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Therapeutic prospect of Syk inhibitors

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Pages 1361-1376 | Published online: 11 Aug 2009

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Kaiwen Lin, Tang Deng, Huijuan Qu, Hongya Ou, Qifeng Huang, Bingmiao Gao, Xiaoliang Li & Na Wei. (2023) Gastric protective effect of Alpinia officinarum flavonoids: mediating TLR4/NF-κB and TRPV1 signalling pathways and gastric mucosal healing. Pharmaceutical Biology 61:1, pages 50-60.
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Peter Norman. (2014) Spleen tyrosine kinase inhibitors: a review of the patent literature 2010 – 2013. Expert Opinion on Therapeutic Patents 24:5, pages 573-595.
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Tadeusz Robak & Ewa Robak. (2012) Tyrosine kinase inhibitors as potential drugs for B-cell lymphoid malignancies and autoimmune disorders. Expert Opinion on Investigational Drugs 21:7, pages 921-947.
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Peter Norman. (2012) Evaluation of WO2011134971, chiral 1,6-napthyridine Syk kinase inhibitors. Expert Opinion on Therapeutic Patents 22:3, pages 335-339.
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Fatih M Uckun & Sanjive Qazi. (2010) Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas. Expert Review of Anticancer Therapy 10:9, pages 1407-1418.
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Susanne Müller & Stefan Knapp. (2010) Targeting kinases for the treatment of inflammatory diseases. Expert Opinion on Drug Discovery 5:9, pages 867-881.
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O.N. Koborova, D.A. Filimonov, A.V. Zakharov, A.A. Lagunin, S.M. Ivanov, A. Kel & V.V. Poroikov. (2009) In silico method for identification of promising anticancer drug targets. SAR and QSAR in Environmental Research 20:7-8, pages 755-766.
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Zhaozhao Wang, Shu Qu, Jiahao Yuan, Wen Tian, Jinglei Xu, Rui Tao, Shilong Sun, Tao Lu, Weifang Tang & Yong Zhu. (2023) Review and prospects of targeted therapies for Spleen tyrosine kinase (SYK). Bioorganic & Medicinal Chemistry 96, pages 117514.
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Deepika Awasthi, Sahil Chopra, Byuri A. Cho, Alexander Emmanuelli, Tito A. Sandoval, Sung-Min Hwang, Chang-Suk Chae, Camilla Salvagno, Chen Tan, Liliana Vasquez-Urbina, Jose J. Fernandez Rodriguez, Sara F. Santagostino, Takao Iwawaki, E. Alfonso Romero-Sandoval, Mariano Sanchez Crespo, Diana K. Morales, Iliyan D. Iliev, Tobias M. Hohl & Juan R. Cubillos-Ruiz. (2023) Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis. Journal of Clinical Investigation.
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Mai M. Anwar. (2023) The orchestrating role of deteriorating neurons and TREM-1 in crosstalk with SYK in Alzheimer’s disease progression and neuroinflammation. Inflammopharmacology.
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Rakesh Sahu, Kamal Shah, Yash Gautam & Kaushilya Sahu. (2023) Pyrazine Moiety: Recent Developments in Cancer Treatment. Current Organic Chemistry 27:10, pages 821-843.
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Mohan Li, Pengbo Wang, Yuanming Zou, Wenbin Wang, Yuanhui Zhao, Mengke Liu, Jianlong Wu, Ying Zhang, Naijin Zhang & Yingxian Sun. (2023) Spleen tyrosine kinase (SYK) signals are implicated in cardio-cerebrovascular diseases. Heliyon 9:5, pages e15625.
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Bachir Latli, Matt J. Hrapchak, Lalith P. Samankumara, Daniel R. Fandrick, Scott Pennino, Heewon Lee & Jinhua J. Song. (2023) Synthesis of BI 894416 and BI 1342561, two potent and selective spleen tyrosine kinase inhibitors, labeled with carbon 14 and with deuterium. Journal of Labelled Compounds and Radiopharmaceuticals 66:4-6, pages 155-168.
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Yanbo Hao, Xiaoqian Tang, Jing Xing, Xiuzhen Sheng, Heng Chi & Wenbin Zhan. (2022) The role of Syk phosphorylation in Fc receptor mediated mIgM+ B lymphocyte phagocytosis in flounder (Paralichthys olivaceus). Fish & Shellfish Immunology 130, pages 462-471.
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Pei Shen, Yezhi Wang, Xiangxiang Jia, Pengfei Xu, Lian Qin, Xi Feng, Zhiyu Li & Zhixia Qiu. (2022) Dual-target Janus kinase (JAK) inhibitors: Comprehensive review on the JAK-based strategies for treating solid or hematological malignancies and immune-related diseases. European Journal of Medicinal Chemistry 239, pages 114551.
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Antonio Giovanni Solimando, Angelo Vacca & Domenico Ribatti. 2022. Encyclopedia of Infection and Immunity. Encyclopedia of Infection and Immunity 798 818 .
Alison R. Walker, John C. Byrd, James S. Blachly, Bhavana Bhatnagar, Alice S. Mims, Shelley Orwick, Tara L. Lin, Howland E. Crosswell, Danjie Zhang, Mark D. Minden, Veerendra Munugalavadla, Lauren Long, Jinfeng Liu, Yang Pan, Thomas Oellerich, Hubert Serve, Arati V. Rao & William G. Blum. (2020) Entospletinib in Combination with Induction Chemotherapy in Previously Untreated Acute Myeloid Leukemia: Response and Predictive Significance of HOXA9 and MEIS1 Expression . Clinical Cancer Research 26:22, pages 5852-5859.
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Holly FosterClare WilsonHelen PhilippouRichard Foster. (2020) Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis. Journal of Medicinal Chemistry 63:21, pages 12213-12242.
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Bernard Barlaam, Scott Boiko, Scott Boyd, Hannah Dry, Lakshmaiah Gingipalli, Timothy Ikeda, Tony Johnson, Sameer Kawatkar, Olivier Lorthioir, Andy Pike, Hannah Pollard, Jon Read, Qibin Su, Haiyun Wang, Huimin Wang, Lianghe Wang, Peng Wang & Scott D. Edmondson. (2020) Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors. Bioorganic & Medicinal Chemistry Letters 30:22, pages 127523.
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Sameer P. Kawatkar, Bernard Barlaam, Paul Kemmitt, Iain Simpson, David Watson, Peng Wang, Scott Lamont, Qibin Su, Scott Boiko, Timothy Ikeda, Joe Patel, Andy Pike, Hannah Pollard, Jon Read, Ujjal Sarkar, Haiyun Wang, Quanshan Wen, Zhiyuan Yan, James E. Dowling, Hannah Dry & Scott D. Edmondson. (2020) Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase. Bioorganic & Medicinal Chemistry Letters 30:18, pages 127393.
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Paige E. Negoro, Shuying Xu, Zeina Dagher, Alex Hopke, Jennifer L. Reedy, Michael B. Feldman, Nida S. Khan, Adam L. Viens, Natalie J. Alexander, Natalie J. Atallah, Allison K. Scherer, Richard A. Dutko, Jane Jeffery, John F. Kernien, J. Scott Fites, Jeniel E. Nett, Bruce S. Klein, Jatin M. Vyas, Daniel Irimia, David B. Sykes & Michael K. Mansour. (2020) Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species . mBio 11:3.
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Cheng Wang, Xin Wang, Yao Li, Tianqi Wang, Zhi Huang, Zhongxiang Qin, Shengyong Yang, Rong Xiang & Yan Fan. (2020) Design and optimization of orally spleen tyrosine kinase (SYK) inhibitors for treatment of solid tumor. Bioorganic Chemistry 95, pages 103547.
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Ananta Ganjoo & Chetti Prabhakar. (2019) In silico structural anatomization of spleen tyrosine kinase inhibitors: Pharmacophore modeling, 3D QSAR analysis and molecular docking studies. Journal of Molecular Structure 1189, pages 102-111.
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Michael D. Barker, John Liddle, Francis L. Atkinson, David Matthew Wilson, Marion C. Dickson, Cesar Ramirez-Molina, Huw Lewis, Rob P. Davis, Donald O. Somers, Margarete Neu, Emma Jones & Robert Watson. (2018) Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease. Bioorganic & Medicinal Chemistry Letters 28:21, pages 3458-3462.
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J.I. Castillo-Arellano, S.L. Guzmán-Gutiérrez, A. Ibarra-Sánchez, S. Hernández-Ortega, A. Nieto-Camacho, O.N. Medina-Campos, J. Pedraza-Chaverri, R. Reyes-Chilpa & C. González-Espinosa. (2018) Jacareubin inhibits FcεRI-induced extracellular calcium entry and production of reactive oxygen species required for anaphylactic degranulation of mast cells. Biochemical Pharmacology 154, pages 344-356.
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Zeina Dagher, Shuying Xu, Paige E. Negoro, Nida S. Khan, Michael B. Feldman, Jennifer L. Reedy, Jenny M. Tam, David B. Sykes & Michael K. Mansour. (2018) Fluorescent Tracking of Yeast Division Clarifies the Essential Role of Spleen Tyrosine Kinase in the Intracellular Control of Candida glabrata in Macrophages. Frontiers in Immunology 9.
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Larry Yet. 2018. Privileged Structures in Drug Discovery. Privileged Structures in Drug Discovery 237 283 .
Antonella Pantaleo, Kristina R. KeselyMaria Carmina PauIoannis Tsamesidis, Evelin SchwarzerOleksii A. SkorokhodHuynh D. Chien, Marta Ponzi, Lucia Bertuccini, Philip S. LowFrancesco M. Turrini. (2017) Syk inhibitors interfere with erythrocyte membrane modification during P falciparum growth and suppress parasite egress. Blood 130:8, pages 1031-1040.
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Neil S. Garton, Michael D. Barker, Rob P. Davis, Clement Douault, Edward Hooper-Greenhill, Emma Jones, Huw D. Lewis, John Liddle, Dave Lugo, Scott McCleary, Alex G.S. Preston, Cesar Ramirez-Molina, Margarete Neu, Tracy J. Shipley, Don O. Somers, Robert J. Watson & David M. Wilson. (2016) Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors. Bioorganic & Medicinal Chemistry Letters 26:19, pages 4606-4612.
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Chao Feng & Carol Beth Post. (2016) Insights into the allosteric regulation of Syk association with receptor ITAM, a multi-state equilibrium. Physical Chemistry Chemical Physics 18:8, pages 5807-5818.
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Man-Man Kang, Shun-Lin Shan, Xu-Yang Wen, Hu-Sheng Shan & Zheng-Jun Wang. (2015) Tumor-Suppression Mechanisms of Protein Tyrosine Phosphatase O and Clinical Applications. Asian Pacific Journal of Cancer Prevention 16:15, pages 6215-6223.
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Jang-Sik Choi, Hae-jun Hwang, Se-Won Kim, Byung Il Lee, Jaekyoo Lee, Ho-Juhn Song, Jong Sung Koh, Jung-Ho Kim & Phil Ho Lee. (2015) Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 25:20, pages 4441-4446.
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Yu Yu, Stephanie Gaillard, Jude M. Phillip, Tai-Chung Huang, Sneha M. Pinto, Nayara G. Tessarollo, Zhen Zhang, Akhilesh Pandey, Denis Wirtz, Ayse Ayhan, Ben Davidson, Tian-Li Wang & Ie-Ming Shih. (2015) Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. Cancer Cell 28:1, pages 82-96.
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Eva Wex, Eva Thaler, Sylvia Blum & David Lamb. (2014) A Novel Model of IgE-Mediated Passive Pulmonary Anaphylaxis in Rats. PLoS ONE 9:12, pages e116166.
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Eleanor M. Pritchard, Elizabeth Stewart, Fangyi Zhu, Cori Bradley, Lyra Griffiths, Lei Yang, Praveen Kumar Suryadevara, Jiakun Zhang, Burgess B. FreemanIIIIII, R. Kiplin Guy & Michael A. Dyer. (2014) Pharmacokinetics and Efficacy of the Spleen Tyrosine Kinase Inhibitor R406 after Ocular Delivery for Retinoblastoma. Pharmaceutical Research 31:11, pages 3060-3072.
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Stephen P. McAdoo, John Reynolds, Gurjeet Bhangal, Jennifer Smith, John P. McDaid, Anisha Tanna, William D. Jackson, Esteban S. Masuda, H. Terence Cook, Charles D. Pusey & Frederick W.K. Tam. (2014) Spleen Tyrosine Kinase Inhibition Attenuates Autoantibody Production and Reverses Experimental Autoimmune GN. Journal of the American Society of Nephrology 25:10, pages 2291-2302.
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Yue Lu, Xian Li, Young Na Park, Okyun Kwon, Donggen Piao, Young-Chae Chang, Cheorl-Ho Kim, Eunkyung Lee, Jong Keun Son & Hyeun Wook Chang. (2014) Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway. Biomolecules & Therapeutics 22:3, pages 193-199.
Crossref
Kevin S. Currie, Jeffrey E. Kropf, Tony Lee, Peter Blomgren, Jianjun Xu, Zhongdong Zhao, Steve Gallion, J. Andrew Whitney, Deborah Maclin, Eric B. Lansdon, Patricia Maciejewski, Ann Marie Rossi, Hong Rong, Jennifer Macaluso, James Barbosa, Julie A. Di Paolo & Scott A. Mitchell. (2014) Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase. Journal of Medicinal Chemistry 57:9, pages 3856-3873.
Crossref
Xian Li, Yue Lu, Ye Jin, Jong-Keun Son, Seung Ho Lee & Hyeun Wook Chang. (2014) Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels. Biomolecules & Therapeutics 22:1, pages 27-34.
Crossref
Young-Su Yi, Young-Jin Son, Chongsuk Ryou, Gi-Ho Sung, Jong-Hoon Kim & Jae Youl Cho. (2014) Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses. Mediators of Inflammation 2014, pages 1-12.
Crossref
Fatih M. UckunSanjive QaziIngrid CelyKazim Sahin, Anoush ShahidzadehIbrahim OzercanQian Yin, Paul Gaynon, Amanda Termuhlen, Jianjun Cheng & Seang Yiv. (2013) Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia. Blood 121:21, pages 4348-4354.
Crossref
Patricia Castellanos Penton, Xiaomin Wang, Hajera Amatullah, Josephine Cooper, Krystal Godri, Michelle L. North, Nivedita Khanna, Jeremy A. Scott & Chung-Wai Chow. (2013) Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma. Journal of Allergy and Clinical Immunology 131:2, pages 512-520.e10.
Crossref
Tatiana V. Rakitina, Alexey A. Zeifman, Ilya Yu. Titov, Igor V. Svitanko, Aleksey V. Lipkin, Viktor S. Stroylov, Oleg V. Stroganov, Fedor N. Novikov & Ghermes G. Chilov. (2012) Efficacy of Novel Syk-Kinase Inhibitors MT-SYK-03 and MT-SYK-322 in Cellular Models of Autoimmunity and Cancer. Mendeleev Communications 22:6, pages 287-289.
Crossref
Rajinder Singh, Esteban S. Masuda & Donald G. Payan. (2012) Discovery and Development of Spleen Tyrosine Kinase (SYK) Inhibitors. Journal of Medicinal Chemistry 55:8, pages 3614-3643.
Crossref
Justin Hall, Ann Aulabaugh, Francis Rajamohan, Shenping Liu, Neelu Kaila, Zhao-Kui Wan, Mark Ryan, Rachelle Magyar & Xiayang Qiu. (2012) Biophysical and Mechanistic Insights into Novel Allosteric Inhibitor of Spleen Tyrosine Kinase. Journal of Biological Chemistry 287:10, pages 7717-7727.
Crossref
Xiaomin Wang, Mirek Mychajlowycz, Christine Lau, Carlos Gutierrez, Jeremy A. Scott & Chung-Wai Chow. (2012) Spleen Tyrosine Kinase Mediates BEAS-2B Cell Migration and Proliferation and Human Rhinovirus-Induced Expression of Vascular Endothelial Growth Factor and Interleukin-8. Journal of Pharmacology and Experimental Therapeutics 340:2, pages 277-285.
Crossref
A. J. Ratcliffe. 2011. Kinase Drug Discovery. Kinase Drug Discovery 218 243 .
Eva Wex, Thierry Bouyssou, Matthias J. Duechs, Klaus J. Erb, Florian Gantner, Michael P. Sanderson, Andreas Schnapp, Birgit E. Stierstorfer & Lutz Wollin. (2011) Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivo. European Journal of Immunology 41:11, pages 3208-3218.
Crossref
John Liddle, Francis L. Atkinson, Michael D. Barker, Paul S. Carter, Neil R. Curtis, Rob P. Davis, Clement Douault, Marion C. Dickson, Dorothy Elwes, Neil S. Garton, Matthew Gray, Thomas G. Hayhow, Clare I. Hobbs, Emma Jones, Stuart Leach, Karen Leavens, Huw D. Lewis, Scott McCleary, Margarete Neu, Vipulkumar K. Patel, Alex G.S. Preston, Cesar Ramirez-Molina, Tracy J. Shipley, Philip A. Skone, Nick Smithers, Donald O. Somers, Ann L. Walker, Robert J. Watson & Gordon G. Weingarten. (2011) Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorganic & Medicinal Chemistry Letters 21:20, pages 6188-6194.
Crossref
. (2011) Current World Literature. Current Opinion in Endocrinology, Diabetes & Obesity 18:1, pages 83-98.
Crossref
Omer Nuri PamukPeter H. LapchakPoonam RaniPolly Pine, Jurandir J. Dalle Lucca & George C. Tsokos. (2010) Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion. American Journal of Physiology-Gastrointestinal and Liver Physiology 299:2, pages G391-G399.
Crossref

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