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Bradykinin receptor antagonists – a review of the patent literature 2005 – 2008

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Pages 919-941 | Published online: 24 Jun 2009

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Fatimunnisa Qadri & Michael Bader. (2018) Kinin B1 receptors as a therapeutic target for inflammation. Expert Opinion on Therapeutic Targets 22:1, pages 31-44.
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Henriette Farkas. (2016) Icatibant as acute treatment for hereditary angioedema in adults. Expert Review of Clinical Pharmacology 9:6, pages 779-788.
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Nelly Blaes & Jean-Pierre Girolami. (2013) Targeting the ‘Janus face' of the B2-bradykinin receptor. Expert Opinion on Therapeutic Targets 17:10, pages 1145-1166.
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Roberto Castelli, Andrea Zanichelli & Massimo Cugno. (2013) Therapeutic options for patients with angioedema due to C1-inhibitor deficiencies: from pathophysiology to the clinic. Immunopharmacology and Immunotoxicology 35:1, pages 181-190.
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Eric T Whalley, Carlos D Figueroa, Lajos Gera & Kanti D Bhoola. (2012) Discovery and therapeutic potential of kinin receptor antagonists. Expert Opinion on Drug Discovery 7:12, pages 1129-1148.
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Éva Bozó, János Éles & György M Keserű. (2012) Bradykinin B1 receptor antagonists: a patent update 2009 – 2012. Expert Opinion on Therapeutic Patents 22:12, pages 1443-1452.
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Articles from other publishers (17)

François Marceau. (2023) Drugs of the Kallikrein–Kinin System: An Overview. Drugs and Drug Candidates 2:3, pages 538-553.
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Sengul Beyaz, Semra Demir, Nida Oztop, Bahauddin Colakoglu, Suna Buyukozturk & Asli Gelincik. (2022) How satisfactory is on-demand icatibant from the patients' perspective in real life?. Allergy and Asthma Proceedings 43:2, pages 148-154.
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Lucas A.D. Nicolau, Pedro J.C. Magalhães & Mariana L. Vale. (2020) What would Sérgio Ferreira say to your physician in this war against COVID-19: How about kallikrein/kinin system?. Medical Hypotheses 143, pages 109886.
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François Marceau, Hélène Bachelard, Johanne Bouthillier, Jean-Philippe Fortin, Guillaume Morissette, Marie-Thérèse Bawolak, Xavier Charest-Morin & Lajos Gera. (2020) Bradykinin receptors: Agonists, antagonists, expression, signaling, and adaptation to sustained stimulation. International Immunopharmacology 82, pages 106305.
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François Marceau, Marie-Thérèse Bawolak, Jean-Philippe Fortin, Guillaume Morissette, Caroline Roy, Hélène Bachelard, Lajos Gera & Xavier Charest-Morin. (2018) Bifunctional ligands of the bradykinin B 2 and B 1 receptors: An exercise in peptide hormone plasticity. Peptides 105, pages 37-50.
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Paula M. Uberman, Carolina S. García, Julieta R. Rodríguez & Sandra E. Martín. (2017) PVP-Pd nanoparticles as efficient catalyst for nitroarene reduction under mild conditions in aqueous media. Green Chemistry 19:3, pages 739-748.
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A.P. Luiz, S.D. Schroeder, G.A. Rae, J.B. Calixto & J.G. Chichorro. (2015) Contribution and interaction of kinin receptors and dynorphin A in a model of trigeminal neuropathic pain in mice. Neuroscience 300, pages 189-200.
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Mathias Hallberg. (2015) Neuropeptides: Metabolism to Bioactive Fragments and the Pharmacology of Their Receptors. Medicinal Research Reviews 35:3, pages 464-519.
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Erika Terzuoli, Stefania Meini, Paola Cucchi, Claudio Catalani, Cecilia Cialdai, Carlo Alberto Maggi, Antonio Giachetti, Marina Ziche & Sandra Donnini. (2014) Antagonism of Bradykinin B2 Receptor Prevents Inflammatory Responses in Human Endothelial Cells by Quenching the NF-kB Pathway Activation. PLoS ONE 9:1, pages e84358.
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Baptiste Lacoste, Xin-Kang Tong, Karim Lahjouji, Réjean Couture & Edith Hamel. (2013) Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer’s disease mice. Journal of Neuroinflammation 10:1.
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Lajos Gera, Caroline Roy, Marie-Thérèse Bawolak, Xavier Charest-Morin & François Marceau. (2012) N-terminal extended conjugates of the agonists and antagonists of both bradykinin receptor subtypes: Structure–activity relationship, cell imaging using ligands conjugated with fluorophores and prospect for functionally active cargoes. Peptides 34:2, pages 433-446.
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Sébastien Talbot & Réjean Couture. (2012) Emerging role of microglial kinin B1 receptor in diabetic pain neuropathy. Experimental Neurology 234:2, pages 373-381.
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Martine Barth, Michel Bondoux, Jean-Michel Luccarini, Vincent Peyrou, Pierre Dodey, Didier Pruneau, Christine Massardier & Jean-Luc Paquet. (2012) From Bradykinin B2 Receptor Antagonists to Orally Active and Selective Bradykinin B1 Receptor Antagonists. Journal of Medicinal Chemistry 55:6, pages 2574-2584.
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Marian C. Bryan, Kaustav Biswas, Tanya A.N. Peterkin, Robert M. Rzasa, Leyla Arik, Sonya G. Lehto, Hong Sun, Feng-Yin Hsieh, Cen Xu, Robert T. Fremeau & Jennifer R. Allen. (2012) Chromenones as potent bradykinin B1 antagonists. Bioorganic & Medicinal Chemistry Letters 22:1, pages 619-622.
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François Marceau. 2011. Kinins. Kinins 69 84 .
S Meini, F Bellucci, C Catalani, P Cucchi, A Giolitti, S Giuliani, L Quartara, L Rotondaro, S Zappitelli & CA Maggi. (2011) Comparison of the molecular interactions of two antagonists, MEN16132 or icatibant, at the human kinin B2 receptor. British Journal of Pharmacology 162:5, pages 1202-1212.
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Marco Cicardi, Aleena Banerji, Francisco Bracho, Alejandro Malbrán, Bernd Rosenkranz, Marc Riedl, Konrad Bork, William Lumry, Werner Aberer, Henning Bier, Murat Bas, Jens Greve, Thomas K. Hoffmann, Henriette Farkas, Avner Reshef, Bruce Ritchie, William Yang, Jürgen Grabbe, Shmuel Kivity, Wolfhart Kreuz, Robyn J. Levy, Thomas Luger, Krystyna Obtulowicz, Peter Schmid-Grendelmeier, Christian Bull, Brigita Sitkauskiene, William B. Smith, Elias Toubi, Sonja Werner, Suresh Anné, Janne Björkander, Laurence Bouillet, Enrico Cillari, David Hurewitz, Kraig W. Jacobson, Constance H. Katelaris, Marcus Maurer, Hans Merk, Jonathan A. Bernstein, Conleth Feighery, Bernard Floccard, Gerald Gleich, Jacques Hébert, Martin Kaatz, Paul Keith, Charles H. Kirkpatrick, David Langton, Ludovic Martin, Christiane Pichler, David Resnick, Duane Wombolt, Diego S. Fernández Romero, Andrea Zanichelli, Francesco Arcoleo, Jochen Knolle, Irina Kravec, Liying Dong, Jens Zimmermann, Kimberly Rosen & Wing-Tze Fan. (2010) Icatibant, a New Bradykinin-Receptor Antagonist, in Hereditary Angioedema. New England Journal of Medicine 363:6, pages 532-541.
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