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Original Articles

Evidence to Practice: Botulinum Toxin in the Treatment of Spasticity Post Stroke

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Pages 115-121 | Published online: 05 Jan 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Edwina Sutherland, Bridget Hill, Barby J. Singer, Stephen Ashford, Brian Hoare, Tandy Hastings-Ison, Klemens Fheodoroff, Steffen Berwick, Fiona Dobson & Gavin Williams. (2022) Do randomised controlled trials evaluating functional outcomes following botulinum neurotoxin-A align with focal spasticity guidelines? A systematic review. Disability and Rehabilitation 44:26, pages 8515-8523.
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Kodai Miyara, Kentaro Kawamura, Shuji Matsumoto, Akihiko Ohwatashi, Yuki Itashiki, Tomohiro Uema, Tomokazu Noma, Keiko Ikeda & Megumi Shimodozono. (2020) Acute changes in cortical activation during active ankle movement after whole-body vibration for spasticity in hemiplegic legs of stroke patients: a functional near-infrared spectroscopy study. Topics in Stroke Rehabilitation 27:1, pages 67-74.
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Carolina Carmona Alcantara, Julia Blanco, Lucilene Maria De Oliveira, Paula Fernanda Sávio Ribeiro, Esperanza Herrera, Theresa Helissa Nakagawa, Darcy S. Reisman, Stella Maris Michaelsen, Luccas Cavalcanti Garcia & Thiago Luiz Russo. (2019) Cryotherapy reduces muscle hypertonia, but does not affect lower limb strength or gait kinematics post-stroke: a randomized controlled crossover study. Topics in Stroke Rehabilitation 26:4, pages 267-280.
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Maria Pais de Carvalho, Daniela Pinto, Melissa Gorayeb & Jorge Jacinto. (2018) Analysis of a 15-years’ experience in including shoulder muscles, when treating upper-limb spasticity post-stroke with botulinum toxin type A. Topics in Stroke Rehabilitation 25:3, pages 194-202.
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Kodai Miyara, Shuji Matsumoto, Tomohiro Uema, Tomokazu Noma, Keiko Ikeda, Akihiko Ohwatashi, Ryoji Kiyama & Megumi Shimodozono. (2018) Effect of whole body vibration on spasticity in hemiplegic legs of patients with stroke. Topics in Stroke Rehabilitation 25:2, pages 90-95.
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Debra S. Ouellette, Susie Wong Okamoto & Emily R. Rosario. (2015) Use of an Algorithm for Assessment and Treatment of The Upper Extremity Post Stroke: A Case Study. Occupational Therapy In Health Care 29:1, pages 1-10.
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Amanda McIntyre, Ricardo Viana, Shannon Janzen, Swati Mehta, Shelialah Pereira & Robert Teasell. (2012) Systematic Review and Meta-Analysis of Constraint-Induced Movement Therapy in the Hemiparetic Upper Extremity More Than Six Months Post Stroke. Topics in Stroke Rehabilitation 19:6, pages 499-513.
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Amanda McIntyre, Taeweon Lee, Shannon Janzen, Rachel Mays, Swati Mehta & Robert Teasell. (2012) Systematic Review of the Effectiveness of Pharmacological Interventions in the Treatment of Spasticity of the Hemiparetic Lower Extremity More Than Six Months Post Stroke. Topics in Stroke Rehabilitation 19:6, pages 479-490.
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Robert Teasell. (2012) Challenges in the Implementation of Evidence in Stroke Rehabilitation. Topics in Stroke Rehabilitation 19:2, pages 93-95.
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Articles from other publishers (34)

Ana Maria Bumbea, Otilia Constantina Rogoveanu, Adina Turcu-Stiolica, Ionica Pirici, George Cioroianu, Diana Iulia Stanca, Oana Criciotoiu, Viorel Biciusca, Rodica Magdalena Traistaru & Danut Visarion Caimac. (2023) Management of Upper-Limb Spasticity Using Modern Rehabilitation Techniques versus Botulinum Toxin Injections Following Stroke. Life 13:11, pages 2218.
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Ayşe Abit Kocaman, Birol Önal, Meral Sertel & Gülten Karaca. (2023) The effect of local vibration applied to the forearm extensor muscles on hand function and muscle activation in stroke patients: a randomized controlled study. Acta Neurologica Belgica.
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Farris Kassam, Brendan Lim, Sadia Afroz, Ève Boissonnault, Rajiv Reebye, Heather Finlayson & Paul Winston. (2023) Canadian Physicians’ Use of Intramuscular Botulinum Toxin Injections for Shoulder Spasticity: A National Cross-Sectional Survey. Toxins 15:1, pages 58.
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Akihiko Hokazono, Seiji Etoh, Yuiko Jonoshita, Kazumi Kawahira & Megumi Shimodozono. (2022) Combination therapy with repetitive facilitative exercise program and botulinum toxin type A to improve motor function for the upper-limb spastic paresis in chronic stroke: A randomized controlled trial. Journal of Hand Therapy 35:4, pages 507-515.
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Rashid Kazerooni, Ileana Howard, Xiaomeng Li & Monica Verduzco-Gutierrez. (2022) Cost Efficiency Analysis for Spasticity Management Based on Physician Botulinum Toxin Prescribing Habits. Archives of Physical Medicine and Rehabilitation 103:6, pages 1205-1209.
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Lorenzo Lippi, Alessandro de Sire, Arianna Folli, Francesco D’Abrosca, Elisa Grana, Alessio Baricich, Stefano Carda & Marco Invernizzi. (2022) Multidimensional Effectiveness of Botulinum Toxin in Neuropathic Pain: A Systematic Review of Randomized Clinical Trials. Toxins 14:5, pages 308.
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Alper Uysal. 2022. Futuristic Design and Intelligent Computational Techniques in Neuroscience and Neuroengineering. Futuristic Design and Intelligent Computational Techniques in Neuroscience and Neuroengineering 138 156 .
Kaleb Vinehout, Kelsey Tynes, Miguel R. Sotelo, Allison S. Hyngstrom, John R. McGuire & Brian D. Schmit. (2021) Changes in Cortical Activity in Stroke Survivors Undergoing Botulinum Neurotoxin Therapy for Treatment of Focal Spasticity. Frontiers in Rehabilitation Sciences 2.
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Jack Scobie & Paul Winston. (2021) Case Report: Perspective of a Caregiver on Functional Outcomes Following Bilateral Lateral Pectoral Nerve Cryoneurotomy to Treat Spasticity in a Pediatric Patient With Cerebral Palsy. Frontiers in Rehabilitation Sciences 2.
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Chuan Zhang, Yen-Ting Chen, Yang Liu, Elaine Magat, Monica Gutierrez-Verduzco, Gerard E. Francisco, Ping Zhou, Sheng Li & Yingchun Zhang. (2021) Improving Botulinum Toxin Efficiency in Treating Post-Stroke Spasticity Using 3D Innervation Zone Imaging. International Journal of Neural Systems 31:04, pages 2150007.
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Nasrin Salehi Dehno, Fahimeh Kamali Sarvestani, Abdolhamid Shariat & Shapour Jaberzadeh. (2020) Relationship of hand strength with paretic upper extremity function and activities of daily living performance in patients with subacute stroke. Physiotherapy Practice and Research 41:1, pages 69-77.
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Anupam Datta Gupta, Renuka Visvanathan, Ian Cameron, Simon A. Koblar, Stuart Howell & David Wilson. (2019) Efficacy of botulinum toxin in modifying spasticity to improve walking and quality of life in post-stroke lower limb spasticity - a randomized double-blind placebo controlled study. BMC Neurology 19:1.
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B. Amatya, L.E. Cofré Lizama, A. Elmalik, A. Bastani, M.P. Galea & F. Khan. (2019) Multidimensional evaluation of changes in limb function following botulinum toxin injection in persons with stroke. NeuroRehabilitation 45:1, pages 67-78.
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Chuan Zhang, Yen-Ting Chen, Yang Liu, Ping Zhou, Sheng Li & Yingchun Zhang. (2019) Three dimensional innervation zone imaging in spastic muscles of stroke survivors. Journal of Neural Engineering 16:3, pages 034001.
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Jin-Young Ahn, Hyeongsu Kim & Chan-Bum Park. (2019) Effects of Whole-Body Vibration on Upper Extremity Function and Grip Strength in Patients with Subacute Stroke: A Randomised Single-Blind Controlled Trial. Occupational Therapy International 2019, pages 1-5.
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Natasha A. Lannin, Louise Ada, Tamina Levy, Coralie English, Julie Ratcliffe, Doungkamol Sindhusake & Maria Crotty. (2018) Intensive therapy after botulinum toxin in adults with spasticity after stroke versus botulinum toxin alone or therapy alone: a pilot, feasibility randomized trial. Pilot and Feasibility Studies 4:1.
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Hyun-Mi Oh, Geun-Young Park, Young Min Choi, Hyung Jung Koo, Yongjun Jang & Sun Im. (2018) The Effects of Botulinum Toxin Injections on Plantar Flexor Spasticity in Different Phases After Stroke: A Secondary Analysis From a Double-Blind, Randomized Trial. PM&R 10:8, pages 789-797.
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Liu Yang, Jing-Yu Tan, Haili Ma, Hongjia Zhao, Jinghui Lai, Jin-Xiu Chen & Lorna K.P. Suen. (2018) Warm-needle moxibustion for spasticity after stroke: A systematic review of randomized controlled trials. International Journal of Nursing Studies 82, pages 129-138.
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Anupam Datta Gupta & David H Wilson. (2018) Botulinum toxin for spasticity: a case for change to the Pharmaceutical Benefits Scheme. Medical Journal of Australia 208:9, pages 379-381.
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Jeffrey LaVallee, Regan Royer & Geoffrey Smith. (2017) Prevalence of Bleeding Complications Following Ultrasound-Guided Botulinum Toxin Injections in Patients on Anticoagulation or Antiplatelet Therapy. PM&R 9:12, pages 1217-1224.
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Deidre Devier, JoAnn Harnar, Leandro Lopez, Allison Brashear & Glenn Graham. (2017) Rehabilitation plus OnabotulinumtoxinA Improves Motor Function over OnabotulinumtoxinA Alone in Post-Stroke Upper Limb Spasticity: A Single-Blind, Randomized Trial. Toxins 9:7, pages 216.
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Yvette N. Lamb & Lesley J. Scott. (2016) IncobotulinumtoxinA: A Review in Upper Limb Spasticity. Drugs 76:14, pages 1373-1379.
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Jung-Sun Lee, Chang-Yong Kim & Hyeong-Dong Kim. (2016) Short-Term Effects of Whole-Body Vibration Combined with Task-Related Training on Upper Extremity Function, Spasticity, and Grip Strength in Subjects with Poststroke Hemiplegia. American Journal of Physical Medicine & Rehabilitation 95:8, pages 608-617.
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Carolee J. Winstein, Joel Stein, Ross Arena, Barbara Bates, Leora R. Cherney, Steven C. Cramer, Frank Deruyter, Janice J. Eng, Beth Fisher, Richard L. Harvey, Catherine E. Lang, Marilyn MacKay-Lyons, Kenneth J. Ottenbacher, Sue Pugh, Mathew J. Reeves, Lorie G. Richards, William Stiers & Richard D. Zorowitz. (2016) Guidelines for Adult Stroke Rehabilitation and Recovery. Stroke 47:6.
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Wing Hong Chu & Anupam Datta Gupta. (2016) Effectiveness of botulinum toxin type A on gait and quality of life in adult post-stroke patients with lower limb spasticity. JBI Database of Systematic Reviews and Implementation Reports 14:6, pages 23-29.
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Adam Kassam, Chetan P. Phadke, Farooq Ismail & Chris Boulias. (2015) Managing Upper Extremity Clonus With Intramuscular Botulinum Toxin-A Injections in a Patient Poststroke. PM&R 7:5, pages 542-546.
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Yu Duan, Xiaoqi Luo, Xing Gao & Chengyan Sun. (2015) Cervical selective dorsal rhizotomy for treating spasticity in upper limb neurosurgical way to neurosurgical technique. Interdisciplinary Neurosurgery 2:1, pages 57-60.
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Einat Ravid & Arthur Prochazka. (2014) Controlled Nerve Ablation With Direct Current: Parameters and Mechanisms. IEEE Transactions on Neural Systems and Rehabilitation Engineering 22:6, pages 1172-1185.
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Wolfgang H Jost. (2014) AbobotulinumtoxinA for the treatment of upper limb spasticity. Clinical Investigation 4:9, pages 847-865.
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Dr. Jodie Copley & Dr. Kathy Kuipers. 2014. Neurorehabilitation of the Upper Limb Across the Lifespan. Neurorehabilitation of the Upper Limb Across the Lifespan 321 338 .
Kodai Miyara, Shuji Matsumoto, Tomohiro Uema, Takuya Hirokawa, Tomokazu Noma, Megumi Shimodozono & Kazumi Kawahira. (2014) Feasibility of using whole body vibration as a means for controlling spasticity in post-stroke patients: A pilot study. Complementary Therapies in Clinical Practice 20:1, pages 70-73.
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Sepideh Pooyania & Brenda Semenko. (2014) Botulinum toxin type-A (BoNTA) and dynamic wrist-hand orthoses versus orthoses alone for the treatment of spastic-paretic upper extremity in chronic stroke patients. Open Journal of Therapy and Rehabilitation 02:01, pages 12-18.
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L. Brewer, F. Horgan, A. Hickey & D. Williams. (2012) Stroke rehabilitation: recent advances and future therapies. QJM 106:1, pages 11-25.
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Toni Bailey, Patrick DohertySimon Rouse. (2012) Impairment and function: the difficulty with definition and measurement of outcome in clinical practice. International Journal of Therapy and Rehabilitation 19:8, pages 463-469.
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