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Antonin Lamaziere, Claude Wolf & Peter J Quinn. (2014) How lipidomics provides new insight into drug discovery. Expert Opinion on Drug Discovery 9:7, pages 819-836.
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Philip A Carpino & Bryan Goodwin. (2010) Diabetes area participation analysis: a review of companies and targets described in the 2008 – 2010 patent literature. Expert Opinion on Therapeutic Patents 20:12, pages 1627-1651.
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Articles from other publishers (30)
Ryo Mizojiri, Daisuke Tomita, Masako Sasaki, Yoshihiko Satoh, Yukiko Yamamoto, Hiroyuki Sumi & Hironobu Maezaki. (2021) Design and synthesis of a monocyclic derivative as a selective ACC1 inhibitor by chemical modification of biphenyl ACC1/2 dual inhibitors. Bioorganic & Medicinal Chemistry 35, pages 116056.
Crossref
Crossref
Ryo Mizojiri, Moriteru Asano, Masako Sasaki, Yoshihiko Satoh, Yukiko Yamamoto, Hiroyuki Sumi & Hironobu Maezaki. (2019) The identification and pharmacological evaluation of potent, selective and orally available ACC1 inhibitor. Bioorganic & Medicinal Chemistry Letters 29:23, pages 126749.
Crossref
Crossref
Xia Wang, Yajing Li, Xiabin Chen, Ziyuan Zhou & Jianzhuang Yao. (2019) Human Acetyl-CoA Carboxylase 1 Is an Isomerase: Carboxyl Transfer Is Activated by Catalytic Effect of Isomerization. The Journal of Physical Chemistry B 123:31, pages 6757-6764.
Crossref
Crossref
Ryo Mizojiri, Noriyuki Nii, Moriteru Asano, Masako Sasaki, Yoshihiko Satoh, Yukiko Yamamoto, Hiroyuki Sumi & Hironobu Maezaki. (2019) Design and synthesis of a novel 1H-pyrrolo[3,2-b]pyridine-3-carboxamide derivative as an orally available ACC1 inhibitor. Bioorganic & Medicinal Chemistry 27:12, pages 2521-2530.
Crossref
Crossref
Wei-Neng Zhou, Yan-Min Zhang, Xin Qiao, Jing Pan, Ling-Feng Yin, Lu Zhu, Jun-Nan Zhao, Shuai Lu, Tao Lu, Ya-Dong Chen & Hai-Chun Liu. (2019) Virtual Screening Strategy Combined Bayesian Classification Model, Molecular Docking for Acetyl-CoA Carboxylases Inhibitors. Current Computer-Aided Drug Design 15:3, pages 193-205.
Crossref
Crossref
Yuji Nishiura, Akira Matsumura, Naotake Kobayashi, Atsuyuki Shimazaki, Shingo Sakamoto, Naohisa Kitade, Yutaka Tonomura, Akira Ino & Takayuki Okuno. (2018) Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy. Bioorganic & Medicinal Chemistry Letters 28:14, pages 2498-2503.
Crossref
Crossref
Ryo Mizojiri, Moriteru Asano, Daisuke Tomita, Hiroshi Banno, Noriyuki Nii, Masako Sasaki, Hiroyuki Sumi, Yoshihiko Satoh, Yukiko Yamamoto, Takeo Moriya, Yoshinori Satomi & Hironobu Maezaki. (2018) Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors. Journal of Medicinal Chemistry 61:3, pages 1098-1117.
Crossref
Crossref
Neil A. Youngson, Margaret J. Morris & J. William O. Ballard. (2017) The mechanisms mediating the antiepileptic effects of the ketogenic diet, and potential opportunities for improvement with metabolism-altering drugs. Seizure 52, pages 15-19.
Crossref
Crossref
Udghosh Singh, Rahul Prakashchand Gangwal, Gaurao V. Dhoke, Rameshwar Prajapati, Mangesh Damre & Abhay T. Sangamwar. (2017) 3D-QSAR and molecular docking analysis of (4-piperidinyl)-piperazines as acetyl-CoA carboxylases inhibitors. Arabian Journal of Chemistry 10, pages S617-S626.
Crossref
Crossref
Matthew P. Bourbeau & Michael D. Bartberger. (2014) Recent Advances in the Development of Acetyl-CoA Carboxylase (ACC) Inhibitors for the Treatment of Metabolic Disease. Journal of Medicinal Chemistry 58:2, pages 525-536.
Crossref
Crossref
Jenny D.Y. Chow, Robert T. Lawrence, Marin E. Healy, John E. Dominy, Jason A. Liao, David S. Breen, Frances L. Byrne, Brandon M. Kenwood, Carolin Lackner, Saeko Okutsu, Valeria R. Mas, Stephen H. Caldwell, Jose L. Tomsig, Gregory J. Cooney, Pere B. Puigserver, Nigel Turner, David E. James, Judit Villén & Kyle L. Hoehn. (2014) Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation. Molecular Metabolism 3:4, pages 419-431.
Crossref
Crossref
Matthew P. Bourbeau, Aaron Siegmund, John G. Allen, Hong Shu, Christopher Fotsch, Michael D. Bartberger, Ki-Won Kim, Renee Komorowski, Melissa Graham, James Busby, Minghan Wang, James Meyer, Yang Xu, Kevin Salyers, Mark Fielden, Murielle M. Véniant & Wei Gu. (2013) Piperazine Oxadiazole Inhibitors of Acetyl-CoA Carboxylase. Journal of Medicinal Chemistry 56:24, pages 10132-10141.
Crossref
Crossref
Liang Tong. (2012) Structure and function of biotin-dependent carboxylases. Cellular and Molecular Life Sciences 70:5, pages 863-891.
Crossref
Crossref
Anuseema Bhadauriya, Gaurao V. Dhoke, Rahul P. Gangwal, Mangesh V. Damre & Abhay T. Sangamwar. (2013) Identification of dual Acetyl-CoA carboxylases 1 and 2 inhibitors by pharmacophore based virtual screening and molecular docking approach. Molecular Diversity 17:1, pages 139-149.
Crossref
Crossref
Chris Limberakis, Jianke Li, Gayatri Balan, David A. Griffith, Daniel W. Kung, Colin Rose & Derek Vrieze. (2012) Complementary α-alkylation approaches for a sterically hindered spiro[pyrazolopyranpiperidine]ketone. Tetrahedron Letters 53:20, pages 2543-2547.
Crossref
Crossref
E. J. Verspohl. (2012) Novel Pharmacological Approaches to the Treatment of Type 2 Diabetes. Pharmacological Reviews 64:2, pages 188-237.
Crossref
Crossref
Scott W. Bagley, James A. Southers, Shawn Cabral, Colin R. Rose, David J. Bernhardson, David J. Edmonds, Jana Polivkova, Xiaojing Yang, Daniel W. Kung, David A. Griffith & Scott J. Bader. (2012) Synthesis of 7-Oxo-dihydrospiro[indazole-5,4′-piperidine] Acetyl-CoA Carboxylase Inhibitors. The Journal of Organic Chemistry 77:3, pages 1497-1506.
Crossref
Crossref
Kevin D. Freeman-Cook, Paul Amor, Scott Bader, Leanne M. Buzon, Steven B. Coffey, Jeffrey W. Corbett, Kenneth J. Dirico, Shawn D. Doran, Richard L. Elliott, William Esler, Angel Guzman-Perez, Kevin E. Henegar, Janet A. Houser, Christopher S. Jones, Chris Limberakis, Katherine Loomis, Kirk McPherson, Sharad Murdande, Kendra L. Nelson, Dennis Phillion, Betsy S. Pierce, Wei Song, Eliot Sugarman, Susan Tapley, Meihua Tu & Zhengrong Zhao. (2012) Maximizing Lipophilic Efficiency: The Use of Free-Wilson Analysis in the Design of Inhibitors of Acetyl-CoA Carboxylase. Journal of Medicinal Chemistry 55:2, pages 935-942.
Crossref
Crossref
Chae Eun Lee, Haeng Jeon Hur, Jin-Taek Hwang, Mi Jeong Sung, Hye Jeong Yang, Hyun-Jin Kim, Jae Ho Park, Dae Young Kwon & Myung-Sunny Kim. (2012) Long-Term Consumption of Platycodi Radix Ameliorates Obesity and Insulin Resistance via the Activation of AMPK Pathways. Evidence-Based Complementary and Alternative Medicine 2012, pages 1-11.
Crossref
Crossref
A. G. Dulloo. (2011) The search for compounds that stimulate thermogenesis in obesity management: from pharmaceuticals to functional food ingredients. Obesity Reviews 12:10, pages 866-883.
Crossref
Crossref
John C. Clapham & Jonathan R.S. Arch. (2011) Targeting thermogenesis and related pathways in anti-obesity drug discovery. Pharmacology & Therapeutics 131:3, pages 295-308.
Crossref
Crossref
Christoffer Bengtsson, Stefan Blaho, David Blomberg Saitton, Kay Brickmann, Johan Broddefalk, Öjvind Davidsson, Tomas Drmota, Rutger Folmer, Kenth Hallberg, Stefan Hallén, Ragnar Hovland, Emre Isin, Petra Johannesson, Bengt Kull, Lars-Olof Larsson, Lars Löfgren, Kristina E. Nilsson, Tobias Noeske, Nick Oakes, Alleyn T. Plowright, Volker Schnecke, Pernilla Ståhlberg, Pernilla Sörme, Hong Wan, Eric Wellner & Linda Öster. (2011) Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorganic & Medicinal Chemistry 19:10, pages 3039-3053.
Crossref
Crossref
Tomomichi Chonan, Daisuke Wakasugi, Daisuke Yamamoto, Miyoko Yashiro, Takahiro Oi, Hiroaki Tanaka, Ayumi Ohoka-Sugita, Fusayo Io, Hiroko Koretsune & Akira Hiratate. (2011) Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group. Bioorganic & Medicinal Chemistry 19:5, pages 1580-1593.
Crossref
Crossref
Jonathan R. S. Arch. 2011. Diabetes - Perspectives in Drug Therapy. Diabetes - Perspectives in Drug Therapy
201
255
.
Stefanie Keil, Marco Müller, Gerhard Zoller, Guido Haschke, Katrin Schroeter, Maike Glien, Sven Ruf, Ingo Focken, Andreas W. Herling & Dieter Schmoll. (2010) Identification and Synthesis of Novel Inhibitors of Acetyl-CoA Carboxylase with in Vitro and in Vivo Efficacy on Fat Oxidation. Journal of Medicinal Chemistry 53:24, pages 8679-8687.
Crossref
Crossref
Li Feng ZHAO, Yasumasa IWASAKI, Wang ZHE, Mitsuru NISHIYAMA, Takafumi TAGUCHI, Makoto TSUGITA, Machiko KAMBAYASHI, Kozo HASHIMOTO & Yoshio TERADA. (2010) Hormonal Regulation of Acetyl-CoA Carboxylase Isoenzyme Gene Transcription. Endocrine Journal 57:4, pages 317-324.
Crossref
Crossref
Kyle L. Hoehn, Nigel Turner, Michael M. Swarbrick, Donna Wilks, Elaine Preston, Yuwei Phua, Himani Joshi, Stuart M. Furler, Mark Larance, Bronwyn D. Hegarty, Simon J. Leslie, Russell Pickford, Andrew J. Hoy, Edward W. Kraegen, David E. James & Gregory J. Cooney. (2010) Acute or Chronic Upregulation of Mitochondrial Fatty Acid Oxidation Has No Net Effect on Whole-Body Energy Expenditure or Adiposity. Cell Metabolism 11:1, pages 70-76.
Crossref
Crossref
Matthew P. Bourbeau, John G. Allen & Wei Gu. 2010.
95
108
.
Song Xiang, Matthew M. Callaghan, Keith G. Watson & Liang Tong. (2009) A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim. Proceedings of the National Academy of Sciences 106:49, pages 20723-20727.
Crossref
Crossref
Tasir S. Haque, Ningning Liang, Rajasree Golla, Ramakrishna Seethala, Zhengping Ma, William R. Ewing, Christopher B. Cooper, Mary Ann Pelleymounter, Michael A. Poss & Dong Cheng. (2009) Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase. Bioorganic & Medicinal Chemistry Letters 19:20, pages 5872-5876.
Crossref
Crossref