cerebrospinal Fluid, Barrier in a Spontaneous Canine P-Glycoprotein Knockout Model. Drug Metabolism and Disposition 36:6, pages 1073-1079.
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Elizabeth Sinclair, Rollie Ronquillo, Nicole Lollo, Steven G Deeks, Peter Hunt, Constantin T Yiannoutsos, Serena Spudich & Richard W Price. (2008) Antiretroviral Treatment Effect on Immune Activation Reduces Cerebrospinal Fluid HIV-1 Infection. JAIDS Journal of Acquired Immune Deficiency Syndromes 47:5, pages 544-552.
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Alireza Minagar, Deborah Commins, J. Steven Alexander, Romy Hoque, Francesco Chiappelli, Elyse J. Singer, Behrooz Nikbin & Paul Shapshak. (2012) NeuroAIDS. Molecular Diagnosis & Therapy 12:1, pages 25-43.
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