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Macrocyclic inhibitors of HCV NS3 protease

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Pages 1277-1303 | Published online: 29 Jun 2009

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Jiachang Gong, Timothy Eley, Bing He, Vinod Arora, Thomas Philip, Hao Jiang, John Easter, W. Griffith Humphreys, Ramaswamy A. Iyer & Wenying Li. (2016) Characterization of ADME properties of [14C]asunaprevir (BMS-650032) in humans. Xenobiotica 46:1, pages 52-64.
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Vinod K Rustgi. (2010) Safety of small molecules in combination with interferon-based therapy for hepatitis C virus. Expert Opinion on Drug Safety 9:6, pages 883-892.
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Eric Marsault. 2013. Diversity-Oriented Synthesis. Diversity-Oriented Synthesis 253 287 .
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Reem Al Olaby, Hassan M. Azzazy, Rodney Harris, Brett Chromy, Jost Vielmetter & Rod Balhorn. (2013) Identification of ligands that target the HCV-E2 binding site on CD81. Journal of Computer-Aided Molecular Design 27:4, pages 337-346.
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Nicholas A. Meanwell, Stanley V. D'Andrea, Christopher W. Cianci, Ira B. Dicker, Kap-Sun Yeung, Makonen Belema & Mark Krystal. 2013. Drug Discovery. Drug Discovery 439 515 .
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Michael T. Rudd, John A. McCauley, John W. Butcher, Joseph J. Romano, Charles J. McIntyre, Kevin T. Nguyen, Kevin F. Gilbert, Kimberly J. Bush, M. Katharine Holloway, John Swestock, Bang-Lin Wan, Steven S. Carroll, Jillian M. DiMuzio, Donald J. Graham, Steven W. Ludmerer, Mark W. Stahlhut, Christine M. Fandozzi, Nicole Trainor, David B. Olsen, Joseph P. Vacca & Nigel J. Liverton. (2011) Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure. ACS Medicinal Chemistry Letters 2:3, pages 207-212.
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Frank Narjes, Benedetta Crescenzi, Marco Ferrara, Jörg Habermann, Stefania Colarusso, Maria del Rosario Rico Ferreira, Ian Stansfield, Angela Claire Mackay, Immacolata Conte, Caterina Ercolani, Simone Zaramella, Maria-Cecilia Palumbi, Philip Meuleman, Geert Leroux-Roels, Claudio Giuliano, Fabrizio Fiore, Stefania Di Marco, Paola Baiocco, Uwe Koch, Giovanni Migliaccio, Sergio Altamura, Ralph Laufer, Raffaele De Francesco & Michael Rowley. (2010) Discovery of (7 R )-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6 H -indolo[1,2- e ][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase . Journal of Medicinal Chemistry 54:1, pages 289-301.
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Montse Llinàs-Brunet, Murray D. Bailey, Nathalie Goudreau, Punit K. Bhardwaj, Josée Bordeleau, Michael Bös, Yves Bousquet, Michael G. Cordingley, Jiamin Duan, Pat Forgione, Michel Garneau, Elise Ghiro, Vida Gorys, Sylvie Goulet, Ted Halmos, Stephen H. Kawai, Julie Naud, Marc-André Poupart & Peter W. White. (2010) Discovery of a Potent and Selective Noncovalent Linear Inhibitor of the Hepatitis C Virus NS3 Protease (BI 201335). Journal of Medicinal Chemistry 53:17, pages 6466-6476.
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Wendy A. LoughlinJoel D. A. TyndallMatthew P. GlennTimothy A. HillDavid P. Fairlie. (2011) Update 1 of: Beta-Strand Mimetics. Chemical Reviews 110:6, pages PR32-PR69.
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John A. McCauley, Charles J. McIntyre, Michael T. Rudd, Kevin T. Nguyen, Joseph J. Romano, John W. Butcher, Kevin F. Gilbert, Kimberly J. Bush, M. Katharine Holloway, John Swestock, Bang-Lin Wan, Steven S. Carroll, Jillian M. DiMuzio, Donald J. Graham, Steven W. Ludmerer, Shi-Shan Mao, Mark W. Stahlhut, Christine M. Fandozzi, Nicole Trainor, David B. Olsen, Joseph P. Vacca & Nigel J. Liverton. (2010) Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor. Journal of Medicinal Chemistry 53:6, pages 2443-2463.
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Maxwell D. Cummings, Jimmy Lindberg, Tse‐I Lin, Herman de Kock, Oliver Lenz, Elisabet Lilja, Sara Felländer, Vera Baraznenok, Susanne Nyström, Magnus Nilsson, Lotta Vrang, Michael Edlund, Åsa Rosenquist, Bertil Samuelsson, Pierre Raboisson & Kenneth Simmen. (2010) Induced‐Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target. Angewandte Chemie International Edition 49:9, pages 1652-1655.
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Maxwell D. Cummings, Jimmy Lindberg, Tse‐I Lin, Herman de Kock, Oliver Lenz, Elisabet Lilja, Sara Felländer, Vera Baraznenok, Susanne Nyström, Magnus Nilsson, Lotta Vrang, Michael Edlund, Åsa Rosenquist, Bertil Samuelsson, Pierre Raboisson & Kenneth Simmen. (2010) Induced‐Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target. Angewandte Chemie 122:9, pages 1696-1699.
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