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Original Articles

Dolutegravir: Clinical and Laboratory Safety in Integrase Inhibitor–Naive Patients

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Pages 199-208 | Published online: 22 Dec 2014

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Annegret Pelchen-Matthews, Jakob Friis Larsen, Leah Shepherd, Josip Begovac, Karen Pedersen, Stéphane De Wit, Andrzej Horban, Elzbieta Jablonowska, Margaret Johnson, Irina Khromova, Marcelo H. Losso, Lars N. Nielsen, Anna Lisa Ridolfo, Brigitte Schmied, Christoph Stephan, Israel Yust, Lloyd Curtis, Vani Vannappagari, Leigh Ragone, Ashley Roen, Dorthe Raben, Ole Kirk, Lars Peters & Amanda Mocroft. (2021) Hypersensitivity reactions, hepatotoxicity, and other discontinuations in persons receiving integrase strand transfer inhibitors: results from the EuroSIDA study. HIV Research & Clinical Practice 22:6, pages 160-168.
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Katya C Corado, Margaret R Caplan & Eric S Daar. (2018) Two-drug regimens for treatment of naïve HIV-1 infection and as maintenance therapy. Drug Design, Development and Therapy 12, pages 3731-3740.
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Jose L. Casado, Marta Monsalvo, Aurora M. Rojo, María Fontecha & Miguel A. Rodriguez-Sagrado. (2018) Dolutegravir and rilpivirine for the maintenance treatment of virologically suppressed HIV-1 infection. Expert Review of Clinical Pharmacology 11:6, pages 561-570.
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Amedeo F. Capetti, Maria V. Cossu, Laura Paladini & Giuliano Rizzardini. (2018) Dolutegravir plus rilpivirine dual therapy in treating HIV-1 infection. Expert Opinion on Pharmacotherapy 19:1, pages 65-77.
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Amedeo F. Capetti, Noemi Astuti, Dario Cattaneo & Giuliano Rizzardini. (2017) Pharmacokinetic drug evaluation of dolutegravir plus rilpivirine for the treatment of HIV. Expert Opinion on Drug Metabolism & Toxicology 13:11, pages 1183-1192.
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Laura Comi & Franco Maggiolo. (2016) Abacavir + dolutegravir + lamivudine for the treatment of HIV. Expert Opinion on Pharmacotherapy 17:15, pages 2097-2106.
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Christopher E Kandel & Sharon L Walmsley. (2015) Dolutegravir – a review of the pharmacology, efficacy, and safety in the treatment of HIV. Drug Design, Development and Therapy 9, pages 3547-3555.
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Tae Eun Park, Abdilahi Mohamed, Julie Kalabalik & Roopali Sharma. (2015) Review of integrase strand transfer inhibitors for the treatment of human immunodeficiency virus infection. Expert Review of Anti-infective Therapy 13:10, pages 1195-1212.
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Pauline Bollen, Peter Reiss, Jonathan Schapiro & David Burger. (2015) Clinical pharmacokinetics and pharmacodynamics of dolutegravir used as a single tablet regimen for the treatment of HIV-1 infection. Expert Opinion on Drug Safety 14:9, pages 1457-1472.
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Articles from other publishers (27)

Kiran Dhonju, Ashmita Gautam, Abhinav Dahal, Niraj Kumar Sharma, Divas Adhikari, Lina Devkota, Prabhat Adhikari, Sampurna Tuladhar, Bishnu Deep Pathak & Sabin Banmala. (2023) Dolutegravir‐induced acquired sideroblastic anemia in a HIV positive patient: A challenging hematologic complication . Clinical Case Reports 11:12.
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Ronald J. Ellis, María J. Marquine, Marcus Kaul, Jerel Adam Fields & Johannes C. M. Schlachetzki. (2023) Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management. Nature Reviews Neurology 19:11, pages 668-687.
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Asaad Mohd, Hiba Sami, ParvezAnwar Khan & HarisM Khan. (2023) A review on the epidemiology of HBV and HIV co-infection. CHRISMED Journal of Health and Research 10:1, pages 1.
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Debbie C. Chen, O. Alison Potok, Dena Rifkin & Michelle M. Estrella. (2022) Advantages, Limitations, and Clinical Considerations in Using Cystatin C to Estimate GFR. Kidney360 3:10, pages 1807-1814.
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Catherine G. Raciti, Leslie A. Enane, Katherine R. MacDonald, Elizabeth C. Whipple, Mary A. Ott & Megan S. McHenry. (2021) Ethical considerations for research involving pregnant women living with HIV and their young children: a systematic review of the empiric literature and discussion. BMC Medical Ethics 22:1.
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Esteban Martínez. (2021) CNS Considerations in ART Simplification Strategies. Current HIV/AIDS Reports 18:6, pages 549-557.
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Marta Rava, Otilia Bisbal, Lourdes Domínguez-Domínguez, Ma Remedios Aleman, María Rivero, Antonio Antela, Vicente Estrada, Esteban Ribera, Adolfo Muñoz, José-Antonio Iribarren, Santiago Moreno, Rafael Rubio & Inmaculada Jarrín. (2021) Late presentation for HIV impairs immunological but not virological response to antiretroviral treatment. AIDS 35:8, pages 1283-1293.
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Sanya J Thomas, Jacob T Kilgore, Bradford A Becken, Coleen K Cunningham & Amelia B Thompson. (2021) Raltegravir-associated Drug-Reaction With Eosinophilia and Systemic Symptoms Syndrome in a Pediatric Patient Without Characteristic Human Leukocyte Antigen B*57:01 or B*53:01 alleles. Journal of the Pediatric Infectious Diseases Society 10:3, pages 363-366.
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Tyler Lanman, Scott Letendre, Qing Ma, Anne Bang & Ronald Ellis. (2019) CNS Neurotoxicity of Antiretrovirals. Journal of Neuroimmune Pharmacology 16:1, pages 130-143.
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Kimberly K. Scarsi, Joshua P. Havens, Anthony T. Podany, Sean N. Avedissian & Courtney V. Fletcher. (2020) HIV-1 Integrase Inhibitors: A Comparative Review of Efficacy and Safety. Drugs 80:16, pages 1649-1676.
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Nicholas Zareifopoulos, Maria Lagadinou, Anastasia Karela, Ourania Kyriakopoulou & Dimitrios Velissaris. (2020) Neuropsychiatric Effects of Antiviral Drugs. Cureus.
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Lucia Taramasso, Patrizia Lorenzini, Antonio Di Biagio, Miriam Lichtner, Giulia Marchetti, Roberto Rossotti, Giuseppe Lapadula, Alessandro Cozzi-Lepri, Francesca Vichi, Andrea Antinori, Stefano Bonora, Antonella d’Arminio Monforte, A d’Arminio Monforte, A Antinori, M Andreoni, A Castagna, F Castelli, R Cauda, G Di Perri, M Galli, R Iardino, G Ippolito, A Lazzarin, G C Marchetti, G Rezza, F von Schloesser, P Viale, A d’Arminio Monforte, A Antinori, A Castagna, F Ceccherini-Silberstein, A Cozzi-Lepri, E Girardi, S Lo Caputo, C Mussini, M Puoti, C F Perno, A Antinori, F Bai, C Balotta, A Bandera, S Bonora, M Borderi, A Calcagno, A Capetti, M R Capobianchi, A Castagna, F Ceccherini-Silberstein, S Cicalini, A Cingolani, P Cinque, A Cozzi-Lepri, A d’Arminio Monforte, A De Luca, A Di Biagio, E Girardi, N Gianotti, A Gori, G Guaraldi, G Lapadula, M Lichtner, S Lo Caputo, G Madeddu, F Maggiolo, G Marchetti, L Monno, C Mussini, S Nozza, C F Perno, C Pinnetti, M Puoti, E Quiros Roldan, R Rossotti, S Rusconi, M M Santoro, A Saracino, L Sarmati, A Cozzi-Lepri, I Fanti, L Galli, P Lorenzini, A Rodano’, M Macchia, A Tavelli, F Carletti, S Carrara, A Di Caro, S Graziano, F Petroni, G Prota, S Truffa, A Giacometti, A Costantini, V Barocci, G Angarano, L Monno, E Milano, F Maggiolo, C Suardi, P Viale, V Donati, G Verucchi, F Castelnuovo, C Minardi, E Quiros Roldan, B Menzaghi, C Abeli, B Cacopardo, B Celesia, J Vecchiet, K Falasca, A Pan, S Lorenzotti, L Sighinolfi, D Segala, P Blanc, F Vichi, G Cassola, C Viscoli, A Alessandrini, N Bobbio, G Mazzarello, M Lichtner, S Vita, P Bonfanti, C Molteni, A Chiodera, P Milini, G Nunnari, G Pellicanò, A d’Arminio Monforte, M Galli, A Lazzarin, G Rizzardini, M Puoti, A Castagna, E S Cannizzo, M C Moioli, R Piolini, D Bernacchia, S Salpietro, C Tincati, C Mussini, C Puzzolante, C Migliorino, G Lapadula, V Sangiovanni, G Borgia, V Esposito, F Di Martino, I Gentile, V Rizzo, A M Cattelan, S Marinello, A Cascio, M Trizzino, F Baldelli, E Schiaroli, G Parruti, F Sozio, G Magnani, M A Ursitti, M Andreoni, A Antinori, R Cauda, A Cristaudo, V Vullo, R Acinapura, D Moschese, M Capozzi, A Mondi, A Cingolani, M Rivano Capparuccia, G Iaiani, A Latini, R Gagliardini, M M Plazzi, S Savinelli, A Vergori, M Cecchetto, F Viviani, G Madeddu, A De Vito, B Rossetti, F Montagnani, A Franco, R Fontana Del Vecchio, D Francisci, C Di Giuli, P Caramello, G Di Perri, S Bonora, G C Orofino, M Sciandra, M Bassetti, A Londero, G Pellizzer, V Manfrin, G Starnini & A Ialungo. (2019) Incidence and risk factors for liver enzyme elevation among naive HIV-1-infected patients receiving ART in the ICONA cohort. Journal of Antimicrobial Chemotherapy 74:11, pages 3295-3304.
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Tamyres dos Santos Vieira, Isabela dos Santos Vieira, Matheus Bresser, Letícia Coutinho Lopes Moura & Marcos de Assis Moura. (2019) O papel do dolutegravir na terapia antiretroviral. HU Revista 44:3, pages 379-385.
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Chris M. Stainsby, Teodora M. Perger, Vani Vannappagari, Karam C. Mounzer, Ricky K. Hsu, Cassidy E. Henegar, James Oyee, Rimgaile Urbaityte, Charlotte E. Lane, Lindsay M. Carter, Gary E. Pakes & Mark S. Shaefer. (2018) Abacavir Hypersensitivity Reaction Reporting Rates During a Decade of HLA ‐B*5701 Screening as a Risk‐Mitigation Measure . Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 39:1, pages 40-54.
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Charlotte Martin, Marie-Christine Payen & Stephane De Wit. (2018) Dolutegravir as a trigger for DRESS syndrome?. International Journal of STD & AIDS 29:10, pages 1036-1038.
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Kristina M Brooks, Jomy M George, Alice K Pau, Adam Rupert, Carolina Mehaffy, Prithwiraj De, Karen M Dobos, Anela Kellogg, Mary McLaughlin, Maryellen McManus, Raul M Alfaro, Colleen Hadigan, Joseph A Kovacs & Parag Kumar. (2018) Cytokine-Mediated Systemic Adverse Drug Reactions in a Drug–Drug Interaction Study of Dolutegravir With Once-Weekly Isoniazid and Rifapentine. Clinical Infectious Diseases 67:2, pages 193-201.
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Riikka Bornhede, Sandra Soeria-Atmadja, Katarina Westling, Karin Pettersson & Lars Navér. (2018) Dolutegravir in pregnancy—effects on HIV-positive women and their infants. European Journal of Clinical Microbiology & Infectious Diseases 37:3, pages 495-500.
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Kasha P. Singh, Megan Crane, Jennifer Audsley, Anchalee Avihingsanon, Joe Sasadeusz & Sharon R. Lewin. (2017) HIV-hepatitis B virus coinfection. AIDS 31:15, pages 2035-2052.
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Erin S. Christensen, Rupali Jain & Alison C. Roxby. (2017) Abacavir/Dolutegravir/Lamivudine (Triumeq)–Induced Liver Toxicity in a Human Immunodeficiency Virus–Infected Patient. Open Forum Infectious Diseases 4:3.
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Anna Fettiplace, Chris Stainsby, Alan Winston, Naomi Givens, Sarah Puccini, Vani Vannappagari, Ricky Hsu, Jennifer Fusco, Romina Quercia, Michael Aboud & Lloyd Curtis. (2017) Psychiatric Symptoms in Patients Receiving Dolutegravir. JAIDS Journal of Acquired Immune Deficiency Syndromes 74:4, pages 423-431.
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Pedro Cahn, María José Rolón, María Inés Figueroa, Ana Gun, Patricia Patterson & Omar Sued. (2017) Dolutegravir-lamivudine as initial therapy in HIV-1 infected, ARV-naive patients, 48-week results of the PADDLE (Pilot Antiretroviral Design with Dolutegravir LamivudinE) study. Journal of the International AIDS Society 20:1, pages 21678.
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George W. Rutherford & Hacsi Horvath. (2016) Dolutegravir Plus Two Nucleoside Reverse Transcriptase Inhibitors versus Efavirenz Plus Two Nucleoside Reverse Transcriptase Inhibitors As Initial Antiretroviral Therapy for People with HIV: A Systematic Review. PLOS ONE 11:10, pages e0162775.
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Glenn J. Treisman & Olivia Soudry. (2016) Neuropsychiatric Effects of HIV Antiviral Medications. Drug Safety 39:10, pages 945-957.
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Amit C. Achhra, Melinda Nugent, Amanda Mocroft, Lene Ryom & Christina M. Wyatt. (2016) Chronic Kidney Disease and Antiretroviral Therapy in HIV-Positive Individuals: Recent Developments. Current HIV/AIDS Reports 13:3, pages 149-157.
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Sarmad Waqas, Mairead O’Connor, Ciara Levey, Paddy Mallon, Gerard Sheehan, Anjali Patel, Gordana Avramovic & John S Lambert. (2016) Experience of dolutegravir in HIV-infected treatment-naive patients from a tertiary care University Hospital in Ireland. SAGE Open Medicine 4, pages 205031211667581.
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Sara H. Bares, Uriel S. Sandkovsky, Geoffrey A. Talmon, Grant F. Hutchins, Susan Swindells & Kimberly K. Scarsi. (2016) Dolutegravir-induced colitis in an HIV-infected patient. Journal of Antimicrobial Chemotherapy 71:1, pages 281-282.
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A. Calcagno, S. Nozza, C. Muss, B. M. Celesia, F. Carli, S. Piconi, G. V. De Socio, A. M. Cattelan, G. Orofino, D. Ripamonti, A. Riva & G. Di Perri. (2015) Ageing with HIV: a multidisciplinary review. Infection 43:5, pages 509-522.
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